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지역사회 성인 여성의 요골에서의 골다공증 유병률과 갑상선기능이 미치는 영향
조윤성 ( Yun Sung Jo ),정현식 ( Hyun Sik Chung ),임선옥 ( Sun Oak Lim ),김장흡 ( Jang Heub Kim ) 대한폐경학회 2009 대한폐경학회지 Vol.15 No.1
Objectives: This retrospective study was conducted to evaluate the the influence of thyroid function on the prevalence of osteoporosis in Korean women in a local community. Methods: Bone status and thyroid function were evaluated in 698 women (mean age, 57.9 years) who visited a public health center in Wonjusi between May and November. 2007. The bone mineral density of the radius was evaluated using dual energy X-ray absorptiometry (BHP-76-P, GE Lunar, USA). Patients were classified as normal, osteopenia, or osteoporosis based on T-scores. For thyroid function, they were classified as normal, hypothyroidism, or hyperthyroidism based on the free T4 level. Results: The prevalences of osteoporosis and osteopenia in menopausal women were 85.5% and 56%, respectively. We found a significant negative correlation between bone mineral density and thyroid hormone level (r=0.11, P<0.05). Conclusion: The prevalence of osteoporosis and osteopenia increased with increasing age. We found that thyroid hormone level, as well as physiological age, were important factors affecting the rate of bone loss in older women. Thus, thyroid function testing and proper thyroid treatment are helpful for the prevention and treatment of osteoporosis in menopausal women.
조윤성 ( Yun Sung Jo ),고현선 ( Hyun Sun Ko ),장동규 ( Dong Gyu Jang ),최윤진 ( Youn Jin Choi ),손현주 ( Hyen Ju Son ),김사진 ( Sa Jin Kim ),신종철 ( Jong Chul Shin ),이귀세라 ( Guisera Lee ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.10
Objective: The purpose of this study was to determine the perinatal outcome in monoamniotic twin pregnancies and to review the recently published literature about the topic. Methods: This retrospective study examined the records of prenatally diagnosed monoamniotic twin pregnancy casese in our institution between January 1997 and April 2010. Results: Among 1,112 twin pregnancies, there were 15 (1.3%) monoamnionic twins, including 2 conjoined twin pregnancies. Twelve (80%), 9 (60%), 5 (33.3%), and 4 pregnancies (26.7%) delivered after 20, 30, 32, and 34 weeks, respectively. Among 12 pregnancies that continued after 20 weeks of gestation, three cases showed one-fetal death and one, both-fetal death. The perinatal mortality rate (from 20 weeks of gestation to 28 days after birth) was 37.5%. The incidence of lethal anomalies and congenital heart anomalies was 20% and 23.3%, respectively. The mean gestational age at delivery was 31.4±4.53 weeks; 16 of 18 neonates (84.2%) were admitted to the neonatal intensive care unit (NICU). Three neonates expired on the first day after birth. The mean duration of the NICU stays for 13 live neonates was 32.0±29.3 days (range, 3 to 114 days). The main causes of perinatal deaths were preterm birth, congenital anomalies, pregnancy loss before 20 weeks, and intrauterine fetal demise that might have resulted form cord entanglement. Conclusion: Perinatal mortality in monoamniotic twins was still very high and the survival rate after 32 weeks of gestation is approximately one-third. Further studies are needed to improve the perinatal mortality.
조윤성 ( Yun Sung Jo ),장동규 ( Dong Gyu Jang ),이귀세라 ( Gui Se Ra Lee ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.7
Objective: To evaluate placental causes of fetal death intrauterine (IUFD) bases on placental pathologic findings. Methods: Retrospective review of 123 placental pathological reports of singleton fetal deaths from 20 weeks of gestation to 41 weeks of gestation. Results: The incidences of maternal causes, fetal causes, inflammatory causes, miscellaneous and unremarkable findings were 45.5%, 28.4%, 16.2%, 23.5%, respectively. The incidence of fetal anomaly was 8.9%. Fetal anomalies were deeply related to fetal cause (P=0.000). Intrauterine growth restriction was significantly associated with maternal causes (P=0.038). Conclusion: No pathological guideline regarding placental examination of intrauterine fetal death exists. In future studies, a better definition of fetal death causes and associated placental pathological findings might aid clinicians in counseling, assessing the risk of recurrence and even preventing fetal death in subsequent pregnancies.
조윤성 ( Yun Sung Jo ),권지영 ( Ji Young Kwon ),임희순 ( Hee Sun Lim ),문영주 ( Young Joo Mun ),이상형 ( Sang Hyoung Lee ),제동성 ( Dong Sung Jae ),한구택 ( Gu Taek Han ),류기성 ( Ki Sung Ryu ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12
Myoma is the most common tumor in gynecologic field. As ultrasonography because popular in antenatal care, the more cases of myoma and those adverse effects during pregnancy are more frequently detected. The management of myoma during pregnancy is conservative, but in rare circumstances, surgical intervention including myomectomy may be required. We have experienced a case of protruded subserosal myoma with the uterine cervix in midtrimester of pregnancy. The patient was managed surgically by transvaginal myomectomy and had successfully maintained pregnancy. We report a case of protruded subserosal myoma through pelvic floor in pregnancy with brief review of literatures.
조윤성 ( Yun Sung Jo ),김두만 ( Du Man Kim ),이귀세라 ( Gui Se Ra Lee ),김민정 ( Min Jeong Kim ),김사진 ( Sa Jin Kim ) 대한주산의학회 2009 Perinatology Vol.20 No.4
Purpose: To determine the means, medians and reference intervals for TSH (thyroid-stimulating hormone) and fT4 (free thyroxine) for each month of gestation and for three trimesters in Korean pregnant women. Methods: Serum samples were collected from 265 pregnant women with singleton gestation. Levels of TSH, fT4 were measured by immunoassay. After exclusion of subjects with positive anti-microsomal autoantibodies, the means, medians and reference intervals based on 2.5th and 97.5th percentiles for TSH, fT4 were determined. Results: The study population consisted of 94 women in first trimester, 49 women in second trimester, and 122 women in third trimester. The trimester-specific reference intervals were: TSH (1st trimester: 0.03~2.72, 2nd: 0.27~2.29, and 3rd: 0.03~2.88 mIU/L), fT4 (1st trimester 4.50~19.75, 2nd: 4.70~12.98 and 3rd: 5.07~11.84 pg1mL). fT4 levels were significantly lower in the second and third trimesters. TSH levels were lower in the first trimester than second and third trimester, with gradual elevation in the second and third trimester. Conclusion: Levels of TSH, fT4 during pregnancy differ from those in non-pregnant women. Gestational age specific reference intervals will play a cental role in screening and diagnosis of thyroid disorders. Further studies for normal reference ranges during pregnancy are needed to create reference intervals in Korean pregnant women.