압박 신경병증을 일으킨 결절종의 수술적 절제의 임상적 결과

정성택,조성범,문은선,이재준,김기형,양현기,Jung, Sung-Taek,Cho, Seong-Beom,Moon, Eun-Sun,Lee, Jae-Joon,Kim, Ki-Hyeoung,Yang, Hyun-Kee The Korean Musculoskeletal Tumor Society 2006 대한골관절종양학회지 Vol.12 No.1

목적: 이 연구의 목적은 말단 신경을 침범하는 결절종을 가진 환자의 수술적 치료를 고찰하는 데 있다. 대상 및 방법: 1995년부터 2000년까지 결절종으로 인한 신경적 증상을 가지고 있었고 수술적으로 치료받았던 12예의 환자를 대상으로 하였다. 평균 나이는 44.3(15-71)세였다. 압박 받았던 신경은 경골 신경이 3예로 가장 많았고 견갑상 신경, 총 비골 신경, 요골 신경, 척골 신경이 각각 2예, 정중 신경이 1예였다. 동통은 6명의 환자에서 있었고, 감각 이상이나 운동력 저하가 각각 7예의 환자에서 보였고 4명의 환자에서는 이 두 증상이 동시에 있었다. 결과: 술전 동통을 호소하였던 6명 모두 술후 동통은 소실되었다. 술전 감각 이상이 있었던 7명의 환자 중 5명에서 호전이 있었으며 술전 운동력 약화를 보였던 환자 모두 호전이 있었다. 술전 감각 이상과 운동력 약화를 동시에 보였던 환자 4명 중 2명만이 완전한 감각의 회복을 보였고 이는 불량한 예후 인자를 암시한다. 결론: 이러한 압박 신경병증을 일으키는 결절종의 정확한 조기 진단 및 절제는 우수한 임상적 결과를 보인다.

소아에서의 성장 예측: 골종양의 치료와 관련된 소아 하지 부동

정성택,정광철,박형원,Jung, Sung-Taek,Jeong, Kwang-Cheul,Park, Hyeong-Won 대한근골격종양학회 2011 대한골관절종양학회지 Vol.17 No.1

The main goals of treatment of malignant bone tumor are the prolongation of life survival and the improvement of quality of life. In growing children, however, leg length discrepancy (LLD) is one of major problem in the treatment of malignant bone tumors. Therefore, the precise understanding of growth in children is essential, and the prediction of LLD is critical in deciding the time and options of surgery. In addition, to use the adequate method of growth expectation, periodic follow-up and collaboration with patient's parents are needed.

종양 절제 후 동반된 비골신경 손상

정성택,정재윤,선종근,조상권,김기형,Jung, Sung-Taek,Chung, Jae-Yoon,Seon, Jong-Keun,Cho, Sang-Gwon,Kim, Ki-Hyeoung 대한근골격종양학회 2004 대한골관절종양학회지 Vol.10 No.1

We retrospectively reviewed the cases of peroneal nerve palsy in seven patients after musculoskeletal tumor resection. Their mean age was 38 years. Three had osteosarcoma in proximal fibula, 2 had chondrosarcoma in proximal fibula and calf and 2 had malignant fibrous histio cytoma in calf. Four of 7 patients had been managed using active dorsiflexion brace. Three patients who underwent tibialis posterior transfer and could walk without brace were able to discontinue the use of the orthosis. Peroneal nerve palsy after wide excision of tumor including peroneal nerve can not resolve spontaneously and results in severe functional disability. To improve the gait function, active surgical treatment should be considered.

Effects of Ibandronate on the Expression of Matrix Metalloproteinases in Human U2OS Osteosarcoma Cells

정성택,서형연,신증봉,김양경,김형원,Jung, Sung-Taek,Seo, Hyoung-Yeon,Xin, Zeng-Feng,Kim, Yang-Kyung,Kim, Hyung-Won The Korean Musculoskeletal Tumor Society 2009 대한골관절종양학회지 Vol.15 No.2

