Distribution and Potential Toxicological Effects of 2,2’,4,4’-tetrabromodiphenyl Ether (BDE-47) as a Endocrine Disrupting Chemical in Human and Animals

정의만,양현,안범수,이근식,현상환,최경철,정의배 사단법인 한국동물생명공학회 2011 한국동물생명공학회지 Vol.26 No.4

Polybrominated diphenyl ethers (PBDEs) are a class of “brominated” (bromine containing) man-made chemicals used as flame retardant additives in plastics, foams, and textiles. PBDEs are found in various environmental contaminants in air, soil, sediment, and water, and 209 individual forms (congeners) of PBDE exist. Among these,2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is the dominant congener found in the environment. Exposure to BDE-47is now worldwide, and levels of BDE-47 have been detected in the blood of animals, including humans. BDE-47 can adversely affect the developmental system in both humans and animals. BDEs have structural similarities to polychlorinated biphenyls and thyroid hormones. However, recent studies have shown that BDEs may act as hormonal disrupting chemicals with detrimental effects. Therefore, a reliable assessment of BDE-47 toxicological action is required to understand the detrimental impacts of BDE-47 on human health. In this review, we overview recent studies on the distribution and potential toxicological effects of BDE-47 in humans and animals

프로 스포츠 활동에서의 윤리적 가치 일탈의 문제

정의권,임석원 중앙대학교 스포츠과학연구소 2003 體育硏究 Vol.- No.19

The essence of sportsmanship as applied to athletics can be determined by the application of the same principle. Honorable victory is the goal of the athlete and, as a reretended to a certain moral relevancy, although its precise place among the moral virtues has been uncertain. In spite of this confusion, distinguished advsult, the code of the athlete demands that nothing be done before, during, or after the contest to cheapen or otherwise detract from such a victory. Fairness or fair play, the pivotal virtue in athletics, emphasizes the need for an impartial and equal application of the rules if the victory is to signify, as it should, athletic excellence. Modesty victory and a quiet composure in defeat testify to an admirable and extraordinary self-control and, in general, dignify and enhance the goal of the athlete.

Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic

정의만,Geun-Shik Lee 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3

Coronavirus disease 2019 (COVID-19) exhibits various symptoms, ranging from asymptomatic to severepneumonia or death. The major features of patients in severe COVID-19 are the dysregulation of cytokinesecretion, pneumonia, and acute lung injury. Consequently, it leads to acute respiratory distress syndrome, disseminated intravascular coagulation, multiple organ failure, and death. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus of COVID-19, influences nucleotidebinding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3), thesensor of inflammasomes, directly or indirectly, culminating in the assembly of NLRP3 inflammasomeand activation of inflammatory caspases, which induce the inflammatory disruption in severe COVID-19. Accordingly, the target therapeutics for inflammasome has attracted attention as a treatment for COVID19. Korean Red Ginseng (KRG) inhibits several inflammatory responses, including the NLRP3 inflammasome signaling. This review discusses the role of KRG in the treatment and prevention of COVID-19based on its anti-NLRP3 inflammasome efficacy.

지방산업활성화 정책과 벤처기업 육성대책

鄭義光 경성대학교 산업개발연구소 1998 산업혁신연구 Vol.14 No.-

Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis

정의만,손영훈,최예원,김진희,이진행,조성엽,김인규 생화학분자생물학회 2016 Experimental and molecular medicine Vol.48 No.-

Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes crosslinking, polyamination or deamidation of glutamine residues in proteins. It has been reported that TG2 is involved in the pathogenesis of various inflammatory diseases including celiac disease, pulmonary fibrosis, cystic fibrosis, multiple sclerosis and sepsis. Recently, using a mouse model of bleomycin-induced lung fibrosis, we showed that TG2 is required to trigger inflammation via the induction of T helper type 17 (Th17) cell differentiation in response to tissue damage. However, the role of TG2 in inflammatory bowel disease (IBD), which is thought to be a Th17 cell-associated disease, has remained elusive. In this study, we investigated the role of TG2 in dextran sulfate sodium (DSS)-induced colitis, the most widely used mouse model for IBD. Age- and sex-matched wild-type and TG2− / − mice were fed 2% DSS for 7 days or 3.5% DSS for 5 days in drinking water. An in situ TG activity assay revealed that DSS treatment activates TG2 in various colon cell types, including columnar absorptive cells and goblet cells. DSS-treated TG2− / − mice showed lower interleukin (IL)-6, but higher IL-17A and RORγt (retinoic acid receptor-related orphan receptor-γt) expression levels in the colon tissues than that in the wild-type mice. Moreover, TG2− / − mice showed higher mortality than the wild-type mice because of DSS treatment. Nevertheless, we found no significant differences in changes of body weight, colon length, morphology, immune cell infiltration and in vivo intestinal permeability between DSS-treated wild-type and TG2− / − mice. These results indicate that TG2-mediated Th17 cell differentiation is not required for the pathogenesis of DSS-induced acute colitis

