일개 대학병원에 내원한 무증상성 열공성 뇌경색 환자와 정상인에서 비만 지수와 대사증후군 유병률 비교

정현윤(Hyun Yun Jeong),김도경(Do Kyung Kim),손호영(Ho Yong Son),신윤리(Yoon Ri Shin),이재욱(Jae Wook Lee),김경민(Kyoung Min Kim),김영균(Young Kyun Kim),권정남(Jung Nam Kwon),박선미(Sun Mi Park) 한의병리학회 2010 동의생리병리학회지 Vol.24 No.3

This clinical study was done to examine comparison the prevalence of metabolic syndrome and obesity index between patients with silent lacunar infarction and normal controls. We compared the components of metabolic syndrome and obesity index between patients silent lacunar infarction(n=62) and normal controls(n=72). The analysis of the data was done by Frequency Analysis, two sample t-test, Chi-square Test. Hypertension and diabetes mellitus was significantly higher in patients of silent lacunar infarctions. Body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome were higher significantly in patients of silent lacunar infarctions than normal controls. Although statistically insignificant, waist circumference showed relatively higher in patients of silent lacunar infarction. This result emphasizes the importance of managing that hypertension, diabetes, body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome in silent lacunar infarction.

반하후박탕(半夏厚朴湯) 추출물이 생쥐에 유발된 심리적 스트레스에 미치는 영향

임세현 ( Se Hyun Lim ),정현윤 ( Hyun Yun Jeong ),원호영 ( Ho Young Won ),김형우 ( Hyung Woo Kim ),최창원 ( Chang Won Choi ),정향숙 ( Hyang Sook Jeong ),김영균 ( Young Gyun Kim ),조수인 ( Su In Cho4 ) 대한본초학회 2012 대한본초학회지 Vol.27 No.4

Objective : Banhahubak-tang is indicated for globus hystericus, marked by a subjective sensation as if something stuffed in the throat, chest distress, cough or vomiting, greasy whitish, taut and smooth pulse. In this study, the effects of Banhahubak-Tang extract (BHTe) were tested for anti-stress action. Methods : BHTe was extracted by pure water using electronic extractor and then fed to ICR male mice (20±2g) orally with the dose of 100㎎/㎏/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : BHTe administered group showed a tendency of decreasing of serum corticosterone secretion when compared with control group, and BHTe administration also significantly up-regulated noradrenaline secretions in the dorsal cortex of brain. Lipid peroxidation of the brain tissues of mice were tested by measuring malondialdehyde, but BHTe showed no significant change. The elevated plus-maze test was designed to detect the effect of anxiolytic drugs, and BHTe administered group showed a significant increase of latency time. Conclusions : These results suggest that BHTe can effectively rid the psychological stress and it`s related diseases.

간성뇌병증 환자의 증례 1례

김도경(Do Gyoung Kim),정현윤(Hyun Yun Jeong),이재욱(Jae Wook Lee),신윤리(Yoon Ri Shin),신철경(Cheol Kyung Sin),김경민(Kyung Min Kim),김영균(Young Kyun Kim),이용태(Yong Tae Lee),권정남(Jung Nam Kwon) 한의병리학회 2010 동의생리병리학회지 Vol.24 No.4

The clinical manifestation of Hepatic encephalopathy is personality change, vacant behavior, lethargy, flapping tremor, muscle twitching, noisy, abusive, violent, coma. The purpose of this clinical study was done to report the improvement of hepatic encephalopathy after oriental medical treatment (herb-med, acupuncture, moxibustion). We applied Ukieum-ja and Sopungsungi-won to patient who had liver cirrhosis and hepatic encephalopathy. We examined the Change of CBC, LFT and Clinical Manifestation to evaluate the effectiveness of oriental medical treatment. We observed that oriental medical complex treatment decreased symtoms and improved general condition of a patient. So we report this clinical study to be helpful in treating patients of hepatic encephalopathy.

급성기 뇌경색의 위험인자와 NIH stroke scale에 관한 임상적 연구

김도경(Do Gyoung Kim),정현윤(Hyun Yun Jeong),손호영(Ho Young Son),이재욱(Jae Wook Lee),이영준(Young Jun Lee),최상옥(Sang Ok Choi),김경민(Kyung Min Kim),김영균(Young Kyun Kim),권정남(Jung Nam Kwon) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.3

This study was done to examine the risk factors between controls group and acute brain infarction patients group, and to compare high risk group with low risk group through NIHSS(National Institutes of Health stroke scale). We compared the risk factors between acute brain infarction patients group(N=180) and controls group(N=93). And according to risk factors, we analyzed 1st NIHss, after 3 weeks improved extent within acute brain infarction patients group. The results were as follows. 1. Among the risk factors, HTN, DM, the blood levels of HCY were significantly higher and the blood levels of HDL-C was significantly lower in patients group than controls group. 2. In scale analysis according to risk factors, 1st NIHss were significantly higher in Hypo-HDL-cholesterolemia, Obesity, High-Homocysteine, HTN, DM, previous CVA history group than low risk group within acute brain infarction patients group. 3. In after 3 weeks improved extent analysis according to risk factors, improved extent were lower in Hyperlipidemia, HTN, DM, previous cardiac history, older age group than low risk group within acute brain infarction patients group. The above results suggest that significant risk factors of acute brain infarction, and shows the High risk group that had risk factor of brain infarction recognized from the former research tends to have higher 1st NIHss. Also the High risk group tends to have lower improved extent, but the results are not statistically significant. Furthur research on subject is needed.

