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Studies on the Physicochemical Properties of Ibuprofen Ball-milled with Calcium Carbonate
조경아 숭실대학교 일반대학원 2014 국내석사
In recent studies, organic-inorganic hybrid materials have been actively researched because of the relatively simple manufacturing process applied to active pharmaceutical ingredients (APIs). There were many advantages to control the physicochemical properties of APIs in the pharmaceutical industry. In this study, ibuprofen and polymorphs of calcium carbonate, calcite and aragonite, were used as model materials and the physicochemical properties of ibuprofen were researched under various conditions controlled by a ball mill with the co-existence of the two materials. Differential scanning calorimetry (DSC) and Thermogravimetric analysis (TGA) were conducted for analyses of crystallinity and thermal stabilities of ibuprofen, and X-ray diffraction (XRD) and Fourier transformation infrared spectroscopy (FT-IR) analyses were also conducted to confirm its changes in crystal structures and interaction between ibuprofen and calcium carbonate. Moreover, the surface area of calcium carbonate and the binding energy between ibuprofen and calcium carbonate were calculated for affectivity of the surface of inorganic materials. As a result, ibuprofen-calcite and ibuprofen-aragonite showed different aspects through experimental and theoretical analyses. When ibuprofen was milled at 25 Hz with aragonite, properties of ibuprofen were changed most dramatically in the crystallinity and thermal stability of ibuprofen and surface area of calcium carbonate. Likewise, the binding energy with aragonite was larger than that with calcite. Ibuprofen on a pH aqueous solution had huge differences in its solubility; especially ibuprofen milled with calcium carbonate on pH 1.2 released more than ibuprofen milled alone. Therefore, these ibuprofen-CaCO3 hybrid materials controlled as milling time and frequency exhibited transformation of ibuprofen state from the crystalline form to the amorphous form partially and an improvement of solubility and dissolution rate although a relatively simple process without organic solvents. 최근 유기-무기 하이브리드에 관한 연구는 비교적 간단한 제조 과정으로 인해 APIs (active pharmaceutical ingredients)에 적용되어 활발히 진행되고 있다. 이는 기존 APIs가 가지고 있던 물리화학적 특성의 제어가 용이하기 때문이다. 본 연구에서는 ball milling의 다양한 조건에서 ibuprofen과 calcium carbonate을 모델 물질로 이용하여 두 물질이 공존할 때 ibuprofen의 물리화학적 특성을 알아보았다. 이 때 calcium carbonate의 종류에 따른 영향을 알아내고자 다형체인 calcite와 aragonite를 이용하였고, ibuprofen 결정에 미치는 영향과 열적 안정성을 살펴보기 위해 differential scanning calorimetry (DSC), thermogravimetric analysis (TGA)를 측정하였고 결정 구조의 변화와 ibuprofen과 calcium carbonate 사이의 상호 작용을 알아보기 위해 X-ray diffraction (XRD)와 Fourier transformation infrared spectroscopy (FT-IR)을 측정하였다. 또한 무기 표면의 특성에 따른 영향을 살펴보기 위해 calcium carbonate 다형체의 표면적과 binding energy를 계산하였다. 실험과 이론적인 분석 결과 ibuprofen-calcite와 ibuprofen-aragonite는 물리화학적으로 다른 양상을 보인다. Aragonite를 첨가하여 25 Hz로 milling 하였을 때 ibuprofen의 결정과 열적 안정성, calcium carbonate 표면적에 가장 큰 변화를 나타내었고 마찬가지로 binding energy의 경우 ibuprofen과 aragonite 사이의 binding energy가 calcite보다 더 크게 나타났다. 또한 ibuprofen의 방출 특성을 알아보고자 pH에 따른 ibuprofen의 용출실험을 진행한 결과 pH에 따라 ibuprofen의 용해도는 크게 차이가 있었으며, 특히 pH 1.2 에서 같은 조건에서 milling 시 Calcium carbonate와의 결합으로 용해도와 용해속도가 증가함을 확인하였다. Milling 조건 하 ibuprofen-CaCO3 하이브리드를 제조함으로써 일부 ibuprofen의 비결정화를 유도하였으며 결론적으로 용해도와 용해 속도를 증가시키는 것에 기여하였다.
