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Fyn Tyrosine Kinase-mediated Tyrosine Phosphorylation of Roundabout (Robo), the Slit Receptor
전은숙(Eun Sook Jeon),배기원(Kee Won Bae),박환태(Hwan Tae Park) 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.3
본 연구에서는 Slit의 세포막 수용체인 Roundabout (Robo)의 tyrosine 인산화의 분자적 기전을 연구하였다. Human embryonic kidney 세포에 인위적으로 발현시킨 Robo의 tyrosine 인산화는 tyrosine phosphatase 억제제의 처리에 의해 증가 되었으며, src family kinase의 억제제인 PP2의 처리에 의해 감소하였다. 활성화된 형태의 Fyn tyrosine kinase (Fyn)를 Robo와 함께 발현시켰을 때 Robo의 tyrosine 인산화의 증가가 관찰되었으나, 비활성 형태의 Fyn은 인산화를 증가 시키지 못하였다. 또한, 인산화된 tyrosine기에 결합하는 Fyn SH2도메인이 Robo와 결합함이 관찰되었으며 이 결합은 tyrosine phosphatase 억제제의 처리에 의해 증가되었다. 따라서 이러한 결과는 Robo의 tyrosine 인산화가 Fyn에 의해 매개됨을 시사한다. In this study, the molecular mechanism of tyrosine phosphorylation of Roundabout (Robo), the transmembrane receptor for slits, was investigated. The tyrosine phosphorylation of intracellular portion of Robo was increased by the treatment of tyrosine phosphatase inhibitors in human embryonic kidney cells transfected with Robo. The Robo tyrosine phosphorylation was inhibited by the treatment of Src family kinase inhibitor, PP2. The co-transfection of constitutively active form of Fyn, not the dominant negative form of Fyn, and Robo dramatically enhanced the tyrosine phosphorylation of Robo. Furthermore, the SH2 domain of Fyn, which binds to phosphorylated tyrosine residues, interact with Robo, and the interaction was increased by the inhibition of tyrosine phosphatases. These findings indicate that the tyrosine phosphorylation of Robo is regulated by Fyn.
치과위생사의 스켈링 작업 시 발현되는 두경부 및 견부 주위 근육들의 표면 근전도를 이용한 특성 분석
전은숙 ( Eun Suk Jeon ),남건우 ( Kun Woo Nam ),하미숙 ( Mi Sook Ha ) 한국치위생과학회 2012 치위생과학회지 Vol.12 No.4
The current research examines the aching part and the muscle activity that happens during scaling practice subject to 20 dental hygienic students and therefore propose a basic data according to the working attitude of the Dental Hygienist. During the scaling we used the free EMG (BTS Inc., Milan, Italy) to measure the muscle activity, and in order to check the musculoskeletal pain area we used the Nordic-style questionnaire, and the measured research results are as following: At the moment of scaling according to posture the occurrence of the pain showed no difference among the groups elbow, back, leg, knee, ankle/foot but in the neck, shoulder, wrist/hand, waist showed a high difference in the degree of pain according to posture. Results from measuring the muscular activity according to posture, in the group that had a good posture, the trapezius and brachial muscles showed a change according to time, and in the group that had a bad posture a high muscle activity was shown in larynx, trapezius and brachial muscles. In the muscle activity, the changing aspect between the two parts, the group that fulfilled a scaling in a good posture showed a low muscle activity, but in the group that fulfilled the scaling in a bad posture the muscle activity increased excessively. Therefore we examined that when fulfilling a scaling maintaining a bad posture can help in using more effectively the activity of the muscle, in the future I think there is a need to raise the office efficiency by subjecting to dental hyginiest that are in the clinics and performing experiments.
인공수정시술주기에서 내인성 LH, GnRH Agonist 및 hCG를 이용한 배란유발후 임신율의 비교연구
이종인,허영문,전은숙,윤정임,정구성,홍기언,유승환,이현숙,홍정의,이지삼,Lee, Jong-In,Hur, Young-Mun,Jeon, Eun-Suk,Yoon, Jeong-Im,Jung, Goo-Sung,Hong, Ki-Eon,You, Seung-Hwan,Lee, Hyeon-Sook,Hong, Jeong-Eui,Lee, Ji-Sam 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3
Objective: This study was designed to evaluate the effects of endogenous LH surge, GnRH agonist (GnRH-a) or human chorionic gonadotropin (hCG) as ovulation trigger on pregnancy rate by intrauterine insemination (IUI). Method: Patients received daily 100 mg of clomiphene citrate (CC) for 5 days starting on the third day of the menstrual cycle followed by human menopausal gonadotropin (hMG) for ovulation induction. Follicles larger than >16 mm in diameter were present in the ovary, frequent LH tests in urine were introduced to detect an endogenous LH surge. Final follicular maturation and ovulation were induced by GnRH-a 0.1 mg (s.c.) or hCG $5,000{\sim}10,000$ IU (i.m.) administration except natural ovulation. Pregnancy was classified as clinical if a gestational sac or fetal cardiac activity was seen on ultrasound. Results: There were no differences in age, duration of infertility and follicle size, but more ampules of hMG were used in GnRH-a group compared to hCG 10,000 IU treated group (p<0.05). Lower level of estradiol ($E_2$) on the day of hCG or GnRH-a injection was observed in hCG 10,000 IU group than other treatment groups (p<0.01). The overall clinical pregnancy rate was 19.8% per cycle (32/162) and 22.2% per patient (32/144). Pregnancy rate was higher in natural-endogenous LH surge group (37.5%, 9/24) than GnRH-a (18.8%) or hCG treated group (20.9% & 13.9%), but this difference was not statistically significant. No patient developed ovarian hyperstimulation. Abortion rate was 22.2% (2/9) in hCG 5,000 IU group. Delivery or ongoing pregnancy rate was 37.5% (9/24), 18.8% (3/16), 16.3% (7/43) and 13.9% (11/79) in endogenous LH surge, GnRH-a, hCG 5,000 IU and hCG 10,000 IU treatment groups, respectively. Conclusion: These results support the concept that use of natural-endogenous LH surge in stimulated cycles may be more effective to obtain pregnancies by IUI than GnRH-a or hCG administration.