무증상성 열공성 뇌경색 환자에서 호모시스테인과 대사증후군의 상관관계에 대한 연구

신윤리,이재욱,이승연,윤용재,정현윤,김경민,김영균,Shin, Yoon-Ri,Lee, Jae-Wook,Lee, Seung-Yeon,Yun, Yong-Jae,Jeong, Hyun-Yun,Kim, Kyoung-Min,Kim, Young-Kyun 대한한방내과학회 2012 대한한방내과학회지 Vol.33 No.3

Objectives : This clinical study was done to examine metabolic syndrome (MS) and plasma homocysteine (HCY) level in patients with silent lacunar infarction (SLI) and in normal controls. Methods : A total of 154 patients, who were over 20 years of age and visited the stroke prevention check-up center of a university hospital from December 2006 to December 2010, were examined by brain CT or brain MRI, and classified into two groups. We compared the components of MS and HCY levels between patients with SLI (n=74) and normal controls (n=80). Modified ATP III definition was used for diagnosis of MS while Korean standard for waist circumference was used. Results : Prevalence of MS was significantly higher in the SLI group than the normal group. HCY was also significantly higher in the SLI group than the noraml, and the odds ratio (OR) for SLI, comparing high HCY level (${\geq}10{\mu}mol/L$) with low HCY level ($<10{\mu}mol/L$), was 3.64 (95% confidence interval (CI); 1.81-7.29, p<.0001). However, there was no correlation between MS and HCY in the SLI group. Prevalence of diabetes and hypertension (HT) was higher in the SLI group than the normal group, but there was no significant difference in blood lipids level between the SLI and normal groups. Of note, HT itself was enough to be an independent risk factor for SLI (OR; 4.58, 95% CI; 1.91-11.01, p=0.001). Body mass index, waist circumference, waist-hip ratio and visceral fat area were significantly higher in the SLI than normal group, and visceral fat area was enough to be an independent risk factor for SLI (OR; 2.41, 95% CI; 1.04-5.59, p=0.040). Conclusions : SLI is shown to have significant correlation with HCY and prevalence of MS, however there is no relationship between HCY and prevalence of MS in patients with SLI.

중풍환자의 구(灸)치료에 따른 기능회복도에 관한 임상연구

이상희,김재규,손연희,정현윤,김정훈,권정남,김영균,Lee, Sang-Hee,Kim, Jae-Kyu,Son, Yeon-Hui,Jeong, Hyun-Yun,Kim, Jung-Hoon,Kwon, Jung-Nam,Kim, Young-Kyun 대한한방내과학회 2008 대한한방내과학회지 Vol.29 No.1

Objective : The purpose of this clinical study was to investigate the effects of moxibustion on functional recovery in stroke patients. Methods : Forty two stroke patients were randomized into either the standard physiotherapy treatment combined with moxibustion group or a control group with standard physiotherapy alone. They were 8 weeks from onset to the start of this study. Moxibustion was applied at 合谷(LI14), 外關(TE5), 曲池(LI11), 太衝(LIV3), 懸鍾(絶骨,G39), 足三里(S36) in hemiplegic upper and lower extremity, once a day for 6 weeks. The effect of treatment on functional recovery was assessed using the Functional Independence Measure scale. Statistical significance was achieved if the probability was less than 5%(p<0.05). Result : These 2 groups had comparable clinical characteristics; sex, age, lesion, and pre-treatment FIM score. After 6 weeks, patients in the moxibustion group performed better on FIM. The differences were significant(P=0.001). Conclusion : These results suggest that moxibustion is an effective treatment for functional recovery in stroke patients.

