http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
조수신 대한흉부심장혈관외과학회 1994 Journal of Chest Surgery (J Chest Surg) Vol.27 No.1
A solitary fibrous tumor in the pleura has been reported occasionally, but extremely rare in themediastinum. The histogenesis of this tumor has been still in controverse, but recent studies paid attention to it a mesenchymal origin by the immunohistochemical and ultrastructural bases. A few cases, reported in the literature, suggest that the mediastinal solitary fibrous tumor occurs more commonly in adult and shows slightly higher incidence in women. Its aggressive behavior such as recurrence rate and distant metastasis, is more prominant than reported in solitary fibrous tumor of the pleura. No single histologic feature allows an assumption definite prognosis. Surgical resection of this tumor is usually curative although the recurrence or distant metastasis are reported in about half of the patients. This report is a case of solitary fibrous tumor in the mediastinum in a 16-year-old female patient.She underwent surgical resection and her postoperative result was satisfactory.
Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells
김윤태,조수신,박영준,이명자,서창국 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.6
Radiation therapy for variety of human solid tumors utilizes mechanism of cell death after DNAdamage caused by radiation. In response to DNA damage, cytochrome c was released from mitochondriaby activation of pro-apoptotic Bcl-2 family proteins, and then elicits massive Ca2+ release from theER that lead to cell death. It was also suggested that irradiation may cause the deregulation of Ca2+homeostasis and trigger programmed cell death and regulate death specific enzymes. Thus, in thisstudy, we investigated how cellular Ca2+ metabolism in RKO cells, in comparison to radiation-resistantA549 cells, was altered by gamma (γ )-irradiation. In irradiated RKO cells, Ca2+ influx via activationof NCX reverse mode was enhanced and a decline of [Ca2+]i via forward mode was accelerated. Theamount of Ca2+ released from the ER in RKO cells by the activation of IP3 receptor was also enhancedby irradiation. An increase in [Ca2+]i via SOCI was enhanced in irradiated RKO cells, while that inA549 cells was depressed. These results suggest that γ-irradiation elicits enhancement of cellular Ca2+metabolism in radiation-sensitive RKO cells yielding programmed cell death.
적출된 쥐심장을 이용한 Fructose-1, 6 diphosphate의 심근보호 효과에 관한 실험
이철주,조수신,류재온,김문환,김세환,이익호,박소라,서창국 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.2
Myocardial protection against ischemic and reperfusion injuries is still in troublesome eventhough couples of the way of myocardial protection have been applied since 1970's. One of the possibility in myocardial protection is adding Fructose-l,6-diphosphate(FDP) in cardioplegic solution. It is assumed that FDP can promote ATP production under anaerobic condition as well as inhibiting the supressing effect of lactate on phosphofructokinase. We compared the myocardial protecting effects of FDP in crystalloid cardioplegic solution (St. Thomas formula, 10$^{\circ}C$, pH = 7.4) and reperfusate using isolated rat hearts in modified Langendorf apparatus by the parameters of preischemic and post reperfusing heart rate, time to first beat, occurance of arrhythmia, time to stabilization, and the rate of left ventricular pressure developing. Group A (n = 10), containing no FDP in cardioplegic and reperfusing solutions was control. Group B (n = 5), containing FDP in cardioplegic solution, showed statistically significant superiority of postischemic left ventricular pressure development than the control group. Group C (n = 5), containing FDP in reperfusate, showed statistically significant myocardial depressing effect than the controls. Other parameters were unremarkable. The cause is uncertain, but it is assumed that the negative feedback inhibition of FDP in energy metabolism or unknown blocking effect of FDP on certain transmembrane ionic currents is present. In conclusion, 1) FDP in cardioplegic solution has beneficial effect on postischemic left ventricular preservation. 2) FDP is strong acid when is hydrolyzed, so precise acid titration is neccessary. 3) FDP in reperfusate has negative left ventricular preservation, otherwise the mechanism is still uncertain.
박세진,조수연,배기수,신재일,Park, Se Jin,Cho, Soo Yeon,Pai, Ki Soo,Shin, Jae Il Korean Society of Pediatric Nephrology 2013 Childhood kidney diseases Vol.17 No.2
Parainfluenza virus 감염은 횡문근융해증의 하나의 원인이 될 수 있다. 횡문근융해증은 지속된 금식기간동안 미토콘드리아 지방산 ${\beta}$-oxidation 장애에 의해 악화될 수 있다. 또한 후기 발생 isovaleric 산증을 가진 환아들에게서 고암모니아혈증이 이화작용을 일으키는 상태 후 발생할 수 있다. 본 케이스는 parainfluenza virus 감염과 후기 발생 isovaleric 산증을 가진 4세 남아가 혼수, 경련 및 심호흡 부전으로 빠르게 진행했던 경우이다. 초기 암모니아와 creatinine kinase는 각각 $385{\mu}Mol/L$과 23,707 IU/L 이었으나 지속적 신대체요법 시행 후 암모니아와 creatinine kinase 수치는 정상으로 돌아왔다. 그러므로 생명을 위협하는 횡문근융해증과 고암모니아혈증을 가진 환아들의 치료에 있어서 즉각적인 지속적 신대체요법의 사용을 권하는 바이다. Parainfluenza virus infection is one of the causes of fatal rhabdomyolysis. Rhabdomyolysis can be aggravated by mitochondrial fatty acid ${\beta}$-oxidation disorders during prolonged periods of fasting. Moreover, in patients with late-onset isovaleric acidemia, hyperammonemia may occur following catabolic stress. In the present report, we describe a case of a 4-year-old boy with parainfluenza virus infection and late-onset isovaleric acidemia that rapidly progressed to coma, seizures, and cardiorespiratory collapse. His serum ammonia and creatinine kinase (CK) levels were $385{\mu}Mol/L$ and 23,707 IU/L, respectively. Continuous renal replacement therapy (CRRT) was initiated using continuous venovenous hemodiafiltration, after which the ammonia and CK levels returned to normal. Thus, we recommend the immediate initiation of CRRT in the management of patients with life-threatening rhabdomyolysis and hyperammonemia.
폐동정맥 기형을 동반한 유전성 출혈경향 말초혈관 확장증 1 예
김삼수,백완기,이준희,김인한,고광곤,조철호,김여주,문태훈,김준미,박찬섭,민수기,조상균,조수신,정원모,주영채 대한내과학회 1996 대한내과학회지 Vol.50 No.4
Hereditay hemorrhagic telangiectasia (Osler-Weber-Rendu disease) is a familial disease that is characterized by delicate, ectatic vessels in the skin, mucous membrane and viscera. These patients have generalized vascular derangement. Pulmonary arteriovenous fistular is a rare congenital condition originated from malformation of capillary development. Direct communications between branches of the pulmonary artery and pulmonary vein cause right-to-left shunts, in which mixed venous blood cannot be oxygenated as it passes throuth the pulmonary circulation, Congenital arteriovenous malformation are associated with Osler-Weber-Rendu disease in 36-57% of cases. Recently, we experienced a rare case of hereditary hemorrhagic telangiectasia with pulmonary arteriovenous malformation.