과체중 성인들에서의 횡이론적 단계별 변화 모형에 의한 체중조절상태와 체중조절에 대한 의사의 충고

정휘수,지선하,남정모,이자경 대한비만학회 2011 The Korean journal of obesity Vol.20 No.1

연구배경: 최근에 체중조절에 대한 관심은 높아지지만, 의사에 의한 체중조절 상담은 여전히 낮다. 본 연구는 과체중 이상의 성인에서 체중조절에 대한 상태 및 의사의 충고 및 교육 여부를 확인하기 위하여 수행하였다. 방법: 2008년 7월 7일부터 10월 31일까지 경북 경주시에 소재하는 일개 대학병원 건강검진센터를 내원한 수검자 중 체질량지수가 23 kg/m2 이상인 과체중 성인 251명을 대상으로 자기 기입식 설문지를 이용하여 자료를 수집하였다. 문항내용에는 인구사회학적 특성, 비만 관련 항목, 의사로부터 체중조절에 대한 충고 및 교육을 받은 경험 유무 등이 포함되었다. 현재 체중조절에 대한 상태에 대해서는 횡이론적 단계별 변화모형을 이용하여 확인하였다. 결과: 횡이론적 단계별 변화모형을 이용하여 체중조절상태를 확인한 결과 전체 대상자 중 준비단계인 대상자가 81 (32.3%)명로 가장 높았다. 체중조절단계를 고려 전 단계, 고려단계, 행동단계로 재 분류했을 때는 행동단계는 106 (42.2%)명이었다. 147 (58.6%)명이 의사로부터 체중조절에 대한 충고를 받은 경험이 있었지만, 체중조절방법에 대해 교육을 받은 경우는 34 (13.5%)명에 불과하였다. 고려 전 단계와 비교하여 고려단계와 유의하게 관련이 있는 요인은 주관적으로 비만하다고 인식하는 경우(교차비 3.61, 95% 신뢰구간 1.42~9.21)와 의사로부터 체중조절충고를 받은 경험(2.55, 1.02~6.40)이었다. 고려 전 단계와 비교하여 행동단계와 유의하게 관련이 있는 요인은 체중조절 경험(2.92, 1.24~6.86)이었으며, 고려단계와 비교하여 행동단계와 유의하게 관련이 있는 요인도 체중조절 경험 (2.20, 1.15~4.20)이었다. 결론: 과체중 성인들은 체중조절에 대해 준비단계가 가장 많았다. 일차진료 의사들은 이들에게 적극적으로 체중 감량에 대한 충고를 해야 할 것이다.

일개 사업장 여성들의 변비와 관련된 생활양식

정휘수,송윤미,이정권,김영욱,한승헌,강석철,김융언 대한가정의학회 2002 Korean Journal of Family Medicine Vol.23 No.3

