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Human bocavirus에 의한 세기관지염이 재발성 천명의 발생에 미치는 영향
조형민 ( Hyoung Min Cho ),나세린 ( Se Rin Na ),임봉칠 ( Bong Chil Im ),유주희 ( Ju Hee You ),유은정 ( Eun Jung You ),김은영 ( Eun Young Kim ),김경심 ( Kyoung Sim Kim ),김용욱 ( Young Wook Kim ),서진종 ( Jin Jong Seo ),정윤석 ( Yoo 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4
목적: 호흡기 감염의 중요 바이러스 중에 하나인 보카바이러스에 의한 세기관지염의 경험이 그 이후의 반복적인 천명과 아토피(atopy)의 발생에 어떠한 영향을 미치는 지를 알아보고자 연구를 진행하였다. 또 세기관지염의 증상의 중증정도 및 여러 위험인자와 천명의 재발과의 관계를 알아보고자 하였다. 방법: 2005년 1월부터 2007년 12월까지 광주 기독병원 소아청소년과에 호흡기질환으로 입원하였던 2430명의 환자에서 호흡기바이러스 검사를 시행하여 보카바이러스가 RT PCR검사에서 양성을 보였던 112명의 환자들을 대상으로 하였다. 이 중 61명에서 2008년 4월부터 2008년 6월 사이에 전화설문과 우편설문을 실시하였으며 또 이 기간 내에 병원에 내원하게 하여 알레르기 검사를 실시하였다. 이 환자들의 입원 당시의 병력지를 조사 하였고, 세기관지염 당시의 증상의 중등도를 호흡곤란지수에 의해 평가하여 경증, 중등도, 중증의 세집단으로 환자들을 분류하였다. 또한 세기관지염 감염 후에 천명의 재발 유무를 설문에 의해 조사하여 천명없음, 1-2회의 간헐적 천명 재발, 3회 이상의 빈번한 천명 재발을 경험한 군으로 환자들을 재분류해 보았다. 결 과: 천명의 재발은 26.2%에서 있었으며 증상의 중증 정도가 심할수록 천명 재발이 의미 있게 증가하였다. 알레르기 검사 양성률도 증상의 중증도가 심한 군에서 높았으나 통계학적으로 의미는 없었으며 환자의 알레르기 질환 동반력 및 가족력, 육아시설 이용 유무, 나이 많은 형제의 유무도 천명의 재발에 영향을 주지 않는 것으로 나왔다. 결론: 보카바이러스 감염은 천명을 동반하는 세기관지염을 일으킬 수 있는 원인이 되며, 영아기에 보카바이러스에 의한 세기관지염을 경험한 것이 그 이후의 천명의 재발 및 알레르기 감작에 영향을 줄 수 있음을 확인하였다. 또한 천명의 재발에 있어 세기관지염 당시의 중등도가 중요함을 알았다. 그러나 본 연구에서 알레르기 검사를 많은 수에서 실시하지 못하여 제한점을 가지며 알레르기 질환의 동반력 및 가족력, 육아시설 이용 유무, 형제의 유무와 천명의 재발에 대해서도 좀 더 연구가 필요할 것으로 사료된다. Purpose: Excluding RSV, the relationship between bronchiolitis caused by viruses and the development of wheezing and atopy in childhood has not been well studied. We studied this relationship in children who had bronchiolitis caused by human bocavirus before 2 years of age. Methods: We retrospectively investigated 2,430 throat swab obstained between January 2005 and December 2007 from pediatric in-patients with acute respiratory tract disease at the Kwangju Christian Hospital. Human bocavirus was detected in 112 patients. A total of 61 patients less than 2 years of age were finally enrolled in this study. Patients were followed up between April and June of 2008. We measured the frequency of wheezing and atopic status using (allergy skin-prick tests, CAP tests and MAST tests). Results: Of the 61 patients, 16 (26.2%) had recurrent wheezing. Of these 16 patients, 8 (13.1%) had Infrequent wheezing (1-2 wheezing episodes) and 8 (13.1%) had frequent wheezing (3 and over wheezing episodes). Of the total 61 patients, 18 (29.5%) completed allergy tests. Of the 18 patients, 10 (55.6%) were sensitized to at least 1 allergen. Recurrent wheezing was significantly associated with the severity of bronchiolitis (mild vs. moderate vs. severe; 9.1% vs. 22.2% vs. 66.7%). Conclusion: Human bocavirus-induced bronchiolitis in childhood are an independent risk factor for development of wheezing in childhood and may be associated with an increased risk of allergic sensitization. The most important risk factor for recurrent wheezing is the severity of lower respiratory tract illnesses. [Pediatr Allergy Respir Dis(Korea) 2010;20:247-255]
항암치료제로서 단백질 프레날화 억제제의 개발 현황 및 가능성
조형민 ( Hyoung-min Cho ),박용빈 ( Yong-bin Park ),신희종 ( Hee-jong Shin ) 서울대학교 인구의학연구소 2015 人口醫學硏究論集 Vol.28 No.-
