류마티스 관절염에 대한 한약의 면역학적 연구동향

최도영,이재동,백용현,이송실,유명철,한정수,양형인,박상도,유미현,박은경,박동석,Choi, Do-young,Lee, Jae-dong,Back, Yong-hyeon,Lee, Song-shil,Yoo, Myung-chul,Han, Chung-soo,Yang, Hyung-in,Park, Sang-do,Ryu, Mi-hyun,Park, Eun-kyung,Park, 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4

Objective : Rheumatoid arthritis is an autoimmune disease that pathogenesis is not fully understood and one of the most intractable musculoskeletal diseases. The concern in the immunopathogenesis of rheumatoid arthritis has been increased since 1980's and many immunotherapeutic agents including disease-modifying antirheumatic drugs (DMARDs) were developed and became the mainstay of treatment of rheumatoid arthritis. However, the cure of the disease has hardly been achieved. In oriental medicine, rheumatoid arthritis is related to Bi-Zheng(痺證), that presents pain, swelling, andlor loss of joint function as major clinical manifestations, and also known to be deeply involved in suppression of immune function related to weakness of Jung-Ki(正氣). The herbal medicine, empirically used, could be a potential resource of development of new immunotherapeutic agents for rheumatoid arthritis. Methods : We developed a search strategy using terms to include "rheumatoid arthritis and herbal medicine" combined with "Chinese medicine" and/or "Oriental medicine". The search was focused on experimental studies of herbal medicine (January 1999 to May 2004), which is known to have effects on immune function of patients with rheumatoid arthritis. Computerized search used Internet databases including KISS and RISS4U (Korea), CNKI (China), MOMJ (Main Oriental Medicine Journal, Japan), and PubMed. The articles were selected from journals of universities or major research institutes. Results : The literature search for experimental studies on effects of herbal medicine on immunity of rheumatoid arthritis retrieved a total of 21 articles (Korea; 8, China ; 12, Japan ; 1). Of 21 articles, 10 were related to single-drug formula, 2 to drug interaction, and 9 to multi-drug formula. Single-drug formula was mainly used for aqua-acupuncture and researches on active components. Studies of drug interaction emphasized harmony of Ki-Hyul(氣血) and balance of Han-Yeul(寒熱). Multi-drug regimen was mainly found among formulas for Bo-Ki-Hyul(補氣血) and Bo-Sin(補腎). Conclusion : Studies on rheumatoid arthritis were performed both in vitro and in vivo in vitro study, LPS-stimulated splenocytes and synoviocytes were treated with herbal medicine, resulting in proliferation and activation of immune cells and suppression of cytokine activities in vivo study CIA animal model demonstrated that herbal medicine decreased antibody production and improved function of immune cells. In cellular and molecular study herbal medicine showed profound effects on the level of mRNA expression of certain cytokines related to immune function. This study revealed that herbal medicine has significant immune modulatory action and could be used for recovery of immune dysfunction of rheumatoid arthritis patients.

베트남의 축산식품 소비현황 및 수출전략

최도영,Choi, Do-Young 한국축산식품학회 2013 축산식품과학과 산업 Vol.2 No.3

이산선택모형을 이용한 승용차 등급선택모형 추정

최도영(Do-Young Choi),이양섭(Yang Seob Lee) 에너지경제연구원 2005 에너지경제연구 Vol.4 No.2

The purpose of this study is to specify the passenger vehicle choice model and estimate the marginal effects of household-specific characteristics on the probabilities of choosing vehicle classes. The data and information for this study were collected in a survey of Korea Energy Economics Institute conducted for about 1,800 households in 2002. The household-specific characteristics variables are household income class, age, gender, driving career of drivers, annual kilometers traveled, registration type of vehicles and the number of cars held. As the dependent variable of the choice model indicates the ordinal classes by engine size, the ordered probit and logit models are applicable for our study. The marginal effects of most explanatory variables on the vehicle class choice probabilities show acceptable signs and appear to be statistically significant at the test size of 5%.

