난소의 태생암종 (Embryonal Carcinoma) 1 예

최광엽,조영아,이금주,장은경 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.6

저자들은 17세 여성에서 발생한 S상 결장 및 우측 난소로 전이된 좌측 난소의 embryonal carcinoma 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Embryonal carcinoma occurs rarely in the ovary and is morphologically identical to embryonal carcinoma of the testis, primarily affecting children and young women. This tumor contains hCG and AFP. The prognosis is poor and optimal therapy is not established yet. We had experienced a case of embryonal carcinoma of the ovary in 17 years old woman. We report this case with a brief review of the literatures.

일반연제 발표 : 종양학 1 ; 자궁경부암 414예의 임상적 분석 및 치료성적

최도영,최광엽,고용석,강정운,신면우 대한산부인과학회 1993 대한산부인과학회 학술대회 Vol.72 No.-

난소의 악성 혼합성 뮬러리안종양 2 예

최유덕,최광엽,조영아,박남규,정기종 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.8

Malignant mixed mullerian tumors(MMMT) of the ovary represent only 1% of the malignant ovarian tumors. They are found in postmenopausal and nulliparous women. Histologically, the tumors consist of pluripotent epithelial and variable mesenchymal derivatives of mesoderm. The tumors are usually advanced when diagnosed and the clinical course is very fatal. We experienced 2 cases of MMMT of the ovary and report with a brief review of literature.

난소섬유육종 1 례

최유덕,최광엽,방보영,권현정,추욱진 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5

Fibromatous tumors of the ovary are considered to originate from specialized ovarian stromal cells and account for approximately 4% of all ovarian neoplasms. Most ovarian fibromatous tumors are benign, but infrequently there are histologically malignant appearances. Malignant fibromatous tumor can be categorized into two separate types of tumors relating to prognosis, cellular fibroma and fibrosarcoma. The cellular fibroma has one to three mitotic counts per 10 high power fields(HPF). Unless an adhesion or rupture appears on this tumor, recurrence should not happen after operation. Furthermore, where the mitotic count per 10 HPF is over four, it is classified as a very bad fibrosarcoma case in terms of prognosis. We have met a case of large ovarian fibrosarcoma with has ten mitotic counts per 10 HPF. We hereby report this case with the brief review of literatures.

자궁경부암 414 례의 임상적 분석 및 치료성적

신면우,김승철,최광엽,박정온,고용석,최도형 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.5

중앙 길병원 산부인과에서는 1989년 3월부터 1993년 3월까지 중앙길병원 산부인과와 치료방사선과에서 자궁경부암으로 진단 및 치료받은 414예의 임상양상과 임상병기별 생존율을 구하여 다음과 같은 결과를 얻었다. 1. 년도별 환자분포는 1989년 67명, 1990년에 88명, 1991년에 90명, 1992년에 139명, 1993년 3월까지는 30명이었다. 2. 연령별 분포는 50-59세군, 40-40세군, 30-39세군의 순서로 많았으나 각각 전체 환자의 25.6%, 24.5%, 24.2%를 차지하여 50대, 40대, 30대가 거의 유사한 발생빈도를 보였다. 3. 임상병기별 분포는 I기가 50.0%로 가장 높은 빈돌ㄹ 보였으며, II기: 24.9%, 0기: 13.7%, III기: 8.5%, IV기: 2.9%였다. 4. 조직병리학적 분포는 편평상피 세포암이 96.6%, 선암이 2.9%, 선편평상피 세포암이 0.5%였다. 5. 임파절전이는 Ia기에서는 3.7%, Ib기에서는 16.9%, IIa기에서는 19.6%였다. 6. 종괴의 크기를 2 cm이하, 2-4 cm, 4 cm이상으로 하였을 때 Ib기인 경우 골반임파절 전이빈도는 각각 10.5%, 20.5%, 35.5%이고, IIa기인 경우에는 각각 10.0%, 14.3%, 62.5%로 종괴의 크기가 클수록 임파절 전이 빈도도 증가하고 있다. 7. 생명표법(life table method)에 의한 침윤성 자궁경부암 I기의 52개월 생존율 1) 대상환자는 Ia기 27예, Ib기 180예였다. 2) 52개월 생존율은 Ia기 100%, Ib기 91.7%였다. 8. Kaplan-Meier method에 의한 침윤성 자궁경부암 IIa기, IIb기, III기의 생존율 1) 대상환자는 IIa기 58예, IIb기 45예, III기 35예였다. 2) IIa기의 45개월 생존율은 86.7%, IIb기의 49개월 생존율은 58.9%, III기의 52개월 생존율은 42.9%였다. 414 cases of uterine cervical cancer, diagnosed and treated from march 1989 to march 1993, were evaluated at Jung-Ang Gils general hospital, Incheon, Korea. The purpose of this study was to analyze the clinical profile and survival rate of cervical cancer. The number of patients were 67 cases in 1989, 88 cases in 1990, 90 cases in 1991, 139 cases in 1992 and 30 cases in 1993. The age distribution of patients were similar in the age group of 50s (25.6%), 40s (24.5%) and 30s (24.2%). The distriution of patients by the clinical stage were as follows: Stage 0, 57 cases (13.7%); Stage 1,207 cases (50.0%); Stage II, 103 cases (24.9%); Stage III, 35 cases (8.5%); and Stage IV, 12 cases (2.9%). The histopathologic types were as follows:Squamous cell carcinoma was 96.6%, adenocarcinoma was 2.9% and adenosquamous cell carcinoma was 0.5%. The frequency of pelvic lymph node metastasis was 3.7% in stage Ia, 16.9% in stage Ib and 19.6% in stage IIa. The incidence of pelvic node metastasis correlated with the size of the tumor, in stage Ib, was 10.5% for tumors less than 2 cm in diageter, 20.5% for tumors 2 to 4 cm, and 35.7% for tumors up to 4 cm. In stage IIa, the incidence was 10.0% for tumors less than 2 cm, 14.3% for tumors 2 to 4 cm, and 62.5% for tumors up to 4 cm. We have evaluated the survival rate by life table method for stage Ia and Ib, and by Kaplan-Meier method for stage IIa, Iib and III$gt; The results were as follows; 100% 52 month survival rate for stage Ia; 91.7% 52 month survival for stage Ib; 96.7% 45 month survival for stage IIa; 58.9% 49 month survival for stage IIb; 42.9% 52 month survival for stage III.