Background: Osteosarcoma is one of the most common primary malignant tumors of bone occurring mainly in children and adolescents. Although surgery combined with chemotherapy has markedly improved patient survival during the last years, the use of anticancer drugs is still associated with serious problem, such as the frequent acquisition of drug-resistant phenotypes and occurrence of "secondary malignancies". Several solid tumors display enhanced expression of matrix metalloproteinases (MMPs), and recently clinical trials have been initiated on MMP-inhibitors. On the other hand, bisphosphonates (BPs) are inhibitors of bone resorption, and widely used to treat osteoclast-mediated bone diseases. Also they appear to possess direct antitumor activity. Methods: One osteosarcoma cell line (U2OS) was treated with ibandronate (0, 0.1, 1, $10{\mu}M$) for 48 hours. Cell viabilities were determined using MTT assay, the mRNA levels of MMP-2 and MT1-MMP were detected by reverse-transcription polymerase chain reaction, the amount of MMP-2 and MT1-MMP protein were measured by Westernblot, the activities of MMP-2 were observed by Gelatin zymography, and Matrigel invasion assays were used to investigate the invasive potential of osteosarcoma cell lines before and after ibandronate treatment. Results: The invasiveness of U2OS cell line was reduced dose-dependently following 48 hour treatment of up to $10{\mu}M$ of the ibandronate at which concentration no cytotoxicity occurred. Furthermore, the gelatinolytic activities and protein and mRNA levels of MMP-2 and MT1-MMP were also suppressed by increasing ibandronate concentrations. Conclusion: Given that MMP-2 is instrumental in tumor cell invasion, it is very likely that the reduction in osteosarcoma cell invasion by ibandronate is a consequence, at least in part, of suppressed expression of both MMP-2 and MT1-MMP. Isolation of a molecule (s) responsible for the bisphosphonate inhibition of tumor cell invasion would pave the way for the development of a new generation of metastasis inhibitors.

임신중 발생한 원발성 부갑상선 기능 항진증을 동반한 상완골 근위부의 Brown tumor

정성택,김현종,이담선,박기헌,Jung, Sung-Taek,Kim, Hyun-Jeong,Lee, Dam-Seon,Park, Gi-Heon 대한근골격종양학회 2007 대한골관절종양학회지 Vol.13 No.2

Brown tumor is tumor like lesion resulted from hyperparathyroidism, and it has been rarely reported recently. We evaluated a 29-year-old woman who had brown tumor on proximal humerus caused by primary hyperparathyroidism. She first had presented pain and swelling over the upper arm, and was suspected as giant cell tumor in biopsy combined with hyperparathyroidism. Wide marginal excision and tumor prosthesis were performed. However, it was confirmed as brown tumor resulted from parathyroid adenoma according to laboratory findings and radioactive isotopes image, and surgical excision of adenoma relieved clinical symptoms. We report this case with a review of literatures.

양성 골 종양의 절제 및 소파술 후 사용한 신선 동결 동종골 이식의 결과

정성택,배봉현,임근영,공일규,Jung, Sung-Taek,Bae, Bong-Hyun,Lim, Keun-Young,Kong, Il-Kyu 대한근골격종양학회 2005 대한골관절종양학회지 Vol.11 No.1

Purpose: We compared the time how much time spent until the bone unions, when we grafted fresh frozen allograft during therapy of benign bone tumor depends on the degrees of bony unions. Materials and Methods: This study selected 29 cases, in which a curettage on the benign bone tumors was conducted and a fresh frozen allograft was transplanted. The area of the focus, the new bone formation, the recurrence of the focus and complications in the plain radiographs were observed. Results: The average time when we could find out bony unions in the radiographs is eleven weeks. The time when we could observe the unions in the radiographs are 11.4 weeks in allograft group, 10.7 weeks in allograft and autograft groups and 13.6 weeks in allograft and bone substitute. On radiologic findings, the average lesion size is 40 cm3. The time when we could find bony unions are 9.3 weeks in less than 40 $cm^3$ and 12.9 weeks in more than 40 $cm^3$. We could observe recurrences in two cases. Conclusion: The authors could get the similar results between fresh frozen allograft, allograft and autograft after curettage of benign bone tumor. We can think the ideal method which is the transplantation of autograft, but if we can’t get autograft enough, the best way which heal the defects is the transplantation of fresh frozen allograft.

