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Single Intravenous-dose Toxicity of Water-soluble Carthami-flos Pharmacopuncture (WCF) in Rats
정다정,육태한,최유민,김석희,김종욱 대한약침학회 2014 Journal of pharmacopuncture Vol.17 No.3
Objectives: This study was performed to analyze the toxicity and to find the lethal dose of the test substance Water-soluble Carthami-flos pharmacopuncture (WCF) when used as a single intravenous-dose in 6-week-old, male and female Sprague-Dawley rats. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices. 20 female and 20 male Spague-Dawley rats were divided into 4 groups of 5 female and 5 male animals per group. The rats in the three experimental groups received single intravenous injections with 0.125-mL, 0.25-mL and 0.5-mL/animal doses of WCF, Groups 2, 3, and 4, respectively, and the control group, Group 1, received a single intravenous injection with a 0.5-mL dose of normal saline. Clinical signs were observed and body weight measurements were carried out for 14 days following the injections. At the end of the observation period, hematology, clinical chemistry, histopathological tests and necropsy were performed on the injected parts. Results: No deaths occurred in any of the groups. Also, no significant changes in body weight, hematological parameters or clinical chemistry test results between the control group and the experimental groups were observed. Visual inspection after necropsy showed no abnormalities. Histopathological tests on the injected parts showed no significant differences, except for Group 1 females; however, the result was spontaneous generation and had no toxicological meaning because it was not dose-dependent. Therefore, this study showed that WCF had no effect on the injected parts in terms of clinical signs, body weight, hematology, clinical chemistry, and necropsy. Conclusion: As a result of single intravenous-dose tests of the test substance WCF in 4 groups of rats, the lethal dose for both males and females exceeded 0.5 mL/animal. Therefore, WCF is a relatively safe pharmacopuncture that can be used for treatment, but further studies should be performed.
Sweet Bee Venom 시술환자 130례에 대한 임상보고
정다정,이형걸,최유민,송범용,육태한,김종욱,Jung, Da Jung,Lee, Hyung Geol,Choi, Yoo Min,Song, Beom Yong,Yook, Tae Han,Kim, Jong Uk 대한침구의학회 2013 대한침구의학회지 Vol.30 No.5
Objectives : The purpose of this study was to prove the clinical safety of Sweet Bee Venom(BV) and observe the physical reaction(percentage of localized itching & pain) after Sweet BV treatment. Methods : This study was carried out on 130 patients who had been injected with Sweet BV in Koran Medicine Hospital of Woosuk University from March 20, 2012 to June 30, 2013. Patients were treated with Sweet BV daily and we checked the physical reaction. After that, we analyzed those according to treatment times and body parts of injection. Results : 37 patients(28.46 %) complained localized itching and 41 patients(31.54 %) complained localized pain after Sweet BV injection. In 37 patients who complained localized itching, 8 patients were experienced itching in the first treatment. And 27 patients were experienced itching in the 1st~5th treatment. Wrist, ankle and toe were the highest percentage of localized itching. Finger was the highest percentage of localized pain. Knee showed a relatively higher percentage of itching, pain, itching & pain than other body parts. Conclusions : This study suggested that Sweet BV treatment was relatively safe treatment and doctors should explain the physical reaction before treating patients. Further studies are needed to propose a guideline for safety and treatment.
7구역진단기의 5구역 정보와 위내시경 소견의 상관성에 관한 연구
정다정,임정균,이형걸,육태한,김종욱,Jung, Jung Da,Im, Jeong Gyun,Lee, Hyung Geol,Yook, Tae Han,Kim, Jong Uk 대한침구의학회 2013 대한침구의학회지 Vol.30 No.1
Objectives : The 7-zone-diagnostic system is a device for predetermining bodily locations by measuring the energy of the living body. The purpose of this study is to examine correlations between gastroscopy results and zone-5 data from the 7-zone-diagnostic system. Methods : This study was carried out with data from gastroscopy procedures. It involved 115 patients who had been diagnosed with gastritis, esophagitis, or gastric ulcers. These patients were divided into three groups according to the different patterns of zone-5 factors AA, FL2 and FL1. Group A was made up of patients for whom the red bar graph of zone-5 was higher than the normal range for factor AA. Group B was made up of patients for whom the red bar graph of zone-5 was within the normal range for factor AA. Group C was made up of patients for whom the red bar graph of zone-5 was lower than the normal range for factor AA. Group D E and F were made up of same way as group A B and C for factor FL2. Group G H and I were made up of same way as group A B and C for factor FL1. After the collection of gastroscopy results and data on zone-5 from the 7-zone-diagnostic system, the data was analyzed statistically. Results : 1. Group D had a higher ratio of medication than group E, and this result was statistically significant. 2. Group D G had a higher ratio of medication than group E G and group E H, and this result was statistically significant. 3. Group G had a higher ratio of esophagitis than group H, and this result was statistically significant. 4. A Group B H had a higher ratio of esophagitis than group B G, group C G, and group C H, and this result was statistically significant. 5. The medication group had a high score on the function index than the non-medication group, and this result was statistically significant. Conclusions : This study suggests that there is a slight correlation between gastroscopy results and zone-5 data from the 7-zone-diagnostic system. The research resulted in significant data that are helpful for diagnosing digestive system problems through the use of the 7-zone-diagnostic system.