Human diploid fibroblasts(HDF) have a limited proliferative potential and lose their ability to divide after a finite number of proliferation doublings. HDFs proliferate rapidly and can be subcultured readily, followed by a period of decreased proliferation and concomitant morphological and physiological changes, which lead to arrest of replication. These progressive events have been defined as cellular aging or senescence. These cells do not respond to growth factors such as epidermal growth factor (EGF), regardless of a normal level of receptors and downstream-signaling molecules. Several signaling molecules are enriched in caveolae, where interaction of those signal related factors with caveolin-1 protein, a major component of caveolae, leads to suppression of signal response. To examine the mechanism which attenuates the signaling process in the senescent state, we investigated the role of caveolin-1 in the MAP kinase cascade upon EGF stimulation. Senescent cells did not phosphorylate Erk-1/2 after EGF stimulation, whereas young cells did. In those senescent cells, we found an increased level of caveolin proteins and strong interactions between caveolin-1 and EGF receptor. Electron microscopic analysis demonstrated an increased number of caveolae structures in senescent cells. More interestingly, brain, spleen, and lung from 26-month-old rats showed substantial increase in caveolin proteins. When we reduced the expression of caveolin-1 in senescent cells by use of antisense-oligonucleotides of caveolin-1, Erk-1/2 was activated by EGF stimulation, suggesting the resuming of signal transduction even in the senescence. Simply by down regulation of caveolin in senescent cells. For the mechanism of caveolin-1 expression during aging, the relationship between caveolin-1 and cholesterol has been studied. Total cholesterol level of old HDF was 1.8 times higher than young HDF, and pretreatment of lovastatin, a specific cholesterol synthesis blocking drug, induced a decrease in caveolin-1 level, which led to the recovery of Erk signaling in these cells. These results suggest that the hyporesponsiveness of senescent fibroblasts to EGF stimulation might be due to the increased level of caveolins, which could be modulated by adjustment of cholesterol level. Therefore, we conclude that the loss of mitogenic signaling of senescent cell is directly related to the high level of caveolin-1, accompanied by high cholesterol level with aging, and these results suggest the strong possibility of functional recovery of the senescent cells by restoring the caveolae-dependent endocytotic pathway.
본 연구는 무용 지도자들이 내면화하고 있는 무용 수행과 관련된 재능을 개념적으로 구조화하고 무용 재능에 대한 인식이 지도자의 무용 경력이나 지도하고 있는 학생의 학교급에 따라 차이가 있는지를 밝히고자 하였다. 이를 위해 예술 재능 혹은 무용 영재성에 대한 선행연구와 이론 모형을 바탕으로 무용 수행과 관련된 재능 요인을 선별하고, 이를 측정할 수 있는 척도를 제작하여 구조적 타당도를 검증하였으며, 무용 재능에 대한 집단별 인식 차이를 확인하였다. 본 연구의 대상은 평균 10년 이상의 무용 경력과 평균 5년 이상의 지도 경력을 가진 남녀 현직 무용교사 및 강사 233명이었으며, 이들에게서 수집된 자료는 SPSS WINDOWS 프로그램과 AMOS 프로그램의 기술통계 분석, 탐색적 및 확인적 요인분석, 다변량 분산분석, 단계적 입력방식에 의한 다중판별분석법 등을 이용하여 분석하였다. 통계절차에 따라 가설 검증을 실시하여 다음과 같은 결론을 도출하였다. 첫째, 무용 지도자들이 인식하고 있는 무용 재능은 동작 리듬감, 자기 통제력, 무용열정, 표현력, 신체조건, 창의성, 사회적 지원의 7개 요인이었다. 둘째, 무용 재능에 대한 지도자의 인식은 지도하고 있는 학생들의 학교급에 따라 다르게 나타났다. 구체적으로 모든 재능 요인에서 중, 고, 대학생을 지도하는 지도자들은 무용 재능에 대한 중요성을 동일하게 보는 것으로 나타났으나 초등 교사들과는 차이가 있었다. 특히, 초등 지도자는 동작 리듬감, 자기통제, 무용열정, 창의성 요인을 다른 학교급의 지도자보다 덜 중요하게 지각했다. 셋째, 무용 재능은 지도자의 무용 경력에 따라 사회 지원과 신체조건을 제외한 5개 재능에서 차이를 보였다. 즉 무용 경력이 많은 지도자일수록 동작 리듬감과 무용 열정을 더욱 중요한 재능으로 인식했으며, 자기 통제력과 표현력 및 창의성요인에서도 26년 이상의 경력 지도자들이 15년 이하의 지도자들보다 더욱 중요하게 지각했다. 