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        • 여우원숭이속(Lepilemuridae)의 핵형 분석을 통해 나타난 Lepilemur edwardsi와 Lepilemur-ruficaudatus 염색체의 기원

          정기윤 순천향대학교 기초과학연구소 2000 순천향자연과학연구 Vol.6 No.2

          The aim of this study was to test the validity of the hypothesis that the karyotypes of four species of Lepilemuridae were formed spontaniously from their ancestral hybrid karyotype. Hypothetical ancestral haploid Karyotype of Lepilemuridae is composed of 18 autosomes and X chromosomes. Lepilemur mustelinus(LMU) karyotype has four tendomly fused chromosomes and one Robertsonian translocated chromosome pairs Lepilemur septentrionalisis septentrionalisis(LSS) karyotype has only two pairs of translocated chromosomes. We reconstruct and suggest ancestral karyotype of LMU(ancLMU) and LSS(ancLSS), from which all four studied species of Lepilemuridae were derived. Hybrids of ancLMU and ancLSS were formed and produce differently fused equillibrated gametes via circular form arrangement during gametogenesis. Seven homologous chromosome pairs were engaged in circular form to form haploid karyotype of Lepilemur ruficaudatus. Only one homologous chromosome pair is disociated and the other chromosome pairs rearranged in the circle to form haploid karyotype of Lepilemur edwardsi. The new gametes can be produced from these circular forms. When the new gamete fertilized with the same type of gamate, The new homozygote is produced as existing Lepilemur edwardsi and Lepilemur ruficaudatus. These results support the theory that new species can be formed in hybrid population through activated chromosome fusion, chromosome rearrangement in circular form at zygotene stage and production of equilibrated gametes to form homozygote new species.

        • SCOPUSKCI등재

          Lemur 진화 과정동안 일어난 Robertsonian Translocation 의 Stromelysine Ⅱ DNA 단편을 이용한 in situ hybridization 에 의한 확인

          정기윤 한국유전학회 1994 Genes & Genomics Vol.16 No.1

          A human Stromelysine II gene derived cDNA was used as a probe for in situ hybridization to the chromosome of the three lemur species. Eulemur fulvus myottensis. Eulemur macaco and Eulemur coronatus. This sequence, a member of collagenase gene famaly locating in cluster at human chromosome 11q23-25. was found on homologous bands of three morphologically similar chromosomes segments. Eulemur fulvus, Eulemur macaco and Eulemur coronatus, confirming that different Robertsonian translocation occured during the evolution of theme three species. The Stromelysine II gene is located at q21-23 of the ancestor chromosome 5 of lemurien.

        • SCOPUSKCI등재

          Prosimian 진화에 있어서 미세하게 일어난 염색체 translocation 의 in situ hybridization 을 이용한 추적

          정기윤 한국유전학회 1994 Genes & Genomics Vol.16 No.1

          Chromlsomal in situ hybridization with radioactive probes allows the detection of small chromosomal rearrangement which were undetectable with other cytogenetic method. In two species of Lemurien ; Microcebus murinus and Eulemur fulvus, the banding patterns of Microcebus murinus chromosome 3 and Eulemur fulvus chromosome 2 demonstrates very simillar ones. excepting position of centromeres. In situ hybrdization with beta-nerve growth factor probes on the chromosomal preparations of these two species detected intra-chromosomal pericentric inversion during chromsomal evolution.