컴퓨터 프로그래밍 실습을 위한 모바일 학습 시스템의 설계 및 구현

최도영(Do Young Choi),정찬선(Chan Seon Jeong),손진곤(Jin Gon Shon) 한국정보과학회 2006 한국정보과학회 학술발표논문집 Vol.33 No.2A

컴퓨터 프로그래밍 실습의 공간적, 시간적 제약 및 프로그램 구입과 관련한 경제적 제약을 극복하기 위해 인터넷 웹 환경에 기반을 둔 학습 시스템에 대한 연구가 지금까지 진행되어 왔다. 본 논문에서는 기존의 웹 기반 학습 시스템을 이동기기를 학습매체로 하는 모바일 학습 환경으로 확장 적용하였으며, 이를 통하여 장소와 시간에 더 독립적인 컴퓨터 프로그래밍 학습 환경을 가능하게 할 수 있다. 본 논문에서 제안하는 모바일 학습 시스템은 PDA를 이용하여 컴퓨터 프로그래밍 실습을 할 수 있도록 설계되고 구현되었으며, 사용자의 PDA에 별도의 클라이언트 프로그램이 필요 없이 브라우저 상에서 바로 실행할 수 있도록 설계 및 구현하였다. 또한, 다양한 PDA 디스플레이 크기를 고려하여, 사전에 여러 규격의 디스플레이 템플릿을 보유하여, 사용자는 자신의 PDA 크기에 적합한 디스플레이를 선택할 수 있다.

불확실성을 수반한 경영의사결정 시 긍정-부정감성이 비즈니스 문제해결 창의성에 미치는 효과에 관한 뉴로사이언스 기반의 실증 연구

최도영(Do Young Choi),이건창(Kun Chang Lee) 한국경영학회 2016 經營學硏究 Vol.45 No.4

만성두통환자에게 적용한 비약물적 치료가 통증행동에 미치는 영향

최도영 ( Do Young Choi ),임사비나 ( Sa Bi Na Lim ),차남현 ( Nam Hyun Cha ),김건식 ( Keon Sik Kim ),이재동 ( Jae Dong Lee ),김수영 ( Su Young Kim ),이윤호 ( Yun Ho Lee ),이두익 ( Doo Ik Lee ) 대한경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.1

Objectives: This study is a random-controlled post-design for confirmation of headache degree, quality of life, and satisfaction to therapeutical effect on chronic headache adults after management of non-medicinal treatment (acupuncture therapy and stellate ganglion block therapy). Methods: 51 clinical experiment participants were gathered arid through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified in to two groups, acupuncture group (AT group, r=28) and stellate ganglion block group (SGB group, n=23). Treatment was applied 2 times a weeks for 4 weeks. The effects of both groups were analyzed using VAS scores, BPI (Brief Pain Inventory) and the satisfaction degree to the therapy. Results: 1. The recognized score of the headache of AT group and SGB group was reduced indicating the degree of the headache was released. 2. The recognition at damage to the quality of life was reduced post therapy of AT group and SGB group, in which general activity, mood, enjoyment of life, personal relationship, and sleeping showed significant improvement of life quality. 3. The satisfaction degree to the therapy showed lower score than expectation to it in AT group and SGB group, however, it was not significant. Conclusions: The results showed that the four-week non-medicinal treatment (AT and SGB) in chronic headache patients was effective for reducing headache and releasing its damage in daily life, however, no difference in superiority was found. Therefore, non-medicinal treatment (AT therapy and SGB) could be utilized in chronic headache patients.

