건강한 한국인 자원자에서 테가세로드(Tegaserod) 반복 투여에 의한 안전성 및 약동학 평가

정재용,임형석,홍경섭,배균섭,유경상,조주연,이소영,고재욱,장인진,신상구,Chung, Jae-Yong,Lim, Hyeong-Seok,Hong, Kyoung-Sup,Bae, Kyun-Seop,Yu, Kyung-Sang,Cho, Joo-Youn,Yi, So-Young,Ko, Jae-Wook,Jang, In-Jin,Shin, Sang-Goo 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.2

Background: Tegaserod is a selective partial agonist at the $5HT_4$ receptor. Tegaserod belongs to a new class of agents in development for the treatment of functional motility disorders of the gastrointestinal(GD tract. This Phase I clinical study was conducted to evaluate the safety and pharmacokinetics(PK) of tegaserod in Korean for bridging foreign clinical data. Methods: A randomized, double blind, placebo controlled, multiple oral dosing(2 mg, 6 mg, twice a day for 7 days) study was conducted in 32 healthy Korean volunteers(M:F=16:16). Serial blood samples for pharmacokinetic analysis were taken. Safety evaluation was performed by adverse event monitoring, physical examination including vital signs, ECG and clinical labororatory analysis. Results: Plasma concentration of tegaserod reached peak levels $1.0{\sim}1.5$ hours after single and multiple dose administration and declined with a terminal half life of about 12 hours. PK parameters of 2 mg group were not calculated well due to low plasma concentration. Tegaserod showed linear pharmacokinetic characteristics, and little accumulation occurred after multiple administrations. There were no gender differences in PK parameters. Neither serious nor dose-limiting adverse events were observed. PK of tegaserod in Koreans was comparable to Caucasian data. Conclusion: Tegaserod was found to be safe and showed similar PK characteristics to Caucasians. This study demonstrates comparability between Korean and Caucasian healthy subjects in the PK of tegaserod and supports the use of Caucasian data in the evaluation of PK, safety, and efficacy for Korean patients.

건강 자원자에서 레베셀$^{\circledR}$주(DDB-S)의 안정성, 약동학적 특성평가를 위한 제 1상 임상시험

정재용,임형석,배균섭,유경상,홍경섭,조주연,이소영,문전옥,이치오,장인진,신상구,Chung, Jae-Yong,Lim, Hyeong-Seok,Bae, Kyun-Seop,Yu, Kyung-Sang,Hong, Kyoung-Sup,Cho, Joo-Youn,Yi, So-Young,Moon, Jun-Ok,Lee, Chi-Oh,Jang, In-Jin,Shin, Sang- 대한임상약리학회 2001 臨床藥理學會誌 Vol.9 No.2

Background : Low solubility and poor oral absorption have been major problems of DDB(Dimethyl Dime-thoxy Biphenylate), the liver protection agent. The purpose of the study was to evaluate safety, tolerablilty, and pharmacokinetics of DDB-S(Dimethoxybiphenylmonocarboxylate hydro-chloride) which was the newly developed soluble injectable form of DDB. Method : Single dose trial was conducted in 24 healthy Korean subjects with single blind, randomized, placebo controlled parallel-group design( 4 groups : 7.5, 15, 30, 60mg). DDB-S was administrated by intravenous infusion during 60 minutes. Serial blood and urine sample were collected till 24 hours after the drug administration. Plasma concentrations were assayed by HPLC. Pharmacokinetic parameters were analyzed by noncompartmental methods. Results : Total 13 cases of adverse events from 7 subjects were reported. All the events were mild, temporary, and spontaneously resolved. There were no differences in dose normalized AUC, dose normalized Cmax, CL, Vd, Tmax, Fe, $CL_R$ and elimination rate constant between groups. Linear regression analysis confirmed PK linearity within this dose range. Half of the dose$(49.86{\pm}10.97%)$ was excreted as an unchanged form through kidney. Conclusion : DDB-S was safe in Korean healthy subjects. It showed linear pharmacokinetic characteristics. Phase II clinical study for patients will be conducted.

