유기용매 내성세균 Pseudomonas mendocina BCNU154에 의한 BTEX분해

정미연,최경순,이상희,정영기,김용균,주우홍 한국생명과학회 2000 한국생명과학회 학술발표회 Vol.29 No.-

엄지 손가락의 Reach Envelope을 고려한 한 손용 Keypad 설계 Protocol 제안

정미연,남성현,백승민,장한솔,장혜지 대한산업공학회 2013 대한산업공학회 추계학술대회논문집 Vol.2013 No.11

Squeak Etoys 활용 알고리즘 학습이 중학생의 문제해결력에 미치는 영향

정미연,이영준,이은경 대한공업교육학회 2008 대한공업교육학회지 Vol.33 No.2

Many former researchers demonstrated that algorithm learning has a positive outcome on students' problem-solving abilities. One of the methods for algorithm learning, the ‘programming learning’ method is highly effective. However, there are numerous constraints in schools for programming learning. This study attempts to overcome these issues. Squeak Etoys, one of the educational visual programming languages for easy and interesting learning, has been selected as a learning tool. We developed the algorithm-learning curriculum for middle school students. They were divided into a control group and an experimental group. The students learned on the basis of equal curriculum but, they used other learning tools through over a total 6 sessions. The result showed that Squeak Etoys based Algorithm learning has a positive effect on improving middle school learners' problem solving abilities, self-efficacies and logical thinking abilities. Although the students' logical thinking abilities in the experimental group are improved a lot more than the students' abilities in control group, the students' logical think abilities in the both groups are improved. Therefore, algorithm education in secondary schools are necessary. In conclusion, Squeak Etoys based Algorithm learning has a positive effect on problem solving ability and self efficacy. The developed curriculum can be applicable as a basis for study on algorithm learning and educational programming language. 알고리즘 학습이 학습자의 창의적 문제해결력, 논리적사고력과 같은 고차원적인 인지 능력 향상에 도움이 되지만, 알고리즘 학습을 처음 접하는 어린 학습자들의 경우 인지적 부담으로 작용할 수 있다. 따라서 프로그래밍을 통한 알고리즘 학습에서 학습자의 인지적 부담을 감소시켜주고 알고리즘 학습에 대한 흥미와 동기 유발을 위한 새로운 교수 설계가 필요하다. 본 연구에서는 중학생의 알고리즘 학습을 위한 프로그래밍 도구로 비주얼 기반 교육용 프로그래밍 언어인 Squeak Etoys를 선정하고 이를 활용한 알고리즘 학습 프로그램을 설계하였다. 설계한 학습 프로그램을 실제 중학교 학습자들에게 적용한 결과, Squeak Etoys 활용 알고리즘 학습이 프로그래밍을 처음 접하는 초보 학습자들의 문제해결성향과 자기효능감, 논리적사고력 향상에 유의미한 영향을 주었음을 확인하였다. 특히 논리적사고력의 경우, 실험집단과 통제집단모두 유의미한 향상을 보였다. 이는 알고리즘을 설계하고 표현하는 과정에 대한 학습경험 자체가 논리적사고력 신장에 효과적임을 의미한다. 따라서 초·중등교육에서의 알고리즘 교육은 의미 있는 학습내용이라고 볼 수 있다. 그러나 Squeak Etoys 활용 알고리즘 학습을 진행한 집단이 통제집단에 비해 논리적사고력 향상의 정도가 유의미하게 높은 것은 Squeak Etoys와 같은 비주얼 기반 프로그래밍 학습 환경이 알고리즘 학습에 대한 외생적 인지부하를 감소시켜주고 문제해결성향 및 자기효능감에 긍정적인 영향을 줌으로써 논리적사고력과 같은 고등정신능력 향상에 도움을 준 것으로 해석할 수 있다. 이러한 연구 결과는 향후 새로운 교육과정 시행될 경우, 알고리즘 학습을 위한 교육용 프로그래밍 언어의 선정 및 교수 학습 설계에 유용한 지침을 제공해 줄 수 있을 것이다.

개인지도가 대학 교양수학 학업성취도 및 수학적 태도에 미치는 영향

정미연,표용수,Jung, Mi-Yeun,Pyo, Yong-Soo 영남수학회 2012 East Asian mathematical journal Vol.28 No.4

In this paper, we carry out personal lessons in order to improve the problem-solving abilities of students who have a low level of university general mathematics, and find the efficient teaching method of the personal lessons by analyzing the mathematic achievement of the participating students.

Fisher 알고리즘에 의한 프랙탈영상압축의 고속처리를 위한 VLSI 어레이 설계 ( Design of VLSI Array for High Speed Processing of Fractal Image Compression by Fisher Algorithm )

정미연,이수진,성길영,김용성,우종호 한국통신학회 1997 한국통신학회 학술대회논문집 Vol.16 No.1

SATURATION-VALUE TOTAL VARIATION BASED COLOR IMAGE DENOISING UNDER MIXED MULTIPLICATIVE AND GAUSSIAN NOISE

정미연 한국산업응용수학회 2022 Journal of the Korean Society for Industrial and A Vol.26 No.3

In this article, we propose a novel variational model for restoring color images corrupted by mixed multiplicative Gamma noise and additive Gaussian noise. The model in- volves a data-fidelity term that characterizes the mixed noise as an infimal convolution of two noise distributions and the saturation-value total variation (SVTV) regularization. The data- fidelity term facilitates suitable separation of the multiplicative Gamma and Gaussian noise components, promoting simultaneous elimination of the mixed noise. Furthermore, the SVTV regularization enables adequate denoising of homogeneous regions, while maintaining edges and details and diminishing the color artifacts induced by noise. To solve the proposed noncon- vex model, we exploit an alternating minimization approach, and then the alternating direction method of multipliers is adopted for solving subproblems. This contributes to an efficient itera- tive algorithm. The experimental results demonstrate the superior performance of the proposed model compared to other existing or related models, with regard to visual inspection and image quality measurements.