        • KCI등재

          입원 환자를 대상으로 한 체계적 금연 교육과 금연 성공률

          정기윤,유상호,마승현,윤종률,김미영,홍선형,이윤상,심은영 대한가정의학회 2009 Korean Journal of Family Medicine Vol.30 No.7

          Background: Inpatient smoking cessation programs have been known to be quite effective for smoking cessation, but it was rarely conducted among Koreans. This study was to investigate the effect of inpatient smoking cessation program among Korean smokers. Methods: From March 1 to April 30, 2008, we carried out a randomized controlled trial for inpatient smoking cessation program among 70 smokers who were 18 years of age or over and admitted to a university hospital in Seoul, Korea. For the intervention group, a trained doctor conducted the systematic educational program for smoking cessation of 30 minutes to an hour. For the control group, they were advised with a 3-minute explanation for smoking cessation. We assessed the abstinence rates of study participants at 1 week, 1 month, and 3 months after discharge. Results: In 3 months after the discharge, the abstinence rate for the intervention group was 37.1% while that of the control group was 14.3%. In simple logistic regression analysis, the smokers among the intervention group were 3.5 times more likely to abstain than those in the control group. After controlling for confounding factors, the smokers among the intervention group was 11.4 times more likely to abstain than those in the control group. Conclusion: For Korean smokers, the inpatient smoking cessation program showed a higher success rate of abstinence compared to simple advice and limited counselling. 연구배경: 흡연이 주요 질병과 사망의 원인으로 널리 알려져 있음에도 불구하고, 우리나라 성인 흡연율은 세계최고 수준 이다. 외국에는 입원 환자를 대상으로 한 체계적인 금연 교육 의 효과를 평가한 연구 결과가 다수 있으나, 국내에는 거의 없 다. 이에 본 연구에서는 입원 환자를 대상으로 한 체계적 금연 교육이 금연 성공에 미치는 효과를 알아보기 위해 권고 수준 의 최소 금연 교육과 비교해 보았다. 방법: 2008년 3월 1일부터 4월 30일까지 일개 대학 병원에 입 원하였던 18세 이상의 환자 중 흡연 중이며, 금연 교육이 가능 한 70명을 대상으로 설문과 교육을 포함하는 무작위 대조 연 구를 시행하였다. 금연 교육은 입원 중에 실시하는 1회의 대면 교육과 퇴원 후 3개월 동안 실시하는 총 3회의 전화 상담으로 구성되었다. 퇴원 후 1주, 1개월 및 3개월째 금연 성공을 전화 설문으로 평가하였다. 결과: 퇴원 후 3개월째 시험군인 체계적 금연 교육군의 금연 성공률(37.1%)은 대조군인 최소 금연 교육군의 금연 성공률 (14.3%)보다 유의하게 높았다(P=0.029). 단순 로지스틱 회귀 분석 결과, 시험군이 금연에 성공할 교차비는 대조군과 비교 하여 3.5배(95% CI, 1.10-11.41) 높았으며, 다중 로지스틱 회귀 분석 결과, 시험군이 금연에 성공할 교차비는 대조군과 비교 하여 11.4배(95% CI, 1.38-99.61) 높았다. 결론: 입원 환자를 대상으로 한 체계적 금연 교육은 권고 수준 의 최소 금연 교육과 비교하여 높은 금연 성공률을 보였다.

        • 여우원숭이속(Lepilemuridae)의 핵형 비교 분석을 통해 나타난Lepilemur dorsalis와 Lepilemur leucopus의 종분화 양상

          정기윤 순천향대학교 기초과학연구소 1998 순천향자연과학연구 Vol.4 No.1

          The aim of this study was to test the validity of the hypothesis that the karyotype of four species of Lepilemuridae were formed spontaniously from their ancestral hybrid karyotype. Hypothetical ancestral haploid Karyotype of Lepilemuridae is composed of 18 autosomes and X chromosomes. Lepilemur mustelinus(LMU) karyotype has four tendomly fused chromosomes and one Robertsonian translocated chromosome pairs otherwise Lepilemur septentrionalisis septentrionalisis (LSS) karyotype has only two pairs of translocated chromosomes. we reconstruct and suggest ancestral karyotype of LMU (ancLMU) and LSS (ancLSS), from which all four studied species of Lepilemuridae were derived. Hybrids of ancLMU and ancLSS were formed and produce differently fused equilibrated gametes via circular form arrangement during gametogenesis. To form Lepilemur leucopus haploid karyotype five homologous chromosome pairs were engaged in circular form arrangement. To form Lepilemur dorsalis haploid karyotype, only one homologous chromosome pair is arranged in other orientation at position in the same circle. When the new gamete fertilized with the same type of gamate to produce the new homozygote as existing Lepilemur dorsalis and Lepilemur leucopus. These results supports the speciation theory that new species can be formed in hybrid population through activated chromosome fusion, chromosome rearrangement in circular form at zygotene stage and production of equilibrated gametes to form homozygote new species.

