Micronucleus Test of $Scutellariae$ $Radix$ Aqueous Extract in Bone Marrow Cells of Male ICR Mice

정인권,전우현,강수진,구세광,이영준,Chung, In-Kwon,Cheon, Woo-Hyun,Kang, Su-Jin,Ku, Sae-Kwang,Lee, Young-Joon Society of Preventive Korean Medicine 2012 대한예방한의학회지 Vol.16 No.1

Objectives : In this research, the genotoxic effect of $Scutellariae$ $Radix$(SR), the dried roots of $Scutellaria$ $baicalensis$ Georgi has been traditionally used as antipyretic agent, was evaluated using the mouse micronucleus test. Methods : SR aqueous extract(yield = 27.2%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide(CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus(MN) in polychromatic erythrocyte(PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Results and Conclusions : Although significant(p<0.01) increase of the number of PCE with one or more nuclei(MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of SR extracts treated mice with over 0.33 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that SR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels - the limit dosage in rodents.

補中益氣湯加味方 투여를 통한 뇌교병변 현훈과 보행실조 환자 치험 2례

임은영(Eun Young Im),이제원(Je Won Lee),장우석(Woo Seok Jang),전우현(Woo Hyun Cheon),정인권(In Kwon Chung),백경민(Kyungmin Baek) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.5

Bojungikki-tang-gamibang is a widely used herbal prescription in traditional medicine in Korea. The aim of this study is to investigate the effectiveness of Bojungikki-tang-gamibang for patients who have pontine stroke. They have problems with type of Qi deficiency(氣虛) in the rehabilitation stage. The type of Qi deficiency caused the dizziness and ataxia for the patients. In this study there are two types of patients. The first case is a patient with dizziness and ataxia because of potine hemorrhage. The second case is a patient who has the same symptoms as the first one but caused by pontine infraction. We treated the two patients with Bojungikki-tang-gamibang. The Improvement of symptom was evaluated by Korean vestibular disorders activities of daily living scale(K-VADL). As a result the degree of dizziness decreased noticeably while other symptoms improved as well. This study suggests that Bojungikki-tang-gamibang may be an effective treatment for patients who suffer stroke with type of Qi deficiency(氣虛) in the rehabilitations stage. However, more cases and methods of diagnosis are required to prove that the oriental medicine, Bojungikki-tang-gamibang can apply to patients universally.

原著 : 근로자들의 심박변이도 검사를 통한 피로도 분석

장우석 ( Woo Seok Jang ),백경민 ( Kyung Min Baek ),전우현 ( Woo Hyun Cheon ),정인권 ( In Kwon Chung ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.2

Objective: This study was designed to analyze the fatigability of workers in the automobile company by Heart Rate Variability (HRV), Method: The subjects consisted of 32,049 workers who had answered about questionnaires of a job position, age, the state of drinking, smoking, exercise and sex, The fatigability was examined by SA3000P, We analyzed the differences of fatigability according to job positions, ages, the state of smoking, drinking, exercise and sex by T-test or ANOVA with SPSS ver17.0, Results Regarding the differences of fatigability among job classes, the fatigability was highest in engineers, lowest in others. Among ages, the fatigability was highest in 20s, lowest in 50s. In smoking, the fatigability was higher in smoking group. In drinking, the fatigability was higher in drinking group. In exercise, the fatigability was higher in non-exercising group. In sex, there was no significant difference. Conclusion: According to these results, we should establish the methods of controlling fatigue from the perspective of Korean traditional medicine.

비틀린 외팔보형 회전날개의 굽힘진동 특성 연구

현천성(Chon-Seong Hyun),이기형(Kee-Hyung Lee),정인성(In-Sung Chung) Korean Society for Precision Engineering 1994 한국정밀공학회지 Vol.11 No.3

대형 설비/구조물 안전성에 있어서 국가참조표준의 역할과 전망

남승훈(Seung Hoon Nahm),이윤희(Yun-Hee Lee),백운봉(Un Bong Baek),정인현(In Hyun Chung),이해무(Hae Moo Lee) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5

In order to guarantee the safety of the facility systems, one of the essential components is information on mechanical properties of materials used for the construction. However, acquisition or accumulation of the mechanical property data in industrial fields is limited because this operation does not yield profit, excepting few materials production companies. Corresponding to the urgent needs and poor economical features, the MOCIE has founded the National Center for Standard Reference Data in the KRISS and also designated the Data Center of Mechanical Properties for Metallic Materials (DCMP) as a principal operating section. The DCMP plays roles of collection, edition and evaluation of the mechanical data and development of reference standards. In this study, several functions of the DCMP and standardization procedures of mechanical properties data will be introduced the prospective of standard reference researches will be discussed based on active feedbacks from industrial fields.

금속소재 역학물성 참조표준이란?

남승훈(Seung Hoon Nahm),이윤희(Yun-Hee Lee),백운봉(Un Bong Baek),정인현(In Hyun Chung),이해무(Hae Moo Lee) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.5

In order to guarantee the safety of the facility systems, one of the essential components is information on mechanical properties of materials used for the construction. Corresponding to the urgent needs and poor economical features, the MOCIE designated the Data Center of Mechanical Properties for Metallic Materials (DCMP). The DCMP plays roles of collection, edition and evaluation of the mechanical data and development of reference standards. In this study, several functions of the DCMP and standardization procedures of mechanical properties data will be introduced.

