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대장의 점막하 침윤암의 심달도와 림프절 전이에 따른 기질단백분해효소와 억제인자의 발현 및 신생혈관 형성
정성애 ( Sung Ae Jung ),양석균 ( Suk Kyun Yang ),김정선 ( Jeong Sun Kim ),심기남 ( Ki Nam Shim ),임석아 ( Seock Ah Im ),명승재 ( Seung Jae Myung ),정훈용 ( Hwoon Yong Jung ),유창식 ( Chang Sik Yu ),김진천 ( Jin Cheon Kim ),홍원선 대한소화기학회 2005 대한소화기학회지 Vol.45 No.6
Background/Aims: Lymph node (LN) metastasis occurs in approximately 10% of patients with submucosally invasive colorectal carcinoma. This study was performed to determine the role of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinase
대장 선종과 대장암에서 기질단백분해효소의 발현: MT1-MMP 및 TIMP-2에 대하여
신정은 ( Jeong Eun Shin ),정성애 ( Sung Ae Jung ),김성은 ( Seong Eun Kim ),주양희 ( Yang Hee Joo ),심기남 ( Ki Nam Shim ),김태헌 ( Tae Hun Kim ),유권 ( Kwon Yoo ),문일환 ( Il Hwan Moon ) 대한장연구학회 2007 Intestinal Research Vol.5 No.2
Background/Aims: This study investigated the expression of membrane type 1-matrix metalloproteinase (MT1-MMP) and the tissue inhibitor of metalloproteinase-2 (TIMP-2) in cases of adenoma-carcinoma sequence. Methods: Thirty-two samples of colon adenoma, 11 samples of early colon cancer (ECC) and 36 samples of advanced colon cancer (ACC) were collected from colonoscopic biopsies. Normal tissues were also collected from the same subjects. The mRNA expression levels of MT1-MMP and TIMP-2 were quantified using semiquantitative RT-PCR. Results: The mRNA expression levels of MT1-MMP were greater in the ACC samples as compared to the adenoma and ECC samples (p<0.05, respectively). However, there was no difference in the mRNA expression levels of MT1-MMP between the adenoma and ECC samples. The mRNA expression levels of TIMP-2 were greater in the ACC samples as compared to the adenoma samples (p<0.001) but did not differ between the adenoma and ECC, and between the ECC and ACC. The expression level of MT1-MMP mRNA was positively related to lymph node metastasis (p<0.05). However, the mRNA expression levels of MT1-MMP and TIMP-2 did not differ for colon cancer according to differentiation and modified Dukes’ stage. Conclusions: The mRNA expression levels of MT1-MMP and TIMP-2 have limitations as useful markers for malignant degeneration of colonic neoplasm and the progression of colon cancer. (Intest Res2007;5:144-150)
대장 선종과 대장암에서 MMP-2, HIF-1α 및 VEGF의 발현
신정은 ( Jeong Eun Shin ),정성애 ( Sung Ae Jung ),김성은 ( Seong Eun Kim ),주양희 ( Yang Hee Joo ),심기남 ( Ki Nam Shim ),김태헌 ( Tae Hun Kim ),유권 ( Kwon Yoo ),문일환 ( Il Hwan Moon ) 대한소화기학회 2006 대한소화기학회지 Vol.50 No.1
목적: 대장암 발생 과정 중 초기 기저막 파괴에 관여하는 MMP-2와 신생혈관 형성에 관여하는 HIF-1α와 VEGF가 대장암 발생 및 각 진행단계에서 발현하는 양상 및 예후 관련 인자와의 연관성을 알아보고자 하였다. 대상 및 방법: 대장선종 32예, 조기 대장암 11예와 진행 대장암 36례의 대장내시경 생검 조직에서 MMP-2, HIF-1α와 VEGF의 mRNA 발현을 역전사 중합효소 연쇄반응을 이용하여 주변의 정상 조직을 기준으로 반정량적으로 측정하였으며, 이 중 암 수술 조직 11예에서 gelatin zymography와 Western blot을 이용하여 활성형 MMP-2 단백과 HIF-1α 단백 발현을 관찰하였다. 결과: MMP-2 mRNA 발현은 대장 선종에 비해 진행 대장암에서 증가하였고(p<0.001), 대장 선종에서 조기 대장암과 진행 대장암으로 갈수록 증가하였다(p<0.05). 대장암에서 MMP-2 mRNA 발현은 림프관 침습이 있는 경우와 중등도와 저분화도일 때 및 병기가 진행함에 따라 증가하였다(p<0.05). Gelatin zymography 결과, 11예 중 10예(91%)의 암조직에서 활성형 MMP-2 단백이 발현되었다. HIF-1α와 VEGF mRNA 발현은 대장 선종에 비해 조기 대장암과 진행 대장암에서 증가하였으나(p<0.05; p<0.001), 조기 대장암과 진행성 대장암 사이에 차이가 없었다. Western blot 결과, 11예 중 9예(82%)의 암조직에서 HIF-1α 단백이 발현되었다. HIF-1α mRNA 발현은 MMP-2 mRNA 및 VEGF mRNA 발현과 유의한 상관관계가 있었다(r=0.52, p< 0.001; r=0.76, p<0.001). 