글릭콜릭산 필링 후 rhEGF and Palmitoyl pentapeotide-4의 피부 재생 효과

주지현 ( Ji Hyun Ju ),김도현 ( Do Hyeon Kim ),박건 ( Kun Park ),김남산 ( Nam San Kim ),김정희 ( Jeonghee Kim ) 한국미용학회 2020 한국미용학회지 Vol.26 No.1

Glycolic acid peel is a popular superficial peeling technique associated with low morbidity and prompt recovery. These processes, as well as the final step of corneodesmolysis, which mediates exfoliation, are often disturbed by environmental conditions, resulting in dry, flaky skin conditions. Therefore, aftercare is required to avoid these side effects and achieve the maximum possible improvement in skin condition. To evaluate the skin regeneration effect of rhEGF and palmitoyl pentapeptide-4 after glycolic acid peeling. A base gel, a gel containing rhEGF, and a gel containing palmitoyl pentapeptide-4 were prepared, and their safety was evaluated by patch test. The 30 healthy female volunteers (age 25-39 years) underwent a glycolic acid (20%) face peel once per week and then the prepared gels were applied to the face for 4 weeks. Stratum corneum hydration, transepidermal water loss (TEWL), and erythema index were then evaluated. No specific skin reaction in prepared gels was detected by a patch test. In the application group of rhEGF and palmitoyl pentapeptide-4, stratum corneum hydration is increased, TEWL and erythema index are reduced. Therefore, the skin regeneration effect was confirmed. The skin regeneration effect of the palmitoyl pentapeptide-4 application group was shown to be the best result in particular. The gels containing rhEGF and palmitoyl pentapeptide-4 were safe and effective for skin recovery after glycolic acid peeling. The palmitoyl pentapeptide-4-containing gel was superior to the rhEGF-containing gel in terms of skin regeneration after peeling.

증례 : 소화기 ; 췌장의 신경내분비종양으로 오인한 고형 변이성 장액성 낭종 1예

장현정 ( Hyun Jeong Jang ),김태효 ( Tae Hyo Kim ),이제운 ( Jae Un Lee ),김현식 ( Hyeon Sik Kim ),주지현 ( Ji Hyeon Ju ),정운태 ( Woon Tae Jung ),이옥재 ( Ok-jae Lee ) 대한내과학회 2015 대한내과학회지 Vol.89 No.1

췌장에서 발생하는 장액성 낭종 중에서 고형 변이성 장액 성 낭종은 매우 드물게 발생하는 질환이지만 악성 혹은 전 암성 병변과의 감별이 어려워서 수술이 필요한 다른 질환으 로 오인되는 경우가 매우 많다. 이에 저자들은 췌장의 신경 내분비종양으로 오인하고 수술을 시행하여 고형 변이성 장 액성 낭종으로 진단된 매우 드문 증례를 경험하였기에 문헌 고찰과 함께 보고한다. Rapid advancements, access to and use of imaging techniques have increased the frequency of identification of pancreatic cystic neoplasms in clinical practice. However, a diagnostic dilemma among pancreatic cystic neoplasms remains. Solid variant serous cystadenoma is extremely rare and difficult to accurately diagnose preoperatively, as they are commonly mistaken for malignant solid tumors of other types. Here, we present a case of a solid variant serous cystadenoma preoperatively misdiagnosed as a neuroendocrine tumor of the pancreas with a review of the relevant literature. (Korean J Med 2015;89:69-73)

염증성 근육병증에 동반된 폐침범의 임상적 특징

김현숙 ( Hyun Sook Kim ),서수홍 ( Soo Hong Seo ),허지안 ( Ji An Hur ),곽승기 ( Seung Ki Kwok ),주지현 ( Ji Hyeon Ju ),윤종현 ( Chong Hyeon Yoon ),김완욱 ( Wan Uk Kim ),홍연식 ( Yeon Sik Hong ),조철수 ( Chul Soo Cho ),김호연 ( Ho Y 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.1