Comparison among Three Different Steroid Therapies for Idiopathic Sudden Sensorineural Hearing Loss
정다정,이지훈,유명훈,이규엽 대한이비인후과학회 2020 대한이비인후과학회지 두경부외과학 Vol.63 No.11
Background and Objectives The optimal dose or type of systemic steroid for treating idiopathicsudden sensorineural hearing loss (ISSNHL) is unclear. Herein, we compare the efficacyof three steroid treatment protocols. Subjects and Method We reviewed the medical records of 140 adult ISSNHL patients froma tertiary medical center. The patients were divided into three groups based on their treatmentregimen: Group 1 received intravenous 10 mg/day dexamethasone combined with intratympanic(IT) steroid injection, followed by prednisolone for 5 days after discharge; Group 2 received 10mg/day dexamethasone for 5 days, followed by 5 mg/day for 5 days over a 10-day hospitalizationperiod; and Group 3 received 10 mg/day dexamethasone combined with IT steroid injectionduring a 5-day hospital stay, followed by 5 mg/day dexamethasone for 5 days after discharge. The hearing thresholds were measured using an automatic audiometer at 0.5, 1, 2, 3, 4, and 8kHz. Hearing recovery on Day 90 was categorized according to Siegel’s criteria. Results Univariate and multivariate analyses showed that patients in Group 3 had the lowesthearing thresholds, and the best results for speech reception threshold and speech discriminationscores. The impact of favorable thresholds in Group 3 was better among patients with abaseline average hearing threshold of <70 dB. Complete recovery was more likely in Group 3than in the other groups, based on the odds ratios. Conclusion Administration of dexamethasone-based systemic steroid combined with IT steroidinjection and a relatively long hospitalization period produced the most favorable result.
정다정 한국중국문화학회 2012 中國學論叢 Vol.35 No.-
随着世界经济一体化趋势的加速和全球资本流动的普遍化,以企业合并、收购、兼并为代表的经营者集中的现象成为20世纪下半叶以来世界经济的主旋律之一。 比较韩国与中国的立法,制度大同小异,但考虑各国所处的经济及非经济因素各异,国家规模、经济发展阶段、地理及经济情况等,中国应根据经济情况和政策等,参考其他国家的经验,朝着最大限度减少企业联合对市场竞争导致的弊害,提高效率性及竞争力,增进国民经济及消费者利益的方向,持续完善和利用该法。虽然存在诸多的不同国情,在中韩两国还是存在很多的可比性和相互借鉴性的。中韩两国应当在未来的反垄断法中加强交流和合作,相互学习,求同存异,相信这对两国制度的完善将会得到一个双赢的结果。
Association of Bone Mineral Density With Hearing Impairment in Postmenopausal Women in Korea
정다정,조현호,이규엽 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.4
Objectives. Previous studies examining the association between osteoporosis (OP) and hearing loss (HL) have shown conflicting results. The objective of the present study was to examine the association between hearing impairment and OP in postmenopausal women, using appropriate statistical analyses. Methods. Total 1,009 participants were included in the current study. The propensity score matched (PSM) cohort was defined as the cohort including participants diagnosed with OP and participants without OP. Three statistical models were developed where model 1 was unadjusted, model 2 included age, and model 3 included age, body mass index, alcohol intake, smoking habit, diabetes mellitus, hypertension, high density lipoprotein cholesterol, triglyceride level, vitamin D, and alkaline phosphatase. Results. There were 776 and 233 participants in the groups diagnosed without and with OP, respectively. For propensity score matching, 233 pairs were selected from the 776 participants without OP. In the total cohort, using statistical models 2 and 3, no significant difference in the four hearing thresholds was identified between the 2 groups. Logistic regression indicated that, in model 3, participants with OP had a 1.128 (P=0.323) increased risk HL. A significant HL risk was not observed in participants with OP. Using statistical model 3, there were no significant associations among lumbar spine or femoral neck T-scores and changes in the hearing thresholds. In the PSM cohort, statistical models also showed similar results. Conclusion. The current study did not demonstrate the association between bone mineral density and hearing impairment in the study population of postmenopausal Korean women.