결론: 이번 연구는 대장암 발생 및 진행에 있어서 MMP-2, HIF-1α와 VEGF의 발현 및 상호 연관성을 확인할 수 있었으며, 이들 인자들의 발현이 대장 내 신생물의 악성화 단계 및 악성 병변의 진행을 예측할 수 있는 한 방법이 될 수 있을 것으로 생각한다. Background/Aims: This study was aimed to investigate the expression of matrix metalloproteinase-2 (MMP-2), hypoxia-inducible factor (HIF)-1α, and vascular endothelial growth factor (VEGF) in colonic adenoma-carcinoma sequence. Methods: Thirty-two tissue samples of colon adenoma, 11 of early colon cancer and 36 of advanced colon cancer were collected by colonoscopic biopsy. Normal colonic tissues were also collected from the same subjects. The mRNA expression levels of MMP-2, HIF-1α, and VEGF were quantitated using semiquantitative reverse transcription polymerase chain reactions. The protein expressions of activated MMP-2 and HIF-1α were examined by gelatin zymography and by Western blot in surgically resected cases, respectively. Results: The expression level of MMP-2 mRNA showed a progressive increase in the advance of the colorectal adenoma-carcinoma sequence (p<0.05). In colon cancer tissues, the expression level of MMP-2 mRNA showed an increasing trend according to differentiation, lymphatic invasion and Dukes` stage (p<0.05). The protein expression of activated MMP-2 was observed in 10 of 11 (91%) cases of cancer tissues. The mRNA expression levels of HIF-1α and VEGF were greater in tissues of early and advanced colon cancer compared with colon adenoma (p<0.05; p<0.001). The protein expression of HIF-1α was observed in 9 of 11 (82%) cases of cancer tissues. The mRNA expression level of HIF-1α showed a positive correlation with MMP-2 and VEGF, respectively (r=0.52, p<0.001; r=0.76, p<0.001). Conclusions: MMP-2, HIF-1α, and VEGF may be useful in detecting early carcinogenesis and progression of colon cancer. (Korean J Gastroenterol 2007;50:9-18)
남준식 ( Jun Sik Nam ),정성애 ( Sung Ae Jung ),김성은 ( Seong Eun Kim ),심기남 ( Ki Nam Shim ),조유경 ( You Kyung Cho ),이종수 ( Jong Soo Lee ),염혜정 ( Hye Jeong Yeum ),이정경 ( Jung Kyong Lee ),유권 ( Kwon Yoo ) 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.2
목적: 골반저 근실조로 진단된 환자들 중에서 변비를 호소하는 환자임에도 불구하고 휴식기 항문압이 비정상적으로 감소된 환자들에서 배변장애의 기전을 이해하기 위하여 항문직장의 생리학적 지표들을 분석하고자 하였다. 대상 및 방법: 2001년 12월부터 2003년 7월까지 골반저 근실조로 진단된 37명의 환자를 대상으로 휴식기 항문압이 감소된 군(이하 감소군) 22명과 정상군 15명을 구분하여 대장통과시간, 항문직장 내압검사와 배변조영술 결과를 후향적으로 비교 Background/Aims: The purpose of this study was to analyze the characteristics of defecation difficulty in obstructive constipated patients showing decreased resting anal pressure (RAP) by manometry. Methods: From December 2001 to July 2003, 37 patients wi
박무인 ( Moo In Park ),신정은 ( Jeong Eun Shin ),명승재 ( Seung Jae Myung ),허규찬 ( Kyu Chan Huh ),최창환 ( Chang Hwan Choi ),정성애 ( Sung Ae Jung ),최석채 ( Suck Chei Choi ),손정일 ( Chong Il Sohn ),최명규 ( Myung Gyu Choi ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.2
While constipation is a common symptom in Korea, there are no existing treatment guidelines. Although constipation may occur as a result of organic cause, there is no obstructive mucosal or structural cause in the vast majority of patients with constipation. The present paper deals with only the management of functional constipation: lifestyle changes; bulking agents and stool softeners; osmotic agents; stimulant laxatives; prokinetics; biofeedback and surgical treatments. Exercise and dietary fiber are helpful in some patients with constipation. Laxatives including bulking agents, stool softeners, osmotic agents, and stimulant laxatives have been found to be more effective than placebo at relieving symptoms of constipation. New enterokinetic agents that affect peristalsis through selective interaction with 5-hydroxytryptamine-4 receptors can be effective in patients with constipation who cannot get adequate relief from current laxatives. Biofeedback can relieve symptoms in selected patients with pelvic floor dyssynergia. Surgical treatments can be helpful in some patients with refractory constipation. (Korean J Gastroenterol 2011;57:100-114)
Polyethylene Glycol 용액의 복용완료시간과 대장내시경 검사시작 시간에 따른 대장 정결도의 비교