이와 같은 정보는 무용 재능에 관한 후속적 연구의 촉진은 물론 무용 재능의 판별이나 무용영재 교육 프로그램의 개발에 기초 자료로 활용될 수 있을 것이다. The purpose of this study was to determine the conceptual structure of talent related dance performance from teachers' point of view and examine the difference in perception by teacher's personal history(teaching careers) and teaching grade of students. For this study, first, multidimensional talents related dance performance were selected based on theoretical model and researches dealing with the art talents and dance giftedness. Second, a reliable and valid instrument to measure dance talent was developed and examined. Data were obtained from a sample of 233 male and female dance teachers and instructors. In order to test the hypothesis of this study, descriptive statistical analysis, exploratory and confirmatory factor analysis, MANOVA, ANOVA, and multiple discriminant analysis were used. The result of these analysis was as follow: first, a series of factor analysis indicated that dance talent perceived by teachers was found to have seven factors: sense of rhythmic action, ability of self control, passion to dance, physical condition, emotion expression, creativity, social support. Second, perception of dance talent was significant different in all factors according to teaching grade of students. Among the middle school, high school, and university student teachers were not different in perception of dance talent. But elementary school teachers were recognized less important to sense of rhythmic action, ability of self control, passion to dance, creativity than the other teacher group. Third, perceived dance talent was significantly different in five factors according to teacher's teaching careers. High career teachers were recognized more important to sense of rhythmic action, passion to dance than low level of career group. Further, ability of self control, creativity, and emotion expression appeared more important in high level of career group(26 years) than in low level of career group(15 years). These results tend to support the basic notion of Bloom's stages of talent development(1985), and provide guidelines for dancer who are going through this developmental process, as well as for teachers and parents, who play an important role throughout the career of dancers.
여성공무원 인사정책의 개선방안에 관한 연구 : 양성평등을 중심으로
In the knowledge-centered society of the 21st century the need of woman power and the number of woman public officials in the bureaucratic society will steadily increases. Despite the qualitative and quantitative increase of woman public officials, however, the Korean government faces criticism due to its inequality in personnel management of woman public officials. The positive and equal utilization of woman public officials is vital for the rise in women's social status and the efficient utilization of human resources. So, it is necessary to examine and analyze the conditions of the personnel inequality for woman officials and to suggest the improvements of personnel policy for woman public officials. Accordingly, this study is intended to examine and analyze the actual conditions of personnel inequality against woman public officials in Korea and to suggest the improvements to solve the problem of personnel inequality against woman public officials. In order to achieve this object this article researches various theories about gender equality and examines the related literature with various statistical date about each stage of appointment, placement, education and training, and promotion. As this result, it is proved that the number of woman public officials steadily increases, but there exits an invisible personnel inequality like a glass-ceiling or glass-wall in placement and promotion, which is conducted as a usual practice, and that woman public officials have less developmental and promotion opportunities than men, showing structural characteristics as the majority occupying subordinate and non-principal post, although they have a great asset in abilities. The preparation of an appropriate alternatives through systematic analysis as to whether both gender officials are treated on gender equality in each stage of personnel management is a prerequisite to rectify the inequality conditions of the Korean personnel policy for woman public officials, and to further the positive utilization of woman power. Now to conclude, there is a need for the introduction of affirmative action in the personnel policy and efforts to strengthen their recognition on the gender equality all over the society.
