Fine Structural Study on Compensation Effect of Red Ginseng against Methylmercury Injury to Brain and Gill of Fightingfish

정희원,이춘구,Chung, Hee-Won,Lee, Choon-Koo Korean Society of Electron Microscopy 1993 Applied microscopy Vol.23 No.1

버들붕어 뇌와 아가미의 미세구조에 미치는 메틸수은의 독성적 영향과 이에 대한 홍삼의 보상효능을 전자현미경적 방법에 의하여 연구하였다. 뇌 신경세포의 미세구조 변화에 있어서 대조군에 비하여 메틸수은만을 투여한 군에서는 수상돌기와 축색돌기가 상당히 확장되고 핵질과 세포질이 부분적으로 손실되었으며 ribosome의 수적감소와 mitochondria의 팽대가 관찰되었다. 그리고 파괴된 핵과 공포화된 mitochondria를 함유한 괴사세포의 출현은 특이한 관찰이었다. 반면 메틸수은과 홍삼을 병행 투여한 군에서는 메틸수은만을 투여한 군에서 보다 수상돌기와 축색돌기의 확장이 감소되고 ribosome의 수가 증가되었으며 mitochondria의 팽대정도가 상당히 감소되었다. 아가미 새판의 미세구조에 있어서는 Pillar cell과 arm의 붕괴, 표피세포의 확장 및 기저막의 비후가 메틸수은만을 투여한 군에서 관찰되었고 메틸수은과 홍삼을 병행 투여한 군에서는 메틸수은만을 투여한 군에서 보다 arm의 붕괴정도와 기저막의 비후정도가 감소되어 정상세포와 거의 같은 정도로 호전되었다. The toxic effects of methylmercury on the ultrastructures of the brain and gill tissues of fightingfish and compensative effects of red ginseng were investigated by means of electron microscopy. The brain neuron of methylmercury exposure group showed dilatation of dendrite and axon, numerical decrease of ribosomes, partial loss of nucleoplasm and cytoplasm and considerable swelling of mitochondria as compared with the normal neuron. And necrotic cell with ruptured nucleus and vacuolated mitochondria was noticeable. While, slight swelling of mitochondria, some dilation of dendrite and axon and numerical increase of ribosome occurred in the neuron of methylmercury-red ginseng treatment group as compared with the methylmercury exposure group. In the gill lamella of methylmercury exposure group, collapse of pillar cells and arms, dilated epithelial cell and thickened membrane were observed. While, in the gill lamella of methylmercury-red ginseng treatment group, arms were slightly disintegrated and basement membrane was some thickend as compared with the methylmercury exposure group. From the above results, it is concluded that red ginseng has detoxication effect on methylmercury toxicity and so takes compensative effect on injured tissues caused by methylmercury intoxication.

Electron Microscopic Study on Detoxication Effect of Red Ginseng Extract on Mouse Liver Injury induced by Methyl Mercury

정희원,Chung, Hee-Won Korean Society of Electron Microscopy 1987 Applied microscopy Vol.17 No.1

생쥐 간세포(肝細胞)의 미세구조(微細構造)에 미치는 메틸수은(水銀)의 독성적(毒性的) 영향(影響)과 이에 대한 홍삼(紅蔘) 추출물(抽出物)의 해독효과를 전자현미경적(電子顯微鏡的)으로 연구하였다. 대조군(對照群)의 간세포(肝細胞)에 비하여 메틸수은(水銀)만을 투여(投與)한 군(群)에서는 핵(核)의 일부가 붕괴(崩壞)되고, mitochondria의 팽대(膨大), cristae의 수축(收縮) 내지 손실(損失) 및 다수의 대형 강포(腔胞)의 출현(出現)이 일어나고 glycogen의 양(量)이 감소되었다. 메틸수은(水銀)과 홍삼(紅蔘) 추출물(抽出物)을 병행(倂行) 투여(投與)한 군(群)에서는 메틸수은(水銀)만을 투여(投與)한 군(群)에서보다 mitochondria의 팽대(膨大) 정도(程度)가 적고 강포(腔胞)의 크기와 수가 감소되었으며 정상(正常) 세포(細胞)와 비슷한 상태로 나타났다. Detoxication effect of red ginseng extract against toxicity of methly mercury on ultrastructure of mouse liver was studied by electron microscopy. The hepatocyte of methyl mercury treatment group showed partial rupture of nucleus, mitochondrial swelling, decrease of glycogen content, and appearance of a great number of large vacuoles. While, the hepatocyte of methyl mercury-red ginseng extract treatment group showed slight mitochondrial swelling and decrease of vacuoles in size and number than those of methyl mercury treatment group.

