Prognostic Factor of Laryngeal Papillomatosis: 20 Years Experience

정은재,홍석진,조재구,백승국,우정수,권순영,정광윤,Chung, Eun-Jae,Hong, Seok-Jin,Cho, Jae-Gu,Baek, Seung-Kuk,Woo, Jeong-Soo,Kwon, Soon-Young,Jung, Kwang-Yoon The Korean Bronchoesophagological Society 2010 大韓氣管食道科學會誌 Vol.16 No.2

Background: Laryngeal papillomatosis, which is cased by human papillomavirus, is the most common benign neoplasm of the larynx. However, the prognosis of this disease remains really unpredictable. The aim of this paper is to determine whether any clinical features at the time of diagnosis could predict its course. Material and Method: Eighty-six patients treated at our institution during the last 20 years were analyzed retrospectively. All patients had microsurgery under general anesthesia. All patients' follow-up period was more than 1 year. We divided the patients into 1) Juvenile versus adult group based on their age 20, 2) single surgical method with laser versus dual surgical method with laser and microdebrider group, and 3) single subsite versus multiple subsites group. And we compared the therapeutic outcome. Results: The recurrence rate was 100% (15 patients) in the JP group and 56% (40 patients) in the AP group. Juvenile versus adult group was the only independent prognostic factor by univariate, and multivariate analysis. Microdebrider resection technique and multiple subsites were not associated with treatment result. Time period from the first surgery to recurrence detection was different statistically only for the age group. The number of surgery in the JP group ranged from 1 to 31 (mean 8.8). In the AP group the number of surgery ranged from 1 to 25 (mean 3.7). It was statistically different. Conclusion: Prognosis for the laryngeal papillomatosis remains unpredictable. Only patients' age was the only independent prognostic factor.

두경부 수술후 발생한 인두피부누공의 치료

정은재,정광윤,Chung, Eun-Jae,Jung, Kwang-Yoon 대한기관식도과학회 2008 大韓氣管食道科學會誌 Vol.14 No.1

Subcutaneous cervicofacial, mediastinal emphysemas are complications associated with head and neck surgery, trauma, infectious processes, tooth extraction. Drill cooling stream and dental syringe air ject are the sources of high pressure air that may enter exposed soft tissue. Since the introduction of the high-speed air turbine drill in the 1960s, The incidence of iatrogenic subcutaneous emphysema has increased. Most cases begin to resolve after 2 to 3 days and residual swelling is usually minimal at the end of 7 to 10 days. Surgical approach is not advised because it is likely to be ineffective. The differential diagnosis of neck swelling after dental procedure includes hematoma, cellulitis, angioedema, allergic reaction, subcutaneous emphysema. We report a rare case of patient with subcutaneous cervicofacial emphysema and mediastinal emphysema secondary to third molar extraction.

The Utility of $^{18}F$-FDG PET/CT for Following Up Head and Neck Cancer

정은재,백승국,우정수,권순영,정광윤,Chung, Eun-Jae,Baek, Seung-Kuk,Woo, Jeong-Soo,Kwon, Soon-Young,Jung, Kwang-Yoon The Korean Society for Head and Neck Oncology 2010 대한두경부 종양학회지 Vol.26 No.2

서 론 : 두경부암의 예후에 가장 중요한 인자는 진단시 병기와 치료 후 재발의 유무이다. 따라서, 재발 병변을 조기에 발견하는 것이 매우 중요하다. 본 연구에서는 두경부암 환자의 추적 관찰에서 $^{18}F$-FDG PET/CT의 유용성에 대해 알아보고자 하였다. 대상 및 방법 : 2004년 4월부터 2008년 8월까지 고려대 안암병원에서 두경부암으로 치료를 완료한 후 추적관찰이 가능하였던 88 예의 환자를 대상으로 하였다. 환자는 본원의 두경부암 추적관찰 양식에 따라 술 후 6, 12개월째 $^{18}F$-FDG PET/CT를 시행하였으며, 원발부위 및 경부 재발, 원격전이와 중복암의 진단에 있어 $^{18}F$-FDG PET/CT의 민감도, 특이도, 양성예측율, 음성예측율을 평가하였고, 기존의 추적관찰 방법과 이를 비교하였다. 결 과 : 원발부위 재발의 진단에 있어 민감도, 특이도, 양성예측율, 음성예측율은 각각 95%, 97%, 90%, 98% 였다. 경부전이 재발의 진단에 있어서는 각각 94%, 98%, 83%, 99%였으며, 원격전이 및 이차암 진단에 있어서는 94%, 100%, 100%, 99%였다. 원발부위 재발은 고식적인 진단 방법, 원격전이와 이차암은 $^{18}F$-FDG PET/CT가 진단에 의미있게 유리하였다. 결 론 : $^{18}F$-FDG PET/CT는 두경부암의 추적관찰 과정에서 재발 여부를 판정하는데 있어 매우 유용하며, 특히 원격전이 및 이차암의 발견에 있어 유용하다. 그러나, 위양성 및 위음성의 가능성으로 고식적인 진단 방법과 병행해야 진단의 효과를 높힐 것으로 생각된다.