클라이언트 폭력이 사회복지사의 직업존중감에 미치는 영향에 관한 연구
조경아 서울시립대학교 도시과학대학원 2019 국내석사
Social workers at social welfare sites are exposed to much of the risk of violence by clients, even if they experience violence, they lack personal treatment and institutional-level countermeasures, and if they do not have proper protection measures from the agency, they will likely suffer continuous loss and professional respect. Furthermore, the experience of violence can even be attributed to the decline in the quality of services, affecting the client inhumanization by social workers who directly deal with them. Therefore, in this study, we want to look at the impact of client violence on the level of job-esteem and client inhumanization on the social worker's individual, to verify the correlation between the two variables based on an ecological approach and interaction theory, and to understand the status, characteristics, and level of countermeasure of client violence. This study conducted an Internet survey (Google) of 120 social workers in charge of visiting services (in charge of case management and service provision) at three welfare centers in Seoul, and conducted an analysis using IBM SPSS statistics 22 statistical package program. The results of the analysis are as follows. First, the analysis of client violence showed that 70 out of 120 respondents had direct and indirect experiences, with more than 60 percent of all respondents having direct and concise experiences against violence. Second, social and psychological damage was the highest among 32 (72%) and violence experienced by clients directly subject to the service was 81% in the case of perpetrators. In addition, more than 50% of respondents with experience of violence responded that there was no response or follow-up. Third, the regression analysis shows that the experience of violence has a significant effect on job respectability and has a significant effect on the three concepts of lower concepts, positive value, negative treatment, and relative benefits. In addition, the overall job-dependence in the proportion of respondents who responded that there was no response or post-action after the experience of violence was statistically significant with negative influence. Fourth, the analysis of client inhumanization levels based on the experience of violence has shown statistically significant effects. In addition, linear regression analysis of client impersonation level according to response level has shown statistically significant effects. Based on this, this study confirmed that