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차호,양은경,이원정,박재식 경북대학교 교육대학원 1993 慶北醫大誌 Vol.34 No.2
심장에 대한 순환계나 신경계의 간접적 영향이 없는 상태에서 에탄올이 직접적으로 심장에 미치는 영향을 알아보기 위해서, 쥐 심장을 적출하여 Langendorff 표본을 만들어 에탄올의 작용을 조사하였다. 실험동물은 Wistar 숫쥐를 사용하였으며 심장을 적출하여 대동맥으로 modified Krebs-Henseleit 용액을 관류하며 15분간 안정시킨 후 10% 및 25%에탄올 용액을 분당 0.5㎖로 관류액에 첨가하여 주입하면서 1, 5 및 10분에 심박수, 좌심실 내압, 심수축력을 반영할 수 있는 심실내압 변화율 및 ANP 분비량을 측정하였다. 대조군에서는 관류 15분부터 45분까지 30분간차이를 보아않았다. 에탄올을 주입한 경우는 좌심실 내압, 내압 변화율 및 용출액량은 유의한 감소를 보였고, 심박수는 큰 차이가 없었다. ANP총량은 에탄올 주입 5분 및 10분에 유의하게 감소하였으며, ANP 농도는 에탄올 주입 후 1분에만 유의하게 증가하였으며 그 후는 주입전 값과 차이가 없었다. ANP 농도가 증가할 때의 값과 측정한 인자들 값간의 상관관계는 용출액량이 가장 큰 상관관계를 보였으며, 관계식은 ANP = 868.1 46.1 × Flow (γ = -0.53, P<0.001)이었다. 대조군과 에탄올 투여군의 10분간의 값 차이는 좌심실 내압, 내압 변화율 및 용출액량에서 서로 유의한 차이를 보였다. 이상의 결과를 종합하면 에탄올은 직접적으로 심기능 저하를 초래함을 알 수 있으며 에탄을 주입 직후의 ANP 농도 증가는 용출액량 즉 관상혈관으로의 혈류량 감소와 관계 있는 것으로 생각된다. Direct effects of ethanol on heart function was examined using the Langendorff preparation. The heart was excised from male Wistar rats and perfused with the modified Krebs-Henseleit's solution through the aorta. After a stabilizing period of 15 min, 10 or 25% (V/V) ethanol was added to the perfusate. Heart rate, intraventricular pressure, rate of change in intraventricular pressure which reflects the ventricular contractility and atrial natriuretic peptide (ANP) concentration were measured at 1, 5 and 10 min after addition of ethanol. Ethanol decreased the intraventricular pressure, ventricular contractility change in intraventricular pressure and the coronary flow. These responses were ethanol-dose dependent. Secretion of ANP was increased during the first minute of ethanol administration but was recovered to the preinfusion level, thereafter. Secretion of ANP was inversely related to the coronary flow: ANP secretion = 868.1 46.1 × Flow (γ = -0.53, P<0.001). At 10 min of ethanol perfusion, intraventricular pressure, rate of pressure change, and flow in ethanol group were significantly different from control. Above results suggest that ethanol depresses the cardiac function, but increases the concentration of ANP only immediately after ethanol infusion.
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오용구,이만길,차호,정영채,임진우 대한내과학회 1987 대한내과학회지 Vol.32 No.1
Acute myocardial infarction may occur in patients with angiographically normal coronary arteries. These patients are generally younger and frequently develop subendocardial infarction. Coronary spasm may be a significant factor in the pathogenesis of this type of infarction. The prognosis is considered to be good. Recently we experienced a case of acute myocardial infarction with normal coronary arteries. He was a 33 year old male who developed severe chest pain on the day of the admission at local hospital. He was admitted to our hospital for further evaluation and treatment Cardiac catheterization, coronary arteriogram and left ventriculogram showed dyskinesia of inferior wall and normal coronary arteries.
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Vim-Silverman 침을 사용한 갑상선결절의 감별진단
박창우,이만길,김병헌,차호,안동철,이영철,박흥근 대한내과학회 1986 대한내과학회지 Vol.31 No.2
One hundred sixty four patients with thyroid nodule(s) were investigated by needle biopsy frorn April 1984 to November 1985 at the 5lasan Koryo General hospital. The results were as follows; 1) Among the 164 patients with thyroid nodules, female patients were 158 (96,3%) and male patients were 6(3.7%) and the age distribution showed the peak incidence in the second and third decades(59.8%). 2) The incidence of thyroid nodules according to their histopathological classification showed 93.3% of benign nodules, 6.7% of malignant nodules, and the benign nodules were follicular adenoma, cyst, adenomatous goiter and Hashimoto's thyroiditis in frequency. 3) The physical findings, thyroid scan and thyroid function test for differential diagnosis of benign and malignant thyroid nodules were insignificant. 4) The complication of thyroid needle biopsy was local bleeding in the 5 cases, but no serious problem was found, The obtainability of adequate tissue specimen by needle biopsy was 97,6%.
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김영재(Young Jae Kim),이영철(Young Chul Rhee),이만길(man Kill Lee),차호(Ho Cha),정영채(Young Chae Jung) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A Comparative analytic review on clinical, endoscopic and histopathological findings was done in 13 cases of young age (under 29), 446 cases of mid age (30~69) and 39 cases of old age (above 70) stomach cancer who were visited Department of Internal Medicine of Masan Koryo General Hospital from March 1981 to July 1985. The following results were obtained: The peak of age incidence was the 5th decade amounting to 36.8%. The ratio between male and female was 2.6:1. The main chief complaint of each group was epigastric pain and it was followed by epigastric fullness. The most patient had the duration of symptom from 3 months to 6 months. For old-age group, mid-age group, major site of lesion in the antrum, meanwhile body for young-age group. The most frequent type of gastric cancer was type III in each group by Borrmanns classification. For each group, adenocarcinoma was major cases in the view of histopathological findings, and incidence of well differentiated type adenocarcinoma were lower in young-age group than others.
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