무당개구리 ( Bombina orientalis ) 의 간장과 심장내 젖산탄수화물에 미치는 온도의 영향

정희원,이경애,이춘구 ( Chung Hee Won,Kyung Ae Lee,Choon Koo Lee ) 한국하천호수학회 1989 생태와 환경 Vol.22 No.1

Effect of low and high temperatures on the total LDH activities and electrophoretic patterns of LDH isozymes in the liver and heart of frog, Bombina orientalis were investigated. Total LDH activities in the liver and heart of low (0 ℃ ) and high (33 ℃ )temperature groups were increased in comparison to those of control (20 ℃ ), while LDH activity of low temperature group was greater than that of high temperature group. There were 6 LDH isozyme fractions in the liver and heart at low temperature exposure. When frogs were exposed to high temperature, 6 LDH bands were fractionated in the liver and 5 LDH fractions appeared in the heart. The percentages of liver and heart LDH isozymes at low and high temperatures showed decrease of LDH₁, and increase of LDH_5 in comparison to those of control.

숨겨진 구조 -Hepokoski & Darcy의 소나타 이론을 적용한 베토벤 《영웅교향곡》 의 제시부 분석-

정희원 ( Hee Won Chung ) 서울대학교 음악대학 2009 음악이론연구 Vol.14 No.-

Even though we are familiar with the term `Sonata form,` in many cases we remain using compendious descriptions on themes and key structures when analyzingSonata-allegro movements. Through a close reading of Elements of Sonata Theory by Hepokoski and Darcy, this paper examines features of the exposition and seeks for the possibility in applying their terminologies and methodologies to an analytical discussion of Beethoven`s Eroica Symphony. This latest Sonata theory provides an opportunity to interpret the exposition of the piece with an innovative perspective, which reads the second theme of the exposition from m. 87 to m. 109 as a Tri-modular Block (TMB). Furthermore, this paper includes a critique of certain ideas regarding the end of the second theme in the writings of Schenker as well as Hepokoski and Darcy. Ultimately, this paper aims to scrutinize the Sonata theory which puts emphasis on closuressuch as the Medial Caesura (MC) and Essential Expositional Closure (EEC) in the exposition.

