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운동훈련이 미만성 축삭손상을 일으킨 흰쥐의 해마에 미치는 영향
천송희(Song-Hee Cheon) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.1
미만성 축삭손상(diffuse axonal injury)은 외상성 뇌손상의 일반적인 형태이며, 인지 장애의 주요 원인으로 생각되어 진다. 흔들린 아기 증후군(shaken baby syndrome)과 같이 뇌에 전단력이 심하게 가해졌을 때도 신체 장애 뿐만 아니라 인지 장애가 특징적으로 나타난다. 신체 활동은 건강 증진과 더불어 기억 및 학습과 관련된 해마의 기능 향상에도 영향을 미친다. 본 연구의 목적은 흰쥐를 대상으로 미만성 축삭손상을 일으킨 후 반복적인 운동 훈련을 통해 운동 수행력을 관찰하고 해마에서 GAP-43의 발현을 통해 축삭 재생의 변화를 관찰하는 것이었다. 실험동물은 운동 훈련을 적용시키는 실험군과 대조군으로 구분하였고, 각각의 군을 다시 1일, 7일 및 14일군으로 구분하였다. 그 결과, 운동 훈련을 적용시킨 실험군이 대조군보다 운동 수행력의 향상이 더 유의했으며, 해마에서 GAP-43의 발현도 같은 양상을 나타냈다. 이러한 차이는 7일군과 14일군보다 1일군과 7일군 사이에 더 크게 나타났다. 그러므로 미만성 축삭손상 후 운동 훈련은 운동 수행력의 향상에 영향을 미치며, 인지와 관련된 해마의 구조적 변화도 야기 시키는 것으로 생각된다. Diffuse axonal injury(DAI) is a common form of traumatic brain injury and thought to be a major contributor to cognitive dysfunction. Physical activity has been shown to beneficial effects on physical health and influences in hippocampus which is an important location for memory and learning. The purpose of this study was to investigate the effect of motor training on motor performance and axonal regeneration in hippocampus through the immunoreactivity of GAP-43 after diffuse axonal injury in the rats. The experimental groups were applied motor training(beam-walking, rotarod, and Morris water maze) but control groups were not. The time performing the motor tasks and GAP-43 immunohistochemistry were used for the result of axonal recovery. There were meaningful differences between experimental groups and control groups on motor performance and GAP-43 immunohistochemistry. The control groups showed increasing tendency with the lapse of time, but experimental groups showed higher. Therefore, Motor training after DAI improve motor outcomes which are associated with dynamically altered immunoreactivity of GAP-43 in axonal injury regions, particularly hippocampus, and that is related with axonal regeneration.
근육열상에 대한 초기 전기자극이 C-fos와 TGF-β1 발현에 미치는 영향
천송희(Cheon Song-Hee),김훈(Kim Hoon) 한국체육과학회 2009 한국체육과학회지 Vol.18 No.1
Pain is the sign to protect body from injurious stimuli. Muscle pain related with exercise results in muscle weakness and range of motion (ROM) decrease. Inappropriate application of the treatment for painful condition induces many poor outcomes. The purpose of this study was to investigate effects of early electrical stimulation on pain and healing process after muscle tearing of rats. Male Sprague-Dawley rats (N=30), ages from 8 to 10 weeks and weight from 270 to 350 g were used for this study. Muscle injuries were produced on the right gastrocnemius muscles. Electrical stimulation was applied to experimental group (N=15) on injured site at 1, 2 and 3 day. The expressions of c-fos on spinal cord and transforming growth factor β1(TGF-β1) at injured site by immunohistochemistry were used for the result of pain and muscle healing, respectively. Between experimental and control group, the c-fos and TGF-β1 expressions after muscle tearing were significant different. Both groups were observed changes of c-fos and TGF-β1 expressions with the lapse of time, but the expressions were more significant in experimental group than in control, and this differences were remarkable at 1 day after muscle tearing. These results suggest that early electrical stimulation after muscle tearing is essential factor for early phase after muscle tearing. In conclusion, electrical stimulation was contributed to pain control and muscle healing and could be used for muscle tearing treatment.