Objective: To investigate the clinical manifestation and prognostic factors of interstitial lung disease (ILD) in Korean patients with idiopathic inflammatory myopathies include with polymyositis (PM) and dermatomyositis (DM). Methods: Clinical and laboratory data of 110 patients with PM/DM in our rheumatology clinic were investigated. Clinical data including history, medication, pulmonary function tests (PFT) findings, radiologic findings, and labaratory findings were obtained from medical records at the first diagnosis of ILD with PM/DM. ILD was diagnosed on the basis of the imaging abnormalities defined above on definite findings of chest X-rays and high resolution computed tomography (HRCT), restrictive changes on PFT with respiratory symptoms. During the course of treatment, we assessed chest radiograph and HRCT findings. Results: Forty-two PM/DM patients (38.2%) developed ILD. Anti-extracellular nuclear antigen (ENA) antibody, anti-Jo-1 antibody and ground glass opacity in HRCT were significantly high in PM-ILD. However honeycoomb appearance (53%:22%) and fibrosis (41%:6%) in HRCT were significantly high in DM-ILD. Interest in aspects of prognosis including initial steroid treatment response in HRCT were favorable in PM-ILD. There were statistically significant association between normal level of CPK and usual interstitial pneumonia (UIP) pattern in HRCT in DM-ILD. Such cases had resistance to steroid therapy. Overall interval between steroid and immunosuppressant therapy was significantly shorter in those with DM-ILD. Conclusion: The clinical manifestations between PM-ILD and DM-ILD in Korean patients were not significant different from those of other populations. DM-ILD is more refractory to steroid treatment, expecting in poor prognosis compared with PM-ILD. So immediate intensive immunosuppressive therapy should be considered in DM-ILD.

항 TNF 제제로 치료한 류마티스관절염 환자에서 발생한 심각한 감염의 발생 빈도

김현옥 ( Hyun Ok Kim ),강귀영 ( Kwi Young Kang ),주지현 ( Ji Hyeon Ju ),김호연 ( Ho Youn Kim ),박성환 ( Sung Hwan Park ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.3

Objective: We wanted to investigate the incidence of serious infections among the rheumatoid arthritis (RA) patients who were treated with tumor necrosis factor α (TNF-α) antagonists Methods: We enrolled the 175 RA patients who were treated with TNF-α antagonists for at least 3 months during February 2003 to July 2008, and these patients were in the SMART-b cohort of Kangnam St. Mary`s hospital. Patients were prescribed infliximab, etanercept or adalimumab. The data was retrospectively collected. Results: The incidence of serious infections among the RA patients treated with TNF-α was significantly increased according to the survival analysis, as compared with that of those patient treated with conventional DMARDs (p<0.01). The most common serious infection was pneumonia. There was no significant difference in the incidence of serious infections among the three TNF-α antagonists used in this study (p=0.96). But the serious infections occurred more often in the patients who received more than 10 mg methotrexate (MTX) per week (p=0.02). Conclusion: RA patients treated with TNF-α antagonists had a higher incidence of serious infection. Therefore, close monitoring for serious infection is needed for RA patients who are receiving TNF-α antagonists.

청각장애학교 교사의 교육과정에 대한 실천적지식의 내,적 정향 요인 분석

최성규 ( Sung Kyu Choi ),주지현 ( Ji Hyun Ju ) 한국특수교육문제연구소 2013 특수교육저널 : 이론과 실천 Vol.14 No.1

