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차정준,권혁문,윤영원,임세중,최의영,홍범기,민필기,김종윤,이병권,조민희,이다령,홍성유 대한심장학회 2013 Korean Circulation Journal Vol.43 No.9
Background and Objectives: We investigated the effect of the additional use of abciximab during percutaneous coronary intervention (PCI) on the level of procoagulant microparticles (MPs) in patients with ST-segment elevation myocardial infarction (STEMI) who had un-dergone primary PCI. Subjects and Methods: In this study, we studied 86 patients with STEMI (72 men, age 58±13) who had undergone primary PCI. The de-cision to administer abciximab immediately prior to PCI was left to the discretion of the operator. Blood samples for analysis of MPs were obtained from the femoral artery before and after PCI. MPs with procoagulant potential were measured using a commercial kit. The cellular origins of MPs were determined by antigenic capture with specific antibodies. Results: Procoagulant MPs captured onto annexin V were not changed significantly after PCI {13.4±13.2 nM vs. 13.2±16.1 nM phosphati-dylserine equivalent (PS eq), p=0.479}. Abciximab was used in 30 of 86 patients (35%) immediately prior to PCI. In patients who had un-dergone PCI without abciximab, no significant change in the level of MPs was observed after PCI. However, in the abciximab group, the level of circulating MPs was significantly decreased after PCI (12.0 ±10.7 nM vs. 7.8±11.7 nM PS eq, p=0.018). Levels of endothelial- and plate-let-derived MPs also showed a significant reduction after PCI in the abciximab group. Conclusion: Primary PCI with additional abciximab significantly reduced the level of procoagulant MPs regardless of their cellular origins in patients with STEMI.
차정준,이경열,정혜문,김인수,최의영,민필기,윤영원,이병권,홍범기,임세중,권혁문,김종윤 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.11
In cryptogenic stroke patients, early detection of new-onset atrial fibrillation (AF) and recurrent stroke is required to prevent poorclinical outcomes. Therefore, we investigated the predictors of new-onset AF and recurrent stroke in cryptogenic stroke patientswithout previously diagnosed AF. In total, 390 patients who were diagnosed with stroke and non-sustained atrial tachycardia(NSAT) on 24-hour Holter monitoring were followed up to assess new-onset AF and recurrent stroke. The 5-year event-free survivalas well as the predictors of recurrent stroke or new-onset AF were investigated. Based on receiver operating characteristicanalysis, frequent premature atrial contractions (PACs) were defined as PACs >44 beats/day. The median follow-up period was 35months. The composite event rate was 11.5%. In Kaplan-Meier analysis, the 5-year cumulative incidence of composite events washigher in cryptogenic stroke patients with frequent PACs than in those without frequent PACs. Multivariate analysis revealed thatcurrent smoking, increased left atrial volume index, and frequent PACs were poor prognostic predictors of composite event, andfrequent PACs were an independent poor prognostic factor of new-onset AF in cryptogenic stroke patients. Therefore, frequentPACs might be associated with poor clinical outcomes (new-onset AF and recurrent stroke) in cryptogenic stroke patients withconcomitant NSAT.
에르고노빈 심초음파로 확진된 승모판 폐쇄부전을 유발한 혈관연축 1예
차정준,경찬희,조장호,김용훈,김혜원,이성주,임세중,최의영 영남대학교 의과대학 2013 Yeungnam University Journal of Medicine Vol.30 No.2
The common causes of organic mitral regurgitation (MR) include mitral valve prolapse (MVP) syndrome, rheumatic heart disease, and endocarditis. MR also occurs secondary to dilated cardiomyopathy and coronary artery disease. In acute severe MR, the hemodynamic overload often cannot be tolerated, and mitral valve repair or replacement must be performed immediately. We report herein a case of severe MR due to coronary vasospasm that was confirmed via ergonovine echocardiography in a 70-year-old man. He was scheduled to undergo mitral valve surgery, but it did not push through and he was put on medical therapy.
차정인,김수현,안석원,성정준,이광우 대한신경과학회 2009 대한신경과학회지 Vol.27 No.4
Crohn’s disease is one of the inflammatory bowel diseases and is characterized by the involvement of the entire depth of the intestinal wall from the anus to the mouth. Neurological complications rarely occur in Crohn’s disease and recurrent transverse myelitis has not yet been described in association with it. We report a 50-year-old man with Crohn’s disease accompanied by recurrent transverse myelitis. Inflammatory bowel diseases and demyelinating disorders may share an autoimmune pathophysiology. Crohn’s disease is one of the inflammatory bowel diseases and is characterized by the involvement of the entire depth of the intestinal wall from the anus to the mouth. Neurological complications rarely occur in Crohn’s disease and recurrent transverse myelitis has not yet been described in association with it. We report a 50-year-old man with Crohn’s disease accompanied by recurrent transverse myelitis. Inflammatory bowel diseases and demyelinating disorders may share an autoimmune pathophysiology.
다발성 경화증 환자에서 진단된 양관자쪽반맹을 보이는 시신경교차부염 1예
김성민,김민정,차정인,성정준,이광우 대한임상신경생리학회 2006 Annals of Clinical Neurophysiology Vol.8 No.2
We report a case of chiasmal optic neuritis in a patient who had been diagnosed as multiple sclerosis, and was presented with bitemporal hemianopsia. The brain MRI revealed a high signal lesion with focal enhancement in optic chiasm, and the visual evoked potential functionally supported it. This is the first case of chiasmal optic neuritis in multiple sclerosis with temporally and spatially disseminated lesions.
백승호,배순준,윤창익,박소은,차치환,안성귀,김영석,노태석,정준 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1
Purpose: The use of immediate breast reconstruction (IBR) has been debated because it may be a causative factor in adjuvant treatment delay and may subsequently increase the probability of recurrence. We investigated whether IBR was related to adjuvant treatment delay and survival outcomes. Methods: We retrospectively analyzed the duration from operation to adjuvant treatment administration and survival outcomes according to IBR status among patients with breast cancer who underwent mastectomy followed by adjuvant chemotherapy from January 2005 to December 2014. Propensity score matching was performed to balance the clinicopathologic baseline characteristics between patients who did and did not undergo IBR. Results: Of 646 patients, 107 (16.6%) underwent IBR, and the median follow-up was 72 months. The median duration from surgery to adjuvant chemotherapy was significantly longer in patients who underwent IBR than in those who did not (14 vs. 12 days, respectively, p = 0.008). Based on propensity score matching, patients who underwent IBR received adjuvant therapy 3 days later than those who did not (14 vs. 11 days, respectively, p = 0.044). The duration from surgery to post-mastectomy radiation therapy (PMRT) did not significantly differ between the 2 groups. Local recurrence-free survival, regional recurrence-free survival, systemic recurrence-free survival, and overall survival were also not significantly different between the 2 groups (p = 0.427, p = 0.445, p = 0.269, and p = 0.250, respectively). In the case-matched cohort, survival outcomes did not change. Conclusion: IBR was associated with a modest increase in the duration from surgery to chemotherapy that was statistically but not clinically significant. Moreover, IBR had no influence on PMRT delay or survival outcomes, suggesting that it is an acceptable option for patients with non-metastatic breast cancer undergoing mastectomy.