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간장질환 환자의 혈중 α₁ - Antitrypsin 과 Prealbumin 에 관한 연구
채종구(Jong Koo Chae),배학연(Hak Yeon Bae),김만우(Man Woo Kim),장경식(Kyoung Sig Chang),정춘해(Choon Hae Chung),조건국(Kun Kook Cho) 대한내과학회 1987 대한내과학회지 Vol.33 No.2
N/A The alpha-1-antitrypsin and prealbumin concentrations were measured in sera of 34 cases of liver cirrhosis, 20 cases of liver cirrhosis with hepatocellular carcinoma, 18 cases of primary hepatocellular carcinoma and 30 normal control cases in Chosun University Hospital from Jan. 1985 to July 1986. The results are follows: 1) The mean concentration of alpha-1-entitrypsin in blood of normal control group was 141±39.9mg%, in liver cirrhosis, liver cirrhosis with hepatocellular carcinoma and primary hepatocellular carcinoma concentrations were increases each 151.4±93.0, 185.8±71.8 (P<0.05) and 163.4±88.6 mg% in comparison with the mean value of normal control group. 2) The mean concentration of prealburnin in blood of normal control group was 174±65 mg9o, in liver cirrhosis, liver cirrhosis with hepatocellular carcinoma and primary hepatocellular carcinoma concentrations were significantly decreased each 101±49, 82±16 and 75±26 mg% fall P<0.01). 3) The mean concentrations of serum prealbumin in each group of liver diseases with low serum alpha-1-antitrypsin levels: liver cirrhosis (79.1±21.1), liver cirrhosis with hepatocellular carcinoma (41.0±12.0) and primary hepatacellular carcinoma (52.5±17.0 mg%) were significantly decreased (all P<0.01). Consequently, in chronic liver diseases, the serum alpha-1-antitrypsin levels were usually increases and prealbumin levels were significantly decreased in comparison with mean value of normal control group. In chronic liver diseases with low serum alpha-1-antitrypsin level, serum prealbumin concentrations were significantly decreased, This study show that patients with low serum alpha-1-antitrypsin level in chronic liver diseases have severe damage of parenchymal cells in liver.
각종 간담도질환에 있어서의 혈청단백여지전기 영동분획상에 관한 연구
노순백(Soon Back Rho),정종훈(Jong Hoon Jung),채종구(Jong Koo Chae),정춘해(Choon Hai Jung),홍순표(Soon Pyo Hong),조건국(Kun Kook Cho) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A There are many reports on the changes of the protein fractions in healthy individuals and in the various disease states, but there are few published data on the relationship between each of the protein fractions and a specific disease entity. In order to investigate whether the changes of any of specific protein fractions in the serum A/G ratio and A/r ratio and A/r ratio have any value in differentiating each of hepatobiliary diseases, 165 patients with hepatobiliary diseases were examined by means of the Helena procedure(Tris- barbital-sodium, barbital buffer pH 8.8, ionic strength 0.067, Wartman No. 1 filter paper under 180 volt/cm and ponceau-s dye). Fifty normal Korean adults were served as the control group. The results were as follows: 1) In fifty normal subjects, the distributions of paper electrophoretically fractionated serum albumin, a1-, a2-, β-and γ-globulin were 54.72±4.52 %, 5.00±1.62%, 7.54±l.63%, 11.92±1.92%, 19.20±3.11% respectively. The albumin/globulin ratio was 1.42±0.31, and A/r ratio 3.17±0.58. 2) Generally, γ-globulin fraction was increased in patients with hepatobiliary diseases, and the markedly increased γ-globulin with markedly decreased albumin was the most outstanding feature with liver cirrhosis. 3) The pattern of abnormally decreased albumin, a2-and β-globulin with markedly increased γ-globulin was the characteristic feature in the cases with the advanced liver cirrhosis but not in the cases with early cirrhosis. 4) Serum albumin, a1-, a2- and β-globulins were progressively increasing as the disease progresses to the chronic state. 5) Alph 1-, a2-and β-globulin were increased in the patients with malignant hepatic diseases. 6) Alpha 1-and alpha 2-globulins were increased in the patients with liver abscess, cholecystitis or cholelithiasis.
