건강인에서 소장의 감각능과 팽창도에 대한 선택적 5-HT4 수용체 부분 작용제 tegaserod의 효과

정정조 ( Jeong Jo Jeong ),최명규 ( Myung Gyu Choi ),조유경 ( Yu Kyung Cho ),전은정 ( Eun Jung Jun ),조영석 ( Young Seok Cho ),정우철 ( Woo Chul Chung ),이인석 ( In Seok Lee ),김상우 ( Sang Woo Kim ),최상욱 ( Sang Wook Choi ),정인 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.1

목적: 위장관의 내장 감각능 이상은 기능성 소화불량증의 중요한 병인으로 알려져 있으나 위장관의 감각을 지각하는 기전은 정확히 알려져 있지 않다. 세로토닌은 위장관의 운동과 감각능을 조절하는데 중요한 역할을 한다. 저자는 5-hydroxytryptamine-4 (5-HT4) 수용체 부분 작용제인 tegaserod가 건강인에서 소장의 감각능과 팽창도에 어떠한 영향을 주는지 알아보고자 하였다. 대상 및 방법: 건강 지원자 16명을 대상으로 위약이나 tegaserod (6 mg 하루 2회) 두가지 약물중 한 약제를 단일 맹검, 무작위 순서로 3일간 전투약한 후 검사를 시행하였다. 십이지장 3부에 최대 용적 120 mL의 풍선이 부착된 검사관을 위치시킨 후 바로스타트에 연결하여 소장의 팽창도 및 소장의 감각능을 평가하였다. 풍선의 용적을 단계적으로 증가시키면서 최초 인지 용적(처음으로 감각을 느끼는 용적), 최대 인내 용적(불편감/통증으로 참기 힘들때의 용적)을 기록하고 압력 변화를 관찰하여 소장 팽창도를 계산하였다. 소장 감각능은 20 mL, 40 mL, 60 mL의 3가지 팽창 자극을 무작위 순으로 3회씩 주어 피험자가 느끼는 감각을 시각적 선형척도에 기록하게 하여 평가하였다. 고칼로리 유동식인 엔슈어를 지속적으로 소장에 주입하면서 다시 무작위 순서로 3가지의 팽창자극을 주면서 피험자의 감각을 측정하였다. 결과: Tegaserod 투여군의 소장 팽창도는 2.59±0.74 mL/mmHg로 위약 투여군의 소장 팽창도 2.25±0.42mL/mmHg에 비해 유의한 차이가 없었다. tegaserod 투여군과 위약 투여군 사이에 최초 인지 용적의 차이는 없었지만 최대 인내 용적은 tegaserod 투여군에서 55.7±12.9 mL로 위약투여군 41.7±7.3 mL에 비해 유의하게 높았다( p<0.05). 20,40, 60 mL의 팽창자극을 하였을 때 오심, 팽만감, 불편감/통증 및 총 감각 지수는 tegaserod 투여군과 위약 투여군 사이에 차이가 없었다. 유동식을 주입하면서 팽창자극을 주었을때에도 두 군간에 팽창 자극에 대한 감각 점수에는 유의한 차이가 없었다. 결론: Tegaserod군과 위약군 사이에 빠른 위상성 팽창 자극에 대한 감각의 차이는 없었으나 단계적 팽창 자극에 대한 최대 인내 용적이 tegaserod군에서 위약군에 비해 유의하게 높아 tegaserod가 소장의 감각을 완화시키는 것으로 추정할 수 있다. Backgr ound/Aims: Disturbances in visceral perception contribute to postprandial symptoms in patients with functional dyspepsia. However, the mechanism of perceiving sensation has not been clearly defined. Our aim in this study was to evaluate the effect of tegaserod on compliance and visceral perception in the proximal small intestine. Methods: Sixteen healthy subjects were included in this study. Subjects underwent single blinded randomization to either a placebo group or a regimen group of 3-day pretreatment with tegaserod (6 mg bid). Thirty minutes after the insertion of a balloon-equipped, double-lumen tube into the duodenum, we sequentially measured the compliance and maximal tolerable volume to stepwise balloon distension. The maximum volume of the balloon was 120 mL, and an electronic barostat was used to maintain a constant volume within the balloon. Sensory function was assessed by grading accompanying symptoms of nausea, fullness, and abdominal discomfort/pain during random-ordered isovolumetric ditension of the balloon at volumes of 20 mL, 40 mL, and 60 mL. We made additional assessments on sensory function by slightly modifying the above method of randomized balloon distension to include continuous infusion of liquid meal into the tube. Results: There was no significant difference in compliance between the two groups. Maximal tolerable volume was significantly larger in the tegaserod group than in the placebo group (55.7±12.9 mL vs. 41.7±7.3 mL, p<0.05). Perceived sensations measured using the visual analogue scale during random ordered rapid phasic distension (20, 40, 60 mL) did not reveal differences between the two groups. Conclusions: Tegaserod had no effect on perceived sensation during rapid phasic distension, but it did increase the maximal tolerable volume during stepwise distension. These results suggest that tegaserod reduces the sensitivity to small bowel distension in healthy subjects. (Kor J Neur ogastr oenter ol Motil 2004;1:35-42)