치과 내원환자의 추천지수에 영향을 미치는 서비스 요인

정은재 ( Eun Jae Jung ),정윤숙 ( Yun Sook Jung ),양해영 ( Hae Young Yang ),김지혜 ( Ji Hye Kim ),최연희 ( Youn Hee Choi ),송근배 ( Keun Bae Song ) 대한구강보건학회 2016 大韓口腔保健學會誌 Vol.40 No.2

Objectives: Many people rely on recommendations from family, relatives, and other information sources in order to select the appropriate dental clinic for treatment. The object of this study was to find out the relationship between quality of dental service and Korean Net Promoter Score (KNPS). Methods: A total of 520 patients were selected through consecutive sampling from four dental clinics in Daegu city. Informed consent of all selected patients was obtained. The patients were required to complete a questionnaire that comprised of three categories of queries related to provision of satisfactory dental service, relation quality, and personal data. Sub-categories of questions included physical and environmental factors, human service factors, patients` satisfaction with related quality and KNPS. Data was collected by interviewing all individuals on a personal basis over a period of 3 months. Statistical analysis was performed using studental t-test, ANOVA and multiple regression analysis using the SPSS 20.0 software (IBM Co., Armonk, NY, USA). Results: Among the various socio-economic factors studied, income was most significantly related to KNPS while satisfaction of relation quality was the largest factor affecting the KNPS. Factors such as satisfactory physical environment, quality of human service, relation quality and income accounted for 52.4% of KNPS. In short, the three major factors that affected KNPS were patient compliance, professionalism of the attending dentist and response of hygienist to patient. Other minor factors influencing KNPS included trust upon the attending dentist, aesthetics of clinicstiinterior, and physical convenience. Conclusions: It is highly recommended that dental clinics should make strenuous efforts to increase the level of patient compliance, professionalism, and response towards patients, which can be achieved by improving the quality of service and through positive marketing of the hospital.

디자인 게임 이론을 활용한 청소년 건축교육 방법론

정은재(Jung Eun Jae),이용규(Yi Yong Kyu) 한국미술교육학회 2017 美術敎育論叢 Vol.31 No.1

최근 다양한 라이프스타일을 지닌 시민들의 등장과 함께 건축을 둘러싼 패러디임 역시 변화하고 있다. 건축이 차가운 콘크리트가 아닌 도심 속 예술과 문화이며, 커뮤니티의 역량이 모아져 만들어지는 건축은 도시의 가치를 높일 수 있는 중요한 수단이 될 수 있다는 인식이 일반화 하고 있는 것이다. 이에, 가치관을 확립하는 시기인 청소년기에 건축의 예술 문화적 가치를 이해하고 커뮤니티 내 역할을 수행할 수 있도록 하는 청소년 교육은 미래에 건강한 시민을 길러내는데 있어 매우 중요한 과제라 할 수 있을 것이다. 특히 타인과의 의견을 공유하고 발전적인 대안을 모색할 수 있는 의사결정에 대한 경험은 가치 있는 도시 건축유산을 만드는데 있어 청소년들에게는 큰 자산이 될 것이다. 본 연구는 커뮤니티 디자인 분야에서 활용되어온 ‘디자인 게임’ 이론에 주목해 청소년을 대상으로 한 건축교육 방법론을 개발하였다. 또한 지역의 여고생들이 참여하는 설계 워크숍을 통해 제안된 방법론의 가능성과 과제를 파악하고자 하였다. 본 연구는 이를 통해 청소년들이 건축을 디자인 하는 과정에서 타인과의 상호작용을 학습하고 예술적 가치를 이해하는 것을 궁극적인 목적으로 한다. 진로탐색에 머물고 있는 건축분야의 청소년 교육에 있어 집단의 지성으로 도시의 예술적 가치를 높일 수 있다는 새로운 경험을 제공한다는 점에서 본 연구의 의의는 크다고 할 수 있을 것이다. Recently, public perception of architecture is changing dramatically. Architecture is an important means of improving art, culture and urban values. Architecture is a great public asset that creates the scenery and gives life pleasure. Thus, citizens participation opportunities are even wider than ever before. Adolescent education is very important task to cultivating healthy citizens in the future can be said to be. Especially, the decision to share opinions with others and seek to develop an advanced alternative is very important. The study focuses on the Design Games which has been utilized in the field of community design, and develops a methodology for targeting youths based. At the same time, the study seeks to identify the possibilities and limitations of methodology by the design workshops of female high school girls participating in Jeju Island. The purpose of this study is to understand the artistic value of architecture and to learn how to interact with others in the process of designing architecture. The main accomplishment of the study is that it provides the youth with the potential to enhance the artistic value of architecture and city by making good decisions.