연구배경: 여성, 노인, 불충분한 식이섬유소 및 수분 섭취와 변비의 연관성은 널리 알려진 반면, 스트레스나 불규칙한 식습관을 포함한 생활양식과 변비의 연관성은 불명확하다. 본 연구는 성인 여성 근로자를 대상으로 변비와 생활양식의 연관성을 파악하기 위해 수행되었다.방법: 본 연구는 단면 연구로 2002년 5월 30일부터 6월 30일 사이에 일개 사업장의 여성 근로자 중 건강검진에 참여하여 배변습관을 묻는 설문 항목을 완전하게 기입한 911명을 연구 대상으로 하였다. 설문지는 인구 사회학적 특성, 배변습관, 생활양식을 묻는 항목으로 구성되었다.결과: 전체 연구대상자의 48.6%에서 기능성 변비의 '제2차 로마 기준' 정의에 의한 변비가 있었다. 가장 많은 비정상 배변증상은 과도한 힘주기(50.0%)였으며 다음으로는 잔변감(45.0%), 딱딱한 변(35.4%), 항문이 막힌 느낌(30.0%)순으로 많았다. 일주일에 2회 이하의 배변을 하는 경우는 16.1%이었다. 스스로 변비가 있다고 인식하는 사람 중 '제2차 로마 기준' 정의에 따른 변비가 있는 경우는 66.0%이었다. 카이 제곱 검정, t-검정에서 변비는 스트레스가 심한 것, 다이어트를 하는 것, 소량의 식이섬유소 섭취, 흡연과 유의한 연관성이 있었다. 중회귀 로짓분석 결과, 심한 스트레스는 변비와 가장 높은 연관성이 있는 것으로 관찰되었으며(교차비: 3.02, 95% 신뢰구간: 1.68∼5.41), 적은 식이섬유소 섭취(교차비: 2.08, 95% 신뢰구간: 1.13∼3.81), 다이어트를 하는 것(교차비: 1.92, 95% 신뢰구간: 1.12∼3.27)도 변비와 유의한 연관성이 있었다. Lifestyle Factors Related to Constipation in Working WomenHwee Soo Jung, Yun Mi Song, Jung Kwon Lee, Young Wook Kim*,Seung Heon Han**, Seok Cheol Kang and Yoong Eun Kim

건강검진 수검자에서 발견된 단순 신낭종과 관련된 요인

정휘수,박기흠,이동욱 동국대학교 의학연구소 2009 東國醫學 Vol.16 No.1

Simple renal cyst is one of renal neoplasm detected incidentally in abdominal ultrasonography (USG). we carried out this study to detect prevalence of simple renal cyst and identify factors relation of simple renal cyst as hypertension. We collected age, sex, body mass index, systolic blood pressure, diastolic blood pressure, serum glucose, serum creatinine, proteinuria, hematuria, report of abdominal USG among 1,762 subjects who had health screening at Dongguk university Gyeongju hospital from Mar 2004 to Jan 2005. Prevalence of simple renal cyst was 3.2% (n=55) and high in subjects who was over 50 years-old (6.3%, p<.0001). Factor related to simple renal cyst was only age. As increasing oneyear old, risk of simple renal cyst increased 1.058 (95% confidence interval 1.029~1.089)times. Other factors as sex, systolic blood pressure, diastolic blood pressure, hypertension, diabetes, serum creatinine, body mass index, obesity, smoke, serum glucose, proteinuria, hematuria were not significantly related to simple renal cyst. Simple renal cyst is commonly detected in health screening of older subjects but is not relation of hypertension and renal function. 단순신낭종은 복부 초음파검사를통해 우연히 발견되는신종물중 하나이다. 저자들은 단순신낭종의 유병률을 확인하고, 고혈압을 비롯한 단순 신낭종 소견과 관련된 요인을 확인하기 위해 본 연구를 수행하였다. 2004년 3월부터 2005년 1월까지 동국대학교 경주병원에서 건강검진을 받았던 1,762명을 대상으로 연령, 성별, 체질량 지수,수축기, 이완기 혈압, 헐당, 크테아티닌, 단백뇨,혈뇨,복부 초음파 검사 결과지를 확인하였다. 단순 신낭종 유병률은 3.2%(55명)였고 50세 이상에서 유의하게 유병률이 증가하였다(6.3%, p<.0001). 단순 신낭종 유무와 유의한 관련성을 보인 요인은 연령만 확인할 수 있었는데, 연령이 한 살씩 증가할수록 신낭종 위험은 1.058배 (95% 신뢰구간 1.029~1.089)높아졌다. 기타 성별,수축기 혈압,이완기 혈압, 고혈압 병력,당뇨 병력, 혈중 크레아티닌 농도,체질량 지수, 비만, 흡연,혈당, 단백뇨, 혈뇨는 단순 신낭종 유무와 유의한 관련성을 보이지 않았다. 단순 신낭종은 연령 증가에 따라 건강 검진에서 비교적 흔히 확인할 수 있지만 혈압과 신장 기능과의 관련성은 없었다.