컬러 매트릭스 모델링에 의한 영상 인쇄물 위변조 검출 기법

최도영(Do-young Choi),김진수(Jin-soo Kim) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.10

2차원 바코드인 QR코드는 사진, 동영상, 지도, 명함 등 다양한 정보를 더 편리하게 담아낼 수 있다. 현재 스마트 폰의 보급으로 QR코드는 다양한 인쇄 매체에 인쇄하여 연결된 인터넷 정보를 손쉽게 검색하는 수단으로 활용되고 있다. 그러나 QR코드는 정보보안이 용이하지 않아, 결재시스템에 활용하기에는 매우 제한적이다. 본 논문에서는 기존의 QR코드와 컬러 도안을 결합하여 새로운 코드를 설계하여, 제품 인증 시스템이 요구되는 분야에 활용할 수 있는 방안을 제안한다. 제안한 방법은 CMYK 컬러 모델로 인쇄된 정품은 전자기기에서 RGB 컬러 모델로 캡처되며, 이때 컬러의 왜곡이 발생하게 되는데, 이를 컬러 매트릭스를 통해 측정하고, 통계 특성에 기초한 정품 인증시스템을 제안한다. 다양한 종류의 컬러 코드를 통해 본 논문에서 제안한 방법이 제품 인증 시스템에 효과적으로 사용될 수 있음을 보인다. 2-dimensional barcode, QR code has been used for containing various information such as image, video, map, and business cards. Currently, a smartphone is used as a QR code scanner, displaying the code and converting it to a standard URL for a website. However, QR codes are not very common in encrypted application and so have a few applications. This paper proposes a new color-code, which integrates the conventional QR code and color design, and can be effectively used in some product certification system. The proposed method exploits the fact that genuine code is produced by CMYK color model, but the counterfeit is captured by RGB color model and during this process, color information of the code is changed. This paper introduces the color matrix model to measure the distortion between genuine code and counterfeit code. By investigating the statistical characteristics of color matrix, an effective detection of print image forgeries are designed. Various experiments with color codes show that the proposed system can be effectively used in product certification systems.

혐기성 소화 가스로부터 황화합물의 제거

최도영 ( Do Young Choi ),장성철 ( Seong Cheol Jang ),안병성 ( Byoung Sung Ahn ),최대기 ( Dae Ki Choi ) 한국공업화학회 2008 공업화학 Vol.19 No.1