During the last 3 decades, oncogenic Ras has been recognized as one of the potent causes of human cancer. But until now, there is no safe and effective Ras inhibitor, because alternative pathway is turned on when Ras inhibitor is treated. So there were many attempts to inhibit the post-translational modification termed farnesylation, which is essential for Ras anchorage into the membrane. Previous attempts to target farnesylation have focused on the development of farnesyltransferase inhibitors, but the performance of such agents in cancer clinical trials has not been as good as hoped. Here, we review novel therapeutic approaches targeting prenylation and prospect the future of using prenylation inhibitors as cancer therapy
천명이 동반된 급성 하기도 감염 소아에서 바이러스 RS, 라이노바이러스 그리고 보카바이러스 감염에 따른 임상 양상의 비교
신현욱 ( Hyun Wook Shin ),조하림 ( Ha Lim Cho ),유주희 ( Ju Hee You ),유은정 ( Eun Jung You ),김은영 ( Eun Young Kim ),김경심 ( Kyoung Sim Kim ),김용욱 ( Yong Wook Kim ),서진종 ( Jin Jong Seo ),조형민 ( Hyoung Min Cho ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.4
Purpose: The purpose of this study was to compare clinical manifestations of human bocavirus (hBoV), respiratory syncytial virus (RSV), and human rhinovirus (hRV) in children with acute wheezing. Methods: We retrospectively investigated 549 virus-positive throat swabs obtained between January 2006 and December 2008 from pediatric inpatients with acute respiratory tract disease at Kwangju Christian Hospital. Among them, 109 patients, who had lower respiratory tract infections with wheezing, were enrolled in this study. The medical records of patients with positive results were reviewed for clinical data. Results: The mean age of the patients with RSV was 7.15 months, 15.66 months in those with hRV, and 15.04 months in those with hBoV. The mean fever duration and frequency of patients with fever was 2.43 days and 47.9% for RSV, 2.86 days and 51.7% for hRV, and 3.75 days and 69.6% for hBoV. The frequency of patients with acute otitis media was 20.8% in the RSV, 20.7% in the hRV, and 13.0% in the hBoV groups. The frequency of lung infiltration on chest X-ray was 12.5% in the RSV, 20.7% in the hRV, and 47.8% in the hBoV groups. Conclusion: We compared the clinical manifestations of respiratory viral infections in infants and children with wheezing. However, further surveillance will be necessary to clarify the clinical manifestations of the viruses. (Pediatr Allergy Respir Dis(Korea) 2011;21:334-343)
불명열(Fever of Unknown Origin, FUO)로 내원한 환아에서 진단된 NOD2 유전자 변이 크론병
박보경(Bo Kyoung Park),김현종(Hyun Jong Kim),장해인(Hae In Jang),조형민(Hyoung Min Cho),김은영(Eun Young Kim),김경심(Kyoung Sim Kim),김용욱(Yong Wook Kim),김서희(Seo-Hee Kim),김령(Young Kim) 조선대학교 의학연구원 2022 The Medical Journal of Chosun University Vol.47 No.2
We apply the term Fever of unknown origin (FUO) to children with fever >38oC of at least eight days’ duration, in whom no diagnosis is apparent after initial evaluation. Fever is a prominent component of inflammatory bowel disease (IBD), especially Crohn’s disease (CD), in many children and may be more common than abdominal symptoms. The pediatric CD rate is rapidly increasing and pediatric onset IBD represents ≥25% of all IBD diagnoses. The nucleotide-binding oligomerization domain (NOD) protein is belonging to the intracellular NOD-like receptor family. NOD2 was the first and is the most replicated locus associated with IBD. In this paper, authors report a case of CD with FUO and NOD2 mutation in a 12-year-old girl.