Perception and Performance of Preventive Behaviors for the Pandemic Influenza in Hospital Employees and Outpatients

정휘수,이동욱,윤창호,이미경,이승준,서영성,김대현 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.1

Purpose: A new strain of the H1N1 subtype of influenza A virus resulted in a pandemic outbreak. In South Korea, cases of pandemic influenza have increased. Therefore, we explored perception or preventive behaviors for this virus in hospital employees and outpatients. Materials and Methods: Data was collected from hospital employees and outpatients at three university hospitals located in Daegu, Gyeongju in South Korea between the 21st and 30th of September, 2009 using a self-administrated questionnaire. We estimated perception by components of The Health Belief Model (HBM), preventive behaviors consisted of avoidance behaviors,and the recommended behaviors by the Korea Center of Disease Control and Prevention (KCDC). Desire for vaccination was identified. Results: The 1,837 participants comprised hospital employees (n = 880, 47.9%) and outpatients (n = 957, 52.1%). Of all hospital employees, 491 (55.8%) and 708 (80.5%) perceived susceptibility of the pandemic influenza and benefits of the preventive behaviors, respectively. Among all outpatients, 490 (51.2%) and 651 (68.0%) perceived susceptibility of the pandemic influenza and benefits of the preventive behaviors, respectively. Recommended preventative behaviors were adopted by 674 (76.6%) of hospital employees and 631 (65.9%) of outpatients. Vaccination was desired by 479 (54.4%) of hospital employees and 484 (50.6%) of outpatients. Factors influencing preventative behaviors included gender, economic status (for hospital employees) and educational level (for outpatients). All HBM components except perception of barriers were associated with the preventive behaviors in both groups. Conclusion: The majority of the surveyed hospital employees and outpatients perceived the benefits of preventive behaviors for pandemic influenza and performed them.

한국형 노쇠측정도구로 평가된 노쇠와 관련된 임상적 요인들

정휘수,이동욱,박기흠,이용국,배상호,강미진,심민성,등건훈 대한노인병학회 2013 Annals of geriatric medicine and research Vol.17 No.2

Background: On the point of entering into the aged society, frailty will be recognized as a new geriatric problem in Korea. This study was conducted to identify clinical factors related to frailty in the community dwelling elderly. Methods: This was a cross-sectional study comprised of 515 participants among 834 potential subjects who were residents of three towns in Gyeong-ju and had health check-ups at a university hospital in the same region. Using the Korean Frailty Index, those with a total score of 5 or more were considered frail and those with scores 3 to 4 as prefrail. Socio-demographics, anthropometry and laboratory data were the selected clinical factors. Those younger than 65 years or with incomplete data were excluded. Finally, 447 participants were analyzed. Results: Among the participants, those identified as frail were 20 (4.5%), prefrail 72 (16.1%) and robust 355 (79.4%). By gender, the percentage of frail, prefrail and robust individuals were 3.2%, 17.4% and 79.5%, respectively, in men and 5.4, 15.2% and 79.4% in women (p=0.447). On ordinal logistic regression analysis, factors related to frailty were increased age (odds ratio [OR], 1.08; 95% confidence interval [CI], 1.01 to 1.17), functional disability (OR, 8.88; 95% CI, 4.46 to 17.68), chronic disease such as pulmonary disease (OR, 4.69; 95% CI, 1.47 to 14.99) or hypertension (OR, 2.23; 95% CI, 1.15 to 4.32), increased waist circumference (OR, 1.06; 95% CI, 1.01 to 1.11), decreased serum cholesterol (OR, 0.98; 95% CI, 0.97 to 0.99) and elevated blood urea nitrogen (OR, 1.07; 95% CI, 1.01 to 1.14). Conclusion: Clinical factors related to frailty were age, functional disability, chronic disease, waist circumference, serum cholesterol and blood urea nitrogen. Primary physicians should assess frailty when seeing elderly patients who have these factors.