the experience of client violence has a significant impact on the level of client inhumanization as well as the level of job-esteem and client inhumanization, as well as the fragmentary variables of the experience of violence, has a significant effect on the level of job-esteem and client inhumanization. Despite such implications, however, it is difficult to generalize the results of the survey by limiting the number of visit-type service to the three welfare centers in Seoul, and it is necessary to develop a measure suitable for the social welfare sector as a measure of job respectability used as a measurement tool in other academic fields. Further, studies show that the level of response measures based on the experience of violence is insufficient, policy-based standardized manuals and schemes are needed, and investigation of client violence should be carried out on a full-scale basis by type and function. 사회복지 현장에서의 사회복지사는 클라이언트의 폭력 위험에 상당 부분 노출되어 있으며, 폭력을 경험하더라도 개인적인 치료 및 기관차원의 대응책이 미비하며 기관으로부터의 적절한 보호 대책이 없는 경우 지속적인 상실감 및 전문가로서의 직업존중감 또한 하락하게 될 가능성이 높다. 나아가 폭력의 경험은 직접 대면서비스를 진행하는 사회복지사의 클라이언트 비인격화까지 영향을 미쳐 서비스의 질적 하락이라는 문제까지도 기인할 수 있다. 따라서 본 연구에서는 클라이언트 폭력이 사회복지사 개인의 직업존중감 및 클라이언트 비인격화 수준에 미치는 영향에 대하여 살펴보고자 하며, 이를 생태체계적 접근, 상호작용이론에 입각하여 두 변수간의 상관관계를 검증하고 클라이언트 폭력의 실태 및 특징, 대응조치 수준 등을 파악하고자 한다. 본 연구는 서울시 내 3종 복지관(노인종합복지관, 장애인복지관, 종합사회복지관)에 종사하는 방문형 서비스 담당(사례관리 및 서비스 제공 담당) 사회복지사 120명을 대상으로 인터넷 설문조사(구글)를 실시하였으며, IBM SPSS statistics 22 통계패키지 프로그램을 활용하여 분석을 실시하였다. 분석 결과를 정리하면 다음과 같다. 첫째, 클라이언트 폭력 실태에 대해 분석한 결과 조사대상자 120명 중 직·간접 경험이 70명으로 전체 응답자의 약 60%이상이 폭력에 대한 직·간점 경험이 있는 것으로 나타났다. 둘째, 피해 유형을 분석한 결과 사회·심리적인 피해가 32명(72%)로 가장 높게 나타났으며, 가해자의 경우 서비스 직접 대상자인 클라이언트로부터 경험하는 폭력이 81%로 나타났다. 또한 폭력 피해 이후 대응 조치에 대한 분석 결과 폭력 경험 응답자의 50%이상이 대응이나 사후조치가 없었다고 응답하였다. 셋째, 회귀 분석 결과 폭력의 경험은 직업존중감에 유의한 영향을 미치며, 하위개념인 긍정적 가치, 부정적 대우, 상대적 효익 3가지 개념에 유의한 영향을 미치는 것으로 분석되었다. 또한 폭력 경험 이후 대응조치나 사후조치가 없었다고 응답한 비율의 전체 직업존중감은 부적인 영향력으로 통계적으로 유의미하게 나타났다. 넷째, 폭력 경험에 따른 클라이언트 비인격화 수준에 대해 분석한 결과 정적인 영향을 미치며, 통계적으로 유의미하게 나타났다. 또한 대응조치 수준에 따른 클라이언트 비인격화 수준의 선형회귀 분석 결과 정적인 영향력으로 통계적으로 유의미하게 나타났다. 이를 바탕으로 본 연구는 클라이언트 폭력의 경험이 사회복지사 개인의 직업존중감을 비롯하여 클라이언트 비인격화 수준에도 유의한 영향을 미치는 것을 검증하였으며, 폭력 경험이라는 단편적인 변수뿐만 아니라 이에 따른 대응 조치 수준 또한 직업존중감과 클라이언트 비인격화 수준에 유의한 영향을 미치고 것을 확인하였다는 것에 긍정적인 함의를 가진다. 그러나 이러한 함의에도 불구하고 방문형 서비스 담당, 서울시 3종 복지관으로 한정하여 조사를 진행함에 있어 해당 결과를 일반화하기에 어려우며, 측정도구로 활용한 직업존중감 척도가 타 학문분야에서 활용하는 척도로서 사회복지 분야에 적합한 척도 개발이 필요하다. 또한 폭력 경험에 따른 대응 조치 수준이 미비하다고 연구 결과 나타난바 정책적으로 표준화된 매뉴얼과 제도 마련이 필요하며 클라이언트 폭력에 대한 조사를 유형별, 직능별로 전수조사를 실시하여 지속적인 후속 연구가 수행되어야 할 것이다.
