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정은재,정광윤,신동진,서규환,백승국,이남준,진성민 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.2
Background and Objectives:Advanced laryngeal cancer is frequently treated by total laryngectomy. This operation is effective eech has been employed as a natural and satisfactory means of communication for laryngectomized patients. Unfortunately, during past decades the success rate has ranged 40- 60%. The purpose of this study was to determine which factors contribute to the proficiency of esophageal spech. Materials and Method:Videofluoroscopy and voice analysis of fourteen alaryngeal male patients who had trained esophageal speech were performed. Results:Aerophagia and air ejection were impossible in poor shimmer and harmonic-to-noise ratio. Conclusion:Aerophagia and air ejection are esential for esophageal spech. Short pseudoglottis (less than 2 cm) affords better esophageal speech. Natural repetitive movements of aerophagia and air ejection with accurate articulatory motion can improve the quality of esophageal speech.
정은재,박찬흠 대한연하장애학회 2015 대한연하장애학회지 Vol.5 No.1
Objective: The purpose of this study was to determine the feasibility of an artificial esophagus using a silk fibroin (SF) scaffold. Method: The artificial esophagus was a three-layered, hybrid-type prosthesis composed of an outer and inner layer of poly(ε-caprolactone) (PCL) with a middle layer of SF. After depositing the inner layer of the PCL scaffold by electrospinning, the lyophilized middle SF layer was created. The outer layer of PCL was produced following the same procedure used to make the inner PCL layer. Result: In the cross-sectional image of the PCL-SF scaffold, we can clearly observe the nanofiber structure and the porous structure of the middle silk layer. The average stress values for the PCL-silk scaffold were 2.3460.12 MPa (dry) and 2.2660.23 MPa (wet). The CCK-8 assay results showed that prepared scaffolds modified with SF are generously nontoxic to the cells and that the presence of silk favored the growth of fibroblasts; therefore, this material is compatible with biomedical applications. Conclusion: Our study proposes a more practical experimental model for studying a three-layered PCL-SF scaffold in the esophagus.
정은재 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.4
본 연구는 석이버섯의 기능성을 검토하기 위하여 석이버섯을 각종 용매로 추출하여 이들 추출물의 전자공여 작용, 항산화 효과 및 아질산염 소거작용을 측정하였다. 석이버섯 diethylether 및 butanol 추출물의 폐놀성 화합물의 함량은 각각 194.20㎍/ml, 98.80㎍/ml으로 높게 나타났다. 그러나 petroleum ether와 hexane 추출물에서는 페놀성 화합물이 거의 존재하지 않았다. 석이버섯 diethylether 및 butanol 추출물의 진자공여 작용은 각각 80.79%, 72.81%로서 높게 나타났으며, DPPH와의 반응초기에 흡광도가 급격히 감소하였다. 석이버섯 diethylether 및 butanol 추출물의 항상화 효과는 대조군보다 우수하였으나, BHA보다는 모두 낮은 항산화 효과를 나타내었다. 석이버섯의 아질산염 소거작용은 diethylether 및 butanol 추출물에서 각각 96.07%, 72.39%으로 나타내었다. 그러나 페놀성 화합물이 거의 없는 petroleum ether와 hexane 추출물에서는 아질산염 소거작용이 각각 15.07%, 7.3%로서 약하게 나타났다. This study was conducted to investigate electron donating ability, antioxidative activity and nitrite-scavenging effect of solvent extracts from Gyrophora esculenta. The phenolic compounds of diethylether, hutanol, petroleum ether and hexane extracts were 194.20㎍/ml, 98.80㎍/ml, 1.60㎍/ml and 0.2㎍/ml, respectively. Electron donating abilities of diethylether and butanol extracts from Gyrophora esculenta were 80.79% and 72.81%, respectively. Absorption of DPPH by diethylether and butanol extracts sharply increased at initial stage. Antioxidative activities of diethylether and butanol extracts by peroxide values are rather high as compared to those of control, but low as compared to those of BHA. Nitrite-scavenging abilities of diethylether, butanol and petroleum etherextracts from Gyropyhora esculenta were 96.07%, 77.39% and 15.07%, respectively.
정은재,정현일 한국미술교육학회 2022 美術敎育論叢 Vol.36 No.1
Jeju has recently seen a rapid increase in migrants. This also means an increase in human resources that can contribute to the region. It also means damage to the locality that has been preserved for a long time. The harmony of these two conflicting values is very important to the community. Community-Based Art Education (CBAE) should be open to everyone who wants to participate in teaching and learning processes. Community-Based Art Education (CBAE) has the advantage of informing learners of the importance and identity of their local culture. Today, citizens of Jeju need to recognize that they are members of a community, not immigrants and residents, majors and non-majors, educators and learners. Jeju's folk painting will be of great significance as a theme of Community-Based Art Education (CBAE) because it can provide an experience to enhance the identity of the community. This study aims to clarify what they have experienced and what folk painting education experiences mean to them for participants in Jeju folk painting art education. This could reveal the essential value of Jeju Community-Based Art Education (CBAE). The philosophical background of this study is Heidegger's ontology. In addition, van Manen's hermeneutic phenomenology based on this was used as a major research method.