이 연구는 청각장애학교 교사의 교육과정에 대한 실천적 지식의 정향을 분석하기 위하여 전국의 청각장애학교에 재직하는 교사 310명의 설문지를 수집하였다. 5점 척도의 24문항으로 구성된 설문지는 상황적 정향 6문항, 사회적 정향 4문항, 개인적 정향 3문항, 경험적 정향 4문항, 그리고 이론적 정향 7문항으로 구성되어 있다. 교육과정 실천적 지식은 내적 정향 (개인적 정향과 경험적 정향)과 외적 정향(상황적 정향, 사회적 정향, 이론적 정향)으로 구분하였다. 설문지의 타당도와 신뢰도를 확보하기 위하여 요인 분석 및 신뢰도 분석을 실행하였고 일원배치분산분석, 상관관계, 중다회귀분석 등을 적용하였다. 청각장애학교 교사의 교육과정 실천적 정향은 경험적 정향과 함께 이론적 정향이 통계적으로 가장 높은 영향력을 제공하며, 다음으로 사회적 정향과 개인적 정향의 순으로 나타났다. 그러나 상황적 정향은 청각장애학교 교사의 교육과정 실천적 지식 구동에 영향력이 낮음을 알 수 있다. 이 연구에서는 또한 청각장애학교 교육과정의 실천적 지식의 정향에 대한 시사점을 제시하고 있다. The purpose of this study was to analyze the relation of the internal and external orientation factor of practical knowledge to curriculum of teachers who were working for students with hearing impairment. The questionnaire which is consisted with 24 questions was divided into five parts such as situational orientation, personal orientation, social orientation, experiential orientation, and theoretical orientation. Internal orientation factors of practical knowledge to curriculum were personal orientation and experiential orientation, however external orientation factors of practical knowledge to curriculum were situational orientation, social orientation, and theoretical orientation. 310 teachers who were working for students with hearing impairment were participated for this study. The validation, reliability, oneway ANOVA, correlation, and regression were utilized for this study. This study concluded that the orientation of practical knowledge to curriculum of teachers for students with hearing impairment was related with theoretical orientation, social orientation, and personal orientation based on experiential orientation. However, the situational orientation factor was not related with the curriculum practical knowledge.

일차성 쇼그렌증후군 환자에서 나타나는 자가항체와 선외증상의 양상

서수홍 ( Soo Hong Seo ),김현숙 ( Hyun Sook Kim ),곽승기 ( Seung Ki Kwok ),주지현 ( Ji Hyeon Ju ),김상현 ( Sang Hyon Kim ),윤종현 ( Chong Hyeon Yoon ),김호연 ( Ho Youn Kim ),박성환 ( Sung Hwan Park ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.1

Objective: To investigate the extraglandular manifestations and serological features of Korean patients with primary Sjogren`s syndrome (pSS). Methods: Clinical and laboratory data of 125 patients with pSS attending rheumatology clinic of Kangnam St. Mary`s hospital, with a mean follow-up period of 64.8 months, were assessed retrospectively. Results: Arthralgia was the most common extraglandular manifestation of pSS. Other extraglandular manifestations, such as myalgia, peripheral neuropathy, Raynaud`s phenomenon, and hypothyroidism were frequently presented, but lymphoma was rare manifestation in Korean patients with pSS. Some extraglandular manifestations of pSS were associated with hypocomplementemia and antibodies against Ro, and La, and antinuclear antibody. Conclusion: The clinical manifestations and extraglandular manifestations of Korean patients with pSS patients were similar to other studies except low prevalence of lymphoma. Positivity of anti-Ro/SS-A, anti-La/SS-B antibodies and hypocomplementemia were closely associated with extraglandular manifestations in patients with pSS.

활동성 전신홍반루푸스 환자의 FSChigh Memory B 세포의 특징 분석

전주연 ( Joo Yeon Jhun ),김영주 ( Young Joo Kim ),주지현 ( Ji Hyun Ju ),박성환 ( Sung Hwan Park ),장숙희 ( Soog Hee Chang ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.3

Objective: To determine phenotypic and functional characteristics of memory B cells in patients with systemic lupus erythematosus (SLE). Methods: The percentage of memory B cell subsets in peripheral blood mononuclear cells (PBMC) from normal control (n=11), inactive (n=15) and active (n=10) SLE patients was determined by Fluorescence Activated Cell Sorter (FACS). In addition, the activation status of memory B cells was measured by the surface expression of CD86 (B7-2). The production of antibodies to chromatin and dsDNA (IgG and IgM type) by isolated memory B cell subsets was examined by enzyme-linked immunosorbent assay (ELISA). Results: In this study, we analyzed 2 subtypes of memory B cells: FSC (Forward Side Scatter)low and FSChigh memory B cell. The percentage of both subtypes from active and inactive SLE patients was significantly reduced compared to that of normal controls (p<0.01). In addition, the expression of activation markers, CD86 on FSChigh memory B cells from active SLE patients was higher than those of inactive SLE patients and normal controls (p=0.014). Upon stimulation with CpG and IL-15 in vitro for 8 days, isolated FSChigh memory B cells from active SLE patients revealed augmented production of autoantibodies to chromatin and dsDNA. Conclusion: Our results suggest that abnormally activated FSChigh memory B cells from active SLE patients might be involved in spontaneous production of autoantibodies and induce transition from inactive to active phase of the patients.