코로나19, 온라인 요가를 통한 신체자각이 여대생의 긍정·부정정서, 불안에 미치는 영향: 수용행동의 매개효과 검증

정희원 ( Chung Hee-won ),육영숙 ( Yook Young-sook ) 한국융합과학회 2022 한국융합과학회지 Vol.11 No.8

연구목적 본 연구의 목적은 코로나19 상황에서 비대면 요가수업에 참여한 여대생의 신체자각이 수용 행동을 매개로 긍정정서, 부정정서, 불안에 미치는 영향을 규명하는데 있다. 연구방법 서울시 S여대생 243명을 대상으로 수집된 자료는 SPSS 25.0 프로그램을 이용하여 탐색적 요인분석 및 신뢰도 분석, SPSS Process Macro 4를 사용한 매개분석을 실시하였다. 결과 첫째, 요가를 통한 신체자각은 여대생의 긍정정서에 직접효과를 보이며, 신체자각의 하위요인인 감각지각, 감각수용, 감각복귀 요인은 수용행동을 매개하는 것으로 나타났다. 둘째, 여대생의 신체자각은 부정정서에 직접효과를 보이지 않으며, 신체자각의 하위요인인 감각지각과 감각수용, 자기조절, 감각복귀, 신뢰 요인은 수용행동을 매개하는 것으로 나타났다. 셋째, 여대생의 신체자각은 불안에 직접효과를 보이며, 신체자각의 하위요인인 감각지각, 감각수용, 자기조절, 감각복귀, 신뢰 요인은 수용행동을 매개하는 것으로 나타났다. 결론 요가를 통한 신체자각은 긍정정서를 높이고, 불안을 낮추며, 신체자각은 수용행동 매개를 통해 긍정정서는 높아지고, 부정정서 및 불안이 낮아졌다. 향후 현대인의 신체적, 심리적 긴장과 위축, 정서불안 완화를 위한 요가 및 움직임에 있어 신체자각을 바탕으로 융복합적인 프로그램 개발이 요구된다. Purpose This study aims to elucidate the influence of Interoceptive Awareness of female college students participating in untact yoga classes in the COVID-19 situation on the positive emotion, negative emotion, Anxiety by using Acceptance and Action as a mediation. Methods For the data collected for 243 S university students in Seoul, exploratory factor analysis and reliability analysis were conducted using the SPSS 25.0 program, and mediating analysis using SPSS Process Macro 4. Result First, female college students' Interoceptive Awareness directly affects positive emotions, and Sensory perception, sensory acceptance, and sensory return, which are sub-factors of Interoceptive Awareness, were found to mediate acceptance behavior. Second, female college students' Interoceptive Awareness does not directly affects negative emotions, and Sensory perception, sensory acceptance, self-control, sensory return, and trust, which are sub-factors of Interoceptive Awareness, were found to mediate acceptance behavior. Third, female college students' Interoceptive Awareness directly affects Anxiety, and Sensory perception, sensory acceptance, self-control, sensory return, and trust, which are sub-factors of Interoceptive Awareness, were found to mediate acceptance behavior. Conclusion Interoceptive awareness through yoga raised positive emotions and lowered anxiety, and Interoceptive awareness increased positive emotions and lowered negative emotions and anxiety through acceptance and action. In the future, it is required to develop a convergent program based on physical awareness in yoga and movement to alleviate physical and psychological tension, atrophy, and emotional anxiety of modern people.

사소함과 소소한 것들: 맥킨지의 『줄리아드 루비니』에 나타난 감성의 사유화

정희원 ( Hee Won Chung ) 한국18세기영문학회 2012 18세기영문학 Vol.9 No.2

This paper examines privatization of Sensibility in Henry Mackenzie`s Julia de Roubigne focusing on the usage of its key words "trifles" and "trivial," which substitute for the word "private" that rarely appears in the novel, As writings "from crossroads of public and private," Eighteenth-century epistolary literature played the central role in the construction of the categories of public and private. Like Richardson`s epistolary novels, Julia de Roubigne consists of letter writings both as private testimony and public history. In contrast to Richardson, however, who idealizes the sincerity of female virtue legible between the lines of heroines` memoirs, Mackenzie makes his third and last novel to doubt the possibility of transmission of sensibility by suggesting the dark prospect of misreading Julia`s letters. I argue that impracticability of sympathy in this novel arose from privatization of Sensibility, which originally presupposed the idealistic synthesis of private and public virtue. In Julia de Roubigne, it is even aggravated by Montauban`s depreciation of "little world of sentiment" and his unreadiness to appreciate the more current and exchangeable value of "trifles." When the sentimental subjects cannot believe in the mutual connections made up through Sensibility, the calamities of conflict lead the sentimental novel to the "indulgence of strong emotionalism, moral polarization and schematization" of melodrama as Peter Brooks defined it.