말기 암 환자에서 감염에 대한 항생제 사용 - 대한가정의학회 완화의학연구회 세미나에 기초한 -

정휘수,김대영,송경포,대한가정의학회 완화의학연구회,서상연,Jeong, Hwee-Soo,Kim, Dae-Young,Song, Kyoung-Po,Korean Family Medicine Palliative Medicine Research Group, Korean Family Medicine Palliative Medicine Research Group,Suh, 한국호스피스완화의료학회 2007 한국호스피스.완화의료학회지 Vol.10 No.1

말기 암 환자에서 감염에 대한 항생제 사용은 의학적 문제에 대해 해결해야 하는 의무와 임종을 앞둔 시점에 생명 연장으로 인한 환자의 고통증가에 대한 부담으로 명확하게 결정하기 어려운 문제이다. 대한가정의학회 완화의학연구회 세미나에서는 65세 남자환자로 직장암 말기에 악취를 동반한 광범위한 피부감염증으로 입원 후 국소 항생제 치료로 증상 호전 중 임종을 맞이한 증례를 토의하였고, 이를 통해 말기 암 환자에서 항생제 치료에 대한 문헌고찰과 토론 후 다음과 같이 의견을 제시하고자 한다. 항생제 치료 목적에 있어 증상조절을 고려해야 하며, 특히 요로계 감염이 있는 경우는 증상조절을 위해 항생제를 사용한다. 또한 감수성 검사를 통해 적절한 항생제를 처방해야 한다. 무엇보다도 우선적으로 고려되어야 할 점은 환자입장에서 무엇이 가장 득이 되는지를 생각하고, 항생제 사용에 대해 환자와 가족들의 의견을 존중하여 판단하며, 환자나 가족이 적극적으로 치료를 요구하는 경우에는 치료로 인한 득실에 대해 환자와 토의를 한 후 사용한다. Decision-making of antibiotics use in infected patients with terminal stage of cancer was difficult for physicians, because of responsibility of solving a medical problem and burden on patients distressed by worthless life expansion. Korean Family Medicine Palliative Medicine Research Group discussed this subject using a case of a 65 year-old male having terminal stage of sigmoid colon cancer with extended cutaneous infection who was treated local antibiotics, improved but expired at the 12th hospital day. We reviewed related literatures and proposed a guide for antibiotics use in inferred patients with terminal stage of cancer. Antibiotics should be used for symptom control as major indication, especially when patients suffered from urinary symptoms. Appropriate antibiotics should be chosen based or sensitivity test. the most important considering factor should be patient and family members' wish about antibiotics use.

입원환자 영양지원에 대한 일개대학병원 의료진의 태도 및 관련 요인

정휘수 ( Hwee Soo Jeong ),등건훈 ( Chen Hsuen Teong ),최유정 ( You Jung Choi ),김우정 ( Woo Jeng Kim ),이아란 ( Ah Ran Lee ) 한국정맥경장영양학회 2014 한국정맥경장영양학회지 Vol.6 No.1

Purpose: Knowledge of nutritional support and attitudes of medical staff both affect patient care. We identified attitudes regarding nutritional support among medical staff as well as changes in attitudes when a nutritional support team is present. Methods: Data were collected from 172 medical staff members who served at a university hospital located in Gyeongju by self-administered questionnaire from June 12∼August 30, 2013. The questionnaire inquired about importance of nutritional support, self-confidence about nutritional support, consideration of nutritional support for patient care, consideration of nutritional support when a nutritional support team is present, and nutritional knowledge training during the past year. Results: A total of 169 subjects (98.3%) thought that nutritional support is important for patient care. Only 19 subjects (11.0%) were highly self-confident about nutritional support. In total, 147 subjects (85.5%) considered nutritional support for some or all patients, whereas 169 (98.3%) considered nutritional support for patient care when a nutritional support team is present. Thirty-eight subjects (22.1%) received nutritional knowledge training during the past year. High self-confidence for nutritional support was related to nutritional knowledge training and service part. Positive changes regarding nutritional support when a nutritional support team is present were associated with nutritional knowledge training and high self-confidence for nutritional support. Conclusion: No differences in nutritional support attitudes for patient care were observed among the medical staff. Nutritional knowledge training and service part affected self-confidence of nutritional support and induced positive changes in attitudes for nutritional support.