공공도서관의 공간환경과 부지 및 지역선정계획

정의성 광주대학교 민족문화예술연구소 1993 論文集 Vol.2 No.-

Purification and Characterization of a Cytosolic Ca^(2+)-Independent Phospholipase A_2 from Bovine Brain

정의만,Kyong Hoon Ahn,Hyung Jin Jeon,Ha Dong Kim,Ho Sup Lee,Kwang Mook Jung,Seok Kyun Kim,Joseph V. Bonventre,김대경 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.5

The Ca^(2+)-independent phospholipase A_2 (iPLA_2) subfamily of enzymes is associated with arachidonic acid (AA) release and the subsequent increase in fatty acid turnover. This phenomenon occurs not only during apoptosis but also during inflammation and lymphocyte proliferation. In this study, we purified and characterized a novel type of iPLA_2 from bovine brain. iPLA_2 was purified 4,174-fold from the bovine brain by a sequential process involving DEAE-cellulose anion exchange, phenyl-5PW hydrophobic interaction, heparin-Sepharose affinity, Sephacryl S-300 gel filtration, Mono S cation exchange, Mono Q anion exchange, and Superose 12 gel filtration. A single peak of iPLA_2 activity was eluted at an apparent molecular mass of 155 kDa during the final Superose 12 gel-filtration step. The purified enzyme had an isoelectric point of 5.3 on twodimensional gel electrophoresis (2-DE) and was inhibited by arachidonyl trifluoromethyl ketone (AACOCF3), Triton X-100, iron, and Ca^(2+). However, it was not inhibited by bromoenol lactone (BEL), an inhibitor of iPLA2, and adenosine triphosphate (ATP). The spot with the iPLA_2 activity did not match with any known protein sequence, as determined by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) analysis. Altogether, these data suggest that the purified enzyme is a novel form of cytosolic iPLA_2.

정부조직개편의 역사제도주의적 분석 : 김대중 정부의 사례

정의창(鄭義昌) 한국정책과학학회 2006 한국정책과학학회보 Vol.10 No.3

이 연구는 역사제도주의적 접근을 원용하여 제도적 맥락과 행위자간의 상호작용을 고찰하고 이를 통해 정부조직개편에 영향을 미친 주된 요인이 무엇인가를 밝혀보고자 하였다. 이 연구는 대한 민국 정부조직, 그 중에서도 정부조직법상의 중앙행정기관을 그 대상으로 하며, 연구의 범위는 김대중 정부를 선택하였다. 이 연구를 통해 도출된 결과를 정리하면 다음과 같다. 정부조직의 변화에 있어서 가장 중요한 요인으로 작용한 것은 행위자들에 대한 제약으로 작용한 정치제도였다. 제도적 맥락이 정부조직변화를 결정하는 핵심적인 요인이었다.

중고등학교 도서관 교육과정의 구성과 그 전개

정의순,Jeong, Ui-Sun 한국도서관협회 1967 圖協月報 Vol.8 No.7

S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes

정의만,Chun Zi Jin,장지현,Zai Hao Zhao,Chun Li Jin,이진항,이기백,김성준,김인규,Yin Hua Zhang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

The myocardium in hypertensive heart exhibits decreased fatty acid utilization and contractile dysfunction, leading to cardiac failure. However, the causal relationship between metabolic remodeling and cardiomyocyte contractility remains unestablished. Transglutaminase 2 (TG2) has been known to promote ATP production through the regulation of mitochondrial function. In this study, we investigated the involvement of TG2 in cardiomyocyte contraction under fatty acid supplementation. Using TG2 inhibitor and TG2-deficient mice, we demonstrated that fatty acid supplementation activated TG2 and increased ATP level and contractility of cardiac myocyte from the normal heart. By contrast, in cardiac myocytes from angiotensin-II-treated rats and mice, the effects of fatty acid supplementation on TG2 activity, ATP level, and myocyte contraction were abolished. We found that TG2 was inhibited by S-nitrosylation and its level increased in hypertensive myocytes. Treatment with inhibitor for neuronal NOS restored fatty acidinduced increase of TG2 activity and myocyte contraction. Moreover, intracellular Ca2+ levels were increased by fatty acid supplementation in both normal and hypertensive myocytes, showing that S-nitrosylation of TG2 but not alteration of intracellular Ca2+ levels is responsible for contractile dysfunction. These results indicate that TG2 plays a critical role in the regulation of myocyte contractility by promoting fatty acid metabolism and provide a novel target for preventing contractile dysfunction in heart with high workload.