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흰쥐의 간손상(肝損傷)에 대한 가미유간탕(加味愈肝湯)의 간(肝) 보호효과(保護效果)
정희,고호연,하유군,여현수,백종우,고성규,박종형,전찬용,강재춘,Jung, Hee,Go, Ho-Yeon,Hsia, Yu-Chun,Yeo, Hyun-Soo,Baik, Jong-Woo,Ko, Seung-Gyu,Park, Jong-Hyung,Jun, Chan-Yong,Kang, Jea-Chun 대한한방내과학회 2008 대한한방내과학회지 Vol.29 No.1
In order to investigate the protective effects of Gami Yugan-tang on liver damage in rats induced by $CCl_{4}$ and d-galactosamine, the serum transaminase(ALT & AST), alkaline phosphatase(ALP), lactic dehydrogenase(LDH), superoxide dismutase(SOD), catalase, glutathione S-transferase(GST), glutathione peroxidase(GPX) for enzyme activities, and lipid peroxidation were measured. All animals were divided into 4 groups: normal group (untreated), control group (treated with 0.9% saline solution), sample I group (treated with 740mg/kg Gami Yugan-tang), and sample II group (treated with 1,480mg/kg Gami Yugan-tang). The results were as follows : 1. The results of liver damage in rats induced by $CCl_4$ : The protective effects of ALT were displayed in sample I and sample II, and AST, ALP, LDH, SOD, catalase, GST, GPX, and lipid peroxidation were noted in sample II group. It showed slight necrosis of hepatic cell and pathologic changes, for example, inflammatory cells infiltration were improved in sample II group compared to the control group. 2. The results of liver damage in rats induced by d-galactosamine : The inhibitory effects of AST, ALT, LDH, and ALP activities were noted in both sample I and sample II groups. The findings from this experiment suggests that Gami Yugan-tang has protective effects against liver damage in rats induced by $CCl_{4}$ and d-galactosamine.
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성요한초제제 임상시험 고찰을 통한 한약기원 항우울제 임상시험 방법론 연구
정희,이지형,장보형,고성규,Jung, Hee,Lee, Ji-Hyung,Jang, Bo-Hyoung,Ko, Seong-Gyu 대한한방내과학회 2007 대한한방내과학회지 Vol.28 No.2
Objectives : This study was undertaken to learn what should be considered in a good clinical trial investigating a herbal medicine as an antidepressant. Methods : Five well-designed clinical trials published from 2000 to 2006 investigating SJWE in depressive disorder were selected. The trials were reviewed and compared in terms of methodology such as trial design, patient selection, efficacy & safety evaluation, and so on. On the basis of this review of the trials and the regulations and guidelines of KFDA, we suggest some points to be considered for a good clinical trial of a herb for depression. Results : Although every trial had its own unique design, procedure, objectives and so on, all trials used randomizing and double blinding methods. If there is no ethical problem, a placebo-controlled design should be considered in a herbal antidepressant clinical trial for depression. Conclusions : Some points to be considered in an optimal & good clinical trial for an antidepressive herbal medicine were suggested as follows: 1) randomizing and double blinding manner is essential, 2) if there is no ethical problem, placebo control design should be considered, 3) the trial period should be 6 weeks, 4) out-patients will be recruited as subjects, 5) investigators will be well-trained psychiatrists or medical doctors, 6) the number of subjects should be calculated by statistical methods, 7) subjects should be diagnosed by DSM-IV criteria, 8) subjects who have current risk of committing suicide should be excluded, etc.
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한의학 분야 악성종양 전문가집단의 악성종양 연구 및 치료에 대한 접근방법 분석을 통한 악성종양에 대한 임상연구 접근방법 모색
정희,정승기,신용철,고성규,Jung, Hee,Jung, Seung-Ki,Shin, Yong-Chul,Ko, Seong-Gyu 대한예방한의학회 2007 대한예방한의학회지 Vol.11 No.1
Recently, Despite improvements of therapeutic methods on malignancy, the need of modalities on the treatment of cancer have been increasing nowadays and Traditional Oriental Medicine have been considered as alternatives and the uses of it have continued to increase in cancer therapy. The aims of this paper is to analysis of approach modality of experts for the research and treatment on cancer and study of clinical research methodology in Korean Medicine.
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