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권건영,조승제,박관규,장은숙,Kwon, Kun-Young,Cho, Seung-Che,Park, Kwan-Kyu,Chang, Eun-Sook 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.2
Bronchoalveolar lavage (BAL) has emerged as a useful technique for the study of pulmonary interstitial disorders. Several types of Information are provided by the evaluation of lavage fluid identification of cellular constituents helps to separate inflammatory process. Recently we have studied cellular constituents of BAL from three cases with histologically confirmed pulmonary sarcoidosis, idiopathic pulmonary fibrosis and hypereosinophilic syndrome. Pulmonary sarcoidosis showed a marked increase in lymphocytes, idiopathic pulmonary fibrosis revealed a predominance of neutrophils, and hypereosinophilic syndrome presented a marked increase in eosinophils in the lavage fluids.
기관지 폐포 세정액에서 뉴우모시스티스 카리니의 면역세포화학적 검출
권건영,조승제,김상표,박관규,장은숙,김정숙,Kwon, Kun-Young,Cho, Seung-Che,Kim, Sang-Pyo,Park, Kwan-Kyu,Chang, Eun-Sook,Kim, Chung-Sook 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1
Pneumocystis carinli is an established cause of pulmonary infections in immuno-compromised hosts. Several cytoiogical stains, such as Papanicolaou, Gomori methenamine sliver(GMS) and Diff-Quik have been used for detection of the organism, but occasionally can be laborious and, due to a degree of nonspecificity, may be misleading. We evaluated the diagnostic utility of immunocytochenmical stains that recognize P. carinii in bornchoalveolar lavage from experimentally Induced P. carinii pneumonia rats(n=15). In audition to routine stains for diagnosis by morphologic recognition of P. carinii on Papanicolaou, GMS and Diff-Quik stains, bronchoalveolar lavage samples were reacted with immunocytochemical stains using monoclonal antibodies(MAB) 092 and 902. In bronchoalveolar lavage P. carinii organisms were detected In 9 of 10 cases(90%) using each MAB 092 and 902, whereas GMS and Diff-Quik stains demonstrated P. carinii in 13(86%) and 11(73%) of 15 cases respectively. In lung tissue specimens(n=15) P. carinii organisms were well identified on GMS stain and immunohistochemical stains using MAB 092 and 902 in ail cases. We believe that the immunocytochemical staining using MAB 092 and/or 902 is a very useful and diagnostic tool In addition to GMS and Diff-Qulk stain to detect P. carinii organisms in bronchoalveolar lavage.
장은숙(Eun Sook Chang),손수상(Soo Sang Sohn),조승제(Seung Che Cho),김인호(In Ho Kim),김상표(Sang Pyo Kim),강중신(Joong Shin Kang) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.1
Although normal thyroid epithelial cells do not constitutively express HLA-DR antigen, their expression in wide spread within thyroid glands obtained from the human with autoimmune thyroid disease and with many neoplastic thyroids. We have, therefore, studied immunohistochemically with regard to the expression of HLA-DR antigen of thyroidectomy specimens from 50 patients of various thyroid diseases with use of paraffin-embedded tissue. One or two sections from each case were stained with commercially available mouse monoclonal antibody for class II HLA-DR antigen(HLA-DR/Alpha, DAKO) and examined by semiquantitative counting system for thyrocytes, neoplastic thyrocytes and other cells expressing HLA-DR antigen. All patients with lymphocytic thyroiditis(2/2) and diffuse hyperplasia(Graves' disease)(5/5), most patients with Hashimoto's disease(9/ll) expressed HLA-DR antigens in thyrocyte with abundant HLA-DR expressing lymphocytic infiltrates with lymph follicle formation in its vicinity or adjacent to the lesion. Most patients with papillary carcinoma(9/1l) had HLA-DR antigen detected in malignant thyrocytes ; while follicular carcinoma(0/3) and follicular adenoma(0/5) did not have detactable HLA-DR immunoreactivity. Adenomatous goiter(3/7) had HLA-DR antigen detected focally in lesser than half cases. Conversely, in four papillary carcinomas and three adenomatous goiters, HLA-DR expression of thyrocytes was found in the absence of HLA-DR expressing lymphoid infiltrates. In such cases therefore other factors more than thyroid autoimmunity must be causative for HLA-DR immunoreactivity. The results of this study indicate as follows. 1) The expression of HLA-DR on thyrocytes involved in autoimmune reactions appeared to be secondary to cytokine release from associated lymphocytic infiltrates. 2) Thyrocytes in thyroid lesions with equal degrees of lymphocytic infiltration without HLADR expression exhibited no HLA-DR immunoreactivity. 3) In neoplastic thyrocytes, most papillary carcinoma(9/11) exhibited detactable HLA-DR expression, while follicular carcinoma/adenoma(0/3/0/5) exhibited no detactable HLA-DR immunoreactivity which suggest the existence of divergent mechanisms inducing and modulating HLA-DR expression of different types of neoplastic thyrocytes.
이상숙,조승제 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4
Multilobated non-Hodgkin's lymphomas (NHL) have been recently recognized as an NHL variant in which more than 30% of malignant cells had a characteristic multilobation. We have recently experienced a case of diffuse large cleaved NHL with prominent nuclear multilobation in a 65-year-old man. He presented with a submental mass. Immunophenotyping revealed B-cell lineage of tumor cells. Considering the rarity of this lymphoid malignancy, we describe here the histological, immunohistological and clinical features of a case of NHL characterized by a diffuse proliferation of large multilobated cells.
이재혁,조승제,박종태 大韓法醫學會 1994 대한법의학회지 Vol.18 No.1
A 22-year old male patient was admitted to the Emergency room of local clinic because of the stuporous mental status. On physical examination, he appeared as a chronically ill, slender man. There was complete absence of the left arm pulse, and a prominent thrill and briuts were present over the right subclavicular area. The blood pressure which checked in the other regions except for the left arm was hypertensive(right arm 180/100, right leg 210/120, and left leg 200/130mmHg). An x-ray film of the chest and doppler ultrasounds showed characteristic dilatation of aortic arch, ascending aorta and innominate artery. The clinical impression was Takayasu's disease. This patients's condition deteriorated rapidly in spite of intensive care and died on the seventh hospital day. At autopsy, the cause of death was massive left brain infarction due to middle cerebral artery embolization. The opened luminal surface of the aorta and its major branches revealed irregulary thick-walled, tree-bark-like appearance. Also in the left common carotid artery, the lumen was nearly obliterated by thromi and intimal fibrous plaques. But the thoraco-abdominal aorta was spared. Microscopic examination disclosed granulomatous and sclerosing arteritis. In the former, the inflammatory process was confined to the media and adventitia and the cell infiltrate consisted predominantly of lymphocytes, plasma cells and histiocytes, with a varying number of giant cells. The latter was characterized bland intimal fibrous hyperplasia, medial degeneration with disrupted elastic lamella, and adventitial fibrosis. The pathologic diagnosis was Takayasu's disease of type I.