이성적 자극과 감성적 자극에 따른 인지처리 기능 및 재인효과 차이에 관한 연구

최도영(Do Young Choi),이건창(Kun Chang Lee) 한국인지과학회 2016 인지과학 Vol.27 No.1

본 논문은 이성적 정보와 감성적 정보에 대해 어떠한 정보 유형이 광고소구의 관점에서 더 효과적인가를 반응시간과 재인 측면에서 검증함과 동시에, 정보의 유형별로 뇌 기능 상의 관계를 fMRI를 이용하여 분석하여 정보유형별 인지처리 상의 차이를 설명하고자 하였다. 이를 위해 두 가지 실험을 수행하였는데, 첫 번째 실험은 두 종류의 자극 유형에 해당하는 광고카피 - 이성에 소구하는 자극과 감성에 소구하는 자극 - 에 대해 어떠한 유형에 해당하는지를 피실험자가 결정하게 하는 과제를 수행하게 하였으며, 자극의 제시로부터 소구 형태를 판단하기까지 소요되는 반응시간의 측정을 통해 각 자극유형별 효과를 측정하고, 이 때 활성화되는 뇌 영역을 분석하여 인지처리 상의 기능을 비교하였다. 두번째 실험은 자극 유형별로 재인효과를 측정하고, 이 때 활성화되는 뇌 기능 영역 간의 차이를 분석하여 재인 시의 인지처리 상의 기능을 비교하였다. 이러한 실험연구를 통한 결과를 요약하면 다음과 같다. 첫째, 반응시간의 측면에서 감성적 자극에 대한 반응시간이 이성적 자극에 대한 반응시간보다 빠르게 이루어 졌고, 재인 측면에서는 이성적 자극에 대한 기억의 효과가 감성적 자극에 대한 기억보다 높게 나타났다. 둘째, fMRI를 이용한 뇌 기능상의 특징을 보면 이성적 자극의 경우 상대적으로 활성화의 수준이 높은 뇌 영역들은 행동 조정 혹은 작업 기억과 연계된 곳이었다. 반면, 감성적 자극의 경우 상대적으로 활성화의 수준이 높은 뇌 영역은 언어처리와 연계된 곳이었다. 본 연구를 통하여 이성적 자극과 감성적 자극의 소구 효과가 다름을 확인할 수 있었고, 각 소구 형태별로 뇌 기능상의 인지적 차이를 확인할 수 있었다. This research investigated that participants’ response time and recognition in the decision-making situation would vary according to either rational or emotional stimuli and analyzed how brain functions are related to each type of stimuli by means of fMRI. We tried to address the difference of cognitive processing between rational stimuli and emotional stimuli in the perspective of information processing theory. In order to achieve the research purpose above, we conducted two kinds of experiment studies. In study 1, subjects conducted decision-making task which selected which kind of information type the stimuli was after stimuli - rational stimuli or emotional stimuli - was randomly seen during experiment. During this experiment, we investigated the effect of each stimuli by measuring the duration from the onset time at which stimuli was shown to the response time at which subjects conducted decision-making. Furthermore, we compared the brain functions by finding out what kinds of brain areas were activated during the decision-making task. In study 2, subjects conducted recognition task at which subjects made a decision whether the stimuli was sees in the previous experiment or not. During the second experiment, we investigated the recognition effect by measuring the memory for each stimuli type. Moreover, we compared the cognitive processes during recognition by analyzing the differences of brain area functions. The results of two experiments above were as following. Firstly, regarding the response time as the effect of stimuli, we found that the effect of emotional stimuli was higher than that of rational stimuli. And regarding the recognition as the effect of stimuli, it was found that the effect of rational stimuli was higher than that of emotional stimuli. Secondly, the explanation about the characteristics of cognitive processes with the result of behavioral response by analyzing brain functions was as following. First of all, regarding the decision-making task which conducted for analyzing the effect of response time, the relatively high activated brain areas of rational stimuli were related with the functions of movement control or working memory, and the relatively high activated brain areas of emotional stimuli were connected with the functions of lingual processing.

다중 비교척도에 의한 영상 인쇄물 위조 감식 시스템

최도영(Do-young Choi),김진수(Jin-soo Kim) 한국산업정보학회 2018 한국산업정보학회논문지 Vol.23 No.4

현재 정품인증을 위한 인쇄물이 다양한 제품에 활용되고 있지만, 고해상도로 정밀하게 재현한 위조 인쇄물이 불법적으로 끊임없이 유통되고 있는 실정이다. 본 논문에서는 정품 인쇄물과 위조 인쇄물을 스마트 폰으로 손쉽게 감식할 수 있는 효율적인 기법을 제시한다. 즉, 제안한 방법은 서버에 원본의 이미지를 저장하며, 이 원본의 이미지에 대한 다중 척도를 특징점으로 추출하여 저장하고, 이 다중 척도에 기초하여 위조 인쇄물이 효과적으로 감식될 수 있는 방법으로 설계되어진다. 다양한 실험을 통하여 제안한 방식은 단일 척도에 의한 위조품 감별 방식에 비해 인식률을 높이고, 오인식률을 낮추는 방식으로 성능이 개선됨을 보인다. 또한, 제안한 방식은 여러 종류의 디자인에 대해 안정적으로 우수한 성능을 보임을 확인한다. Currently, a large amount of printed matter associated with code authentication method are diffused widely, however, they have been reproduced with great precision and distributed successively in illegal ways. In this paper, we propose an efficient code authentication method which classifies authentic or counterfeit with smart-phone, effectively. The proposed method stores original image code in the server side and then extracts multiple comparison measures describing the original image. Based on these multiple measures, a code authentication algorithm is designed in such a way that counterfeit printed images may be effectively classified and then the recognition rate may be highly improved. Through real experiments, it is shown that the proposed method can improve the recognition rate greatly and lower the mis-recognition rate, compared with single measure method.