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증가된 C-Reactive Protein은 관상동맥 중재술 후 재협착에 대한 유일한 예측인자
정우곤,정명호,김계훈,이상록,박옥영,염주협,김원,김주한,류제영,안영근,조정관,안병희,서순팔,박종춘,김상형,강정채 대한내과학회 2002 대한내과학회지 Vol.62 No.4
Background : Current techniques of percutaneous coronary interventions (PCI) remain limited by the restenosis. Recent studies provide evidence that inflammation plays a role in the pathogenesis of cardiovascular disease. Methods : We prospectively tested whether inflammatory markers are predictors of subsequent restenosis in 272 consecutive patients with angiographically proved coronary artery disease. The patients who underwent PCI at Chonnam National University Hospital between Sep. 1999 and Mar. 2001 were divided into two groups according to the occurrence of restenosis on follow-up coronary angiogram: patients with restenosis (Group I : n=99, 59.5±10.8 years, M : F=77:22) and patients without restenosis (Group II : n=173, 58.8±10.2 years, M : F=131:42). IgG seropositivity and titer of CMV, C. pneumoniae, H. pylori, levels of C-reactive protein (CRP) were compared between two groups. Results : There were no statistical differences in the seropositivity of CMV IgG, C. pneumoniae IgG, H. pylori IgG between two groups (Group I vs. II : 100% vs. 100%, 24.7% vs. 25.7%, 62.2% vs. 63.7% in group I vs. II respectively). Among angiographic parameters, low TIMI flow (TIMI 0 or I) was more common in Group I than in Group II (p=0.038). The patients with elevated CRP (>0.5 mg/dL) were more common in Group I than those in Group II (57.6% vs. 36.4%, p=0.001) and the value of CRP was higher in Group I than in Group II (3.3±5.8 mg/dL vs. 1.3±2.6 mg/dL, p=0.001). According to multiple logistic regression analysis, CRP was the only predictor of restenosis with odd ratio of 2.1169 (95% C.I. 1.2062-3.7154, p=0.009). Conclusion : The value of CRP is the most important predictor of restenosis after PCI.(Korean J Med 62:405-414, 2002) 연구배경 : 최근에 동맥경화 및 관상동맥 질환의 발생의 중요한 역할을 하는 감염 및 염증인자에 대한 연구가 활발히 이루어지고 있다. 본 연구에서는 관상동맥 중재술 후 발생하는 재협착과 염증인자의 상관관계 및 CMV, C. pneumoniae, H. pylori 등의 감염과 상관관계에 대해서 전향적 조사를 하였다.대상 및 방법 : 1999년 9월부터 2001년 3월까지 처음으로 관상동맥 질환으로 진단된 후 관상동맥 중재술을 시행한 후 추적 관상동맥 조영술을 시행받았던 272예 중 재협착이 발생하였던 재협착군 (99명, 134병변, 59.5±10.8세)과 재협착이 발생하지 않았던 비재협착군 (173명, 211병변, 58.8±10.2세)으로 나누어, 양군간의 세 가지 감염항체의 양성률 및 역가와 CRP를 측정하여 재협착과 연관성 등을 전향적으로 분석하였다.결과 : 재협착군과 비재협착군에서 C. pneumoniae, H. pylori, CMV의 항체 양성률은 각각 27.3%와 26.0%, 61.6%와 63.6%, 100%와 100%로서 양군간에 유의한 차이는 없었다. CRP의 양성률은 재협착군과 비재협착군에서 각각 57.6%와 36.4%로서 재협착군에서 유의하게 높았고 (p=0.001), CRP의 측정치는 3.38±5.80 mg/dL와 1.36±2.62 mg/dL로서 재협착군에서 유의하게 높았다 (p=0.001). 관상동맥 재협착 예측인자에 대한 다변량 회귀 분석에서 CRP는 상대위험도 2.1169, 95% 신뢰구간 1.2062∼3.7154 (p=0.009)로서 재협착 발생에 대한 유일한 독립적인 위험인자이었다.
개발권양도제 적용방안에 관한 연구 - 광주광역시 주거지를 중심으로 -
정우곤,Jeong, Woo-Gon 한국주거학회 2012 한국주거학회 논문집 Vol.23 No.5
This study applied the value of floor-area-ratio standard calculation method to case areas and analyzed them to overcome the limits of previous studies in calculation methods for area standards and land price (value) standard development rights. The results are presented as follows: First, criteria to select sending areas and receiving areas are needed. Second, calculation methods based on the value of floor-area-ratio standard can be widely used as standardized criteria in various areas. Third, for the connection of sending areas with receiving areas, the connections of 1:1, n:1, 1:n, and n:n are available and the location of possible dealing areas should be considered. Also, the choice of connecting unions that meet the purpose of TDR presented by local governments is available. Fourth, for Gwangju, as receiving areas downtown provide higher profits than previous renewal projects, the application of TDR is available. Application methods to overcome problems are presented as follows: First, criteria to select sending and receiving areas should be prepared and implemented in an order of priority. Second, in calculating development rights, methods based on the value of floor-area-ratio standard should be used. Third, the standards and principles of sending and receiving areas should be designated and possible dealing areas should not be limited.