Moderately Differentiated Neuroendocrine Carcinoma of the Larynx
정은재,백승국,권순영,우정수,정광윤 대한이비인후과학회 2008 Clinical and Experimental Otorhinolaryngology Vol.1 No.4
Neuroendocrine neoplasm of the larynx is a morphologically heterogeneous group of tumors. This unusual neoplasm includes the four different type of tumors. Paraganglioma is the best-known neural origin tumor. The epithelial origin tumor is further divided based on the degree of differentiation into well, moderately, and poorly differentiated carcinoma. The diverse biological behavior of neuroendocrine neoplasm of larynx makes an accurate diagnosis of paramount importance, since treatment depends on diagnostic accuracy. The diagnosis is based primarily on light microscopy, and immunohistochemical and/or ultrastructural investigations are needed to diagnose correctly. The mainstay of treatment of moderately differentiated neuroendocrine carcinoma of the larynx is surgery. Elective neck treatment should be performed considering the high likelihood of cervical lymph node metastases. The 5-yr survival rate approximates 50%, and 10-yr survival rate is only 30%. Neuroendocrine neoplasm of the larynx is a morphologically heterogeneous group of tumors. This unusual neoplasm includes the four different type of tumors. Paraganglioma is the best-known neural origin tumor. The epithelial origin tumor is further divided based on the degree of differentiation into well, moderately, and poorly differentiated carcinoma. The diverse biological behavior of neuroendocrine neoplasm of larynx makes an accurate diagnosis of paramount importance, since treatment depends on diagnostic accuracy. The diagnosis is based primarily on light microscopy, and immunohistochemical and/or ultrastructural investigations are needed to diagnose correctly. The mainstay of treatment of moderately differentiated neuroendocrine carcinoma of the larynx is surgery. Elective neck treatment should be performed considering the high likelihood of cervical lymph node metastases. The 5-yr survival rate approximates 50%, and 10-yr survival rate is only 30%.
정은재,서규환,김웅식,정광윤 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.3
Parathyroid carcinoma is an uncommon endocrine tumor. Its usual clinical presentation is that of primary hyperparathyroi-dism with elevated serum calcium and parathyroid hormone levels. Nonfunctioning carcinoma of the parathyroid gland with normal serum calcium levels is very rare and more agressive. Histologically, the neoplastic cells may be of variable size and agnosis of carcinoma based on cytologic detail is unreliable, and local invasion and metastasis constitute the only reliable criteria of malignancy. In both functional and nonfunctional carcinoma, early surgery has proven to be the only curative tr-eatment approach whereas both chemotherapy and radiation therapy fail to produce systemic or regional benefit when used alone. En bloc excision of primary lesion with removal of any involved structures should be performed. This paper is a case report of a nonfunctioning parathyroid carcinoma and a review of the literature. (Korean J Otolaryngol 2002;45:303-5)
정은재,김기환,정인환,정평수,김진영,우한영 한국물리학회 2012 Current Applied Physics Vol.12 No.1
Alternating donoreacceptor type copolymers, poly[{5,11-di(90-heptadecanyl)indolo[3,2-b]carbazole}-alt-{2,5-di(thiophen-2-yl)thiazolo[5,4-d]thiazole-5,50-diyl}] (PIC-TZ) and poly[{6,60,12,120-tetraoctylindeno [1,2-b]fluorene}-alt-{2,5-di(thiophen-2-yl)thiazolo[5,4-d]thiazole-5,50-diyl}] (PIF-TZ), were synthesized and examined for applications in polymeric photovoltaic cells. The polymers have a fused coplanar main backbone with good planarity for intermolecular packing and high charge mobility. The indolocarbazole and indenofluorene units contain two or four binding sites for alkyl substituents that have pronounced solution processiblity compared to the carbazole and fluorene moieties. The number-average molecular weights (Mn) of the synthesized polymers were determined to be 11,000 g/mol (PDI ¼ 2.27) for PIC-TZ,and 17,000 g/mol (PDI ¼ 1.77) for PIF-TZ. The optical band gap of PIC-TZ and PIF-TZ in film was determined to be 2.14 eV and 2.21 eV, respectively, and an electrochemical study confirmed the desirable HOMO/LUMO levels of the copolymers, which enabled efficient electron transfer and a high open circuit voltage (VOC) when blending them with fullerene derivatives. The space charge limited current mobility measurements showed a hole mobility of 103 cm2 V1 s1 for the copolymers. When the polymers were blended with [6,6]phenyl-C61-butyric acid methyl ester (PCBM), PIC-TZ showed the best performance with VOC, short-circuit current and power conversion efficiency of 0.86 V, 4.16 mA/cm2 and 1.64%,respectively, under AM 1.5G illumination conditions (100 mW cm-2).
