구연 : 혈액종양 ; 폐암환자의 새로운 특징 -국립암센터에 내원한 환자를 중심으로-

천종호,이홍기,윤성민,이대호,한지연,조재일,이진수 대한내과학회 2002 대한내과학회 추계학술대회 Vol.63 No.-

Impact of Trastuzumab on Ipsilateral Breast Tumor Recurrence for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer after Breast-Conserving Surgery

천종호,원지영,정지광,김홍규,한원식,이한별 한국유방암학회 2021 Journal of breast cancer Vol.24 No.3

Purpose: Trastuzumab is effective in early and advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, few studies have reported the effect of trastuzumab on ipsilateral breast tumor recurrence (IBTR), whose incidence is higher in the HER2-positive subtype than in other subtypes. Methods: We retrospectively investigated 959 patients who underwent breast-conserving surgery (BCS), chemotherapy, and radiotherapy for HER2-positive breast cancer between 2000 and 2017. IBTR was compared between the patients who received neoadjuvant or adjuvant trastuzumab (Tmab group) for a total duration of 1 year and those who received no trastuzumab (N-Tmab group). Results: Propensity score matching designated 426 and 142 patients in the Tmab and N-Tmab groups, respectively. The median follow-up period for all patients after matching was 73.79 months. The IBTR-free survival rate was significantly higher in the Tmab group than in the N-Tmab group (10-year IBTR-free survival rate, 92.9% vs. 87.3%; p = 0.002). The multivariate analysis showed a significant association between the N-Tmab and Tmab group (hazard ratio, 3.03; 95% confidence interval, 1.07–8.59) and IBTR in addition to close or positive resection margin and hormone receptor (HR) positivity. The subgroup analysis showed that adjuvant treatment with trastuzumab significantly reduced IBTR among the patients with HR-negative or lymph node-negative breast cancer. Conclusion: Significantly reduced IBTR after BCS was observed in the patients who received 1 year of adjuvant/neoadjuvant trastuzumab treatment for HER2-positive breast cancer

인생 고비에서 운명처럼 만난 천사

천종호,지은아(그림) 샘터사 2020 월간 샘터 Vol.608 No.-

취소소송에서의 제3자의 원고적격(하)

천종호 한국지방자치연구소 2002 自治硏究 Vol.12 No.1·2

행복한 가정, 행복한 자녀

천종호 가정과삶의질학회 2013 가정과삶의질학회 학술발표대회 자료집 Vol.2013 No.11

Residual Risk of Ipsilateral Tumor Recurrence in Patients Who Achieved Clear Lumpectomy Margins After Repeated Resection

천종호,김홍규,이한별,한원식,문형곤 한국유방암학회 2023 Journal of breast cancer Vol.26 No.6

Purpose: Patients with breast cancer with positive lumpectomy margins have a two-fold increased risk of ipsilateral breast tumor recurrence (IBTR). This can be the result of either technically incomplete resection or the biological characteristics of the tumor that lead to a positive margin. We hypothesized that if achieving negative margins by re-excision nullifies the IBTR risk, then the increased risk is mainly attributed to the technical incompleteness of the initial surgeries. Thus, we investigated IBTR rates in patients with breast cancer who achieved clear margins after re-excision. Methods: We retrospectively reviewed patients who underwent breast lumpectomy for invasive breast cancer between 2004 and 2018 at a single institution, and investigated IBTR events. Results: Among 5,598 patients, 793 achieved clear margins after re-excision of their initial positive margins. During the median follow-up period of 76.4 months, 121 (2.2%) patients experienced IBTR. Patients who underwent re-excision to achieve negative margin experienced significantly higher IBTR rates compared to those achieving clear margin at first lumpectomy (10-year IBTR rate: 5.3% vs. 2.6% [25 vs. 84 events]; unadjusted p = 0.031, hazard ratio, 1.61, 95% confidence interval [CI], 1.04–2.48; adjusted p = 0.030, hazard ratio, 1.69, 95% CI, 1.05–2.72). This difference was more evident in patients aged < 50 years and those with delayed IBTR. Additionally, no statistically significant differences were observed in the spatial distribution of IBTR locations. Conclusion: Patients who underwent re-excision for initial positive margins had an increased risk of IBTR, even after achieving a final negative margin, compared to patients with negative margins initially. This increased risk of IBTR is mostly observed in young patients and delayed cases.

취소소송에서의 제3자의 원고적격 (상)

천종호 한국지방자치연구소 2001 自治硏究 Vol.11 No.1·2

Comparison of Quality of Life and Cosmetic Outcome of Latissimus Dorsi Mini-Flap With Breast Conservation Surgery Without Reconstruction

김장일,천종호,정지광,김유미,임창진,한이레,전숙영,홍기용,이한별,한원식 한국유방암학회 2023 Journal of breast cancer Vol.26 No.4

