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Anti-inflammatory Effect of LFR on LPS-stimulated THP-1 Cells
정승기,Sul, Mu-Chang,Kim, Hong-Yeoul,Roh, Young-Lae,Jung, Hee-Jae,Jung, Sung-Ki 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2
Background and Objective: Luffae Fructus Retinervus (LFR) is used for investigating symptoms of inflammation. We have evaluated the anti-inflammatory effect of LFR by analyzing the expression of pro-inflammatory cytokines. Materials and Methods : We differentiated THP-l cells into macrophage-like cells by treatment with PMA. Inflammation was induced by treatment with LPS and PMA. We determined the safe concentration of LFR by using the MTS and MTT assays and using PD 98059 as a negative control for comparison of the anti-inflammatory effect of LFR. Results : The MTS and MTT analysis showed that the cell survival rate was >80% within the LFR concentration range of 10-100 ng/ml and began to decrease to >80% at 1 ${\mu}g/ml$. By RT-PCR analysis, the gene expression of TNF-${\alpha}$, IL-8, TGF-${\beta}$, IL-6, IL-${\beta}$1, and IL-10 levels were down-regulated when monocyte-derived macrophages were treated with concentrations of LFR between 10 ng/mL and 100 ng/mL. Conclusion : We conclude that LFR exerts an anti-inflammatory effect by inhibiting the expression of pro-inflammatory activity. The results suggest a promising way to treat general inflammatory diseases.
어성초(魚腥草) 약침(藥鍼)이 Melanoma B16 피부암(皮膚癌)의 증식억제효과(增殖抑制效果)와 Mononuclear cell subsets에 미치는 영향(影響)
정승기,Jung, Sung-Ki 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3
Experimental studies were performed to investigate the effect of Houttuyniae herba Aqua-acupuncture on the growth of Melanoma 816 tissue and Mononuclear cell subsets in mice. The results are as follows : 1. In the study of lymphocytes numbers in mice circulating blood, Houttuyniae herba Aqua-acupuncture showed inhibitory effect, but without stastistical significance. 2. In the study of $CD4^+$ T cell percentage in mice circulating blood, Houttuyniae herba Aqua-acupuncture showed inhibitory effect, but without stastistical significance. 3. In the study of $CD8^+$ T cell percentage in mice circulating blood, Houttuyniae herba Aqua-acupuncture showed inhibitory effect, with stastistical significance. 4. in the study of lymphocytes numbers in mice spleen tissue, Houttuyniae herba Aqua-acupuncture showed inhibitory effect, but without stastistical significance. 5. In the study of $CD4^+$ T cell percentage in mice spleen tissue, Houttuyniae herba Aqua-acupuncture showed inhibitory effect, but without stastistical significance. 6. In the study of $CD8^+$ T cell percentage in mice spleen tissue, Houttuyniae herba Aqua-acupuncture showed inhibitory effect, but without stastistical significance. 7. In the measurement of melanoma tissue weight, Houttuyniae herba Aqua-acupuncture showed increasing effect, but without stastistical significance. According to above results, it is concluded that Houttuyniae herba Aqua-acupuncture is effective upon immune responses in Melanoma 816 inoculated mice.
정승기(Sung-ki Jung) 대한미병의학회 2021 대한미병의학회지 Vol.2 No.1
Objectives The purpose of this article was to convey relevant information to help you understand cough. Methods This article was written by reviewing literature through specialized books and papers. Results The mechanisms of cough, types and characteristics of chronic cough, suspected diseases according to cough patterns, and side effects of cough are summarized. Conclusion Cough not only predicts respiratory disease, but also predicts the healing and progression of the disease. From the perspective of sub-health, understanding cough is thought to help prevent the relevant diseases.