The Utility of $^{18}F$-FDG PET/CT for Following Up Head and Neck Cancer
정은재,백승국,우정수,권순영,정광윤,Chung, Eun-Jae,Baek, Seung-Kuk,Woo, Jeong-Soo,Kwon, Soon-Young,Jung, Kwang-Yoon The Korean Society for Head and Neck Oncology 2010 대한두경부 종양학회지 Vol.26 No.2
서 론 : 두경부암의 예후에 가장 중요한 인자는 진단시 병기와 치료 후 재발의 유무이다. 따라서, 재발 병변을 조기에 발견하는 것이 매우 중요하다. 본 연구에서는 두경부암 환자의 추적 관찰에서 $^{18}F$-FDG PET/CT의 유용성에 대해 알아보고자 하였다. 대상 및 방법 : 2004년 4월부터 2008년 8월까지 고려대 안암병원에서 두경부암으로 치료를 완료한 후 추적관찰이 가능하였던 88 예의 환자를 대상으로 하였다. 환자는 본원의 두경부암 추적관찰 양식에 따라 술 후 6, 12개월째 $^{18}F$-FDG PET/CT를 시행하였으며, 원발부위 및 경부 재발, 원격전이와 중복암의 진단에 있어 $^{18}F$-FDG PET/CT의 민감도, 특이도, 양성예측율, 음성예측율을 평가하였고, 기존의 추적관찰 방법과 이를 비교하였다. 결 과 : 원발부위 재발의 진단에 있어 민감도, 특이도, 양성예측율, 음성예측율은 각각 95%, 97%, 90%, 98% 였다. 경부전이 재발의 진단에 있어서는 각각 94%, 98%, 83%, 99%였으며, 원격전이 및 이차암 진단에 있어서는 94%, 100%, 100%, 99%였다. 원발부위 재발은 고식적인 진단 방법, 원격전이와 이차암은 $^{18}F$-FDG PET/CT가 진단에 의미있게 유리하였다. 결 론 : $^{18}F$-FDG PET/CT는 두경부암의 추적관찰 과정에서 재발 여부를 판정하는데 있어 매우 유용하며, 특히 원격전이 및 이차암의 발견에 있어 유용하다. 그러나, 위양성 및 위음성의 가능성으로 고식적인 진단 방법과 병행해야 진단의 효과를 높힐 것으로 생각된다.
Prognostic Factor of Laryngeal Papillomatosis: 20 Years Experience
정은재,홍석진,조재구,백승국,우정수,권순영,정광윤,Chung, Eun-Jae,Hong, Seok-Jin,Cho, Jae-Gu,Baek, Seung-Kuk,Woo, Jeong-Soo,Kwon, Soon-Young,Jung, Kwang-Yoon The Korean Bronchoesophagological Society 2010 大韓氣管食道科學會誌 Vol.16 No.2
Background: Laryngeal papillomatosis, which is cased by human papillomavirus, is the most common benign neoplasm of the larynx. However, the prognosis of this disease remains really unpredictable. The aim of this paper is to determine whether any clinical features at the time of diagnosis could predict its course. Material and Method: Eighty-six patients treated at our institution during the last 20 years were analyzed retrospectively. All patients had microsurgery under general anesthesia. All patients' follow-up period was more than 1 year. We divided the patients into 1) Juvenile versus adult group based on their age 20, 2) single surgical method with laser versus dual surgical method with laser and microdebrider group, and 3) single subsite versus multiple subsites group. And we compared the therapeutic outcome. Results: The recurrence rate was 100% (15 patients) in the JP group and 56% (40 patients) in the AP group. Juvenile versus adult group was the only independent prognostic factor by univariate, and multivariate analysis. Microdebrider resection technique and multiple subsites were not associated with treatment result. Time period from the first surgery to recurrence detection was different statistically only for the age group. The number of surgery in the JP group ranged from 1 to 31 (mean 8.8). In the AP group the number of surgery ranged from 1 to 25 (mean 3.7). It was statistically different. Conclusion: Prognosis for the laryngeal papillomatosis remains unpredictable. Only patients' age was the only independent prognostic factor.