食用色素開發에 關한 硏究

鄭輝秀,陳甲德 嶺南大學校 環境問題硏究所 1984 環境硏究 Vol.4 No.2

A study for development of natural red pigment in food and drug industry was proceeded to anthocyanin from prunus yedoensis Matsum, isolated through silica gel column and further subjected to TLC. The color effect and stability from several factors was detected by spectrophotometry in 520 nm and was compared to amaranth and then 1/200 times of it. The content of the color of the fruits of Prunus yedoensis Matsum was 0.6%. As this pigment was more safe about 7.4 times in ??,but was influenced by pH(3.0-8.0) and by some metal ions (??, ??, ??, ??),and respectively stable to temperature, sun light, ultra violet ray and organic acids than amaranth, and was not given a bad infouences by sugars, recovery of another characteristics of this pigment or co-factors to compensate and promote the color effect, for example Cu(), is expected.

多變量分析에 依한 琴湖江의 水質評價

朴永圭,李哲熙,鄭輝洙 嶺南大學校 環境問題硏究所 1986 環境硏究 Vol.6 No.1

The results of the multivaraite analysis in order to estimate water quality of the Kum-ho river were as follows: 1. The water quality of the Kum-ho river estimated by the factor scores were seasonably homogeneous throughout the period of this research. 2. The cumulative proportion includings the third principal components was ranked as high as 97.8%. 3. The first principal components except water temperature, which the factor loading of which marked over 0.9, are composed of 14 items of water quality, and it was thought to be closely related to the river pollution caused by human activities and the waste water from near by factories. 4. In the relationship between the water quality and the flow of Kum-ho river was founded that COD and the factor scores related closely to each other from the relationship. Therefore, the run-off loading rate could be explained most completely by COD(Cr) and factor scores. And the run-off loading rate of the Kum-ho river basin showed almost no variation at the lower reaches, where the pollutions were mainly contributed by the point sources.

아토바스타틴의 새로운 약물 적응증 탐색을 위한 비정형 데이터 분석

정휘수 ( Hwee-soo Jeong ),강길원 ( Gil-won Kang ),최웅 ( Woong Choi ),박종혁 ( Jong-hyock Park ),신광수 ( Kwang-soo Shin ),서영성 ( Young-sung Suh ) 한국보건정보통계학회(구 한국보건통계학회) 2018 한국보건정보통계학회지 Vol.43 No.4

Objectives: In recent years, there has been an increased need for a way to extract desired information from multiple medical literatures at once. This study was conducted to confirm the usefulness of unstructured data analysis using previously published medical literatures to search for new indications. Methods: The new indications were searched through text mining, network analysis, and topic modeling analysis using 5,057 articles of atorvastatin, a treatment for hyperlipidemia, from 1990 to 2017. Results: The extracted keywords was 273. In the frequency of text mining and network analysis, the existing indications of atorvastatin were extracted in top level. The novel indications by Term Frequency-Inverse Document Frequency (TF-IDF) were atrial fibrillation, heart failure, breast cancer, rheumatoid arthritis, combined hyperlipidemia, arrhythmias, multiple sclerosis, non-alcoholic fatty liver disease, contrast-induced acute kidney injury and prostate cancer. Conclusions: Unstructured data analysis for discovering new indications from massive medical literature is expected to be used in drug repositioning industries.