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조영학,유세종,배석환,선종률,김성호,이원정 한국방사선학회 2024 한국방사선학회 논문지 Vol.18 No.1
본 연구에서는 의료기관에서 방사성동위원소를 이용하여 암을 비롯한 여러 질환을 검사하는 PET/CT 검사에서 환자의 움직임으로 인한 영상의 질 저하와 판독 오류를 발생할 수 있는 점을 보완하기 위해 AI 기반의 Algorithm을 이용하여 개발한 Mothion Free 소프트웨어를 이용하여 호흡으로 인한 움직임의 보정 정도를 확인하고 유용성을 평가하여 임상에서의 적용을 위한 연구를 하였다. 실험 방법은 RPM Phantom을 사용하여 방사성동위원소 18F-FDG를 진공 바이알과 서로 다른 크기 NEMA IEC body Phantom의 sphere에 방사성동위원소를 주입하고 이것의 움직임을 호흡 시 움직이는 병소로 연출하여 영상을 획득하였다. 진공 바이알은 서로 다른 위치에서 움직임 정도를 다르게 하였고, 서로 다른 크기 NEMA IEC body Phantom의 sphere는 서로 다른 병소의 크기를 연출 하였다. 획득한 영상을 통하여 병소의 체적, 최대 SUV, 평균 SUV를 각각 측정하여 Mothion Free가 움직임 보정 정도를 정량적 평가를 하였다. 움직임 정도를 크게 설정한 진공 바이알 A의 평균 SUV는 23.36 %, 움직임 정도를 작게 설정한 진공 바이알 B는 29.3 % 오차율이 감소하였다. NEMA IEC body Phantom의 sphere 37 mm, 22 mm에서의 평균 SUV는 각각 29.3 %, 26.51 % 오차율이 감소하였다. 오차율을 산출한 네 가지 측정치의 평균 오차율 30.03 % 감소하여 보다 정확한 평균 SUV 값을 나타내었다. 이 연구에서는 2차원적인 움직임 만을 연출할 수 있었기에 보다 정확한 데이터를 얻기 위해서는 실제 인체의 호흡 운동을 구현할 수 있는 Phantom을 이용하고, 움직임의 범위의 다양성을 구성한다면 보다 정확한 유용성 평가를 할 수 있다고 연구된다. In this study, an AI-based algorithm was developed to prevent image quality deterioration and reading errors due to patient movement in PET/CT examinations that use radioisotopes in medical institutions to test cancer and other diseases. Using the Mothion Free software developed using, we checked the degree of correction of movement due to breathing, evaluated its usefulness, and conducted a study for clinical application. The experimental method was to use an RPM Phantom to inject the radioisotope 18F-FDG into a vacuum vial and a sphere of a NEMA IEC body Phantom of different sizes, and to produce images by directing the movement of the radioisotope into a moving lesion during respiration. The vacuum vial had different degrees of movement at different positions, and the spheres of the NEMA IEC body Phantom of different sizes produced different sizes of lesions. Through the acquired images, the lesion volume, maximum SUV, and average SUV were each measured to quantitatively evaluate the degree of motion correction by Motion Free. The average SUV of vacuum vial A, with a large degree of movement, was reduced by 23.36 %, and the error rate of vacuum vial B, with a small degree of movement, was reduced by 29.3 %. The average SUV error rate at the sphere 37mm and 22mm of the NEMA IEC body Phantom was reduced by 29.3 % and 26.51 %, respectively. The average error rate of the four measurements from which the error rate was calculated decreased by 30.03 %, indicating a more accurate average SUV value. In this study, only two-dimensional movements could be produced, so in order to obtain more accurate data, a Phantom that can embody the actual breathing movement of the human body was used, and if the diversity of the range of movement was configured, a more accurate evaluation of usability could be made.
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조영학,이민석,박성현,김예솔,이은정,임성갑 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.2
For last two decades, the demand for precisely engineered three-dimensional structures has increased continuously for the developments of biomaterials. With the recent advances in micro- and nano-fabrication techniques, various devices with complex surface geometries have been devised and produced in the pharmaceutical and medical fields for various biomedical applications including drug delivery and biosensors. These advanced biomaterials have been designed to mimic the natural environments of tissues more closely and to enhance the performance for their corresponding biomedical applications. One of the important aspects in the rational design of biomaterials is how to configure the surface of the biomedical devices for better control of the chemical and physical properties of the bioactive surfaces without compromising their bulk characteristics. In this viewpoint, it of critical importance to secure a versatile method to modify the surface of various biomedical devices. Recently, a vapor phase method, termed initiated chemical vapor deposition (iCVD) has emerged as damage-free method highly beneficial for the conformal deposition of various functional polymer films onto many kinds of micro- and nano-structured surfaces without restrictions on the substrate material or geometry, which is not trivial to achieve by conventional solutionbased surface functionalization methods. With proper structural design, the functional polymer thin film via iCVD can impart required functionality to the biomaterial surfaces while maintaining the fine structure thereon. We believe the iCVD technique can be not only a valuable approach towards fundamental cell-material studies, but also of great importance as a platform technology to extend to other prospective biomaterial designs and material interface modifications for biomedical applications.
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Cerebral venous thrombosis in a patient with Crohn’s disease
조영학,채민규,차재명,이정일,주광로,신현필,백일현,전정원,임준욱,홍인택,기혜진,강재빈 대한장연구학회 2016 Intestinal Research Vol.14 No.1
Patients with inflammatory bowel disease (IBD) have an elevated risk of venous thromboembolism compared with the general population. The most common sites of venous thromboembolism in IBD patients are the deep veins of the legs, the pulmonary system, and portal and mesenteric veins. However, cerebral venous thrombosis is rarely associated with IBD. This report describes a case of cerebral venous thrombosis in a patient with Crohn’s disease. A 17-year-old girl, diagnosed 4 years earlier with Crohn’s disease, presented with headache and vomiting. Magnetic resonance imaging of the brain with venography showed venous thrombosis in the cortical veins, superior sagittal sinus, right transverse sinus, and right internal jugular vein. The patient immediately started anticoagulation therapy with intravenous heparin infusion followed by daily oral rivaroxaban 10 mg. Follow-up imaging after 2 weeks showed resolution of the thrombosis, with recanalization of the cortical veins, superior sagittal sinus, right transverse sinus, and right internal jugular vein. She continued rivaroxaban therapy for 6 months, and remained well, without neurologic sequelae. A high level of concern for cerebral venous thrombosis may be important when treating active IBD patients, because anticoagulation treatment can prevent fatal complications.
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