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방사선 유도 돌연변이체 블랙베리로 제조한발효음료의 간 손상 회복 효과
조병옥,소양강,이창욱,조정근,우현심,진창현,정일윤 한국방사선산업학회 2013 방사선산업학회지 Vol.7 No.1
This study was conducted to investigate the effect of fermented blackberry drinks (BD)on carbon tetrachloride (CCl4)-induced liver injury in rats. Male Sprague-Dawley rats were randomlydivided into four groups with 6 rats per group: control, CCl4, CCl4 plus BD 3 ml kg-1, andCCl4 plus BD 6 ml kg-1. We found that the levels of serum aspartate aminotransferase (AST) andalanine aminotransferase (ALT) were significantly increased and the activity of antioxidant enzymeglutathione peroxidase (GPx) in the liver was decreased in rats treated with CCl4 alone when comparedwith the control group. However, the administration of BD attenuated the levels of serumAST and ALT in CCl4-treated rats. Moreover, the administration of BD significantly increasedthe activity of GPx in CCl4-treated rat livers. Taken together, these results suggest that BD couldprotect the liver from CCl4-induced hepatic damage.
조병옥,박춘매,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2
Ku is a protein which act as a repairing enzyme for the DNA double strand breaks (DSBs). It has a heterodimeric structure composed of two subunits, Ku70 and Ku86. The detail mechanism of Ku in DNA repair processes is still not unknown, but it is certain that Ku is a one of key protein in maintenance of chromosomal integrity and cell survival. Recent studies reported that dysfunction of Ku protein is related to the development of radioresistance in case of overexpression of Ku and tumorigenesis with Ku underexpression. As Ku may act as either a tumor suppressor or an oncoprotein, precise regulation of Ku function may be important for the tumor suppression. Ku may be used for the treatment of cancer to resist radiotherapy or chemotherapy.
Cyanidin-3-glucoside Ameliorates CCl4-induced Liver Injury in Mice
조병옥,이창욱,소양강,진창현,강시용,김동섭,서권일,육홍선,정일윤 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4
The protective effect of cyanidin-3-glucoside(C3G) against carbon tetrachloride (CCl4)-induced liverinjury in mice was investigated. Administration of C3Gattenuated the levels of serum aspartate aminotransferase,alanine aminotransferase, and liver lipid peroxidation inCCl4-treated mice. Histopathological examination of mouselivers showed that C3G reduced the incidence of liverlesions induced by CCl4. Moreover, C3G prevented DNAdamage and decreased the protein levels of γ-H2AX inCCl4-treated mouse livers. C3G also increased the activityof the antioxidant enzymes superoxide dismutase, catalase,glutathione peroxidase, and glutathione reductase, whichwere decreased due to CCl4 administration in CCl4-treatedmouse livers. C3G inhibited the expression levels of IL-6and iNOS in CCl4-treated mice. C3G apparently protectsthe liver from CCl4-induced hepatic damage throughantioxidant and anti-inflammatory mechanisms.
고농도 오존발생기 성능평가 곡선을 활용한 대상물질 최적처리를 위한 운영비용 평가
조병옥,이광희,남숙현,김은주,황태문 한국수처리학회 2023 한국수처리학회지 Vol.31 No.4
This study had two aims: 1) based on a performance evaluation, to set the optimal operating range for a high-concentration ozone generator recently developed with domestic technology; 2) to establish a model-based control strategy to achieve the removal of target compounds. To determine the optimal operating range of the ozone generator, this study considered the energy consumption and oxygen cost per unit ozone generation, as these factors have the greatest influence on the operating cost. This method was in accordance with the methods proposed by the American Ozone Association and the US Environmental Protection Agency. The optimal operating range of the ozone generator was found to be approximately 2 to 14%. Within this range, the total operating cost is minimized, as determined by comparing the generated ozone concentration, oxygen cost, and power consumption. An operation of below 12% capacity may increase the cost of ozone production. Based on the performance evaluation curve, the ozone concentration required to reach the target substance removal rate of 80% can be calculated according to the change in water quality and flow rate of the ozone treatment facility at the wastewater treatment plant and by applying an ozone kinetic model. This method can be used to estimate the per unit production cost. For example, the average total ozone generated and unit production cost required to remove 80% of the group 4 compound iopromide were determined to be at least 17% greater than those required to remove the same amount of sulfamethazine, a group 1 compound. This study proposes a practical control strategy and evaluation method for calculating the operating cost of the ozone generator needed to achieve the target removal rate for categorized target substances. .
옥수수수염, 들깻잎 및 포도줄기 복합추출물의 UVB 조사 피부 손상 및 Compound 48/80 유도 가려움증 개선 효과
조병옥,신재영,데니스,황영민,이현서,유철,최지원,장선일 (사)한국방사선산업학회 2016 방사선산업학회지 Vol.10 No.4
This study was conducted to evaluate the synergistic protective effects of mixtures of corn silk, perilla leaf and grape stem extract (CPG mixture) against UVB-induced skin damage and compound 48/80-induced pruritus in mice. The results showed that treatment with CPG mixture exhibited much stronger suppressive effect on erythema and melanin index as well as melanin formation than treatment with ascorbic acid (AA) in UVB-irradiated mice. Moreover, the treatment with CPG mixture showed ameliorative effect on immune cell infiltration and collagen fiber destruction in UV-irradiated mice. The treatment with CPG mixture inhibited glutathione (GSH) depletion, lipid peroxidation and production of pro-inflammatory cytokines in UVB-irradiated mice. Furthermore, the treatment with CPG mixture inhibited compound 48/80-induced scratching behavior and histological changes in mice. Taken together, these results indicated that CPG mixture has potentials as functional and therapeutic materials against skin damage and itch-related skin diseases.
조병옥,박하영,류형원,진창현,최대성,김동섭,임승택,서권일,변명우,정일윤 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.6
The aim of this study was to elucidate the protective ability of the Perilla frutescens cv. Chookyoupjaso mutant water extract (PFWE) against oxidative injury in vitro and in vivo. In in vitro experiments, our results showed that PFWE indicated the intracellular reactive oxygen species (ROS) scavenging activity as well as cytoprotective effect in SIN-1-treated HepG2 cells. The intracellular ROS scavenging activity of PFWE was 44%at 50 μg/mL, 50% at 100 μg/mL, and 56% at 200 μg/mL. Furthermore, in vivo results showed that treatment with PFWE attenuated the activity of serum alkaline phosphatase (ALP) and lipid peroxidation increased by carbon tetrachloride (CCl_4) and also markedly recovered the activity of superoxide dismutase (SOD), catalase (CAT),glutathione peroxidase (GPx), and glutathione reductase (GR) decreased by CCl4 in BALB/c mice. GPx activity was elevated almost 3-fold compared to control group at 50 mg/kg of PFWE. The present study suggests that PFWE possesses significant protective effects against oxidative injury.