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진수현 ( S. H. Jin ),김원호 ( W. H. Kim ),김태일 ( T. I. Kim ),한동수 ( D. S. Han ),강진경 ( J. K. Kang ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> Thalidomide는 염증성 장질환을 포함한 일부 염증성 질환과 종양질환에서 항염증효과와 신생혈관생성 억제를 통한 항암효과를 보여왔다. 이를 설명하는 기전으로 thalidomide에 의한 TNFα생성 억제 등이 보고 되어 왔지만 그 구체적인 기전은 아직 규명되어져 있지 않다. 여러 염증 반응에 관련된 전사인자로 알려진 NFκB는 면역반응과 TNFα, IL-8 같은 염증성 유전자 발현의 중요한 조절인자로 알려져 있고, 신생혈관생성에 관련된 성장
비스테로이드성 소염제(NSAIDs)에 의한 세포사멸과정에서 Mitogen-activated Protein Kinase (MAPK) 활성화의 역할
김태일 ( T. I. Kim ),진수현 ( S. H. Jin ),강은혜 ( E. H. Kang ),김원호 ( W. H. Kim ),강진경 ( J. K. Kang ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 비스테로이드성 소염제에 의한 암억제효과의 기전은 아직 알려지 않은 부분이 많으며, 이러한 기전중의 하나로 세포사멸 유발이 보고되어왔다. 본 연구는 세포 증식과 사멸과정의 중요한 매개체 중의 하나로 알려져 있는 mitogen-activated protein kinase (MAPK)가 비스테로이드성 소염제에 의한 대장암 세포의 사멸과정에서 어떠한 역할을 하는지 규명하고, 세포사멸에 의미있는 MAPK 활성화와 가능성 있는 관련 신호전달 경로로서 NF
곽지연,김서연,김자영,이혜연,정문정,진수현,천선우,하소현,한희진,양숙자,김지연 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50
Purpose: The purpose of this study was to identify college student's perception and practice of 'National Cancer Prevention Actions' and the factors that influence the perception and practice. Method: The participants were 310 undergraduates selected by convenience sampling at colleges in Seoul. Instrument was 2014 Survey of Perception and Practice of National Cancer Prevention Actions by National Cancer Center(2014), and has been modified for the purpose of the study. The data were analyzed by t-test, ANOVA and Scheffe test with SPSS 23.0 Windows software. Results: The most recognized action for cancer prevention in college students was "Do not smoke, also avoid smoking smoke"(96.8%) while the most unrecognized was "Get a type B hepatitis vaccination"(58.7%). The most practiced action for cancer prevention in college students was "Sexually as to safe sex"(94.8%) while the most unpracticed was "Exercise five times a week or more, for at least 30 minutes a day"(33.9%). Among general characteristics, participants' age (t=-2.015, p<.05), major (F=3.109, p<.001), and residential type (F=4.959, p<.01) were statistically significant in the recognition of Cancer Prevention Actions and major(F=3.341 p<.05) and residential type(F=3.827, p<.05) were also significant in the practice of Cancer Prevention Actions. Among health characteristics, health concern(F=3.154, p<.05) and education in cancer(t=-3.112, p<.01) showed statistically significant differences in the recognition of Cancer Prevention Actions while health concern(F=7.896 p<.001) and subjective health status(F=9.913, p<.001) showed differences in the practice of Cancer Prevention Actions. Conclusion: These findings showed the gap between the perception and practice of cancer prevention actions. Considering the importance of individual characteristics, it is essential to develop a differentiated cancer prevention education program for college students. Also, nursing intervention program should be developed to raise the alertness of cancer in order to enhance cancer preventive practice.