폐암환자에서 급성호흡부전과 장천공을 동반한 분선충 감염증

김현식 ( Hyeon Sik Kim ),김유은 ( Yu Eun Kim ),윤은영 ( Eun Young Yun ),주지현 ( Ji Hyun Ju ),마정은 ( Jeong Eun Ma ),이기동 ( Gi Dong Lee ),조유지 ( Yu Ji Cho ),김호철 ( Ho Cheol Kim ),이종덕 ( Jong Deok Lee ),황영실 ( Young Sil 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.1

Strongyloides stercoralis is an intestinal nematode that is a parasite to humans. The infecting filariform larvae of S. stercoralis enters the host body via the bloodstream, passes through the lungs, penetrates the alveoli, and then ascends the airway to transit down the esophagus into the small bowel. The infection can persist for decades without causing major symptoms and can elicit eosinophilia of varying magnitudes. Of note, this infection can also develop into a disseminated, often fatal, disease (hyperinfection) in patients receiving immunosuppressive corticosteroids. A 65-year-old man who was receiving corticosteroid therapy for the treatment of spinal stenosis was admitted to the emergency room with complaints of abdominal pain and severe dyspnea. We detected many S. stercoralis larvae in the sputum and in the bronchoalveolar-lavage sample collected by bronchoscopy. Here, we report a fatal case of strongyloidiasis with acute respiratory failure and intestinal perforation. In addition, we provide a brief review of the relevant medical literature.

한국인 조기 류마티스관절염 환자에서의 2010 ACR/EULAR 분류 기준의 유용성 및 한계

문수진 ( Su Jin Moon ),이창훈 ( Chang Hoon Lee ),김윤성 ( Yun Sung Kim ),박윤정 ( Yun Jung Park ),강귀영 ( Kwi Young Kang ),곽승기 ( Seung Ki Kwok ),김해림 ( Hae Rim Kim ),주지현 ( Ji Hyeon Ju ),김현숙 ( Hyun Sook Kim ),서영일 ( Y 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.6

The 2010 New American College of Rheumatology/ European League Against Rheumatism (ACR/EULAR) criteria for rheumatoid arthritis (RA) was raised to identify patients with early RA and replaced the 1987 ACR classification criteria. The aims of this study are to assess the availability of new classification criteria and to evaluate its Methods. A total of 408 patients with newly diagnosed RA were included from 13 secondary or tertiary hospitals in South Korea. The symptom duration was less than 12 months before the diagnosis of RA. RA was defined as either 1987 ACR classification criteria or new 2010 ACR/EULAR criteria. We compared the full details of both classification criteria. Results. The mean symptom duration was 5.1 months. The majority (76.2%) of the patients were female. Two hundred and seventy three patients (66.9%) fulfilled both of the 2010 and 1987 classification criteria. Forty-seven (14.7%) of the 320 patients fulfilling the 1987 criteria did not fulfill the new classification criteria. On the other hand, eighty-eight (24.4%) of the 361 patients fulfilling the 2010 ACR/EULAR classification criteria did not fulfill the 1987 ACR criteria. Thirty-six (55.4%) of the 65 patient with seronegative RA failed to meet the 2010 classification criteria. In case of seropositive RA (n=343), 85 additional patients (24.8%) could be diagnosed as RA using new classification criteria. The new 2010 ACR/EULAR classification criteria enable physicians to diagnose more patients with early RA via the help of serology. However, the sensitivity for the diagnosis of seronegative RA is projected to decrease.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)