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        • KCI등재

          라만분광학의 바이오메디컬 응용

          정경복 한국물리학회 2017 New Physics: Sae Mulli Vol.67 No.6

          Raman spectroscopy has attracted great interest as a powerful analytical tool that can be used to detect changes in the structure and the composition of biological samples (cells, tissues, biofluids, etc.) at the molecular level. Its high sensitivity and specificity, a small amount of sample preparation, and non- or minimally-invasive use have recently led to an increase in the number of biomedical applications of Raman spectroscopy. This paper reviews the recent biomedical applications of Raman spectroscopy, which are considered to be multi-functional and powerful toolkits for probing the biochemical properties of biomedical samples in medical science. The basic principles of Raman spectroscopy and surface-enhanced Raman scattering (SERS) are briefly introduced. Furthermore, the biomedical applications of Raman spectroscopy, including diagnostic assessment (orthodontic tooth movement), pharmacotherapy (antibiotic effect, cytotoxicity of tissue adhesive), medical device therapy (collagen cross-linking treatment for the restrain of progressive myopia), and finally in-vivo Raman diagnosis, are described. 라만 분광법은 분자수준에서 바이오 샘플 (세포, 조직, 체액 등)의 구조 및 조성 변화를 감지하는데 사용할 수 있는 강력한 분석 도구로써 매우 큰 관심을 모으고 있다. 높은 민감도와 특이성, 적은 양의 샘플준비, 비침습성 방법은 최근 라만 분광학의 바이오메디칼 응용의 증가로 이어졌다. 본 논문에서는 바이오 샘플의 생화학적 특성을 조사하기 위하여 다기능적이고 강력한 툴킷으로 간주되는 라만 분광학의 바이오메디칼 응용을 리뷰하였다. 라만 분광법과 표면증강라만산란 (surface enhanced Raman scattering, SERS)의 기본 원리를 소개하였고, 이를 이용한 바이오메디칼 응용: 진단 (치아교정 과정에서의 치아이동), 약물평가 (항생제 효과, 생체접착제의 세포 독성) 및 의료기기 요법 (근시 억제를 위한 콜라겐 교차 결합 치료), 라만진단 등의 라만분광학의 다양한 바이오메디칼 응용을 논하였다.

        • 低周波 電磁場 속에서 불활성 기체 원자에 의한 電子의 산란단면적

          정경복,장차익,최승평 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

          The scattering cross section is the physical quantity which is susceptible of a reasonably direct experimental measurement and which at the same time lends itself readily to calculation, and which establish contact between scattering theory and scattering experiment to assist each other. We have calculated one-photon free-free absorption cross sections without target distortion at the frequencies of the CO_2, Nd, and ruby lasers, for targets consisting of the ground states of He, Ne, Ar. The calculations yield total cross sections averaged over all orientations of the polarzation, which is taken to be linear. Electron energies are in the range up to about 13 eV. The atomic potential used to represent the interaction of the atom in our calculation is the same one that is replaced atom by the potential used by Robinsion and Geltman in the evaluation of photodetachment cross-sections. We used the Numerov method for numerical integration of our differential equations. This method appears to be most efficient numerical intergration scheme available for second-order differential equations with the first derivative absent.

        • KCI등재

          Physicochemical and surface properties of acrylic intraocular lenses and their clinical significance

          정경복,진경현,박헌국 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.5

          To analyze and compare several commercially available acrylic intraocular lenses (IOLs) with particular regard to their clinical significance, we examined the physicochemical and surface properties of four currently available acrylic IOLs using static water contact angle, atomic force microscopy (AFM), Raman spectroscopy, and differential scanning calorimetry (DSC) measurements. The hydrophobic acrylic IOLs, ZA9003, and MA60BM, had contact angles ranging from 77.9° ± 0.65° to 84.4° ± 0.09°. The contact angles in the hydrophilic acrylic (970C) and heparin-surface-modified (HSM) hydrophilic acrylic IOLs (BioVue) were 61.8° ± 0.45° and 69.7° ± 0.76°, respectively. The roughness of the IOL optic surface differed depending on the type of IOL (p < 0.001). The surface roughness of BioVue had the lowest value: 5.87 ± 1.26 nm. This suggests that the BioVue IOL may lead to reduced cellular adhesion compared to the unmodified IOLs. All IOLs including those composed of acrylic optic materials from different manufacturers showed distinct Raman spectra peaks. The glass transition temperatures ( Tg) for the hydrophobic acrylic IOLs were between 12.5 and 13.8 °C. These results suggest that the intraoperative and postoperative behavior of an IOL can be predicted. This information is also expected to contribute greatly to the industrial production of reliable biocompatible IOLs.

