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Epidemiological Trends and Environmental Influences on Scrub Typhus in South Korea from 2001 to 2023
김채원,조남혁 대한미생물학회 2025 Journal of Bacteriology and Virology Vol.55 No.1
Scrub typhus, a mite-borne disease caused by Orientia tsutsugamushi, has shown an increasing incidence in South Korea, with 143,035 cases reported between 2001 and 2023. This study analyzes trends and environmental factors influencing the dynamics of the disease. The results reveal a significant annual rise in cases, along with a shift toward earlier seasonal onset and a higher incidence in the southern provinces. Incidence was notably higher among elderly women, identifying them as a primary risk group. A positive correlation between climatic factors, including rising temperature and relative humidity, and increased cases suggests that these environmental changes may be contributing to shifts in seasonality and regional distribution. These findings highlights the need for targeted public health measures and continued research to mitigate scrub typhus risks.
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Cellular and Systemic Interactions of Orientia tsutsugamushi with Mammalian Host
김세윤,최명식,조남혁 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.4
Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi infection and one of main causes of febrile illness in the Asia-Pacific region. It has been estimated that one billion people are at risk and one million new cases arise each year in the endemic region. Despite of aggressive attempts to develop a prophylactic vaccine against scrub typhus during last several decades, all approaches have failed to generate long lasting immunity. In addition, little is known about the immunological pathogenesis of scrub typhus. In this review, we summarized recent findings of cellular and systemic interaction of O. tsutsugamushi with mammalian host, especially focusing on the molecular basis of intracellular invasion and immunological changes observed during the bacterial infection.
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박선희,김연숙,정영희,최수영,조남혁,정혜원,허중연,윤지현,이재갑,천신혜,손경목 대한감염학회 2016 Infection and Chemotherapy Vol.48 No.2
Background: A Middle East Respiratory Syndrome coronavirus (MERS-CoV) outbreak in South Korea in 2015 started by a single imported case and was amplified by intra- and inter-hospital transmission. We describe two hospital outbreaks of MERS-CoV infection in Daejeon caused by a single patient who was infected by the first Korean case of MERS. Materials and Methods: Demographic and clinical information involving MERS cases in the Daejeon cluster were retrospectively collected and potential contacts and exposures were assessed. The incubation periods and serial intervals were estimated. Viral RNAs were extracted from respiratory tract samples obtained from the index case, four secondary cases and one tertiary case from each hospital. The partial S2 domain of the MERS-CoV spike was sequenced. Results: In Daejeon, a MERS patient (the index case) was hospitalized at Hospital A in the first week of illness and was transferred to Hospital B because of pneumonia progression in the second week of illness, where he received a bronchoscopic examination and nebulizer therapy. A total of 23 secondary cases (10 in Hospital A and 13 in Hospital B) were detected among patients and caregivers who stayed on the same ward with the index case. There were no secondary cases among healthcare workers. Among close hospital contacts, the secondary attack rate was 15.8% (12/76) in Hospital A and 14.3% (10/70) in Hospital B. However, considering the exposure duration, the incidence rate was higher in Hospital B (7.7/100 exposure-days) than Hospital A (3.4/100 exposure-days). In Hospital B, the median incubation period was shorter (4.6 days vs. 10.8 days), the median time to pneumonia development was faster (3 days vs. 6 days) and mortality was higher (70% vs. 30.8%) than in Hospital A. MERS-CoV isolates from 11 cases formed a single monophyletic clade, with the closest similarity to strains from Riyadh. Conclusion: Exposure to the MERS case in the late stage (2nd week) of diseases appeared to increase the risk of transmission and was associated with shorter incubation periods and rapid disease progression among those infected. Early detection and isolation of cases is critical in preventing the spread of MERS in the hospital and decreasing the disease severity among those infected.
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논문 : AISI 316L스테인리스강의 소형펀치 크리프 거동에 미치는 마찰계수의 영향
김범준 ( Bum Joon Kim ),조남혁 ( Nam Hyuck Cho ),김문기 ( Moon K. Kim ),임병수 ( Byeong Soo Lim ) 대한금속재료학회(구 대한금속학회) 2011 대한금속·재료학회지 Vol.49 No.7
Small punch creep testing has received attention due to the convenience of using smaller specimens than those of conventional uniaxial creep tests, which enables creep testing on developing or currently operational components. However, precedent studies have shown that it is necessary to consider friction between the punch and specimen when computing uniaxial equivalent stress from a finite element model. In this study, small punch creep behaviors of AISI 316L stainless steel, which is widely used in high temperature-high pressure machineries, have been compared for the two different ceramic balls such as Si3N4 and Al2O3. The optimal range of the friction coefficient is 0.4~0.5 at 650℃ for the best fit between experimental and simulation data of AISI 316 L stainless steel. The higher the friction coefficient, the longer the creep rupture time is. Therefore, the type of ceramic ball used must be specified for standardization of small punch creep testing.
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