당귀 추출물의 피부 흡수 증가를 위한 마이크로에멀젼 조성

정은재(Eun-Jae Jung),최준호(Joonho Choi),박충범(Chun-Geon Park),최애진(Ae-Jin Choi),정세호,정석재(Suk-Jae Chung),심창구(Chang-Koo Shim),김대덕(Dae-DuK Kim) 대한약학회 2012 약학회지 Vol.56 No.3

Angelica gigas is one of the most widely used herbal medicines in Asia. Root extract of Angelica gigas is known to have anti-oxidant activity and skin whitening effect. The aim of this study was to prepare microemulsion system of root extracts of Angelica gigas for topical delivery. Microemulsion was successfully prepared by using MCT (medium chain triglyceride) as an oil phase, Labrasol as a surfactant, and the mixture of propyleneglycol and phosphatidylcholine (4 : 1) as a cosurfactant. In vitro and in vivo skin permeation and deposition of decursin, as a marker, was determined using hairless mouse. Microemulsion significantly increased the in vitro skin permeation of decursin for up to 12 hours and was significantly higher than the control (water). Moreover, microemulsion formulation showed significantly higher skin deposition of decursin compared to the control in both in vitro and in vivo studies. Thus, microemulsion could be a useful vehicle for topical application of root extracts of Angelica gigas.

편평세포암 동물 모델에서 고려인삼잎-다당체(MB40)의 항암치료효과

주은정(Eun Jung Joo),최 준(Jun Choi),정은재(Eun Jae Chung),홍석진(Seok Jin Hong),조재구(Jae Gu Cho),백승국(Seung Kuk Baek),우정수(Jeong Soo Woo),정광윤(Kwang Yoon Jung),권순영(Soon Young Kwon) 대한두경부종양학회 2009 대한두경부 종양학회지 Vol.25 No.1

Background and Objectives:Panax ginseng C.A. Meyer is a medical plant that has been widely utilized as a tonic and nutritional agent since ancient times in Korea. Ginseng has anti-metastatic property of cancer and immunomodulating activity. The novel acidic polysaccharide compound(MB40) was isolated from the leaves of Panax ginseng C.A. Meyer. To determine immunomodulating activities of MB40, we evaluate anti-cancer and anti-metastatic effects of MB40 in tumor bearing immune competent mice. Material and Methods:C3H mice were divided into three equal groups(Cisplatin treatment group, MB40treat- ment group, Cisplatin and MB40 treatment group) and were transplanted SCC(Squamous Cell Carcinoma) cells(2×106) to the lateral side of abdomen. From day 4 after transplantation, MB40 was administrated at dose of 10mg/kg, respectively, every other day by intratumoral injection. Cisplatin was systemically administrated at doses of 1mg/kg, respectively, every week by intraperitoneal injection. Results:5 days after administration, tumors can be palpated in every mice group. After 13 days of administra-tion, the mice group to which MB40 were administrated exhibited reduction in tumor size respectively, com-pared to cisplatin group. Overall status of mice such as body weight and activity were superior in MB40 group than cisplatin group. Conclusion:The result of this study indicates MB40 may have significant therapeutic effect and decreases com-plications induced by systemic chemotheraphy. MB40 may be developed as a novel and potent immunotropics to improve the cell immune system and anti-cancer drug for the treatment of cancer patients in head and neck squamous cell carcinoma.

The Utility of 18 F-FDG PET/CT for Following Up Head and Neck Cancer

Eun-Jae Chung(정은재),Seung-Kuk Baek(백승국),Jeong-Soo Woo(우정수),Soon-Young Kwon(권순영),Kwang-Yoon Jung(정광윤) 대한두경부종양학회 2010 대한두경부 종양학회지 Vol.26 No.2

