뇌조직의 수분함량에 관한 실험적 연구

주인수 고려대학교 의과대학 1976 고려대학교 의과대학 잡지 Vol.13 No.1

뇌조직의 수분함량에 관한 실험적 연구 : 실험적 뇌압박 Experimental Brain Compression

주인수,주정화 고려대학교 의과대학 1976 고려대 의대 잡지 Vol.13 No.1

The changing patterns of water content were studied in cerebral gray and white matter of 42 rabbits by inducing cerebral edema for the purpose of being identify the pathophysiology and mechanisms of cerebral edema. The cerebral compression and edema were successfully produced by the expansion of the stalk of laminaria in the right epidural space of the rabbits. By weighting the wet and dry brain tissues, and by calculating the percentage of water content and that of swelling, with the rate of per cent water content to that of control group, the studies of the occurrence and changes of experimental brain edema have been observed. In the normal rabbit, the average per cent water content of cerebral gray and white matters were 79.9±0.7% and 73±1.0%, respectively. The percentage of water content and swelling of cerebral gray and white matters in the compression site showed higher values than those in control group. As compared with normal group, the rate of per cent water content of cerebral gray matter at the site of compression showed gradual increasing tendency as time elapsed by 24 hours, while that of white matter demonstrated rapid increase of it by 6 hours and decreased gradually the reafter. And it appeared that the value of the cerebral white matter showed higher than that of gray matter throughout the period of 24 hour's Compression. Cerebral edema induced by laminaria compression was more evident and severe in the white matter than in the gray, which was more striking at the early stage of cerebral compression.

인간 골격근세포주(HM4)에서 Interleukin-6 생성에 대한 정맥내 글로불린의 효과

주인수,주억식,김성희,이용범 대한신경과학회 2004 대한신경과학회지 Vol.22 No.3

Background: Intravenous immunoglobulin (IVIg) has been widely used in the management of patients with various autoimmune neurological diseases, however, its action mechanisms have not fully been elucidated yet. This study focused on the effects of IVIg on the production of interleukin-6 (IL-6), one of major proinflammatory cytokine, using a human skeletal muscle cell line (HM4). Methods: After HM4 cells were cultured in Dulbecco's modified eagle's medium (DMEM) containing 5% fetal bovine serum for 24 h, the culture medium was changed with serum-free media. TNF-α (tumor necrosis factor-α, 100 ng/mL) and IVIg (5 mg/mL) were treated alone or in combination and cultured for various time. RT-PCR and ELISA kit were employed for mRNA expression and secretion of IL-6, respectively. Results: Treatment with TNF-α or/and IVIg significantly induced IL-6 mRNA expression (p<0.001). Although IL-6 production was markedly increased by TNF-α (p<0.001), IVIg treatment alone or in combination with TNF-α had no effect on the production of IL-6 except at 6 h after the treatment. Conclusions: IVIg seems not to have a significant effect on IL-6 production as an action mechanism of its immunomodulatory capabilities, at least in the HM4 cell line.

저전압 감전(感電)에 의해 유발된 척수위축성마비 1예

주인수 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.2

Electrical injury can damage any structure in the peripheral and central nervous system through which it passes. Spinal atrophic paralysis is a syndrome of focal muscular atrophy occurring after a shock from man-made electricity. A previously healthy 29-year-old male has suffered from non-progressive atrophy of both upper extremities, especially hands, which insidiously progressed and became static for a few years, after electrical injury to right hand by household, low-tension current (110 V, a.c.) when he was 17-year-old. There was a noticeable muscle wasting of both hands with mildly diminished muscle power. Sensation was normal. Nerve conduction studies showed low CMAP amplitude of right ulnar nerve and absence or prolongation of F-wave of right ulnar and median nerves. Needle EMG of the muscles of right upper extremity demonstrated giant, polyphasic motor unit potentials of long duration without active denervation potentials. There was mid- to lower-cervical cord atrophy on the spinal MRI.

인간 골격근세포주(SKM14)에서 사이토카인과 케모카인 mRNA 발현

주인수,허균,이용범,김승업 대한신경과학회 2003 대한신경과학회지 Vol.21 No.1

Oral Administration of Memantine Prolongs Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

주인수,황동훈,석정임,신상건,김승업 대한신경과학회 2007 Journal of Clinical Neurology Vol.3 No.4

Background and Purpose: N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and oxidative stress have been implicated in the etiology of amyotrophic lateral sclerosis (ALS). Memantine is a low-affinity, noncompetitive NMDA receptor antagonist that may protect against motor neuron degeneration. Methods: Thirty transgenic mice expressing the G93A SOD1 mutation were randomly divided into control, lowdose memantine (30 mg/kg/day), and high-dose memantine (90 mg/kg/day) groups, with memantine supplied daily with drinking water beginning at 75 days of age. Body weight, survival, and behavioral performances including a rotarod test, paw grip endurance, and hindlimb extension reflex were assessed in the control and memantine-diet groups. Results: Clinical symptoms were evident in the G93A transgenic mice by 11 weeks of age. Memantine was tolerated well. Compared to control, mice treated with memantine performed better in the rotarod test and hindlimb extension reflex. Moreover, low-dose memantine treatment significantly prolonged the survival of the transgenic mice relative to control mice (141 vs 134 days, p<0.05). Conclusion: These findings suggest that memantine, even when administered at the time of symptom onset, has beneficial effects on patients with ALS.

흉부척수증 환자에서 후경골신경 감각유발전위검사 중추전달속도의 임상적 유용성에 관한 연구

주인수,이광우 대한신경과학회 1994 대한신경과학회지 Vol.12 No.2

신경통의 치료효과

주인수 약업신문사 1998 의약정보 Vol.1998 No.1

당뇨병성 다발신경병증의 조기 진단에서 신경전도검사의 유용성에 관한 논란

주인수 대한임상신경생리학회 2008 Annals of Clinical Neurophysiology Vol.10 No.1

Diabetic polyneuropathy (DPN) is the most frequently encountered form of neuropathy in diabetic patients, and it either relentlessly progresses or remains relatively stable for many years, not showing any trend towards improvement. From this point of view, early detection of DPN is very important to prevent the irreversible change of the peripheral nerve from diabetic insults. Although a number of clinical symptoms and/or deficit scales have been developed for clinical or research purposes, nerve conduction study (NCS) has been known one of the most objective and sensitive tools to detect peripheral nerve dysfunctions in diabetic patients. NCS, however, also have several shortcomings. The next two consecutive articles will focus on debates about diagnostic usefulness of NCS and on recent updates of other diagnostic tests including quantitative sensory testings and skin biopsy in the field of diabetic polyneuropathy.

신경병성통증의 중요성과 과제

주인수 대한의사협회 2021 대한의사협회지 Vol.64 No.7

Background: Pain is a complex and subjective symptom frequently encountered in many clinical fields. Acute pain is usually physiological, but chronic pain is a pathological condition that seriously affects the patientsʼ normal daily activities and quality of life. In addition, chronic pain has profoundly detrimental effects on their family and social relationship as well as a national healthcare system. Current Concepts: Neuropathic pain is accompanied by diverse neurological disorders in the central and peripheral nervous systems. Neuropathic pain is also a type of chronic pain and has mechanisms unresolved completely yet. Despite recent advances in basic and clinical researches of neuropathic pain including an individualized therapy, the treatment has not been satisfactory. Another problem is the increasing prevalence of neuropathic pain because of the rapid increase of the elderly population as in the case of Korea. Discussion and Conclusion: The clinician should be aware of a clinical entity of neuropathic pain to make an accurate diagnosis and to treat the patients more effectively.