빅토리아 중기 영국사회의 고딕적 현실과 고딕 (여성)주체 샬럿 브론테의 『빌레뜨』 읽기

정희원 ( Hee Won Chung ) 영미문학연구회 2013 안과 밖 Vol.0 No.35

Starting from the assumption that the Gothic can historicized apart from its conventions as a genre, this essay reads Charlotte Bronte`s Villette as mid-Victorian Gothic. I argue that the traditional Gothic elements in this novel have close connection with the actual social aspects of the mid-Victorian period: denomination of single women as “redundant women”; domestic ideology idealizing women as the “angle in the house” and simultaneously marginalizing them as ghosts; incommensurable division of the public and the private; utilitarian principles that tended to flatten individual beings either into agents or objects of surveillance. Lucy Snowe is a kind of Gothic subject who buries her powerful interior impulse under the mask of a cipher, so others consider her unconsciously as a shadow or a ghost. Through her reticence, however, and manipulation of the narrative, Lucy resists the male gaze that considers her as a non-entity and succeeds in narrating “the unspeakable” in her “heretic narrative” of Villette.

급성 진행성 인지장애로 발현한 일차성 쇼그렌 증후군

정희원 ( Hee Won Chung ),유종진 ( Jong Jin Yoo ),최병용 ( Byoong Yong Choi ),조현정 ( Hyun Jung Cho ),강은하 ( Eun Ha Kang ),송영욱 ( Yeong Wook Song ),이윤종 ( Yun Jong Lee ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.5

Primary Sjogren`s syndrome (pSS) is characterized by chronic inflammation and dysfunction in exocrine organs; however, it also has protean clinical features, including neuropsychiatric symptoms. A major neurological manifestation is peripheral neuropathy and involvement of the central nervous system is uncommonly described in pSS. A 52-year-old female was admitted because of depression, dysarthria, gait abnormality, and memory disturbance, which had developed over two months, and was diagnosed as pSS. She was treated successfully with high-dose glucocorticoid and cyclophosphamide pulse therapy without recurrence during the follow-up period of two years. Herein, we describe the first Korean case of pSS presenting with rapidly progressive cognitive impairment along with a review of the literature.

『공감의 힘, 혹은 자연의 승리』에 나타난 “자연”과 공화주의

정희원 ( Hee Won Chung ) 한국영어영문학회 2013 영어 영문학 Vol.59 No.1

This paper aims to elucidate the meanings of “Nature” in William Hill Brown`s The Power of Sympathy: or, the Triumph of Nature (1789) in the premise that concept of Nature is of great consequence in the discourses of Republicanism in the early America. Nature was charged with the contested meanings in the battle of ideologies between the advocates of English monarchy and the republicans; the opposite parties derived the authority of their arguments from the various demarcations of defining “nature” and “natural” in their own ways. In this novel, meanings of “nature” vary from the humanistic impulse against God`s grace to human mind as in the scene when Mr. Holmes argues that reading books is like the cultivation of nature. Finally, as the catastrophe surge of incest destroys the ill-starred lovers Harrington and Harriot, “nature” that presides over their tragedy gives us even a glimpse of its deterministic character. In Brown`s novel, I argue, the ideal of republicanism that theoretically disavows class differences is undermined when the revelation comes that it was from their mutual affinity as half-blooded siblings that the peril of incest originates, despite of their seemingly republican love that had overcome the consciousness of class distinctions. As the major assumption of republicanism is stranded on the reef of the impediments to republican marriage and the affliction caused by homogeneity, the meaning of nature encompassing hypotheses of Enlightenment and Sentimentalism is simultaneously ruptured and impaired.

체계 : 쇼팽의 《발라드》Op. 23의 형식에 관한 고찰

정희원 ( Hee Won Chung ) 서울대학교 서양음악연구소 2008 음악이론연구 Vol.13 No.-