개발제한구역 내 도시의 지속가능한 개발을 위한 연구

정재용(Chung, Jae-Yong),오민준(Oh, Min-Jun) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.12

본 연구는 지속가능한 개발을 위한 컴팩트시티형 도시개발의 기본전략과 계획요소를 도출하여 개발제한구역 내 도시들의 개발사업들을 분석하고자 하였다. 분석을 통해 얻은 결과는 다음과 같다. 첫째, 20세기 후반부터 선진국 들은 컴팩트시티를 지속가능한 도시개발의 기준으로 삼고, 세부적인 도시개발계획을 추진하였다. 둘째, 이와 같은 지 속가능한 컴팩트시티형 도시개발은 지속가능한 개발과 컴팩트시티 이론을 바탕으로 하며, 이 개발계획을 도시공간, 도시환경, 도시커뮤니티, 도시관리로 구분하여 계획요소를 도출하였다. 이를 바탕으로 개발제한구역 내 적용가능한 요 소를 산정하고 컴팩트시티와의 관련 유형으로 분류하였다. 셋째, 과천, 의왕, 하남의 개발제한구역 내 다수의 개발계 획들을 지속가능한 컴팩트시티형 도시개발과 비교해본 결과 유사점과 한계를 볼 수 있다. 이에 본 연구에서 분석한 바를 고려하여, 앞으로 개발제한구역 내 도시개발사업에 있어서 지속가능한 컴팩트시티형 도시개발의 정책적인 반영 이 필요하다. This study suggests Compact City type urban development strategies and planning elements with the purpose of sustainable development. The suggestions are based on analysis of the development projects promoted in the cities within Green-Belt. Following are the findings of this study: First, in the late 20th century, Compact-City has been suggested as standard of sustainable urban development in the developed countries, and this promoted urban development plans were presented in detail. Second, The development plans are suggested plan elements by urban environment, space, community, and management. It was classified as an applicable element in Green belt and Compact City type. Finally, after comparing several city development projects (Gwacheon, Uiwang, Hanam), differences and Limitations between the Compact-City type urban development. Considering analysis of this study, urban development projects in Green Belt should be prepared to sustainable Compact city type urban development.

영국의 건축사 자격과 등록에 대한 제도

정재용(Chung, Jae-Yong) 대한건축학회 2016 建築 Vol.60 No.3

브릿지 모델 지역학습센터(C.L.C)를 통한 유네스코의 국제협력과 의의

정재용(Chung, Jae Yong) 한국교육시설학회 2017 敎育施設 Vol.24 No.4

브릿지 모델 지역학습센터(르완다) 설계 모형 연구

정재용(Chung, Jae-Yong),박훈(Park, Hoon) 대한건축학회 2018 대한건축학회논문집 Vol.34 No.1

UNESCO has continued to work in Africa, especially in the six southern sub-Saharan countries, and Asia, where international cooperation is needed. The CLC (Rwanda Community Learning Center) covered in this study aims to create a regional learning center in Rwanda and to recover local communities and provide learning environment. During the course of this study, we conducted field trips for actual planning and reviewed the current state of educational and cultural facilities that recently opened and are operated, and found implications. In consultation with the Rwandan Educational Commission, the site for CLC was decided, the building was designed, and the construction is about to start. The results of this study are as follows. First, in addition to the efforts of the activists in the village, which can be considered the smallest unit of a local community, the approach for establishing an architectural space and active education and community environment can be evaluated as a result of experimental efforts. Second, we can pay attention to the attempts to realize local communities. The bridge business is based on the multi-purposes such as early childhood education, technical education for adults, and community restoration of local residents and it reflects space and program plans for this purposes. It also reflects detailed plans such as differentiating the flow planning depending on users’ time of use. Third, we can explain the characteristics of architectural planning considering local characteristics such as active use of local materials. Due to the characteristics of a developing country, there were significant considerations on maintenance, and to this end, the plan included plans for the environment and use of materials that are easily maintained. In addition, the participation of local residents in the process of establishment was suggested as a possibility to serve an educational role.