        • SCOPUSKCI등재

          여우원숭이속의 핵형 비교 분석을 통해 나타난 새로운 종 분화 양상

          정기윤 한국유전학회 1997 Genes & Genomics Vol.19 No.1

          Karyotype of six species and subspecies in genus Lamur (Eulemur) were analyzed comparatively. All the metacentric chromosomes in each (sub)species were composed of same chromosome arms but the combination mode of arms for metacentric chromosomes in each (sub)species were totally different besides two haploid chromosomes which are identical in all six (sub)species. Speciation mode of these species is proposed. In genus Eulemur, hybrid of Eulemur fulvus fulvus and Eulemur macaco macaco was formed and produced equillibrated new-gametes which are formed by centromeric fusion followed circular form arrangement at pachytene stage. In circular form arrangement due to centromeric fusion, the chromosome members can be combinated differently to form another circular arrangement. Some of many circular forms can give fertile new gametes corresponding to the haploid karyotype of pre-species. When new gamete fertilized with the same type of gamete to produce new homozygote (pre-species), additional chromosomal rearrangements were followed to produce karyotypes of existing Eulemur species. Due to these complementing rearrangement, each new species are differentiated from their ancestral species.

        • SCOPUSKCI등재

          여우원숭이 속(Lemuridae)의 핵형 분석을 통해 나타난 Eulemur macaco 의 종 분화 기전

          정기윤 한국유전학회 2000 Genes & Genomics Vol.22 No.1

          The karyotypes of four species of Eulemur were known to be formed spontaneously from hybrid population of Eulemur macaco and Eulemur fulvus. This research is to elucidate speciation mechanism of Eulemur macaco and Eulemur fulvus. Based on the results of the karyotype analysis, Eulemur macaco karyotype might be formed from hybrid population of Eulemur fulvus and Varecia variegara. Ten metacentric chromosomes of Varecia variegate could be arranged in a circular form by pairing with 18 homologous acrocentric chromosomes of Eulemur fulvus. The other chromosomes might be arranged bivalently for normal segregation at pachytene stage during meiosis. For circularly rearranged chromosomes, neighboring chromosomes originated from Eulemur fulvus might be fused to form metacentric chromosomes of Eulemur macaco. After equilibrated gametogenesis, newly fused metacantric chromosomes could reside in the hybrid population until being fertilized with the same type of gamete. This homozygote seems to be developed in pre-macaco. It is suggested that a subsequent additional fission has occurred to give existing Eulemur macaco karyotype, meaning that F2+2 chromosome is fissioned to give F2 and 2.

        • KCI등재

          여우원숭이속(Lepilemuridae)의 핵형 분석을 통해 나타난 Lepilemur 6종(L. mustelinus, L. dewardsi, L. dorsalis, L. leucopus, L. ruficaudatus, L. septentrionalis)의 종 분화 양상