        • KCI등재

          Label-free Noninvasive Characterization of Osteoclast Differentiation Using Raman Spectroscopy Coupled with Multivariate Analysis

          정경복,강인순,이영주,김도현,박헌국,이기자,김채균 한국광학회 2017 Current Optics and Photonics Vol.1 No.4

          Multinucleated bone resorptive osteoclasts differentiate from bone marrow-derived monocyte/macrophageprecursor cells. During osteoclast differentiation, mononuclear pre-osteoclasts change their morphology andbiochemical characteristics. In this study, Raman spectroscopy with multivariate techniques such asPrincipal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) were used to extractbiochemical information related to various cellular events during osteoclastogenesis. This technique allowedfor label-free and noninvasive monitoring of differentiating cells, and clearly discriminated four differenttime points during osteoclast differentiation. The Raman band intensity showed significant time-dependentchanges that increased up to day 4. The results of Raman spectroscopy agreed with results from atomicforce microscopy (AFM) and tartrate-resistant acid phosphatase (TRAP) staining, a conventional biologicalassay. Under AFM, normal spindle-like mononuclear pre-osteoclasts became round and smaller at day 2after treatment with a receptor activator of nuclear factor-κB ligand and they formed multinucleated giantcells at day 4. Thus, Raman spectroscopy, in combination with PCA-LDA, may be useful for noninvasivelabel-free quality assessment of cell status during osteoclast differentiation, enabling more efficientoptimization of the bioprocesses.

        • KCI등재
        • KCI등재

          패션페인팅(Fashion Painting)을 이용한 의상디자인 연구

          정경복,이정희 복식문화학회 2010 服飾文化硏究 Vol.18 No.1

          In modern society as people adapt to social and cultural changes, people prefer high-scarcity designed products rather than standardized ones. Consequently, this adaptation lays a foundation in art and cultural domains to express uniqueness and individuality. The purpose of this study is to develop fashion designs by fusing fashion painting and handicraft techniques through creative and various artistic expressions. The researchers studied the sociocultural background of modern handicraft fashion using document-based research methods. Based on the characteristics of modern handicraft, we produced six garments that applied fashion painting techniques. In this study, the origin of fashion painting was found in ornaments such as tattoo or body-painting. We determined that modern designers were using various fashion painting techniques and motives as unique and advanced ornamentary skills. Harmonizing various handicraft techniques(dyeing, embroidery, quilt, patchwork, beads, fashion painting, etc.) centered on fashion painting enabled creation of unique fashion design through varieties of artistic expressions.

        • KCI등재

          SERS-Based Sandwich Immunoassay for Alzheimer’s Disease Biomarker Detection Using Antibody Conjugated Magnetic Nanoparticles

          백성진,정경복,이예론,박정희 한국물리학회 2019 New Physics: Sae Mulli Vol.69 No.7

          Surface-enhanced Raman scattering (SERS)-based immunoassays have been developed for fast and ultrasensitive detection of biomarkers. In this study, we report a SERS-based sandwich immunoassay for the detection of the Alzheimer’s disease biomarker amyloid(A). A method combining magnetic separation and SERS was developed to detection of A. Gold-coated magnetic nanoparticles (Fe3O4@Au MNPs) were prepared by immobilizing anti-A antibodies and was used in the separation and the concentration of the A. Gold nanoparticles (Au NPs) were modified with detection antibodies, and antibody-conjugated Au NPs were labeled with 3, 3, diethylthiatricarbocyanine iodide (DTTC), as the SERS probes. The correlation between the A concentration and the SERS signal was found to be linear within the range from 1 fM to 1 M. As a result, we were able to detect A with a much lower limit of 1 fM. This technique allows for straightforward SERS-based bioassays for the quantitative detection of biomarkers and has potential for clinical applications.