포스트 코로나19 도시계획의 과제와 방향

정재용(Chung, Jae-Yong) 대한건축학회 2020 建築 Vol.64 No.6

환경론의 가치 이념과 생태건축의 연관성에 대한 연구

정재용(Chung, Jae-Yong),한주형(Han, Ju-Hyung) 한국생태환경건축학회 2003 한국생태환경건축학회 논문집 Vol.3 No.2

도시공간의 특성에 따른 단독주택지의 유형연구

정재용(Chung Jae-Yong),박훈(Park Hun) 대한건축학회 2009 대한건축학회논문집 Vol.25 No.2

This study aims to analyse the differences in the characteristics of single family dwellings over space with the hypothesis that the development in single family dwelling has taken place with urban planning consideration such as residential density and privacy needs, particularly in the U.K. The need for this study came from the current situation in Korea, that is, domestic single-unit houses are developed uniformly in terms of type and scale which has resulted in the inefficient use of land, lack of privacy and low quality of housing environment, thus the single dwelling housing became unpopular as mass housing type. On the other hand, single-family houses in UK have diversified with regard to housing types, lots, and block types as well as environmental quality and land use efficiency. Thus, this study analyzed 8 cases in the UK. in terms of physical and environmental elements such as density, block and lot size and shape, open spaces such as garden including front yard and back yard, road, etc. over different spatial (urban) hierarchy. The result showed that in the case of houses at the city center, housing had narrow lot types and terraced construction methods to secure high density, while in the cases of suburban areas tried to balance high density features with environmental needs. In all cases, regardless of location in the spatial hierarchy, all developments secured seasonable environmental condition and privacy conditions using various planning components from block and lot design to housing layout to openspace design. Based on the study results, a development direction for domestic single-unit houses is presented in the conclusion.

생태건축의 공간 특성에 관한 연구

정재용(Chung Jae-Yong),박훈(Park Hun) 대한건축학회 2008 대한건축학회논문집 Vol.24 No.2

Urban development was spearheaded by modern architecture, which caused many problems since the late 20th century. Environmental issues, in particular, have emerged as one of the most serious problems. So this study is an interdisciplinary research that aims to seek the interrelationship between environmental discourses, typology of environment-friendly architecture and urban space. This study undertook a broad range of case studies including office buildings, residential-commercial mixed use buildings and housing in Britain, Germany, Japan, Australia and South Korea in order to analyse a broad range of environmwntally friendly architecture. These case studies were first analysed in terms of three main environmental theoretical approaches such as technocentrism, ecocentrism and anthropocentrism (or eco-socialism as it is better known). This result was mapped on the urban hierarchy, technocentric typological buildings mainly being office buildings were located in or near the city centre. Anthropocentric type buildings that eccentuates the need for community and social sustainability were found in the general urban to suburban urban areas In the meanwhile, cases of biocentrism largely featured in the outskirts of cities and countryside as they need more land for self-sufficiency for food and treating waste organically with emphasis on small commune type developments. Environmental discourses such as technocentrism, biocentrism and anthropocentrism, which proposes different visions of future settlements should not be regarded as opposing political solutions but should be used as different spatial strategies. This study suggests that three approaches are all relevant environmental strategies in different locations, ie each approach are spatial strategies in different urban hierarchy. The technocentrism and its architectural types are ecological solution for urban core, whereas anthropocentrist approach a solution for social sustainability in general residential areas in urban and suburban locations and biocentrist solution being appropriate for the rural areas. The necessity of economic sustainability of cities dictate the differentiated locational factors of ecological techniques as well as density of developments. And, therefore, appropriate adoption of differentiated types of ecological approaches and related buildings in accordance with the hierarchy of urban spaces are needed in order to address the sustainability of human environment.