뇌졸중후 인지기능저하의 한약치료에 대한 임상적 고찰

김재규,허정은,손연희,정현윤,신철경,민성순,권정남,김영균,Kim, Jae-Kyu,Heo, Jeong-Eun,Son, Yeon-Hui,Jeong, Hyun-Yun,Sin, Cheol-Kyung,Min, Sung-Soon,Kwon, Jung-Nam,Kim, Young-Kyun 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.4

Objectives The aim of study was to evaluate the effect of Herbal medicine on post stroke cognitive deficit. Methods All groups were treated with acupunture treatment, moxa treatment, herbal medicines, physical and occupational therapy for 4 weeks, additionally cardiotonic pills(CP) were taken in the cardiotonic pills group. The effect of treatment was assessed using Verval fluency, MMSE-KC, Word List Immediate Recall test. Statistical significance was achived if the probability was less than 5%(p,0.05). Results Verval fluency, MMSE-KC, Word List Immediate Recall test scores increased in both group. MMSE-KC, Word List Immediate Recall test scores were significantly increased in the CP group. Verval fluency, MMSE-KC, Word List Immediate Recall test scores were significantly increased in the control group. In the Verval fluency, MMSE-KC, Word List Immediate Recall test of the CP group more increased compared to the control group. There were no significant differences between two groups. In the CP group, the scores of the infarction group more increased compared to the hemorrhage group. Conclusions According to the these results, herbal medicines are effective to improve post stroke cognitive-deficit. Futher studies are needed to know cardiotonic pills in the ischemic stroke.

뇌경색 위험인자로서의 혈중 지질에 대한 임상적 연구

손연희,이상희,김재규,정현윤,김영균,권정남,Son, Yeon-Hui,Lee, Sang-Hee,Kim, Jae-Kyu,Jeong, Hyun-Yun,Kim, Young-Kyun,Kwon, Jung-Nam 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.4

Objective The purpose of this case-control study was done to examine the relationship among the acute brain infarction, silent brain infarction and blood lipids. Methods We compared the components of blood lipids among acute brain infarction patients group (n=99), silent brain infarction patients group(n=101) and controls group (n=153). The analysis of the data was done by Frequency Analysis, one-way ANOVA, Post Hoc Test(Duncan), Pearson's Correlation. Results The results were as follows. High density lipoprotein cholesterol(HDL-Chol) was significantly lower in patients of acute brain infarctions group. The blood levels of total cholesterol(T-Chol) was significantly higher in patients of silent brain infarctions. A study on the relationship among the significant variables ; In T-Chol and HDL-Chol, DM(No=0, Yes=1) and Age, they had positive correlation each other. Between Sex(Female=0, Male=1) and HDL-Chol, Age and HDL-Chol, DM and HDL-Chol, they had negative correlation each other. Conclusions These results suggest that low HDL-Chol may be risk factor of acute brain infarction.

환자-대조군 연구를 통한 뇌경색 위험인자에 대한 통계적 고찰

손연희(Yeon Hui Son),정현윤(Hyun Yun Jeong),김도경(Do Gyung Kim),이재왕(Jae Wang Lee),김영균(Young Kyun Kim),권정남(Jung Nam Kwon),신철경(Cheol Kyung Sin),박선미(Sun Mi Park) 한의병리학회 2009 동의생리병리학회지 Vol.23 No.5

TCD를 이용한 정상군과 고지혈증군의 혈류측정에 관한 비교연구

박선미(Sun Mi Park),김영균(Young Kyun Kim),권정남(Jung Nam Kwon),신우진(Woo Jin Shin),손연희(Yeon Hui Son),정현윤(Hyun Yun Jeong),한현영(Hyun Young Han),박가영(Ga Young Park) 한의병리학회 2009 동의생리병리학회지 Vol.23 No.6

The purpose of this study was to compare cerebral blood flow between hyperlipidemic patient group and normal healthy adult group using transcranial doppler ultrasonography(TCD). I investigated cerebral blood flow of 63 hyperlipidemic patients and 42 healthy adults. To evaluate the cerebral blood flow, I measured the systolic peak velocity(Vs) and mean flow velocity(Vm) of the middle cerebral artery(MCA), anterior cerebral artery(ACA), posterior cerebral artery(PCA), basilar artery(BA), internal carotid artery(ICA) in the two groups using TCD. In normal healthy adults, subjects showed a decrease in Vs and Vm with advancing in age. There was a significant difference in the Vm of ICA. There was no significant differences in the Vm of ACA and ICA. In normal healthy adults, females showed high velocities of all examined vessel. There was a significant difference in the Vs of ICA. There was a significant differences in the Vm of MCA and ICA. Normal healthy adults higher than hyperlipidemic patients in the Vs of MCA, ACA, PCA. There was no significant difference in the Vs of all examined vessels. Hyperlipidemic patients increase higher than normal healthy adults in the Vm of ACA. There was a significant difference in the Vs of BA. In the patients aged under 50's, normal healthy adults higher than hyperlipidemic patients in the Vs and Vm except BA. But there was no significant difference in all examined vessels. In the patients aged over 50's, hyperlipidemic patients higher than normal healthy adults in all examined vessel expect PCA. There was a significant difference in the Vs of BA and ICA. And hyperlipidemic patients higher than that normal healthy adults in all examined vessels. There was a significant difference in BA and ICA. In this study, visible differences in blood flow between hyperlipidemic patient group and normal healthy adult group were shown. However, these results do not come up to the previous values that were reported and known worldwide.