          정기윤 한국산학기술학회 2004 한국산학기술학회논문지 Vol.5 No.2

          이 연구의 목적은 Lepilemuridae(여우원숭이속) 4종의 핵형은 그들의 선조격인 두 종의 교잡된 핵형으로부터 형성되었음을 검증하는데 목적이 있다. 여우원숭이 속의 가상적인 선조종의 반수체 핵형은 18개의 상염색체와 x염색체로 구성된다. L. mustelinus(LMU}의 핵형은 염색체 4개가 연속적으로 융합된 염색체와 하나의 Robertsonian 전이 염색체 쌍을 가진다. LSS의 핵형은 단지 2쌍의 상호전위된 염색체를 가지고 있다. 우리들은 LMU와 LSS의 조상핵형(ane LMU and ane LSS)을 재구성할 수 있었고, 그로부터 다른 4종의 Lepilemur가 생성될 수 있었다. ane LMU 와 ane LSS의 교잡종은 배우자 형성시 환형의 배치를 거치면서 전혀 다른 형태로 융합된 유전적으로 완전한 배우자를 형성할 수 있다. L. dorsalis의 핵형이 구성되기 위해서는 교잡종의 5조의 Trivalent염색체가 감수분열 중기에 환의 모양으로 배열되면서 인접한 단부동원체들이 융합되어 새로운 핵형인 L. dorsalis의 핵형이 만들어진다. L. leucopus의 핵형은 위와 같이 환모양을 구성하기 위해 배열된 Trivalent 염색체 조들 중에서 단지 한 조가 먼저와 다른 방향으로 환속에 위치하게 되므로써 이웃한 단부동원체들이 융합되어 L. leucopus의 핵형을 형성한다. L. ruficaudatus의 반수체 핵형이 만들어 지는 데에는 환으로 배열될 때 7개의 상동염색체 쌍이 배열되고 이웃하는 단부동원체들의 융합에 의해 새로운 조합으로 된 L. ruficaudatus의 반수체 핵형이 형성된다. L. edwardsi의 반수체 배우자가 형성될 때는 LRE가 만들어 질 때의 환형에서 단지 하나의 삼동염색체 쌍이 분리되므로써 LED의 반수체 핵형이 생성된다. 이러한 기전에 의해서 만들어진 새로운 완전한 배우체들은 동일한 형태의 배우자와 수정되므로써 새로운 상동염색체를 가진 종 L. dorsalis, L. leucopus, L. ruficaudatus, L. edwardsi가 형성되었다. 이 결과들은 유전 적으로 완전한 새로운 종이 교잡종의 군집으로부터 활성화된 염색체들의 융합, 접합기에서 환형으로의 배열 기전을 통해 형성될 수 있다는 이론을 뒷받침한다. The aim of this study was to test the validity of the hypothesis that the karyotypes of four species of Lepilemuridae were formed spontaneously from their ancestral hybrid karyotype. Hypothetical ancestral haploid Karyotype of Lepilemuridae is composed of 18 auto somes and X chromosomes. Lepilemur mustelinus karyotype has four tandem fused chromosomes and one Robertsonian translocated chromosome pairs. Lepilemur septentrionalis septentrionalis karyotype has only two pairs of translocated chromosomes. We reconstruct and suggest ancestral karyotype of LMU(ancLMU) and LSS(ancLSS), from which all four studied species were derived. Hybrids of ancLMU and ancLSS were formed and produce differently fused equilibrated gametes via circular form arrangement during gametogenesis. Five unit of trivalent homologous chromosome pairs were engaged in a circular form to give new gamete corresponding to the karyotype of L. dorsalis, orientation of one unit of trivalent was inversed in the circle to gave new gamete corresponding to the karyotype of L. leucopus. Seven homologous chromosome pairs were engaged in circular form to give haploid karyotype of Lepilemur ruficaudatus. Only one homologous chromosome pair is dissociated and the other chromosome pairs rearranged in the circle to form haploid karyotype of Lepilemur edwardsi. The new gametes could be produced from these circular forms. When the new gamete fertilized with the same type of gamete, The new homozygote is produced as existing L. dorsalis, L. leucopus, L. edwardsi and L. ruficaudatus. These results support the theory that new species could be formed in hybrid population through activated chromosome fusion, chromosome rearrangement in circular form at zygotene stage and production of equilibrated gametes to form homozygote new species.

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