ATP1A2 유전자의 돌연변이를 동반한 소아 교대성 편마비 1예
전우진(Woo Jin Jeon),김용욱(Yong Wook Kim),김경심(Kyoung Sim Kim),조형민(Hyoung Min Cho),김령(Young Kim),장해인(Hae In Jang),김은영(Eun Young Kim) 조선대학교 의학연구원 2020 The Medical Journal of Chosun University Vol.45 No.2
Alternating hemiplegia of childhood (AHC) is a neurological disorder characterized by recurrent paroxysmal hemiplegic episodes that involve either or both sides of the body. We experienced AHC with typical clinical features such as recurrent alternating hemiplegia, dystonic spells, abnormal eye movement and developmental delay before 18 months after birth. And we found a heterozygous Ala297Thr variant, missense de novo mutation in the ATP1A2 genetic test. Although AHC is a rare disease, it is expected that the prognosis for development will be good if we are well aware of the characteristics of the disease, perform early diagnosis and management. Here we report a review of the literature, including genetic advances on AHC.
권장훈(Jang Hoon Kwon),서현성(Hyun Sung Seo),장해인(Hae In Jang),조형민(Hyoung Min Cho),김은영(Eun Young Kim),김경심(Kyoung Sim Kim),김용욱(Yong Wook Kim),김 령(Young Kim) 조선대학교 의학연구원 2023 The Medical Journal of Chosun University Vol.48 No.2
Inflammatory bowel disease (IBD), comprised of two major disorders, Crohn disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders that can affect the gastrointestinal tract. It is known that IBD commonly presents with extraintestinal manifestations (EIMs). Children and adolescents with IBD are often at risk for suboptimal bone health because of undernutrition, delayed puberty, and prolonged glucocorticoid (GC) use. The authors report a case of a child with IBD and osteolysis in this report.
고호준(Ho Joon Ko),장해인(Hae In Jang),조형민(Hyoung Min Cho),김은영(Eun Young Kim),김경심(Kyoung Sim Kim),김용욱(Yong Wook Kim),김령(Young Kim) 조선대학교 의학연구원 2021 The Medical Journal of Chosun University Vol.46 No.1
Background: The incidence of intestinal metaplasia(IM) of stomach mucosa in children was reported ranging from approximately 1 to 3 percent. But, clinical implications, treatment, long-term prognosis, and surveillance protocols of this finding are not well established in this population. Study Objectives: This study aimed to evaluate the relationship between Helicobacter pylori (HP) infection and IM, and the treatment and long-term consequences of IM. Methods: During 6.5 years from March 2013 through August 2019, endoscopy with CLO test and multiple non-targeted biopsies were performed on 423 children and adolescents, 1 to 20 years of age, with alarm features associated with ulcer disease and gastritis. The clinical and laboratory records, macroscopic and microscopic findings of endoscopy were reviewed retrospectively. Results: Thirty-two cases (7.6%) of IM were identified. Two cases (6.3%) with HP infection were detected in 32 cases of IM, and 38 cases (9.7%) in 391 cases of non-IM. The Odds ratio was 0.619 (0.142-2.693). Proton pump inhibitor (PPI) was prescribed for six months in all cases of IM, and endoscopic follow-up was performed after a year in 11 cases. The disappearance of IM was detected in 6 cases (18.8%). Conclusions: The association of HP infection and IM was very low. After six months of PPI medication, the disappearance of IM was detected in a few cases. A close and prolonged clinical and endoscopic follow-up is needed for children and adolescents with IM.
