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Effectiveness of the Use of Standardized Vocabularies on Epilepsy Patient Cohort Generation
정혜실,이호영,유수영,황희,백현영 대한의료정보학회 2022 Healthcare Informatics Research Vol.28 No.3
Objectives: This study investigated the effectiveness of using standardized vocabularies to generate epilepsy patient cohortswith local medical codes, SNOMED Clinical Terms (SNOMED CT), and International Classification of Diseases tenth revision(ICD-10)/Korean Classification of Diseases-7 (KCD-7). Methods: We compared the granularity between SNOMED CTand ICD-10 for epilepsy by counting the number of SNOMED CT concepts mapped to one ICD-10 code. Next, we createdepilepsy patient cohorts by selecting all patients who had at least one code included in the concept sets defined using eachvocabulary. We set patient cohorts generated by local codes as the reference to evaluate the patient cohorts generated usingSNOMED CT and ICD-10/KCD-7. We compared the number of patients, the prevalence of epilepsy, and the age distributionbetween patient cohorts by year. Results: In terms of the cohort size, the match rate with the reference cohort was approximately99.2% for SNOMED CT and 94.0% for ICD-10/KDC7. From 2010 to 2019, the mean prevalence of epilepsy definedusing the local codes, SNOMED CT, and ICD-10/KCD-7 was 0.889%, 0.891% and 0.923%, respectively. The age distributionof epilepsy patients showed no significant difference between the cohorts defined using local codes or SNOMED CT, but theICD-9/KCD-7-generated cohort showed a substantial gap in the age distribution of patients with epilepsy compared to thecohort generated using the local codes. Conclusions: The number and age distribution of patients were substantially differentfrom the reference when we used ICD-10/KCD-7 codes, but not when we used SNOMED CT concepts. Therefore, SNOMEDCT is more suitable for representing clinical ideas and conducting clinical studies than ICD-10/KCD-7.
황기의 성분연구 (3) - Triterpenoids and Sterols
정혜실,이은주,이제현,김주선,강삼식 한국생약학회 2008 생약학회지 Vol.39 No.3
Astragali Radix, known as Huangqi, is the most important tonic in the traditional oriental medicine. It reinforces “qi” (vital energy), strengthens the superficial resistance and promotes the discharge of pus and the growth of new tissue. It has long been used as an anti-perspirant, anti-diuretic or a tonic. Eleven compounds were isolated from the hexane and EtOAc fractions from the roots of Astragalus membranaceus (Leguminosae) and their structures were identified as four triterpenoids [lupenone (1), friedelin (2), lupeol (3), soyasapogenol E (9)] and seven sterols [β-sitosterol (4), stigmastane-3,6-dione (5), 7α- hydroxysitosterol (6), 5α,6β-dihydroxysitosterol (7), 7-oxo-β-sitosterol (8), β-sitosterol glucoside 6'-O-palmitate (10), β-sitosterol glucoside (11)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. Among these compounds, lupenone (1), friedelin (2), lupeol (3), stigmastane-3,6-dione (5), 7α-hydroxysitosterol (6), 5α,6β-dihydroxysitosterol (7), 7-oxo-β-sitosterol (8), soyasapogenol E (9), and β-sitosterol glucoside 6'-O-palmitate (10) were isolated from this plant for the first time.
Cavernous Hemangioma of the Uterus in a Postmenopausal Woman - A Case Report -
정혜라,조치흠,권상훈,권선영 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.5
Cavernous hemangioma of the uterus is an uncommon mesenchymal tumor. Most cases have been reported in young, pregnant women and the condition is very rare in a postmenopausal patient. An 81-year-old woman presented with a huge pelvic mass. Abdominal computed tomography and magnetic resonance imaging results suggested a leiomyoma with degenerative change and hemorrhage. Microscopically, large, thick-walled and variable-sized vascular channels were evident in the majority part of myometrium; the lining cells were immunohistochemically reactive for CD31. Vascular tumors of the female genital tract should be cautiously excised due to the profuse intra-operative bleeding. The pathological examination of a hysterectomy specimen is the only method to confirm the diagnosis of this tumor.