서 론 두경부암의 예후에 가장 중요한 인자는 진단시 병기와 치료 후 재발의 유무이다. 따라서, 재발 병변을 조기에 발견하는 것이 매우 중요하다. 본 연구에서는 두경부암 환자의 추적 관찰에서18F-FDG PET/CT의 유용성에 대해 알아 보고자 하였다. 대상 및 방법 2004년 4월부터 2008년 8월까지 고려대 안암병원에서 두경부암으로 치료를 완료한 후 추적관찰이 가능하였던 88예의 환자를 대상으로 하였다. 환자는 본원의 두경부암 추적관찰 양식에 따라 술 후 6, 12개월째 18F-FDG PET/ CT를 시행하였으며, 원발부위 및 경부 재발, 원격전이와 중복암의 진단에 있어 18F-FDG PET/CT의 민감도, 특이도, 양성예측율, 음성예측율을 평가하였고, 기존의 추적관찰 방법과 이를 비교하였다. 결 과 원발부위 재발의 진단에 있어 민감도, 특이도, 양성예측율, 음성예측율은 각각 95%, 97%, 90%, 98% 였다. 경부전이 재발의 진단에 있어서는 각각 94%, 98%, 83%, 99%였으며, 원격전이 및 이차암 진단에 있어서는 94%, 100%, 100%, 99%였다. 원발부위 재발은 고식적인 진단 방법, 원격전이와 이차암은 18F-FDG PET/CT가 진단에 의미있게 유리하였다. 결 론 18F-FDG PET/CT는 두경부암의 추적관찰 과정에서 재발 여부를 판정하는데 있어 매우 유용하며, 특히 원격전이 및 이차암의 발견에 있어 유용하다. 그러나, 위양성 및 위음성의 가능성으로 고식적인 진단 방법과 병행해야 진단의 효과를 높힐 것으로 생각된다.

웹 통합문서의 효율적 생성과 검색을 위한 자동링크지원 시스템의 설계 및 구축

이원중,정은재,주수종,이승용,Lee, Won-Jung,Jung, Eun-Jae,Joo, Su-Chong,Lee, Seung-Yong 한국정보처리학회 2003 정보처리학회논문지 A Vol.10 No.2

분산 컴퓨팅과 웹 서비스 기술의 발달과 함께, 급증하는 인터넷 사용자는 웹 기반의 맞춤형 정보를 편리하게 작성하고 제공받을 수 있는 서비스들을 요구하고 있다. 이를 위해, 본 논문에서는 맞춤형 정보로서 웹 기반의 통합문서를 생성하고, 사용자 요구에 따라 다양한 검색을 지원할 수 있는 자동링크지원 시스템(ALSS : Automatic Linking Support System)을 구축하고자 한다. 본 시스템의 구성은 클라이언트/서버 환경을 기반으로, 서버는 어휘분석, 질의처리 및 통합문서생성 기능들을 제공하는 자동링크엔진과 사전, 이미지 컨텐츠 및 URLs로 이루어진 데이터베이스를 지원하도록 구축하였다. 클라이언트 측은 서버 측의 자동링크엔진과 데이터베이스를 접근하여 웹 기반의 통합문서를 생성하는 웹 에디터와 검색 서비스를 지원하는 웹 도우미로 구축하였다. 웹 에디터나 웹 도우미 프로그램은 클라이언트 측에 별도의 설치 없이 서버로부터 다운로딩하여 실행할 수 있으며, 서버의 실행기능들의 일부를 글라이언트 측에 분산시키므로써 서버의 부하를 감소시켰다. 본 시스템의 구현으로서, 사용자 인터페이스는 JDK 1.3 기반의 SWING을 이용하고, 클라이언트와 서버간의 연동을 위한 자바 RMI 기법을 적용하였으며, SQL Server 7.0을 사용하여 데이터베이스를 구축하였다. 마지막으로 웹 에디터와 웹 도우미에 의해 자동링크엔진과 데이터베이스를 접근하는 과정과 그들의 실행결과를 보였다. With the advent of distributed computing and Web service technologies, lots of users have been requiring services that can conveniently obtain and/or support well-assembled information based on Web. For this reason, we are to construct Automatic Linking Support Systems for generating Web-based integrated information and supporting retrieval information according to user's various requirements. Our system organization is based on client/server system. A server environment consisted of automatic linking engine that can provide lexical analyzing, query processing and integrated document generating functions, and databases that are made of dictionaries, image and URL contents. Also, client environments consisted of Web editor that can generate integrated documents and Web helper that can retrieve them via automatic linking engine and databases. For client's user-friendly interfaces, web editor and helper programs can directly execute by down leading from a server without setup them before inside clients. For reducing server's overheads, Parts of server's executing modules are distributed to clients on which they can be executing. As an implementation of our system, we use the JDK 1.3, SWING for user interfaces like Web editor and helper, RMI mechanism for interaction between clients and a server, and SQL server 7.0 for database development, respectively. Finally, we showed the access procedures of automatic document linking engine and databases from Web editor or Web helper, and results appearing on their screens.

이하선에 발생한 원발성 편평 세포암종 2예

김우주(Woo-Joo Kim),정은재(Eun-Jae Jung),정광윤(Kwang-Yoon Jung),백승국(Seung-Kuk Baek) 대한두경부종양학회 2009 대한두경부 종양학회지 Vol.25 No.2

Squamous cell carcinoma, which is a common primary head and neck malignant neoplasm that is usually restrict-ed to the mucosal surfaces of the upper aerodigestive tract and skin, is very unusual in the major salivary gland. A-mong them, few cases are regarded as primary carcinomas. In this article, we present two cases of squamous cell carcinoma in the parotid gland, who first presented with painful mass on infraauricular area.