윤장혁 ( Jang Hyuk Yoon ),박동일 ( Dong Il Park ),신정은 ( Jeong Eun Shin ),김성은 ( Seong Eun Kim ),정성애 ( Sung Ae Jung ),이석호 ( Suck Ho Lee ),장동경 ( Dong Kyung Chang ),은창수 ( Chang Soo Eun ),한동수 ( Dong Soo Han ),김현 대한장연구학회 2010 Intestinal Research Vol.8 No.1
Background/Aims: Polyethylene glycol (PEG) solution is the most widely used bowel preparation agent for colonoscopy because of its safety and efficacy in colon cleansing. It has been hypothesized that the timing of colon preparation may influence the quality of colon cleansing, and therefore affect the diagnostic yield of colonoscopy. The aim of this study was to determine the optimal interval of time between complete ingestion of PEG and performing colonoscopy. Methods: We prospectively enrolled 1,355 patients who had undergone a PEG-based bowel preparation on the day of colonoscopy in 11 tertiary hospitals in Korea between March 2008 and February 2009. All colonoscopies were performed in the afternoon. The start time of PEG ingestion, completion time of PEG ingestion, dose of PEG ingested, start time of colonoscopy, and the quality of bowel cleansing were recorded. Results: There was no difference of cleansing quality of bowel preparation between three groups of less than 7 hours of elapsed time (2≤ and <3 hours, 3≤ and <5 hours, 5≤ and <7 hours). However, group of more than 7 hours of elapsed time presented poor cleansing quality than others (P<0.01). Conclusions: If >7 hours elapses after ingestion of PEG, the quality of bowel preparation is poor. Therefore, depending on the time colonoscopy is scheduled, the start time of PEG ingestion may need to be adjusted. (Intest Res 2010;8:24-29)
갑상선기능항진증의 간소엽중심부 간세포손상의 진단적 평가를 위한 isocitrate dehydrogenase 활성도 측정
최원범(Won Bum Choi),정영화(Young Hwa Chung),정성애(Sung Ae Jung),송병철(Byung Cheol Song),김정아(Jeong A Kim),김정원(Jung Weon Kim),송일한(Il Han Song),장우영(Woo Young Chang),송영기(Young Kee Shong),이영상(Yung Sang Lee),서동진(Don 대한내과학회 2000 대한내과학회지 Vol.58 No.2
N/A Background : The zonal differentiation of hepatic necrosis is important in the aspect of treatment, follow-up and prognosis of patients. The purpose of this study was evaluating the clinical usefulness of serum isocitrate dehydrogenase (ICDH) as a marker of centrilobular hepatic necrosis in patients with hyperthyroidism. Methods : We determined the serum ICDH and alanine aminotransferase (ALT) activities in 56 patients with hyperthyroidism, 16 patients with chronic viral hepatitis, and 17 normal controls. Results : The activities of serum ICDH were significantly higher in patients with hyperthyroidism than those of patients with chronic viral hepatitis or normal control (p<0.01), even though those of serum ALT were higher in patients with chronic viral hepatitis (p<0.01). The ratio of serum ICDH and ALT activities were markedly different between the patients with hyperthyroidism and chronic viral hepatitis (p<0.001). There was a significant correlation between the serum ICDH and ALT activities in patients with hyperthyroidism as well as in those with chronic viral hepatitis (p<0.05). In patients with hyperthyroidism, the serum ICDH levels were more significantly correlated with serum triiodothyronine (T3) than thyroxine (T4) levels. In a patients with hyperthyroidism and elevated ALT levels, the serum ICDH activity decreased progressively and was normalized ultimately, as serum ALT level and thyroid function were normalized with antithyroid medication. Conclusion : The serum ICDH or ratio of serum ICDH and ALT activities might be useful clinically in differentiating the centrilobular from periportal hepatic necrosis, and following up the degree of hepatic necrosis in patients with hyperthyroidism.(Korean J Med 58:189-196, 2000)