한방에서의 비만관리

정미연 한국산업간호협회 2001 한국산업간호협회지 Vol.8 No.3

Mycobacterium intracellurare에 의한 뇌농양 1예

정미연,주덕윤,이현아,정우신,양재영,염준섭 대한감염학회 2011 Infection and Chemotherapy Vol.43 No.4

Mycobacterium avium intracellulare complex (MAC) usually causes an opportunistic pulmonary infection in immunocompromised hosts who have underlying structural lung disease. Central nervous system infection due to MAC is very rare even in an immunocompromised host. Most previous reports of central nervous system infection due to MAC have been meningoencephalitis in patients infected with human immunodeficiency virus (HIV). Only four cases of brain abscess due to MAC have been reported worldwide. We report a case of brain abscess due to MAC in a non-HIV patient. Although drugs used for treatment of MAC have limited central nervous penetration, an azithromycin-based antituberculous therapy after surgical drainage of the abscess showed improvement. To the best of our knowledge, this is the first reported case of MAC brain abscess in the Korean literature. Key Words: Mycobacterium

Anti‐obesity effect of Allomyrina dichotoma (Arthropoda: Insecta) larvae ethanol extract on 3T3‐L1 adipocyte differentiation

정미연,윤영일,황재삼,구태원,윤은영 한국곤충학회 2014 Entomological Research Vol.44 No.1

Although Korean horn beetle (Allomyrina dichotoma) larvae have been long used as an oriental medicine for the treatment of liver diseases in Korea, there is little scientific evidence of their effects. In this study, we investigated the anti‐obesity activity of A. dichotoma larvae extract (ADE) by using 3T3‐L1 cells as an in vitro model of adipogenesis. To analyze its role as an inhibitor of adipogenesis, 3T3‐L1 cells were treated with both ADE and differentiation inducer (DM) at the same time, and then the amount of lipid was quantified. We then analyzed the mRNA and protein expression level of adipogenic or lipogenic genes. The results showed that formation of lipid droplets in differentiated 3T3‐L1 cells was markedly decreased, and triglyceride content was reduced by 22.15% in response to 2000 μg/mL ADE. In addition, ADE downregulated mRNA and protein expression of transcription factors peroxisome proliferator‐activated receptor (PPAR)‐γ and CCAAT/enhancer binding protein (C/EBP)‐α implicated in adipogenesis, and significantly decreased the expression levels of adipocyte fatty acid binding protein (aP2), fatty acid synthase (FAS), stearoyl‐coenzyme desaturase‐1 (SCD1), and lipoprotein lipase (LPL) related to lipogenesis. Our results demonstrate that ADE suppressed adipogenesis and lipogenesis in 3T3‐L1 cells, suggesting that ADE has anti‐obesity activity as a food supplement.

A Case of Colonic Mucinous Adenocarcinoma in 19-year-old Male Patient

정미연,박영숙,Sang Ryul Ryu,안상봉,Seong Hwan Kim,Yunju Jo,Jun Kil Han,Jong Eun Joo 대한소화기내시경학회 2012 Clinical Endoscopy Vol.45 No.1

Colorectal cancer is rare in teenagers, especially without known risk factors. Colon cancer in young age is more likely to be diagnosed at advanced-stage, to present unfavorable tumor histology such as mucinous carcinoma, and poor outcome. We report a case of sporadic mucinous adenocarcinoma of the colon in a 19-year-old male patient without any risk factors. He complained of severe left abdominal pain that developed 1 month ago. He had a distended abdomen with severe tenderness on the left lower quadrant. A distal descending colon mass causing mechanical obstruction was observed on abdominal computed tomography. Emergency colonoscopy showed a large, fungating mass obstructing the lumen at 40 cm from the anal verge. Biopsy of the colonic mass suggested a mucinous adenocarcinoma. After decompression by colonic stent, the patient was transferred to the general surgery department for left hemicolectomy. The lesion was confirmed to be a mucinous adenocarcinoma (7.0×4.5 cm). For hereditary nonpolyposis colorectal cancer evaluation, immunohistochemical staining for MLH1 and MSH2 was normal. Reverse transcription polymerase chain reaction analysis did not detect microinstability in any of the markers tested. The patient had no familial history of cancer. Mucinous adenocarcinoma has high frequencies of poor differentiation, advanced tumor stage, loss of mismatch repair gene expression, and increased MUC2 expression. A mucinous histology is considerably more frequent in children and adolescent than in adults. Adequate invasive study is also necessary for young age patients.