참조팝나무의 成分 Alkaloid 에 關한 硏究

진갑덕,Jin, Kab-Dukc 대한화학회 1967 대한화학회지 Vol.11 No.3

韓國 山野에 野生하는 참조팝나무 Spiraea Koreana Nakai(Spiraeceae)엽으로 부터 m.p. 182~$184^{\circ}C$의 苦味를 갖인 Alkaloid를 無色 柱狀의 結晶으로 얻었다.(收得率 0.13%). 이 物質은 光學的으로 活性이며(比旋光度$[{\alpha}]d^{19}+3.4^{\circ}$ in $CHCl_3$), Mass Spectrometry에 依해 決定한 分子式은 $C_{23}H_{33}NO_3$이다. 文獻未記載의 것임으로 Spirajine이라 命名하였다. Spiraea Koreane N. 葉 中에는 이 外에도 다른 2種의 알칼로이드가 微量으로 含有되어 있음을 Thin Layer Chromatography로 確認하였으나 結晶으로는 못 얻었다. Spirajine의 部分化學構造에 對해 化學反應, UV, IR, NMR, MS, ORD 等으로 分析檢討함과 아울러 Mass Spectrogram의 Cracking Pattern으로부터의 Fragmentation Analysis의 結果, 分子 中 Cyclohexane 및 Cyclopentane 고리들을 갖으며 그 中 하나는 ${\alpha},{\beta}$ 不飽和 Cyclohexenone고리이고 그 外에 methyl基, 카보닐基, 水酸基, N-Methyl基 等 여러 作用基의 存在를 決定하였다. A new alkaloid named Spirajine(m.p. 182~$184^{\circ}C$ $[{\alpha}]d^{19}+3.4^{\circ}$ in $CHCl_3$, $C_{23}H_{33}NO_3$, colorless prism) was isolated from the leaves of Spiraea Koreana Nakai (Spiraeceae) (Korean name "Chamjopab namu") which grows in the mountaineous area of Korea, by process of Scheme I (yields 0.13%). Another two unidentified alkaloids (not yet crystallized) were separated by the method of thin layer chromatography. (The Rf values of the two unidentified alkaloids were 0.66, 0.77, respectively and Spirajine 0.72) Spirajine were subjected to the structural investigation with the use of ultra violet and infra red spectrophotometry, and opical rotatory dispersion. The alkaloid contains two ketonic carbonyl groups, tertiary hydroxyl group, methyl groups, N-methyl group and both cyclohexane ring and cyclopentane ring.

율무의 이용과 개발에 관한 연구

진갑덕 한국약제학회 1975 Journal of Pharmaceutical Investigation Vol.5 No.3

희염水溶性抽出物이 肝障害 Rat의 sulfobromophthalein 體內動態에 미치는 影響

陳甲德,李神雄,金英嬉,孫炳哲 영남대학교 자원문제연구소 1988 資源問題硏究 Vol.7 No.-

Effects of water extract of Siegesbeckiae Herba on the pharmacokinetics of sulfobromo-phthalein (BSP) and patho-physiological aspects in the rat of hepatic failure induced by carbon tetrachloride were examined. 1. CCl4 -induced decrease of body weight and increase of liver weight, liver to body weight ratio, GOT and GPT There significantly inhibited by Siegesbeckiae Herba. 2. The spots of BSP excreted into bile that were identified on TLC were observed at the same Rf values (0.30, 0.44, 0.65, 0.76) in each group. 3. Siegesbeckiae Herba increased plasma disappearance rate, amount of biliary excretion and K(I) (fast rate constant) value of BSP. 4. Although the two transfer constants K12 and K21, showed no significant changes with respect to those of the CCl4 treated rats, the ratio of K12 /K21 which was defined as the 'affinity' of BSP for liver showed a significant increase in CCl4 & Siegesbeckiae Herbs treated rats. 5. The transfer constants, K23 and K34 were also increased in Siegesbeckiae Herba treated rats. However, the K12 V1 and bile flow rate were not significantly changed by Siegesbeckiae Herba.

人蔘根 製濟의 製造 및 指肪酸 吸收에 미치는 影響에 關한 硏究

李相稷,金英熙,李神雄,陳甲德 嶺南大學校 環境問題硏究所 1984 環境硏究 Vol.4 No.2

Effect of perilla oil emulsion prepared by ginseng powder on absorption of free fatty acid of rat small intestine were investigated in this study. The results were as follow; 1. 4g of ginseng powder could enulsify 1g of perilla oil. 2. Total crude saponin could be separated and identified by method of Namba and Shibata et al, and be measured by weight and volumn. 3. The content of total crude saponin containing in fuor years old ginseng root caltivated in Gum San was 2.26 to 2.70% of total root weight. 4. Ginseng powder increased the absorption of free fatty acid and emulsion prepared by ginseng powder induced more effective increase in free fatty acid absorption than that of non-emulsion form in rat small intestine. 5. Emulsion prepared by ginseng powder was o/w type and more stable in lower water and higher mucosity than in high water and low mucosity. 6. Emulsion was stable for 36days at 5℃~8℃.