편평상피세포 담낭암 1 예

정인식 ( In Sik Chung ),이인석 ( In Seok Lee ),최명규 ( Myung Gyu Choi ),박두호 ( Doo Ho Park ),김상우 ( Sang Woo Kim ),양영상 ( Young Sang Yang ),허원행 ( Won Haing Hur ),조영석 ( Young Seok Jo ),정정조 ( Jung Jo Jung ),김병기 ( 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5

Squamous cell carcinoma of gallbladder is rare and its pathogenesis is unknown. A 63-year-old woman presented with right upper quadrant pain. Investigations revealed irregular and ill-defined heterogenous soft tissue mass in gallbladder fossa, which was infiltrated to the liver, pancreatic head, and duodenum on CT scan. Biopsy of liver and duodenum confirmed it as squamous cell carcinoma. Because the normal gallbladder does not have a squamous epithelium, squamous cell carcinoma of gallbladder has been the subject of interest in several publications. We report a case of squamous cell carcinoma of gallbladder. (Korean J Gastroenterol 2001;38:389- 392)

동하중을 받는 복합재의 파동전파에 관한 연구

안국찬(Kook-Chan Ahn),정인조(In-Jo Jeong),정대식(Dae-Sik Jung) 한국기계가공학회 2012 한국기계가공학회지 Vol.11 No.4

This research is to analyze the wave propagation characteristics of anisotropic materials subjected to the low-velocity impact. For this purpose, a higher-order finite element program is used to simulate the dynamic behaviors according to the changes of material property, stacking sequence and dimension etc.. Materials for simulation are composed of [0°]10s, [45°/-45°]5s and [90°]10s stacking sequences. Finally, the results of this simulation are compared with those of wave propagation theory and then the impact responses and wave propagation phenomena are investigated.

포스터 전시 : 하부위장관 6 ; 혈전성 혈소판 감소성 자반증을 동반한 출혈성 대장염 1예

조영석 ( Young Seok Cho ),채현석 ( Hiun Suk Chae ),정정조 ( Jeong Jo Jung ),김성수 ( Sung Soo Kim ),한석원 ( Suk Won Han ),이창돈 ( Chang Don Lee ),최규용 ( Kyu Yong Choi ),정인식 ( In Sik Chung ),선희식 ( Hee Sik Sun ) 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-

초등학교 과학과 에너지영역의 STS 내용 변천

서승조,조태호,백남권,김성규,박강은,정인재 晋州敎育大學校 科學敎育硏究所 2001 科學敎育硏究 Vol.27 No.-

This research compared and analyzed the content ratio of the STS (Science-Technology-Society) Education and subjects and types of learning activities to determine the characteristics of STS education in science classes of elementary schools. In the 5th curriculum, the STS-related content on energy section took up 6.6% , in the 6th curriculum, compared with that of the 5th, the STS content ratio on the energy section increased 7.9% and the STS content on the energy section in the 7th curriculum showed an increased 20.8% proportion. Comparing the main subjects of the STS in the energy section for the science class according to curriculum in the 5th, they obviously have influenced technological development, energy, the development of space studies, and sociology of science, in that order. In the 6th curriculum. compared with that of the 5th, the energy section decreased and the sociology of science increased much. There were no significant changes in other subjects. In the 7th, the STS elements were distributed evenly but the extent of the STS main subjects reduced compared to that of the 6th. The STS education activities represented in science textbooks of elementary schools were mainly executed through discussion, research activities, and actual activities. Other activities such as role-playing, simulation tests, problem solving and decision making, data analysis, research design, case studies, etc. were hardly made.

독일변호사의 성공보수규제에 관한 법리

李淸助,金珍綺,鄭寅經 東亞大學校 1998 東亞論叢 Vol.35 No.-

Die wesentliche Aufgabe des Rechtsanwalts muβ der Geist des Dienstes and der Offentlichkeit sein, weil er die hochste Idess seiner Aufgabe und kein Handelsgeist, sondern unhandelgeist ist. Abser die doppelte, wiederholte Bezahlung, die als Gebuhren und die Bezahlung fur den Erfolg an das gleiche Ereignis nach der Bezahlungsbestimmung der koreanische Anwaltschaft bestimmt wird, kommt in das soziale Problem. Da diese Bezahlung fur den Erfolg gegen die wesentliche Aufgabe des Rechtsanwalts verletzt, ist sie unverbindlich in Deutschland. Also es wird der geschichtliche Ablauf uber die Regelung der Bezahlung fur den Erfolg und ihr Prajudiz analysiert und uberpruft. In gegenwartige Zeit ist die Bezahlung fur den Erfolg nach der Bestimmung BGB §138. I. und der Bestimmung des Rechtsanwalts unverbindlich. Diese Regelung der Bezahlung fur den Erfolg des Rechtsanwalts ist Hilfe der Problemslosung der Bezahlung fur den Erfolg des Rechtsanwalts in Korea.