임상간호사의 간호전문직관, 직무스트레스, 간호근무환경이 인간중심간호에 미치는 영향
본 연구는 임상간호사를 대상으로 간호전문직관, 직무스트레스, 간호근무환경과 인간중심간호의 정도를 알아보고, 변수들 간의 관계 및 인간중심간호에 영향을 미치는 요인을 파악하기 위해 시도되었다. 연구대상자는 강원지역 500병상 이상의 병원에 근무하며 6개월 이상의 임상 경력을 가진 간호사 162명으로 하였다. 자료 수집은 2020년 1월 6일부터 2월 28일까지 간호전문직관, 직무스트레스, 간호근무환경, 인간중심간호에 대해 구조화된 설문지를 이용하여 조사하였으며, 수집된 자료분석은 SPSS 24.0 프로그램을 이용하여 빈도, 백분율, 평균과 표준편차, independent t-test와 one-way ANOVA, Pearson’s correlation coefficient, stepwise multiple regression analysis를 실시하였으며, 사후검정으로 Scheffé’s post-hoc analysis를 이용하였다. 본 연구의 결과는 아래와 같다. 1. 대상자의 연령은 20대가 60.5%였고 평균연령은 29.41±6.48세였으며, 미혼이 75.3%였다. 학력은 학사가 75.9%, 종교는 무교가 72.2%, 임상 경력은 5년 이상에서 10년 미만이 30.2%였다. 주요 과는 내과계가 53.7%, 간호제공형태는 팀간호법이 54.9%로 나타났다. 2. 대상자의 간호전문직관 정도는 5점 척도에 평균 3.45±0.41점, 직무스트레스 정도는 5점 척도에 평균 3.28±0.23점, 간호근무환경은 4점 척도에 평균 2.48±0.29점, 인간중심간호 정도는 5점 척도에 평균 3.35±0.48점이었다. 3. 대상자의 일반적 특성에 따른 인간중심간호 정도는 학력(F=3.12, p=.047)에, 직무스트레스는 주요 과(F=3.23, p=.042)에, 간호근무환경은 학력(F=3.95, p=.021)에 유의한 차이가 있었으나 일반적 특성에 따른 간호전문직관은 어떠한 변수와도 유의한 차이가 없었다. 4. 대상자의 인간중심간호는 간호전문직관(r=.43, p<.001), 간호근무환경(r=.34, p<.001)과 통계적으로 유의한 정(+)적 상관관계를 보였다. 5. 대상자의 인간중심간호에 영향을 미치는 요인은 간호전문직관(β=0.37, p<.001), 직무스트레스(β=0.21, p=.005), 간호근무환경(β=0.19, p=.007), 석사 이상의 학력(β=0.15, p=.036)의 순서로 인간중심간호에 유의한 정(+)의 영향을 미치는 것으로 나타났으며, 모형의 설명력은 26.6%였다. 이상의 연구 결과를 통하여 임상간호사의 일반적 특성 중 학력과 간호전문직관, 직무스트레스, 간호근무환경은 인간중심간호에 영향을 미치는 요인임을 확인할 수 있었다. 이를 바탕으로 임상간호사가 양질의 인간중심간호를 제공하기 위해서는 간호전문직관 수준 강화, 직무스트레스의 조절, 간호근무환경의 개선이 필요하다고 생각된다. This study was attempted to investigate the degree of nursing professionalism, job stress, nursing work environment, and person-centered care of clinical nurses, and also to identify the relationship between variables and the factors affecting person-centered care. The subjects of this study were 162 nurses with clinical experience of six months or more, who have worked at hospitals with more than 500 beds in Gangwon Province. Data collection was conducted from January 6 to February 28, 2020, using structured questionnaires on nursing professionalism, job stress, nursing work environment, and person-centered care. The collected data analysis frequency, percentage, mean and standard deviation, independent t-test, and one-way ANOVA, Pearson’s correlation coefficient, and stepwise multiple regression analysis using the SPSS 24.0 program. The results of this study are as follows. 1. Among the subjects, 60.5 percent were in their 20s, and the average age of the subjects was 29.41±6.48, and 75.3% of the subjects were unmarried. 75.9% of the subjects had a bachelor's degree, 72.2% had no religion, and 30.2% had a clinical experience of more than five years to less than 10 years. 53.7% of the subjects worked in the internal department as major, and the main nursing delivery type was the team nursing method, measured at 54.9%. 2. The average of nursing professionalism was 3.45±0.41 out of 5, the average of job stress level was 3.28±0.23 out of 5, the average of nursing work environment was 2.48±0.29 out of 4, and the degree of person-centered care was 3.35±0.48 out of 5. 3. There were significant differences in person-centered care depending on the education level (F=3.12, p=.047), in job stress depending on the major department (F=3.23, p=.042), in nursing work environment depending on education level (F=3.95, p=.021). Nursing professionalism had no significant difference with any variables. 