Purpose: Latissimus dorsi mini-flap (LDMF) reconstruction after breast-conserving surgery (BCS) is a useful volume replacement technique when a large tumor is located in the upper or outer portion of the breast. However, few studies have reported the impact of LDMF on patients’ quality of life (QoL) and cosmesis compared with conventional BCS. Methods: We identified patients who underwent BCS with or without LDMF between 2010 and 2020 at a single center. At least 1 year after surgery, we prospectively administered the BREAST-Q to assess QoL and obtained the patients’ breast photographs. The cosmetic outcome was assessed using four panels composed of physicians and the BCCT.core software. Results: A total of 120 patients were enrolled, of whom 62 and 58 underwent LDMF or BCS only, respectively. The LDMF group had significantly larger tumors, shorter nipple-to-tumor distances in preoperative examinations, and larger resected breast volumes than did the BCS-only group (p < 0.001). The questionnaires revealed that QoL was poorer in the LDMF group, particularly in terms of the physical well-being score (40.9 vs. 20.1, p < 0.001). Notably, the level of patients’ cosmetic satisfaction with their breasts was comparable, and the cosmetic evaluation was assessed by panels and the BCCT.core software showed no differences between the groups. Conclusion: Our results showed that cosmetic outcomes of performing LDMF are comparable to those of BCS alone while having the advantage of resecting larger volumes of breast tissue. Therefore, for those who strongly wish to preserve the cosmesis of their breasts, LDMF can be considered a favorable surgical option after the patient is oriented toward the potential for physical dysfunction after surgery.

Ipsilateral Lymphadenopathy After COVID-19 Vaccination in Patients With Newly Diagnosed Breast Cancer

하수민,천종호,이수현,김수연,박아름,김연수,연희라,이유경,조나리야,문우경,장정민 한국유방암학회 2022 Journal of breast cancer Vol.25 No.2

This study aimed to evaluate the imaging and pathological findings in axillary lymph nodes in patients with breast cancer who received concurrent ipsilateral coronavirus disease 2019 (COVID-19) vaccination. Of the 19 women with breast cancer who received concurrent COVID-19 vaccination shot in the arm ipsilateral to breast cancer, axillary lymphadenopathy was observed in 84.2% (16 of 19) of patients on ultrasound (US) and 71.4% (10 of 14) of patients on magnetic resonance imaging (MRI), and 21.0% (4 of 19) of patients were diagnosed with metastasis. Abnormal US and MRI findings of cortical thickening, effacement of the fatty hilum, round shape, and asymmetry in the number or size relative to the contralateral side were noted in more than half of the non-metastatic and metastatic lymph nodes; however, statistical significance was not noted. Axillary lymphadenopathy is commonly observed in patients with breast cancer who receive concurrent ipsilateral COVID-19 vaccination without specific differential imaging features. Thus, understanding the limitations of axillary imaging and cautious interpretation is necessary to avoid overestimation or underestimation of the axillary disease burden.

전대장 내시경 검사 505예에 대한 임상적 고찰

조문숙,김형준,김동규,원정일,천종호,신원창,이진호,최원충,김관엽 인제대학교 1996 仁濟醫學 Vol.17 No.4

대장질환은 지역과 인종에 따라 다소 차이가 있지만 과거에 비해 진단기술의 발달과 더불어 증가하고 있고, 특히 우리나라에서는 대장암의 발생이 현저히 늘고 있다. 이에 필연적인 검사 또한 기기의 발달 및 삽입기술의 향상, 대장암을 조기에 발견할 수 있는 장점으로 인해 많이 이용되고 있다. 저자들은 1990년 3월부터 1996년 2월까지 인제대학교 의과대학 부속 상계백병원에 입원 및 외래를 통하여 시행한 대장내시경 검사 505 예를 후향적 의부기록 분석을 통하여 다음과 같은 결과를 얻었다. 1.30대와 40대가 전체의 38.4%로 가장 많았고 다음으로 60대가 18.2%로 많았다. 남녀비는 1.01:1이었다. 2.환자의 주소는 복통 36.5%, 혈변 18.0%, 설사 17.2%, 복부팽만감 7.5%, 배변습관의 변화 6.7% 순이었다. 3.대장질환은 대장염 26.1%, 대장암 14.8%, 용종 8.3%, 치핵 4.3%. 정상 38.8%였다. 4.용종은 42예로 18예(39.0%)에서 내시경으로 절제하였고 조직검사 결과 관상 선종이 54%로 가장 많았고 2예에서 용종내에 암이 내재되어 있었다. 5.전대장 삽입의 성공률은 대상환자의 95.6%, 실패원인은 불충분한 대장 정결 및 통증이었다. In this report, we analysed the clinical findings of 505 cases that undertook total colonoscopic examination from March, 1990 to March, 1996. The results were followings ; 1) The most common age groups were 30's and 40's which were 38.4% of tonal patients. The sex ratio of male to female was close to one. 2) The patients' chief complaints were abdominal pain(36.5%), bloody stool(18%), diarrhea(17.2%), abdominal bloating(7.5%), bowel habit change(6.7%) in order. 3) Among the 505 cases of total colonoscopic findings, colitis was found in 132 cases(27.1%), colon cancer in 75 cases(14.8%), polyps in 42 cases(8.3%), hemorrhoid in 22 cases(4.3%) and normal in 196 cases(38.8%) . 4) Among the 42 cases of polyps, gastroscopic polypectomy was done in 18 cases(39.0% ). The most common histologic type was tubular adenoma which included 25 cases(54.0%). Two cases out of 25 cases in tubular were colorectal cancer with polyp remnant. 5) The success rate of total colonoscopy was 95.6% with failure in 4.4%. The causes for the failure of total colonoscopic examination turned out to be poor preparation in 12 cases(54.5%) and pain in 9 cases(40.9%).