흰쥐의 피부화상 후 저강도 레이저 조사가 Substance P의 발현에 미치는 영향
구현모,이선민,남기원,김석범,천송희,강종호,김진상,Koo Hyun-Mo,Lee Sun-Min,Nam Ki-Won,Kim Souk-Boum,Cheon Song-Hee,Kang Jong-Ho,Kim Jin-Sang 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3
This study was performed to investigate the effect of low power laser irradiation on Substance P(SP) expression in the burned skin of the rats. Burns of about 3cm in diameter were created with $75^{\cric}C$ water on the back of the rats, and the lesion of experimental group were irradiated on days 1, 2, 3 and 4 postwounding. Control leasions were not irradiated. After burns, low power laser irradiation was applied by using 1000Hz, 830nm GaAlAs(Gallium-aluminum-arsenide) semiconductor diode laser. The expression of evaluated Substance P(SP) immunohistochemistry on rabbit anti-SP The results of this study wereas follows 1. The Substance P was expressed in the lamina I and II of dorsal horn of spinal cord. In expression of SP, the lesion of control group made SP to more induce significantly than experimental leasions. 2. SP immunoreactivity in burned leasion of spinal cord were decreased markedly 4 days after burns, and decreased gradually from 1 day to 2 days in burns which is laser irradiation These data suggest that low power laser have a pain release effect in the burned skin of the rats.
lacZ가 삽입된 PRV-Bartha 종의 신경친화성 및 무릎시상하부로 추적시 발현양상 분석
김진상(Jin-Sang Kim),박은세(Eun-se Park),천송희(Song-Hee Cheon),김민희(Min-Hee Kim),방현수(Hyun-Soo Bang),권영실(Young-Shil Kwon),이봉희(Bong-Hee Lee),김영철(Young-Chul Kim) 한국독성학회 2006 Toxicological Research Vol.22 No.4
To localize the connection between intergeniculate nucleus and suprachisasmatic nucleus through geniculohypothalamic tract in postnatal mongolian gerbil, we injected lacZ inserted PRV-Bartha strain into suprachiasmatic nucleus and tried to immunostain against it with Rb134 and mouse anti-β-galactosidase. The numbers of immunoreactive neurons in intergeniculate leaflet were 8 ± 3.2 in P1 period, 10 ± 4.1 in P3 period and 13 ± 6.2 in P7 period, and was statistically significant (p < 0.05) and had tendency to increase with time consuming. The results showed that intergeniculate leaflet had projected some axons into suprachiasmatic nucleus through geniculohyptothalamic tract in postnatal mongolian gerbil. But we could not exclude the possibility of direct projections from dorsal and ventral geniculate nuclei into suprachisamatic nucleus completely.
유전자 조작된 Pseudorabies Virus 변종을 이용한 무릎사이작은핵의 시ㆍ공간적 가소성
김진상(Jin-Sang Kim),박은세(Eun-Se Park),천송희(Song-Hee Cheon),김민희(Min-Hee Kim),방현수(Hyun-Soo Bang),권영실(Young-Shil Kwon),이봉희(Bong-Hee Lee),김영철(Young-Chul Kim) 한국독성학회 2006 Toxicological Research Vol.22 No.4
This study was carried out to investigate the spaciotemporal plasticity of intergeniculate leaflet in postnatal mongolian gerbil using genetically modified pseudorabies virus recombinant, which was a kind of excellent neurotracer with the ability to transpass the neuronal synaptic cleft. In addition, we tried to evaluate the special role of intergeniculate leaflet as a signal controler of circardian rhythm by expression of various neurotransmitters in suprachiasmatic nucleus. The PRV-BaBlu, a genetically modified strain of PRV-Bartha with lac-Z gene, was injected into vitreous body of postnatal mongolian gerbil, and immunostained. The PRV-Bablu infected the neurons in intergeniculate leaflet of postnatal mongolian gerbil, and the degree of viral infection in postnatal period of experimental animals had tendency to increase with time consuming. This results showed that the mutant PRV-Bartha strain with lac-Z gene, PRV-BaBlu, was a very excellent neurotracer to localize the retinogeniculate tract with infection of neurons in intergeniculate leaflet specially.