4. Person-centered care showed statistically significant positive correlation with nursing professionalism (r=.43, p<.001) and nursing work environment (r=.34, p<.001). 5. The adjusted R2 was 0.266, meaning that the measured variables explained 26.6% of the variance in person-centered care. Nursing professionalism had the greatest impact on person-centered care in clinical nurse (β=0.37, p<.001), followed by job stress (β=0.21, p=.005), nursing work environment (β=0.19, p=.007), and master's or higher degree (β=0.15, p=.036). In conclusion, the results of this study show that there are four factors which affect person-centered care: nursing professionalism, job stress, and nursing work environment, and education level. According to this, it seems that, for clinical nurses to provide high-quality person-centered care, it is necessary to strengthen nursing professionalism level, adjust job stress level and improve nursing work environment.
역할극을 활용한 의사소통능력 강화 프로그램의 개발 및 효과 : 정신간호실습교육 중심으로
본 연구는 간호대학생의 정신간호실습을 위해 역할극을 활용한 의사소통능력 강화 프로그램을 개발하고, 그 효과를 검정하기 위한 연구이다. 이를 위해 포커스 그룹 인터뷰와 문헌고찰을 통해 우울 및 자살위험 사례 중심의 프로그램 초안을 개발하였다. 개발된 프로그램 초안은 전문가 타당도와 예비평가를 통해 수정·보완하여 1회기당 120분, 총 6회기의 최종 역할극을 활용한 의사소통능력 프로그램으로 개발되었다. 프로그램 효과 검증은 단일군 반복측정 실험설계로 자료수집 및 교육중재 기간은 2016년 10월∼12월까지 약 2개월간이었다. 연구대상은 정신간호실습경험이 없는 학생으로 3년제 간호과 2학년 31명이었다. 측정도구는 연구자가 개발한 의사소통 지식 및 수행능력 측정도구, Larson 외(1992)이 개발한 의사소통 자기효능감, Keller (2004)가 개발한 학습동기, Ayres (2005)가 개발한 전이동기, 김미옥(2015)이 개발한 교육만족도 측정도구를 사용하였다. 실험처치는 본 연구에서 개발한 역할극을 활용한 의사소통능력 강화 프로그램을 교과외 과정으로 주 3회, 2주간 운영하였다. 자료수집은 프로그램 교육 중재 전, 교육 종료 후, 교육 종료 2주 후 각각 의사소통 지식, 의사소통 자기효능감, 학습동기, 전이동기, CPX로 의사소통 수행능력, 교육만족도를 측정하였다. 자료 분석은 SPSS 18.0을 이용하여 반복측정 분산분석(Repeated Measures of ANOVA)과 독립표본 t-test를 이용하여 분석하였다. 본 연구결과는 다음과 같다. ① 역할극을 활용한 의사소통능력 강화 프로그램을 제공받은 간호대학생의 의사소통 지식 점수는 교육 직전보다 교육 직후(p=.003)와 교육 2주후(p=.033)에 유의하게 증가하였다. ② 역할극을 활용한 의사소통능력 강화 프로그램을 제공받은 간호대학생의 의사소통 수행능력 점수는 교육 직후의 점수가 교육 직전 점수보다 유의하게 높았다(p<.001). ③ 역할극을 활용한 의사소통능력 강화 프로그램을 제공받은 간호대학생의 의사소통 자기효능감은 교육 직전보다 교육 직후(p<.001)와 교육 2주후(p<.001)에 유의하게 향상되었다. ④ 역할극을 활용한 의사소통능력 강화 프로그램을 제공받은 간호대학생의 학습동기는 교육 직전보다 교육 직후(p<.001)와 교육 2주후(p<.001)에 유의하게 증가하였다. ⑤ 역할극을 활용한 의사소통능력 강화 프로그램을 제공받은 간호대학생의 전이동기는 교육 직전, 교육 직후, 교육 2주후에 따른 유의한 변화가 없었다(p=.64). ⑥ 역할극을 활용한 의사소통능력 강화 프로그램을 제공받은 간호대학생의 교육만족도는 교육 직후가 교육 직전보다 유의하게 높았다(p<.001). 이상의 연구결과를 종합해보면 역할극을 활용한 의사소통능력 강화 프로그램은 간호대학생의 의사소통 지식, 의사소통 자기효능감, 학습동기, 의사소통 수행능력과 교육만족도를 향상시킴을 알 수 있다. 따라서 본 연구에서 개발된 프로그램은 간호대학생에게 정신간호실습을 하기 전에 적용함으로써 환자와의 의사소통능력 향상을 통해 효능감과 교육만족도 증진에 기여할 수 있을 것이다. This study was conducted to develop and evaluate the effects of a communication competency enhancement program using role-play for nursing students. The preliminary program which was centered on cases of depression and suicide was developed on the basis of the literature reviews and focus group interviews conducted with nursing students who experienced mental health nursing practice during the course of the research. After revising and supplementing the preliminary program developed through expert validity and preliminary evaluation, it was finalized program consisting of 6 sessions, each 120 minutes per session. The effectiveness of the program