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Sprouty1 유전자 발현 조절이 배아줄기세포의 생장에 미치는 영향 분석
정지은 ( Jee Eun Jung ),박경순 ( Kyung Soon Park ) 한국조직공학·재생의학회 2010 조직공학과 재생의학 Vol.7 No.5
Sprouty gene encodes cytoplasmic membrane-associated proteins that inhibit receptor tyrosine kinase signaling. Four orthologs of Drosophila Sprouty (dSpry) (Sprouty1-4) have been identified in mammals. However, has not been reported. In this study, we report that Spry1 and Spry4 are expressed in mouse ESCs. Under the ESC culture condition, Spry1 overexpression promoted the growth of mESCs whereas knockdown of the gene resulted in the opposite effect. The results of cell cycle and apoptotic cell analysis suggest that the changes in the cell growth induced by Spry1 might be induced by the regulation of apoptosis. Treatment of U0126 to Spry1 knockdowned mESCs resulted in increasing the cell number, which suggests that Spry1 in undifferentiated mESCs may play important roles in the cell survival and apoptosis by regulating ERK pathway.
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국내 입원한 성인 암환자의 정맥영양 사용에 대한 후향적 연구
박효정 ( Hyo Jung Park ),손유민 ( You Min Sohn ),정지은 ( Jee Eun Chung ),김정태 ( Jung Tae Kim ),양진아 ( Jin A Yang ),배혜정 ( Hye Jung Bae ),성예원 ( Ye Won Sung ),김선화 ( Sun Hwa Kim ),조지윤 ( Ji Yoon Cho ),정경미 ( Kyung Mi 한국정맥경장영양학회 2020 Annals of Clinical Nutrition and Metabolism(한국정맥경장 Vol.12 No.2
Purpose: There have been no clinical studies on the characteristics of parenteral nutrition (PN) for adult cancer inpatients in South Korea. The published evidence describing modern PN practices in these patients is also extremely limited. Therefore in this retrospective multicenter cross-sectional study, we aimed to investigate the PN support practice in hospitalized adult cancer patients. Methods: The study included adult cancer patients hospitalized in nine hospitals in South Korea and received PN, during the period from August 1st, 2017 to October 30th, 2017. We evaluated the relevant hospital-based PN practices in this group. Results: Among the 11,580 inpatient admissions during this period, 759 cancer patients received PN (6.6%). The majority of enrolled patients (97.2%) used commercially available PN and 71.2% of these used peripheral PN formulations. The average in-hospital PN duration was 16.1±19.9 days. Patients received only 65.4±25.4% calories of the recommended target calories. The in-hospital mortality of enrolled patients was 26.1%. Conclusion: We conclude that commercial PN is the most common form of PN administered to hospitalized adult cancer patients and the overall in-hospital mortality in the patients using PN is higher in South Korea compared to other countries.
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사진실(Sa Jin-Shil),정지은(Jung Jee-Eun) 비교민속학회 2011 비교민속학 Vol.0 No.46
이 연구에서는 조선시대 임금을 중심으로 왕실 놀이문화의 규범과 의미를 밝히고자 하였다. 중세 왕실의 문화는 하나의 정점인 최고 통치자를 향해 수렴되었으므로 놀이에 참여하는 임금의 행동 방식은 왕실 놀이문화의 특성을 가장 잘 나타낸다고 할 수 있다. 『조선왕조실록』에 나타난 임금의 놀이 종목은 각각 ‘유(遊)’와 희(戱)’로 표현된다. 유(遊)의 놀이와 희(戱)의 놀이는 공간의 이동성 및 놀이공간의 구축 양상에서 차이가 나는데, 전자는 일상공간 속에서 움직이는 가운데 놀이가 진행된다면 후자는 일상공간과 단절된 고정적인 공간에서 놀이가 진행된다. 도성의 대로에서 거행된 축제인 환궁의식(還宮儀式)은 유(遊)의 놀이를 전체적인 틀로 유지하면서 희(戱)의 놀이를 채워 넣는 방식으로 조성되었다. 행렬의 중심에 있는 임금에게 모든 이목이 집중되었기 때문에 임금은 정해진 규례에 따라 ‘임금다운’ 절제된 모습을 연기하는 ‘몸’의 놀이를 수행하였다. 궁궐 안에서 거행되는 관나(觀儺) 등의 행사에서 임금은 놀이의 적극적인 참여자가 되었다. 그러나 경기 형식이나 공연 형식을 불문하고 임금 스스로 놀이의 행위자가 되기는 어려웠다. 특히 임금 스스로 광대가 되어 몸을 놀리는 것은 금기 사항이었다. 이러한 한계 속에서 임금은 눈의 감각과 뇌의 지성을 극대화한 ‘눈’의 놀이를 수행하였다. 놀이하는 임금은 ‘눈’의 놀이를 통하여 후원자와 기획자, 관객의 역할을 겸비하는 왕실 놀이의 주체가 되었다. 신하들은 백성이 지켜보고 있다는 사실을 들어 ‘놀이하는 임금’의 몸을 통제하고자 하였다. 왕실의 놀이에 대한 조정의 논쟁은 임금의 놀이 본능에 따른 일탈과 통제였으며 임금을 둘러싼 정치세력들이 힘을 겨룬 견제와 명분의 줄다리기였다. 놀이의 오락성과 제의성, 정치성을 적절하게 당기고 풀어주는 균형감은 왕실문화의 건전성을 유지하는 바탕이 되었다고 할 수 있다. This research aims to provide insight on royal entertainment of the Chosun Era focusing on the King. The King’s role best shows the characteristics of the royal entertainment because the royal culture of medieval kingdoms was centered around the ruler. Records indicate two kinds of entertainment enjoyed by the King, Yu(遊) and Hui(戱). They differ in structural arrangement and utilization of the playing space. The former takes the procession within the real world while the latter takes fixed space separated from the real world. The festive parade on the central road of the capital consisted of Yu(遊) as the overall structure and Hui as the inside content. Here the King was forced to show a reserved movement like ‘acting the king of dignity’ because he was constantly under scrutiny by the public. He can be said to take ’Play of Body[몸의 놀이]’ for Yu(遊). On the other hand, the King took on the role of an active participant of the royal entertainment inside the palace. However, it was still difficult for the King himself to be the entertainer for Hui(戱). Within the such confines, the King took ‘Play of Eye[눈의 놀이]’ emphasizing sense and intelligence. Therefore the ‘Playing King’ took multiple roles as the patron, the planner, and audience of royal entertainment. Court ministers tried to control the ‘Playing King’ based on the scrutiny by the public. The controversy surrounding royal entertainment seems to set on the conflict between the regulation and deviation of the King’s instinctive attraction to entertainment. However, actually it derived from the power struggle between the political sects. The balance between tension and relaxation related to entertainment was the one of the keys to maintaining the court culture of Chosun.
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신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2
As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.
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