내피세포 Nitric Oxide 유리를 통한 산사의 혈관이완 작용
채종구,김길훤,신흥묵 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.1
It had been known for a while that Crataegi Fructus(CF; Crataegus pinnatifida Bunge) had only a digestive effect. Recently, it has been demonstrated that CF also has an ant-hypertensive effect. However, its mechanism of relaxant effect has not been investigated yet This study was examined to investigate the mechanism of vascular relaxation effect of CF in isolated rat thoracic aorta. CF revealed significant relaxation to phenylephrine(PE)-induced arterial contraction but much less to KCI-induced one. When CF was pretreated, it inhibited PE-induced contraction non-competitively. Methylene blue(10^(-6)M) completely blocked the relaxant effect of CF whereas L-NAME(10^(-5)M) did almost completely. However, atropine(10^(-6)M) did not have any influence on vascular relaxation effect of CF. Regarding cNOS activity, CF significantly increased its activity from rat whole brain homogenate in a dose dependent manner which was inhibited by L-NAME(10^(-5)M). On the other hand, CF did not affect on expression of TNF-α mRNA in RAW 264.7 calls, suggesting that CF is not related to iNOS activity. These results indicate that CF would be effective in relaxing vascular contraction through release of endothelial nitric oxide.
비화농성 삼출성 복수를 동반하는 질환에서 복막 침생검의 진단적 의의
정종훈,서용태,오덕환,채종구,정춘해,조건국 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1
Percutaneous needle biopsies of peritoneum with Abrams needle and Cope needle were done un 64 patients with non-purulent exudative ascites, who was admitted to the department of internal medicine, Chosun University hospital, from January 1978 to Deccmber 1983. The diagnostic significance and safety of the needle biopsy was estimated. The results were as follows. 1. Adequate peritoneal tissue for pathological diagnosis was obtained in 53 cases(82.8%) among 64 cases. (Abrams needle 84.8%, Cope needle 80.6%) 2. Definitive diagnosis was obtained in 31 cases among 53 cases (58.6%). (Tuberculosis 23 cases, malignancy 8 cases). 3. As compared final diagnosis with biopsy result, the rate of final diagnosis corresponding with biopsy diagnosis was 58.8% in tuberculosis and 26.3%, in malignancy, but the rate of biopsy diagnosis corresponding with final diagnosis was 100% in both tuberculosis and malignancy. 4. Cases of chronic non-specific inflammation which were diagnosed by biopsy were 13cases(24.5%)among 53 cases, and among these cases, tuberculosis was 69.2% and malignancy 30.8% on final diagnosis and among 53 cases, histologically normal was 9 cases(16.9%) of which 33.3% was tuberculosis and 66.7% was malignancy on final diagnosis. 5. Of the malignant cases on final diagnosis, Positive cytologic examination of ascitic fluid was 16.7% 6. Primary losions of cancerous peritonitis were stomach cancer (38.9%) hepatocellular cancer(22.2%) colon cancer (11.1%) ovarian cancer (11.1%) Pancreatic cancer (5.6%). 7. Complication of percutaneous peritoneal biopsy was local swelling with leakage of ascitic fluid and the accident rate were 36.4,% in Abraham needle and 3.2% in Cope needle.
각종 암종질환에서 혈청구리 및 아연농도의 변화에 관한 연구
김만우,오금탁,장경식,채종구,홍순표,조건국 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1
The copper and zinc concentrations were measured in sera of 27 cases of hepatoma, 20 cases of stomach ca., 7 cases of esophageal ca., 12 cases of colorectal ca., 9 cases of lung ca., 18 cases of ovarian ca. and 48 cases of normal control in Chosun University Hospital from Jan. 1986 to July 1986. The results are as follows; 1. The mean concentration of copper in serum of normal control group was 96.0±5.02㎍/㎗ (Mean±2SE), in hepatoma, stomach ca., esophageal ca., colorectal ca., lung ca. and ovarian ca. concentrations were significantly increased each 126.4+12.77, 125.6±11.29, 140.5±14.23, 117.3±11.91, 181.4±30.56 and 130.5±13.80㎍/㎗ (P < 0. 001) in comparison with the mean value of normal control group. 2. The mean concentration of zinc in serum of normal control group was 104.8±3.40㎍/㎗ (Mean±2SE), in hepatoma and lung ca. concentrations were significantly decreased each 65.1±7.27 and 72.7±12.86 ㎍/㎗ (P < 0. 00l). 3. The ratio of serum copper level to zinc level (Cu/Zn ratio) in serum of normal control group was 0.94±0.057 in hepatoma, stomach ca., esophageal ca., lung ca. and ovarian ca. concentration ratios were significantly increased each 2.09±0.324, 1.86±0.122, 1.50±0.114, 2.55±0.513 and 1.51±0. 243 (P < 0.001).