정다정,장정훈,이규엽 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.2
Objectives. The aim of this study was to evaluate whether body mass index (BMI) is associated with age-related hearing loss (ARHL) in the Asian elderly population. Methods. Data from the Korean National Health and Nutrition Examination Survey 2009–2012 were used for the analyses. The pure tones at 0.5 and 1 kHz of both ears of each subject were averaged to obtain the low-frequency, those at 2 and 3 kHz were averaged to obtain the mid-frequency, and those at 4 and 6 kHz were averaged to obtain the high-frequency. The average hearing threshold (AHT) was calculated as pure tone average at 4 frequencies in the better ear. ARHL was defined as the AHT >25 dB. Results. Univariate analyses revealed an increase in the BMI tertile in men was associated with a decreased low-frequency threshold, while an increase in the BMI tertile in women was associated with decreased mid- and high-frequency thresholds. Multivariate analyses adjusted for confounders show no significant differences in low-, mid-, or high-frequency. There was no significant difference in the prevalence of ARHL by BMI tertiles. Linear regression analyses show no association between BMI and low-, mid-, and high-frequency or AHTs. The area under the receiver operating characteristic curve values for AHT was 0.515 in men and 0.522 in women. The logistic regression analyses showed no association between BMI and ARHL in either sex. Conclusion. BMI is not advantageous for the prediction of ARHL. In future epidemiological studies, BMI as a covariate of obesity may be replaced by other active metabolic parameters that have better predictive ability of ARHL than BMI.
어린이 급식소의 효율적인 급식관리를 위한 위생 · 안전지수 · 영양지수 관리 웹 & 앱 프로그램 개발 및 적용
정다정,강현주 대한영양사협회 2020 대한영양사협회 학술지 Vol.26 No.3
The Center for Children’s Foodservice Management periodically visited children’s foodservice facilities for hygiene, safety and nutrition management, and the ‘HSQ (Hygiene Safety Quotient) and NQ (Nutrition Quotient) Management Web & App Program’ was developed and applied to improve the health, safety, and nutrition management status of children’s foodservice facilities. The HSQ is a comprehensive hygiene and safety index consisting of six categories from the hygiene and safety checklist for children’s foodservice facilities provided by the Ministry of Food and Drug Safety. The NQ is a nutrition index for foodservice facilities consisting of five categories from the nutrition checklist. First, this program can be used to efficiently understand the actual conditions of children’s foodservice. Foodservice facilities are provided with the result report prepared by the center without restrictions on time or place. Second, it can be used as “a channel for comfortable communication with foodservice facilities”. Foodservice facilities are provided with a route where questions and resolutions can be communicated to the center. Third, it is easy to compare and review the results of foodservice facilities by institution and number of visits while downloading the results data at the same time, as the result report is written based on hygiene, safety, and nutrition visits. Through such programs, it is believed that standardized work and integrated management will improve the work efficiency of the center’s employees. It is also thought that these programs will promote healthier life-styles in children by establishing a safe food environment for children’s foodservice.
한반도 겨울철 및 봄철 PM<SUB>2.5</SUB> 농도의 통계적 예측
정다정,유창현 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.10
본 연구에서는 다중선형회귀 모형을 개발하여 한반도의 겨울철과 봄철의 PM2.5의 농도에 대한 계절예측을 진행하였다. PM2.5 농도 자료는 서울특별시 보건환경연구원의 25개 관측소와 에어코리아에서 전국 권역별로 선정한 9개의 관측소의 데이터를 연결하여 2005.7 -2019.6 기간에 대해 사용하였다. 계절내 예측의 예측 인자를 추출하기 위하여 대기 순환의 경계조건이 되는 해수면 온도 및 토양 수분이 분석되었으며, 추가적으로 지면 대기 온도가 사용되었다. 한반도의 PM2.5 농도와 1-3개월의 지연상관 관계를 확인하였으며, 지속적으로 강한 상관관계가 나타나는 지역들을 잠재적인 예측 인자로 검증하는 stepwise regression 방법을 적용하였다. 결과적으로 예측 인자 간의 독립성을 검토하여 겨울철 및 봄철에 대하여 각각 2개의 예측 인자를 선정하였고 PM2.5 농도의 추세가 고려되었다. 겨울철 PM2.5 농도의 예측인자로는 적도 대서양의 해수면 온도와 동유럽의 토양 수분을 채택하였고, 봄철 PM2.5 농도의 예측인자로는 북태평양의 해수면 온도와 동아시아의 2미터 상공의 온도를 채택하였다. 해당 예측 인자들은 한반도 지역 남서풍을 유도하고 한반도 풍하측 지역 고기압 형태 순환장을 형성하였다. 개발된 다중선형회귀 모형은 1-3개월 선행시간에 대해서까지 겨울철은 0.93, 0.89, 0.73, 봄철은 0.92, 0.89, 0.76의 높은 예측 성능을 보였다. 본 연구에서는 한반도의 겨울철 및 봄철 평균 PM2.5 농도에 대하여 높은 성능의 통계적 계절 예측이 가능함을 제시하였다. 또한 기후 변동 및 변화가 한반도 미래 대기질의 변화에 중요한 요소임을 시사한다.