증례 : 순환기 ; QRS 간격이 확장된 전격성 심근염 환자에서의 지연된 전도 및 수축력 회복

정재훈 ( Jae Hoon Chung ),정인현 ( In Hyun Jung ),김태훈 ( Tae Hoon Kim ) 대한내과학회 2015 대한내과학회지 Vol.89 No.4

A 54-year-old diabetic man presented to the hospital with shock and bradycardia. His initial estimated left ventricular ejection fraction (LVEF) was 15% and the electrocardiogram showed a junctional escape rhythm with a wide QRS complex and no P wave. Intensive supportive therapy was initiated after inserting a pacemaker and starting extracorporeal membrane oxygenation. A myocardial biopsy confirmed acute lymphocytic myocarditis with extensive myocyte necrosis, and cardiac transplantation was planned. However, the patient survived without transplantation after vigorous hemodynamic support for 2 weeks. After discharge, he had limited activity for 4 months due to dyspnea caused by a reduced systolic heart function (LVEF, 21%) with a junctional escaped beat. His systolic function recovered markedly 6 months after stopping the hemodynamic support, with the presence of a P wave and narrowed QRS complex. (Korean J Med 2015;89:439-443)

맥파전도속도(PWV)를 이용한 체질별 죽상동맥경화 위험인자에 대한 상관관계 연구

임은영,이제원,장우석,백경민,전우현,정인권,Im, Eun-Young,Lee, Je-Won,Chang, Woo-Seok,Baek, Kyung-Min,Cheon, Woo-Hyun,Chung, In-Kwon 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Object : The purpose of this study was to investigate the correlation of atherosclerosis risk factors and pulse wave velocity (PWV) of carotid-femoral artery with Sasang constitution. This study also aimed to investigate the relationship between PWV and risk factors of atherosclerosis, including serum cholesterol and homosisteine, hs-CRP. Methods : We enrolled 160 patients without experience strokes who visited our hospital for a medical examination from January 1, 2008 to April 30, 2010 except patients whose body constitutions were undetermined according to QSCCII. We investigated the correlation between serum cholesterol values, blood pressure, body mass index(BMI), homosistein, hs-CRP and PWV. Pearson's correlation and partial correlation analysis were applied to examine the relationship between PWV and risk factors of atherosclerosis. Result : Among the 160 subjects, 54 were Taeumin, 54 were Soyangin, and 52 were Soeumin. The prevalences of high BMI (P-value <0.01), high hs-CRP(P-value <0.05), and high PWV(P-value <0.05) of Taeumin were higher than those of the other constitutions. PWV of carotid-femoral artery was significantly different among the three constitutional groups(Taeumin: $8.12{\pm}1.64m/sec$, Soyangin: $7.48{\pm}1.16m/sec$, Soeumin: $7.49{\pm}1.12m/sec$)(P-value <0.05). This research has show a statistical significance between the average amount of carotid-femoral artery PWV that is higher in Taeumin. Age factor of Taeumin was the effective determinant of the increase of mean PWV of carotid-femoral arteries. Conclusions : There were significant differences in the prevalence of atherosclerosis according to Sasang constitution. This study showed that atherosclerosis was more prevalent in Taeumin. Therefore, according to our results, risk of atherosclerosis was higher in Taeumin than among other constitutions.

우황청심원 관련 최근 연구 동향 : 국내 논문에 대한 고찰

이제원,백경민,백영두,임은영,장우석,전우현,정인권,Lee, Je-Won,Baek, Kyung-Min,Baek, Young-Doo,Im, Eun-Young,Chang, Woo-Seok,Cheon, Woo-Hyun,Chung, In-Kwon 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

Objectives : Woohwangchungsim-won has been used for acute diseases such as cerebrovascular disease (stroke), heart disease. The aim of this study was to determine the effects, significance & necessity of Woohwangchungsim-won in acute stages of these disease by reviewing Korean articles about Woohwangchungsim-won. Methods : Article searches were performed on 8 major Korean web article search engine from January 1980 to August 2010. There were no restrictions on the types of publication, including grey articles. Results : Forty-three articles were included. Twenty one were efficacy tests, thirteen were comparative efficacy tests, eight were toxicity tests, and one was new method development. Eighteen articles were multicenter studies and twenty five were single center studies. Thirty two articles were animal testing, only ten articles were clinical articles. Thirty seven articles presented the composition and quantity of Woohwangchungsim-won, but six did not. Conclusions : The results of Korean articles about Woohwangchungsim-won can not strongly support the effects, significance & necessity of Woohwangchungsim-won. More rigorous studies are required for determination of the effects of Woohwangchungsim-won.

Alloy 617 용접부의 피로 수명 예측

박영수(Young-Soo Park),김대웅(Dae-Woong Kim),한준희(Jun-hee Hahn),정인현(In Hyun Chung) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.2