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주고운,신승진,전병승,상병인 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
C<sub>6</sub> branched (isovaleric acid) and linear chain carboxylic acid (n-hexanoic acid) are organic compounds commonly found in the flavor of cheese or wine and their esters are applied to various chemicals, such as perfumery, plasticizer, lubricant, and pharmaceutical. This compounds can be biologically produced together by Megasphaera hexanoica (MH). In this study, medium compositions were investigated in order to produce isovaleric acid and hexanoic acid selectively. Significant factors for optimum medium were selected as follows: leucine, acetate and yeast extract. Significant factors were evaluated using central composite model of response surface methodology (RSM) and its results were analyzed by Design Expert®. The medium composition optimized by RSM was verified using the batch reactor and its production performance was improved using process equipped with extractive system.
주고운,박원,임미진,권성렬,윤지열 대한의학회 2011 Journal of Korean medical science Vol.26 No.9
Early differentiation between bacterial infections and disease flares in autoimmune disease patients is important due to different treatments. Seventy-nine autoimmune disease patients with symptoms suggestive of infections or disease flares were collected by retrospective chart review. The patients were later classified into two groups, disease flare and infection. C-reactive protein (CRP) and serum procalcitonin (PCT) levels were measured. The CRP and PCT levels were higher in the infection group than the disease flare group (CRP,11.96 mg/dL ± 9.60 vs 6.42 mg/dL ± 7.01, P = 0.003; PCT, 2.44 ng/mL ± 6.55vs 0.09 ng/mL ± 0.09, P < 0.001). The area under the ROC curve (AUC; 95% confidence interval) for CRP and PCT was 0.70 (0.58-0.82) and 0.84 (0.75-0.93), which showed a significant difference (P < 0.05). The predicted AUC for the CRP and PCT levels combined was 0.83, which was not significantly different compared to the PCT level alone (P = 0.80). The best cut-off value for CRP was 7.18 mg/dL, with a sensitivity of 71.9% and a specificity of 68.1%. The best cut-off value for PCT was 0.09 ng/mL, with a sensitivity of 81.3% and a specificity of 78.7%. The PCT level had better sensitivity and specificity compared to the CRP level in distinguishing between bacterial infections and disease flares in autoimmune disease patients. The CRP level has no additive value when combined with the PCT level when differentiating bacterial infections from disease flares.
주고운,박원,정문현,임미진,정경희,허윤석,권성렬 대한의학회 2013 Journal of Korean medical science Vol.28 No.2
Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of fever accompanied by peritonitis, pleuritis, arthritis, or erysipelas-like erythema. It is known to occur mainly among Mediterranean and Middle Eastern populations such as non-Ashkenazi Jews, Arabs, Turks, and Armenians. FMF is not familiar to clinicians beyond this area and diagnosing FMF can be challenging. We report a 22-yr old boy who presented with fever, arthalgia and abdominal pain. He had a history of recurrent episodes of fever associated with arthalgia which would subside spontaneously or by antipyretics. Autosomal recessive periodic fever syndromes were suspected. Immunoglobulin D (IgD) level in the serum was elevated and DNA analysis showed complex mutations (p.Glu148Gln, p.Pro369Ser, p.Arg408Gln) in the MEFV gene. 3D angio computed tomography showed total thrombosis of splenic vein with partial thrombosis of proximal superior mesenteric vein, main portal vein and intrahepatic both portal vein. This is a case of FMF associated with multiple venous thrombosis and elevated IgD level. When thrombosis is associated with elevated IgD, FMF should be suspected. This is the first adult case reported in Korea.
Prevention of Comorbidity and Acute Attack of Gout by Uric Acid Lowering Therapy
주고운,권성렬,임미진,정경희,주호연,박원 대한의학회 2014 Journal of Korean medical science Vol.29 No.5
The object of this study was to evaluate the effect of uric acid lowering therapy in reducingthe new development of comorbidities and the frequency of acute attacks in goutpatients. We retrospectively reviewed patients who were diagnosed to have gout with atleast 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uricacid level (sUA) < 6 mg/dL and 147 patients with mean sUA ≥ 6 mg/dL. Comorbidities ofgout such as hypertension (HTN), type II diabetes mellitus (DM), chronic kidney disease,cardiovascular disease (CVD) and urolithiasis were compared in each group at baseline andat last follow-up visit. Frequency of acute gout attacks were also compared between thegroups. During the mean follow up period of 7.6 yr, the yearly rate of acute attack andthe new development of HTN, DM, CVD and urolithiasis was lower in the adequatelytreated group compared to the inadequately treated group. Tight control of uric aciddecreases the incidence of acute gout attacks and comorbidities of gout such as HTN, DM,CVD and urolithiasis.
주고운,정문현,백지현,현인영,이진수 대한감염학회 2013 Infection and Chemotherapy Vol.45 No.2
Injection of N-butyl-2-cyanoacrylate has been used successfully for treatment of gastric variceal bleeding. Bacteremia after injection of N-butyl-2-cyanoacrylate is well known, however, the method for diagnosis of infected endovascular injected material has remained uncertain. This is the first case reporting use of F-18 FDG PET/CT in detection of the source of infection after control of endoscopic bleeding with N-butyl-2-cyanoacrylate.
Cholestatic Hepatitis Caused by Tongyeong Strain of Orientia tsutsugamushi
주고운,김미경,김준미,강재승,정문현,길세희 대한감염학회 2009 Infection and Chemotherapy Vol.41 No.2
In Korea, the clinical manifestation of scrub typhus in humans appears to be severe in the northern regions of the country and mild in the southern areas. Studies on the geographic distribution of the serotype of Orientia tsutsugamushi revealed that the Boryong serotype is predominant in the southern Korean peninsula, whereas the Gilliam, Karp, and Gilliam-Karp serotypes prevail in the northern or central peninsula. We report a case of severe scrub typhus caused by the Japanese Gilliam type of Orientia tsutsugamushi in a 66-year-old woman from Tongyeong, a city located in the southern part of Korean peninsula. The patient was admitted to the hospital with fever on August 29th, 2001. Scrub typhus complicated by shock, pneumonitis, and encephalitis was diagnosed. Additionally, markedly elevated alkaline phosphatase levels was observed, which necessitated an ultrasonographic examination, which showed an ill-defined hyperechogenic mass on the right hepatic lobe. Liver biopsy showed cholestatic hepatitis and blood culture showed growth of O. tsutsugamushi. Gene sequencing of the amplicons of a polymerase chain reaction using primers for the amplification of the gene encoding the 56-kDa protein of O. tsutsugamushi revealed a nucleotide sequence that matched Yonchon strain of O. tsutsugamushi.