        • KCI등재

          Effects of Pr Concentration and Annealing Temperature on the Structural and Optical Properties of Y2O3:Pr3+ Nanopowders by High-energy Ball-milling

          조기표,정경복 한국물리학회 2021 New Physics: Sae Mulli Vol.71 No.7

          Pr3+-doped Y2O3 powders were synthesized using high-energy ball milling. Their structural and photoluminescence properties were investigated as functions of the concentration of the praseodymium and the annealing temperatures. The X-ray diffraction peaks of the Y2O3:Pr3+ powders matched the standard X-ray diffraction(XRD) peaks of the cubic Y2O3 phase without impurities well. The intensity of the XRD peak increased with increasing annealing temperature, as did the photoluminescence emission intensity. These results indicate that the crystallinity of the powder improved with increasng annealing temperature. The highest PL emission intensity was observed at an annealing temperature of 1200 ◦C and Pr3+ concentration of 0.1 mol%. The PL spectra showed characteristic peaks at 618 (3P0 ! 3H6), 630 (2D1 ! 3H4), 644 (3P0 ! 3F2), and 509 nm (3P0 ! 3H5) at an excitation wavelength of 285 nm.

        • KCI등재

          고성능 PVK계 광굴절 고분자 복합체

          장차익,양회룡,정경복,최승평 한국물리학회 2004 New Physics: Sae Mulli Vol.49 No.4

          A diraction eciency of nearly 100 % with a 100 m thick sample has been reported for acomposite of a hole-transporting polymer, poly (n-vinyl carbazole) (PVK), doped with DMNPAA, ECZ, and TNF. However, there are two drawbacks to this material. One is the short lifetime caused by crystallization. BisCzPro can be used as a plasticizer instead of ECZ to avoid the crystallization. The other issue is the slow response. The photorefractive time constant is typically on the order of 100 ms to seconds at a recording beam intensity of 1 W/cm2 under moderate external electric eld. In this research, by modifying the structure of DMNPAA, we developed new photorefractive polymer composites that have fast response time constants on the order of 10 ms and high diraction eciency . The idea is that if the structure of the NLO is modied to have exible side chains, the NLO becomes much more mobile in an electrical eld without reducing the of large anisotropy in the polarizability. Alkyl groups are substituted in DMNPAA to realize this idea. Rahn et al. reported that the substitution of alkyl can enhance the birerngence of chromophores. We synthesized several new NLOs and measured the response rate of the reorientation and the induced birefringence. We also discuss the inuence of the dispersivity and the glass transition temperature on the rapidity of the reorientation rate in the modied NLOs.

        • KCI등재

          원자현미경을 이용한 마이토마이신 노출 시간에 따른 공막 표면 콜라젠의 변화 관찰

          이희재,최삼진,정유진,정경복,진경현,박헌국,이승준,Hui-Jae Lee,MD,Samjin Choi,PhD,Youjin Cheong,MD,PhD Candidate,Gyeong Bok Jung,PhD,Kyung-Hyun Jin,MD,Hun-Kuk Park,MD,PhD,Seung Jun Lee,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.6

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Purpose: To investigate the effects of mitomycin C on the scleral collagen surfaces using atomic force microscopy (AFM). Methods: Two non-contact mode AFM machines were used to observe changes in the morphological characteristics of human scleral surfaces before and after one, three, and five minutes of 0.02% mitomycin C application. Based on AFM topography and deflection images of the collagen fibril, the morphological characteristics of scleral fibrils including the fibril diameter and D-period were measured using the line profile. Results: The sclera collagen fibril treated with 0.02% mitomycin C for one minute did not show any significant increases in mean fibril diameter (155.04 ± 17.46 nm) or mean D-periodicity (70.02 ± 3.33 nm), compared to those of the control group. However, the scleral collagen fibrils treated with 0.02% mitomycin C for three and five minutes showed significant increases in mean fibril diameter (182.33 ± 16.33 nm, 199.20 ± 12.40 nm, respectively) and mean D-periodicity (70.27 ± 13.66 nm, 72.75 ± 19.32 nm, respectively), compared to those of the control group. Conclusions: The present study examined the structural changes in the scleral collagen fibrils before and after mitomycin C application according to atomic force microscopy. The results indirectly suggest that three or more minutes of 0.02% mitomycin C application affects the morphology of scleral collagen. J Korean Ophthalmol Soc 2011;52(6):671-678

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