辯護士와 依賴人關係의 基礎的 法理

李淸助,鄭寅經 동아대학교 법학연구소 1998 東亞法學 Vol.- No.24

정신보건 관련 시설의 재원 기간 및 관련 요인에 대한 연구

조성진,이병조,조맹제,김용익,서동우,정인과 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Object : This study was aimed to find the contributing factors that influence the length of stay in mental health related facilities and to present future direction for the mental health policy. Methods : The 1,875 patients who are aged between eighteen and sixty-five are chosen by the stratified random sampling from ten psychiatric hospitals, six psychiatric nursing facilities and five homeless asylums. We investigate about length of stay of all subjects by sociodemographic characteristics, socioeconomic status, functional status, disease related characteristics and analyse contributing factors. Results : From total subjects, average length of stay was 1,906 days, and facilities, where subjects are institutionalized, explains 40% of length of stay. Other related factors are female, old age, single, lack of supportive system before admission and after discharge, medical assistance type I, unavailable of public transportation and utility, long duration of illness, and psychotic disorder. Conclusion : For lowering the rate of long-term hospitalization, evaluation of appropriateness is needed for admission to nursing facility and homeless asylum and make up for the medical payment system and the supportive system from family and community.

Benzalconium chloride액 오염에 의한 Burkholderia cepacia 위감염

김상화,유계선,정인경,서환조 대한감염학회 1998 감염 Vol.30 No.6

목 적 : 소독제의 오염에 의한 감염의 집단 발생은 심각한 문제가 될 수 있다. 또한, 혈액 배양 검사를 위한 피부 소독시에 오명ㅁ된 소독제의 사용은 가균혈증을 야기하고 다른 검체의 미생물 검사에서도 위감염의 원인이 된다. 소독제 오염의 원인 균으로는 Burkholderia cepacia, Pseudomonas aeruginosa, Xanthomonas maltophilia, Pseudomonas fluorescens 등이 있으며, 특히 B. cepacia의 오염으로 인한 감염과 위감염은 종종 보고된다. 경희의료원 미생물 검사실에 의뢰된 미생물 배양검사 결과 중 B. cepacia의 분리건수의 급격한 증가가 있어 오염된 소독제에 의한 세균의 집단 발생 여부를 확인하고자 하였다. 방 법 : 1996년 4월부터 1997년 4월까지 경희의료원 미생물 검사실에 의뢰된 미생물 배양검사 결과 중 B. cepacia의 전체 분리건수와 부서별 특징을 후향적으로 조사하였다. 또한, B. cepacia 가 동정 된 환자의 병록지를 분석하여 임상 양상을 파악하였다. 경희의료원 산부인과 외래에서 내진 시 사용하는 speculum과 forcep 그리고 소독제로 사용중인 0.1% benzalconium액과 0.1% benzalconium 액으로 만들어진 스폰지를 대상으로 하고 미생물 배양 검사 및 항생제 감수성 검사를 실시 하였다. 결 과 : 오염된 benzalconium액을 소독제로 사용한 부서에서 의뢰된 미생물 배양 검사에서 B. cepacia의 분리건수가 현저히 증가 하였다. 또한, 동정된 B. cepacia 는 ciprofloxacin과 trimethoprim-sulfamethoxazole에는 감수성을 보였으나 gentamicin, ampicillin, cephalexin, ampicillin-sulbactam에는 높은 내성을 보였다. 결 론 : 소독제의 오염 여부에 대한 정기적 검사가 필요하며 소독제의 관리 방법을 재검토할 필요가 있다. Background : Outbreaks of infection as a result of contaminated antiseptics and disinfectants have been reported. The major contaminants reported have been Burkholderia cepacia, Pseudomonas aerugnosa, Xanthomonas maltophilia and Pseudomonas fluorescens. A marked increase in the number of B. cepacia isolates was observed in a microbiology laboratory in Kyung Hee Univeresity Hospital. We investigated an outbreak of pseudoinfection caused by benzalconium-chloride solution contaminated with B. cepacia. Methods : We reviewed microbiology laboratory records from April 1996 to April 1997 to identify B. cepacia isolates and medical records of the patients from whom B. cepacia was cultured. Samples of 0.1% benzalconium solutions, benzalconium chloride-soaked cotton balls, specula, and forceps used in the outpatient department were examinated. Results : The majority was isolated from vaginal cultures in outpatients of gynecology department. The source of this outbreak was identified as the contaminated benzalconium-chloride solution. Investigation revealed that positive cultures were due to contamination of benzalconium-chloride solution and clinically insignificant in most cases. B. cepacia isolates were susceptible to ciprofloxacin and trimethoprim-sulfamethoxazole, but the majority were resistant to gentamicin, ampicillin, cephalexin, and ampicillin-sulbactam. Conclusion : It is necessary to check for microbial contamination of antiseptics and disinfectants when an outbreak caused by B. cepacia is observed in hospital patients.