was evaluated using on experiment that was designed where repetitive measurements were taken for a single group of students both before and after taking the program. The data collection and intervention period took about two months from October to December in 2016. The subjects of this study were 31 second-year nursing students who were sophomore and had not experienced psychiatric mental health nursing practice. The measurement tools used were based on communication knowledge and skills measurement tools developed in this study, self-efficacy for communication developed by Larson et al. (1992), motivation to learning developed by Keller (2004), motivation to transfer developed by Ayres (2005), and learning satisfaction developed by Kim (2015). The communication competency enhancement program using role-play developed by the researcher was conducted three times a week, for a total of six sessions as an extracurricular course. The data were collected before the start of the program training intervention, at the end of the program training, and two weeks after the program training had finished. For the evaluation of the program, communication knowledge, communication self-efficacy, learning motivation, transfer motivation, communication skills through CPX, and learning satisfaction were measured. The results of this study are as follows, 1. The communication knowledge score of nursing students who were provided with the communication competency enhancement program using the role-play increased significantly just after training (p=.003) and two weeks after training (p=.033), compared to before training. 2. The communication skills score of the nursing students when they had just finished the training program was significantly higher than that before they had received the training (p<.001). 3. The self-efficacy of communication score of nursing students who were provided with the training program using the role-play increased significantly just after training (p<.001) and two weeks after training (p<.001), compared to before training. 4. The motivation to learning score of nursing students who were provided with the training program using the role-play increased significantly just after training (p<.001) and two weeks after training (p<.001), compared to before training. 5. There were no significant changes in the students' motivation to transfer score regardless whether it was before, straight after, or two weeks after receiving the training(p=.64). 6. The learning satisfaction score of the nursing students when they had just finished the training program was significantly higher than that before they had received the training (p<.001). In conclusion, the communication competency enhancement program using role-play developed in this study was effective at improving communication knowledge, self–efficacy for communication, and communication skills, increasing motivation to learning and learning satisfaction for nursing students. Therefore, it can be expected to contribute to their enhancement of efficacy and educational satisfaction through improvement of their communication ability with patients, by applying the program developed in this study to nursing students before they do psychiatric mental health nursing practice.