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조수연 ( Su Yeon Cho ),문현종 ( Hyeon Jong Moon ),김지원 ( Ji Won Kim ),조석기 ( Suk Ki Cho ),김병관 ( Byeong Gwan Kim ),주세경 ( Sae Kyung Joo ),김영훈 ( Young Hoon Kim ),박진선 ( Jin Sun Park ),최원제 ( Won Jae Choi ),김수환 ( S 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2
목적: 저자들은 식도 점막하종양을 수술로 치료한 예를 분석 하고 과거 보고와 비교하여 국내에서의 식도 점막하종양의 특 성을 파악하고 이를 통해 향후 방침을 세우는 데 참고하고자 하였다. 대상 및 방법: 2005년부터 2012년까지 서울특별시보라매병 원과 분당서울대학교병원에서 식도 점막하종양을 진단받고 수술을 시행받은 18예를 후향적으로 분석하였다. 결과: 환자의 평균 연령은 48.9세였고, 남녀 비는 2.6:1였고, 대부분 무증상(77.8%)이었다. 대부분은 중부(55.6%)와 하부 식도(44.4%)에 위치하였고, 크기는 3-5 cm (55.6%)과 3 cm 이하(33.3%)인 경우가 많았다. 내시경초음파에서 병변은 대 부분 네번째 층(83.3%)에 존재하였고, 저에코 (72.2%)로 관찰 된 경우가 많았으며, 고에코 (11.1%) 또는 혼재된 에코(11.1%) 로 관찰된 경우도 있었다. 평활근종으로 진단한 경우가 가장 많았고(55.6%), 수술을 시행한 이유는 악성이 의심되거나 (38.9%) 병변의 크기가 큰 경우(33.3%) 및 크기 증가(11.1%) 등이었다. 수술은 대부분 흉강경을 이용한 적출술(83.3%)을 시행하였고, 병변의 평균 크기는 5.4 cm였으며, 6-10 cm 사 이인 경우(38.9%)가 가장 많았고, 3-5 cm 사이인 경우 (33.3%)가 그 다음으로 많았다. 최종 진단은 평활근종이 대부 분이었고(88.9%), 나머지는 위장관 기질종양(11.1%)이 차지 하였다. 결론: 식도 점막하종양은 평활근종이 가장 흔하였으나, 내시 경초음파로 위장관 기질종양과의 감별이 매우 어려웠다. 악성 이 의심되거나 증상을 동반하는 경우에는 흉강경을 이용한 최 소 침습 수술이 치료에 적절할 것으로 판단된다. Background/Aims: Submucosal tumors of the esophagus are rare lesions among all esophageal neoplasms. The purpose of this study was to evaluate the clinicopathologic features of esophageal submucosal tumors treated by surgical approach. Methods: We analyzed the clinicopathologic and endoscopic ultrasonographic features of 18 esophageal submucosal tumors which were treated by surgical approach at Boramae Medical Center and Seoul National University Bundang Hospital from January 2005 to June 2012. Results: The mean age was 48.9 years old and male to female ratio was 2.6:1. Asymptomatic patients were most common (77.8%). In endoscopic ultrasonographic finding, the majority tumor arouse in the middle (55.6%) and lower (44.4%) esophagus, and appeared as hypoechoic lesion (72.2%) in the 4th layer (83.3%). The most common indication for surgical approach was unclear biological behavior of the tumor. Minimally-invasive technique using thoracoscopy was applied for the enucleation (83.3%). The mean diameter of the tumor was 5.4 cm, and the final diagnosis was leiomyoma (89.9%) and gastrointestinal stromal tumor (11.1%). Conclusions: Leiomyoma was the most common submucosal tumor in esophagus. However, endoscopic ultrasonography was not able to differentiate between leiomyoma and gastrointesinal stromal tumor. For more accurate diagnosis and treatment, minimally-invasive approaches may be suitable for the surgical enucleation of indicated esophageal submucosal tumor.
NADPH oxidase p22phox C242T 유전자 다형성이 8주간의 유산소성 훈련에 따른 운동수행능력 및 산화적 손상에 미치는 영향
조수연 ( S. Y Cho ),백일영 ( I. Y Paik ),진화은 ( H. E Jin ),노희태 ( H. T Roh ) 한국운동생리학회(구 한국운동과학회) 2012 운동과학 Vol.21 No.4
본 연구는 성인 남성과 여성을 대상으로 NADPH oxidase p22phox C242T 유전자 다형성이 8주간의 유산소성 훈련에 따른 운동수행력 증진 및 1회성 운동시 산화적 손상에 미치는 영향을 규명하는데 있다. 본 연구를 위한 실험대상자 선정을 위해 남자대학생 118명, 여자대학생 112명을 대상으로 NADPH oxidase C242T 유전자형을 분석한 후 남성 CC genotype, 남성 T allele, 여성 CC genotype, 여성 T allele 그룹에각각 12명씩 총 48명을 배정하였다. 사전, 사후 운동검사는 트레드밀을 이용하여 85%V O2max all-out 운동을 수행하였으며, 채혈은 총 5번(안정시, 운동 종료시, 회복 30분, 회복 4시간, 24시간) 실시되었다. 채혈된 혈액을 통해 혈장 lactate와 SOD, 임파구 DNA 손상에 대한 분석을 실시하였다. 유산소성 훈련은 8주간(3일/주), 70%HRR의 강도로 트레드밀 런닝을 실시하였으며, 연구 결과에 대한 결론은 다음과 같다. 8주간의 유산소성 훈련 후 85%V O2max all-out 운동수행시간은 네 그룹 모두 유의하게 증가되었다. 85%V O2max all-out 운동수행에 따른 혈장 lactate 농도는 트레이닝 후 동일 시점에서 감소되었으며, 유전자다형성 간 차이는 나타나지 않았다. 또한, 트레이닝 후 동일시점에서 혈장 SOD가 감소하였으며, 이와 함께 임파구세포 DNA 손상 역시도 감소하는 것으로 나타났다. 그리고, T allele보다 CC genotype이 트레이닝에 대한 효과가 더 큰것으로 나타났다. The purpose of this study was to investigate the effects of NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative damage in response to acute and chronic exercise. Medically healthy 118 men and 112 women were analyzed with the genotype of p22phox C242T and then 48 men and women were finally selected and divided into two different polymorphism groups(CC genotype: 24, T allele:24). Before and after exercise tests were measured at 85%V O2max until all-out and blood samples were taken 5 t imes( rest, end of exercise, after 30 min, 4 h and 24 h of recovery) to measure the concentration of plasma lactate, SOD(antioxidant enzyme) and lymphocyte DNA damage. 8 weeks of exercise training were performed 3 times a week at 70%HRR on the treadmill. The results of the research are as follows. it was shown that the eight-weeks aerobic training related to NADPH oxidase p22phox C242T genotype executed in this study not only increased maximal oxygen uptake and exercise performed time but also decreased the plasma lactate level. In addition, both CC genotype and T allele groups showed decreases in plasma SOD after the training and reductions in lymphocyte DNA damage as well. Furthermore, CC genotype than T allele showed a greater effect from the training.