저등급 자궁내막 간질성육종 1 례

김정숙,최유덕,최광엽,박남규,정기종 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10

A case of low grade endometrial stromal sracoma in a 45 year old woman is presented. It shows occasional local recurrence, which might arise from endometrial stroma, from adenomyosis, and rarely from endometriosis. It was revealed to be a low grade endometrial stromal sarcoma, showing metastatic ovarian invasion. The clinicopathologic findings of stromal sarcoma was described briefly.

일반연제 발표 : 비파열 자궁외임신에 있어서 Methotrexate 근주의 치료 효과

최유덕,김승철,박정온,최광엽,김광준 대한산부인과학회 1994 대한산부인과학회 학술대회 Vol.73 No.-

다발성 선천성기형을 동반한 단안아 1 예

최유덕,박지홍,김승철,박정은,최광엽 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.3

저자들은 인천 중앙길병원 산부인과에서 경험한 34세의 경산부에서 자궁내사된 태아를 자궁절개술로 분만후 단안증 및 제헤르니아와 다지증이 동반된 태아로 판명된 1례를 보고하며, 그 분류 및 발생원인에 관하여 문헌적 고찰과 함께 보고하는 바이다. Cyclopia is a rare congenital fetal occular anomaly in which the eyes are fused together and located in a single orbit. It is commonly associated with hydrocephalus, anencephalus, polydactyly, hermaphroditism, hernia, and etc. Recently, we have experienced a case of cyclopia with omphalocele and polydactyly observed in 34-year-old multiparous woman, and report it with a brief reivew of related literatures.

제 73 차 춘계학술대회 : 일반연제발표 ; 비파열 자궁외임신에 있어서 Methotrexate 근주의 치료효과

최유덕,김승철,박정온,최광엽,김광준 대한산부인과학회 1993 춘계학술대회 Vol.- No.-

난소 상피성종양에서 원발성과 전이성을 감별 진단하기 위한 면역조직화학적 연구

최유덕,이미자,전호종,최광엽,방보영,권현정,추욱진,김휴 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5

To determine the distinction of primary ovarian carcinoma from metastatic ovarian carcinoma, the author studied total 40 cases of malignant tumors(13 primary ovarian carcinomas: 7 serous, 4 mucinous, and 2 endometrioid, 7 metastatic ovarian adenocarcinomas, 10 gastric adenocarcinomas and 10 colonic adenocarcinomas) using primary antibody to CEA, CK7, CK20 and CK18. The results were summerised as follows: The expression of CK7 was demonstrated in all(7) serous and 3 out of 4 mucinous adenocarcinoma, and 1 out of 10 each gastric and colonic adenocarcinoma. The CK20 positivity was seen in 4 out of 10 cases of colonic adenocarcinoma and 3 out of 7 cases of metastatic adenocarcinoma. All primary ovarian carcinoma and gastric adenocarcinoma were negative for CK20 except for focal positivity in only 1 ovarian mucinous adenocarcinoma. All types of serous and endometrioid adenocarcinoma were negative for CEA. But, the vast majority of mucinous adenocarcinoma, metastatic adenocarcinoma, gastric and colonic adenocarcinoma were positive for CEA. The CK18 may not be helpful to differentiate the primay or metastatic carcinoma because all cases examined were positive for CK18 except for 1 ovarian mucinous carcinoma. Immunostainning for CK7 may be helpful on differential diagnosis of primary and metastatic ovarian carcinoma, especially mucinous adenocarcinoma and metastatic gastric and colonic adenocarcinoma. The CK20 may be a useful marker for differential diagosis in primary and metastatic ovarian carcinomas. The CEA may be of value on differential diagnosis of mucinous and nonmucinous(serous and endomerioid) ovarian carcinomas, and metastatic colonic adenocarcinoma and endometrioid carcinoma. In conclusion, immunohistochemical study for CEA, CK7, and CK20 may be helpful in differential diagnosis between primary and metastatic ovarian carcinoma.