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이여주 ( Yeo Joo Lee ),초가기 ( Jia Qi Chu ),이서용 ( Seo Yong Lee ),김수미 ( Su Mi Kim ),이광녕 ( Kwang Nyeong Lee ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ),남석현 ( Seok Hyun Nam ),박종현 ( Jong H 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.2
Foot-and-mouth disease (FMD) is one of the most infectious diseases affecting cloven-hoofed animals including cattle, sheep, goats, and pigs. Seven serotypes of foot-and-mouth disease virus with multiple subtypes within each serotype have been identified until now. In particular, it has been demonstrated that the outbreak of the serotype Asia1 reported from China, Mongolia and North Korea since 2005 is mostly classified into genetic group V. Though it has been recommended that Asia1 Shamir strain can be used as a high priority vaccine by World References Laboratory for FMD, the complete nucleotide sequences of the strain has not yet been determined. In this study, to be prepared for Asia1 type viruses that may be brought into Korea, the complete genome sequence of this vaccine strain Asia1 Shamir including its 5` and 3` non-coding region was identified.
이여주 ( Yeo Joo Lee ),초가기 ( Jia Qi Chu ),이서용 ( Seo Yong Lee ),김수미 ( Su Mi Kim ),이광녕 ( Kwang Nyeong Lee ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ),남석현 ( Seok Hyun Nam ),박종현 ( Jong H 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.2
Asia1/Shamir that has been recommended by World Reference Laboratory for foot-and-mouth disease (FMD) is used as a vaccine strain, and is being prepared in many countries including Korea. Although it is assumed that vaccine strain Asia1/Shamir has a wide antigenicity, sufficient molecular biological analysis has not been accomplished yet. Complete genome sequence analysis showed that the region with the most severe variations was 1D region of structural protein-coding sequence; particularly amino acid 141~157 residues in 1D region RGD sites for binding to susceptible cells. In addition, five amino acids in 1D region were identified as characteristic sites that are different from other known Asia1 viruses. Asia1/Shamir strain was shown to be genetically similar to group VI that had occurred in the Middle East, but showed low level of genetic similarity to the group V viruses that had occurred in the Southeast Asia and China. It is considered that, if these viruses, group I and II including group V are introduced into Korea, care would be paid in case of inoculating the vaccine strain Shamir available in Korea.