수도(水稻) 백엽고병(白葉枯病)의 저항성(抵抗性) 유전(遺傳)에 관(關)한 연구(硏究)
최범렬,조수연,Choi, B.R.,Cho, S.Y. 충남대학교 농업과학연구소 1976 Korean Journal of Agricultural Science Vol.3 No.1
한국(韓國)에서 발병(發病) 되고있는 수도(水稻) 백엽고병(白葉枯病) 균계(菌系) 71-23에 대(對)한 WASE AIKOKU 3, ZENITH, TETEP 및 TKM 6품종등(品種等)의 저항성(抵抗性) 유전양식(遺傳樣式)을 구명(究明)하기 위(爲)하여 이들 저항성품종(抵抗性品種)을 이병성품종(罹病性品種)에 교배(交配)하여 모본(母本) 및 부본(父本)과 더불어 $F_1$ 및 $F_2$ 세대(世代)의 집단(集團)에서 검정(檢定)한 결과(結果)이들 품종(品種)의 저항성(抵抗性)은 1개(個)의 우성유전인자(優性遺傳因子)에 의(依)하여 지배(支配)되었다. This study was conducted to determine the inheritance of resistance in some rice varieties such as WASE AIKOKU 3, ZENITH, TETEP and TKM 6 to isolate 71-23 of Xanthomonas Oryzae in Korea. From the test in $F_1$ and $F_2$ populations of crosses between resistant and susceptible parents, it was observed that resistance of them were controlled by one dominant gene.
H. C. Choi(崔海椿),G. S. Chung(鄭根植),S. Y. Cho(趙守衍),B. S. Choi(崔富述),C. Y. Kim(金七龍),T. S. Kwark(郭泰淳),D. C. Lee(李東昌),N. K. Park(朴南圭) 한국육종학회 1984 한국육종학회지 Vol.16 No.2
To evaluate stability for grain yield of rice breeding lines and to identify the environmental status of some rice breeding sites, twenty one breeding lines (japonica; 13, indica; 8) and four check cultivars were grown at seven locations(Suwon, Cholwon, Chinbu, Yonkok, Unbong, Yongdok, Hwaso) in 1983 and the data for grain yield and other agronomic characters was analyzed by the method of stability analyses3,4) and principal component analysis.8) The results are summarized as follows; 1. Yongdok showed similar growth duration with Suwon, but other sites showed about 5-14 days longer duration than Suwon in the order of Hwaso < Unbong < Cholwon < Chin bu < Yonkok. Un bong pointed out the highest mean grain yield, 698 kg/10a and it was followed by the order of Suwon > Chol won> Hwaso > Yongdok > Chinbu > Yonkok. Yonkok might be a desirable site for selecting tolerant materials to so-called delaying-type cold, since it showed the most delayed heading time, the widest intervarietal variation of heading, the lowest level and smallest intervarietal variation in grain yield. 2. Among seven locations Cholwon, Unbong and Hwaso revealed similar ecological reaction by principal component analysis using mean value and standard deviation of some agronomic characters, but Unbong, Hwaso and Yongdok were similarly characterized by meteorological factors during the rice growing period. Yonkok and Chinbu showed nearly similar ecological response but were diff erently characterized by meteorological factors. Seven locations were classified largely into two regions by clustering based on correlation coefficients between genotype×environment (G×E) interaction term for grain yield at each location. 3. The yield stability of rice breeding lines can be evaluated by any parameters such as regression coefficients, residual mean squares deviated from the regression3), and 1st principal component extracted from G × E interaction term 8). Most indica lines revealed higher yield potential but lower stability than japonica strains. 4. The 1st principal component extracted from G×E interaction term for grain yield indicated close correlationship with the regression coefficients, deviations from the regression, average grain yield and coefficients of variation for yield. Also the regression coefficients showed significant positive correlation with deviations from the regression and average grain yield. 5. Contributions of the components to grain yield were largely different between locations; that is, number of panicles per hill acted decisive role on grain harvest at Yonkok and Yongkok, while number of spikelets per panicle mainly contributed to yield at Suwon, Unbong and Hwaso. 6. Average grain yield at each location were closely correlated with mean air temperature and average daily sunshine hours during the grain filling period.