양성 골종양을 동반한 소아 대퇴골의 병적 골절

정성택,김병수,문은선,이근배,서형연,Jung, Sung-Taek,Kim, Byung-Soo,Moon, Eun-Sun,Lee, Keun-Bae,Seo, Hyoung-Yeon 대한근골격종양학회 2005 대한골관절종양학회지 Vol.11 No.2

Purpose: We evaluate the results of treatment of pathologic femur fractures secondary to bone tumors in children. Materials and Methods: Between January 1995 and June 2004, 18 patients(20 cases) were evaluated. Their mean age of the first episode of fracture was 10.2 years and mean follow-up period is 42.5 months. Primary bone tumors, the location of fracture, time to union and complications were evauated. Results: Fractures occurred at proximal portion in 14 cases, shaft 3 cases and distal portion 3 cases. The bone tumors causing pathologic fracture were fibrous dysplasia(9 c ases), simple bone cyst(4 cases), aneurysmal bone cyst(4 cases), nonossifying fibroma(2 cases) and eosinophilic granuloma(1 case). In the treatment for fractures, cast was in 11 cases, internal fixation 8 cases and external fixation in 1 case. In the treatment for tumors, observation was in 11 cases, curettage & bone graft in 8 cases and resection in 1 case. In polyostotic fibrous dysplasia, all cases were treated by cast initially but deformity developed in all cases. Fracture prevention and deformity correction were obtained with intramedullary nailing. Conclusion: Adequate choice of treatment of bone tumor and fracture will result in good prognosis.

포상 연부 육종 - 2례 보고 -

정성택,서형연,신상규,박용철,Jung, Sung-Taek,Seo, Hyoung-Yeon,Shin, Sang-Gyoo,Park, Yong-Cheol 대한근골격종양학회 2003 대한골관절종양학회지 Vol.9 No.2

As we know, alveolar soft part sarcoma is usually found at the head region in children and thigh in adults. It is very rare tumor that has poor prognosis due to its late detection after distant metastasis in spite of its slow growth rate. It is histologically characterized by pseudoalveolar pattern tumor cells. And metastasis usually occur in the site of lung, brain and skeleton in order lately. We have managed two cases of the sarcoma, one which took place in relatively rare part, pelvic bone and has spread to the brain, the other which primarily occured in the calf. For its varity, we report these two cases with reviewing of the literatures.

족모지 조갑하 외골종

정성택,송은규,이영근,Jung, Sung-Taek,Song, Eun-Kyoo,Lee, Young-Keyn 대한족부족관절학회 1998 대한족부족관절학회지 Vol.2 No.1

Subungal exostosis is a rare benign cartilaginous tumor affecting the distal phalanx. From 1995 to 1996, six subungal exostoses of the hallux were treated in the Chonnam national university hospital. The symptoms were subungal pain, mass on the distal phalanx elevating the nail or causing ulceration of the nail bed. The plain radiological examination showed a bony mass occurring on the dorsomedial or medial aspect of the distal phalanx. The diagnosis of the subungal exostosis of the hallux were suspected from clinical presentation and confirmed with radiographic examination. Histological patterns were fibrocartilaginous cap with the mature trabecular bone. Complete excision of the lesion including overlying nail bed was curative without recurrence in all cases.

종골 골절후 외상성 관절염에 대한 삼중 관절 고정술의 임상적 결과

정성택,노성만,정재윤,송은규,이근배,Jung, Sung-Taek,Rowe, Sung-Man,Chung, Jae-Yoon,Song, Eun-Kyoo,Lee, Keun-Bae 대한족부족관절학회 2002 대한족부족관절학회지 Vol.6 No.2

Purpose: To analyze the clinical outcome of triple arthrodesis for the posttraumatic arthritis after calcaneal fractures. Materials and Methods: We retrospectively reviewed 22 posttraumatic arthritis patients who underwent a triple arthrodesis from March 1991 to May 1998. The mean duration of follow up was 74 months(range, 36-123 months). The pain, function and alignment were evaluated by the modified ankle-hindfoot scale of the American Orthopaedic Foot and Ankle Society(AOFAS) clinically and the union rate, the duration of union and the degenerative change of adjacent joints radiographically were evaluated. Results: The mean duration from injury to arthrodesis was 33 months (range, 12-132 months). The AOFAS score improved from 36.4 points(range, 14-64) preoperatively to 67.6(range, 25-90) postoperatively. The union rate was 90.1% radiographically, the mean duration of union was 14.3 weeks(range, 12-21 weeks) and the degenerative change in the adjacent joint was showed in 12 patients(54.5%). There were 2 cases of talonavicular nonunion, one superficial wound infection and one partial skin necrosis. Conclusion: Triple arthrodesis for posttraumatic arthritis after calcaneal fractures is a useful method for relief of pain and correction of posttraumatic hindfoot deformity, as an evidenced by the satisfactory clinical outcome. Although a high prevalence of subsequent arthritis of the ankle and midtarsal joint was noted radiographically, we found that it was not clinically relevant.