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봉독약침(蜂毒藥鍼)과 청열사습탕(淸熱瀉濕湯)이 제Ⅱ형 collagen 유도 관절염(關節炎)에 미치는 영향
정순구 ( Soon Ku Chung ),설재욱 ( Jae Uk Sul ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2006 한방재활의학과학회지 Vol.16 No.3
Objectives : This study was carried out to investigate the effects of Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) extract on type Ⅱ collagen-induced arthritis rats. Then, we compare separateness with combination of Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang). Methods : We observed inhibitory effect of edema, analgesic effects by hot plate, analysis of blood chemistry(WBC, ALT, AST), western blot(IL-6, cPLA2), histopathological and radiological changes. Results : Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) extract significantly inhibited the rate of paw edema compared with control group and reduced WBC, the time of heat threshold, AST(Asparatate transaminase), ALT(Alanine transaminase), the mass of IL-6, cPLA2 in synovia compared with control group in immunological test. On the histopathological view, all experimental groups were relieved and reproduced the erosion of arthritic site compared with control group. On the radiological view, all experimental groups were improved. Conclusions : Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) can be used for curing rheumatoid arthritis. Anti-inflammatory effects may be somewhat better in combination of BV and CST.
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