박준형(June Hyung Park),장해인(Hae In Jang),조형민(Hyoung Min Cho),김은영(Eun Young Kim),김경심(Kyoung Sim Kim),김용욱(Yong Wook Kim),김 령(Young Kim) 조선대학교 의학연구원 2021 The Medical Journal of Chosun University Vol.46 No.2
Background: The sentinel polyp (SP) is a term used to refer to inflammatory polyps that are commonly associated with gastroesophageal reflux resulting in esophagitis. However, not only clinical progress, but also relationship of clinical characteristics with clinical outcomes are not well established in children and adolescents. Study Objectives: This study aimed to evaluate the relationship between clinical progress and individual characteristics and the prognosis of SP. Methods: During 8 years from March 2013 through April 2021, 125 patients with symptoms of chronic gastritis or gastroesophageal reflux disease were evaluated and followed with upper gastrointestinal endoscopy and biopsy at least twice. The clinical and laboratory records, macroscopic and microscopic findings of endoscopy were reviewed retrospectively. Results:Eleven cases of SP were identified. Proton pump inhibitors and antacids were prescribed for six months each in 8 cases of SP, and endoscopic follow up was performed after a year in 8 cases. The resolution of SP was detected in 5 (62.5%) cases (improved group). 3 out of 5 cases had a well-controlled diet in the improved group, and 2 out of 3 in the not improved group. Odds ratio was 0.75, and the P-value was 0.85. Conclusions: After 1 year of PPI and antacids medication, SP showed improvement in more than half of the cases (5 out of 8, 62.5%). The association of SP improvement and diet control appeared to be low. A further research is needed on a larger scale.
소아에서 단일 폐 결절로 보인 폐쇄성 세기관지 기질화 폐렴 1례
이은지 ( Eun Ji Lee ),강양집 ( Yang Jib Kang ),조형민 ( Hyoung Min Cho ),김용욱 ( Yong Wook Kim ),김경심 ( Kyoung Sim Kim ),김은영 ( Eun Young Kim ),유은정 ( Eun Jung You ),유주희 ( Ju Hee You ),국훈 ( Hoon Kook ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.4
폐쇄성 세기관지 기질화 폐렴은 병리 조직 소견에서 세기관지와 폐포 내의 육아 조직 증식을 보이고 흉부 방사선에서 양측성 반점상 침윤을 흔히 보이는 질환이다. 본 증례에서는 소아에서 드물게 단일 결절의 폐쇄성 세기관지 기질화 폐렴을 발견하여 보고하였으며 흉부 방사선에서 단일 결절 소견이 보일 경우 폐감염 또는 종양 등과 함께 폐쇄성 세기관지 기질화 폐렴에 대한 감별도 필요할 것으로 생각된다. Bronchiolitis obliterans organizing pneumonia (BOOP) is a pulmonary disorder that exhibits various radiographic findings. It often shows bilateral, patched, or ground glass interstitial infiltrate, but a solitary nodular pattern rarely appears. We report a case of an 8-year-old boy suffering from BOOP that showed a single nodular pattern of the lung in the chest radiography. We conclude that when there is a solitary nodule discovered in the lungs of children or adolescence, the differential diagnosis must include BOOP. [Pediatr Allergy Respir Dis(Korea) 2012;22:433-437]
아미노산 분유로 변경 후 병증이 호전되어 우유 단백 유발 알러지로 진단된 신생아 4예
김현종(Hyun Jong Kim),유명환(Myung Hwan Yoo),서현성(Hyun Sung Seo),장해인(Hae In Jang),조형민(Hyoung Min Cho),김은영(Eun Young Kim),김경심(Kyoung Sim Kim),김용욱(Yong Wook Kim),김령(Young Kim) 조선대학교 의학연구원 2023 The Medical Journal of Chosun University Vol.48 No.1
Cow’s milk protein allergy(CMPA) or cow’s milk protein-induced allergy is the most common food allergy in children. It has been reported to have a 2 to 3% prevalence in infants within one year of age, but the exact prevalence in newborns within one month of age has not yet been accurately reported. In children who have non-specific symptoms such as diarrhea, bloody stool, vomiting, and urticaria within a few weeks of exposure to milk protein, if the symptoms improve when changing to a diet without milk protein, a milk allergy can be diagnosed without additional tests. The extensively hydrolyzed formula is generally recommended first as a diet with milk protein eliminated, but amino acid-based formula can be considered preferentially as milk allergy may recur due to residual immunologically active proteins in the extensively hydrolyzed formula. In this report, the authors report four cases of newborns diagnosed with CMPA after changing to amino acid-based formula.