大黃水渡液이 물김치의 酸度變化에 미치는 影響

金英嬉,李正秀,蘇三燮,陳甲德 嶺南大學校 環境問題硏究所 1989 環境硏究 Vol.8 No.2

Effect of water and ethanol extract of Rheum coreanum N. on changes of pH in different NaC1 concentration and temperature in Juicy Kimchi was investigated and then, compared with it to sodium benzoate. The following results were obtained. 1. Addition of 0.03% water and ethanol extract of Rheum coreanum N. to juicy Kimchi preserved above pH 4.0 in whole experimental period at 30℃. 2. Addition of 0.1% water extract of Rheum coreanum N. induced less pH changes than control and preserved above pH 4.5 after 7 day at 18℃. 3. It was observed that water estract of Rheum coreanum N. was greater than ethanol extract in preservative potency. 4. Preservative potency of 0.03% water extract of Rheum coreanum N. was superior to 0.1% sodium benzoate. 5. Addition of 0.03% water extract of Rheum coreanum N. prolonged the tasty period of juicy Kimchi, which was more effective than sodium benzoate.

쌀 調理過程 中 麥飯石의 Cd除去 能力에 關한 硏究

陳甲德,裵基哲,李正秀,金英姬 嶺南大學校 環境問題硏究所 1989 環境硏究 Vol.9 No.1

It was investigated Cadmium eliminating capacty of Quartz Porphyry(Q.P.) during washing, swelling, and cooking process in rice contaminated artificially. 1. After washing the rice four times with water, the eliminating rate of Cadmium from artificially contaminated sample were 16% in control group, 28% and 42% in 25g/kg and 50g/kg Q.P. treated group, respectively. 2. Swelling of rice in water about 20 minutes didn't change the Cadmium level in Q.P. treated group. 3. Cadmium eliminating efficiency by cooking was significantly increased in Q.P. treated group (43~54%) compared to control group(31%). 4. These results suggest that treatment of rice with Q.P. is very effective to remove the Cadmium contamination in rice.

食用色素開發에 關한 硏究

鄭輝秀,陳甲德 嶺南大學校 環境問題硏究所 1984 環境硏究 Vol.4 No.2

A study for development of natural red pigment in food and drug industry was proceeded to anthocyanin from prunus yedoensis Matsum, isolated through silica gel column and further subjected to TLC. The color effect and stability from several factors was detected by spectrophotometry in 520 nm and was compared to amaranth and then 1/200 times of it. The content of the color of the fruits of Prunus yedoensis Matsum was 0.6%. As this pigment was more safe about 7.4 times in ??,but was influenced by pH(3.0-8.0) and by some metal ions (??, ??, ??, ??),and respectively stable to temperature, sun light, ultra violet ray and organic acids than amaranth, and was not given a bad infouences by sugars, recovery of another characteristics of this pigment or co-factors to compensate and promote the color effect, for example Cu(), is expected.

Cetyl Alchol을 利用한 坐制基劑에 關한 硏究

陳甲德,金英姬,李壽根,白琇鉉,李神雄 嶺南大學校 環境問題硏究所 1986 環境硏究 Vol.6 No.1

Some basic propeties of suppository bases containing cetyl alcohol(C), lanoline(L), and propylene glycol(P) were investigated in this study. The results were as follows. 1. Suppository could be molded easily in the higher amount of cetyl alcohol than that of lanoline or propylene glycol. 2. Suppository was molded by 28 kinds of different C:L:P ration could be soften in rectum temperature and the proper ratios of C:L:P to release sodium salicylate from suppository were 5:3:1, 3:1:2, 4:3:1, 5:3:2. 3. The softening times of suppository with these ratios of C:L:P were 9 min to 20 min. 4. Softening temperature and time were not changed after storage for 1, 11, 38, 54 days at 20℃ or 4℃ 5. The most appropriate ratio of this base was 5:3:1 in sodium salicylate suppository.

압척초가 高血糖 家토의 血中葡萄糖 濃度에 미치는 影響

陳甲德,李神雄,金英姬,白琇鉉,鄭炷燮 영남대학교 자원문제연구소 1990 資源問題硏究 Vol.9 No.-

The effect of methanol extract of Commelina communis L. (C.M.E. ) on blood glucose level in alloxan -diabetic rabbit and acute toxicity of C.M.E. were investigated. C.M.E. decreased blood glucose level significantly but did not affect the normal blood glucose level and LD50 was about 6.250 mg / kg.

環境敎育의 意義와 重要性

陳甲德 嶺南大學校 環境問題硏究所 1981 環境硏究 Vol.1 No.2