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- 저자 : 정지형 ( Ji Hyung Chung ) (검색결과 1 건)
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정지형 ( Ji Hyung Chung ),황기철 ( Ki Chul Hwang ),장양수 ( Yang Soo Jang ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.3
The overexpression of crystallin-αB confers protection against ischemia/reperfusion, hypoxia/reoxygenation, hypertonic stress and reactive oxygen stresses. Some evidences have suggested that increasing the expression of crystallin-αB represents a potential therapeutic strategy for the cardiac injury. In this study, we studied the potential cytoprotective effect of HSP27 as a therapeutic protein using protein transduction domain system in cardiac cells. Crystallin-αB gene was fused with a gene fragment encoding TAT protein transduction domain in a bacterial expression vector. TAT-crystallin-αB protein was rapidly transduced into cardiac cells. Its transduction showed cytoprotective effect against the hypoxic stress, which was accompanied by reduced caspase-3 activity. These results suggest that delivered TAT-crystallin might protect cell death from hypoxic stress by modulating caspase activation pathway in vitro and this may be of potential therapeutic benefit in ischemic diseases.
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