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박순효 ( Sun Hyo Park ),전영준 ( Yong June Jeon ),권건영 ( Kun Young Kwon ),한승범 ( Seung Beom Han ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.1
The spontaneous regression (SR) of cancer is defined as the complete disappearance of a malignant disease without adequate treatment. SR is a very rare biological event, particularly in a pulmonary sarcoma. We report the first documented case of an endobronchial sarcoma that regressed spontaneously in Korea. We encountered a rare case of a 72-year-old woman with an undiagnosed intrapelvic cystic mass, who presented with a smooth surfaced endobronchial tumor obstructing the orifice of the right lower lobe bronchus on a bronchoscopic examination. She had a prior history cervical cancer and adenocarcinoma in the right middle lobe lateral segment of her lung for which she had undergone radiation therapy. The tumor was diagnosed as an endobronchial sarcoma by the histopathology findings and immunohistochemistry. It was unclear if the tumor was a primary sarcoma of the lung or a metastatic lesion of an intrapelvic cystic mass because she refused a diagnostic exploratory laparotomy. Two months later, obstructive pneumonia of the right lower lobe with parapneumonic effusion developed with fever above 38.5℃ for 10 days. After recovering from pneumonia, she was followed up regularly in the outpatient clinic without any specific treatment. One year later after treating the obstructive pneumonia, the follow-up bronchoscopy revealed complete SR of endobronchial sarcoma. It is believed that the obstructive pneumonia accompanied by fever above 38.5℃ for 10 days might have played a role in this SR. (Tuberc Respir Dis 2007; 63: 94-99)
이준호(Jun Ho Lee),김경찬(Kyung Chan Kim),한승범(Seung Bum Han),전영준(Young June Jeon),박기수(Ki Soo Park),김창호(Chang Ho Kim),박재용(Jae Yong Park),정태훈(Tae Hoon Jung),조영복(Young Bok Jo),정진홍(Jin Hong Chung),이관호(Kwan Ho L 대한내과학회 1997 대한내과학회지 Vol.53 No.5
N/A Objectives: Mediastinal tumors are not uncommon but almost half of them are asymptomatic because of the potential space of the mediastinum. Recently owing to the routine screening chest roentgenography and frequent chest CT scans the incidence have increased. Mediastinal masses are both benign or malignant. Even benign masses may continue to enlarge and compromise vital organ function or rupture, bleed, and become infected. Mediastinal tumors have their own predilection site. There are different incidences of these masses in adults and children, sexes, and there may be difference in incidence between races. There are only a few reports about these tumors in Korea, and we are interested in the clinical manifestations of mediastinal tumors in Korea, Methods: We retrospectively reviewed medical records of 286 cases of mediastinal tumors which were pathologically confirmed at Keimyung, Kyungpook, and Yeungnam University Hospital in Taegu from 1985 to 1994 but excluded metastatic lesion, tuberculosis, and tumor originated from esophagus, heart, and large vessels. Results: Mediastinal tumors were more frequent in male(60.8%) than female and age distribution was relatively even. Thymoma was most common mediastinal tumor(107 cases, 37.4%). The most common tumor in anterior mediastinum was thymoma (107/212, 50.5%). In posterior mediastinum, neurogenic tumor was the most common(52/67, 77.6%) and teratodermoid tumor was common in middle mediastinum(3/7, 42.9%). The most common symptom was chest discomfort(129 cases, 45.1%) and 67 cases were asymptomatic(23.4%). Benign tumors were more common(175 cases, 61.1%) than malignant tumors. In therapies, complete or partial resections were done in 190 cases(79.8%), chemotherapy or radiotherapy in 71 cases(29.8%), in 24 cases(10.1%) only biopsy was taken without any treatment. Neurogenic tumors have been reported as the most common tumors in western countries and neurogenic and teratodermoid tumor were found to be the most common tumors in the past Korean reports. But thymoma was the most common tumor in this study. Conclusion: Thymoma was the most common mediactinal tumor in this study. And thymoma was the most common tumor in anterior mediastinum neurogenic tumor in posterior rnediastinum and teratodermoid tumor in middle mediastinum
치료 후 기류제한이 호전된 만성폐쇄성폐질환 환자에서 폐용적의 변화
박훈표 ( Hun Pyo Park ),박순효 ( Soon Hyo Park ),이상원 ( Sang Won Lee ),서용우 ( Yong Woo Seo ),이정은 ( Jeong Eun Lee ),서창균 ( Chang Kyun Seo ),곽진호 ( Jin Ho Kwak ),전영준 ( Young June Jeon ),이미영 ( Mi Young Lee ),정인성 ( 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.2
한승범,이인규,박근용,전영준,황재석 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.1
To compare the preoperative localization procedures, a total of 30 parathyroid tumors were scanned preoperatively using 99mTc-201Tl subtraction scan, high-resolution ultrasonography and computerized tomography (CT). Twenty-three cases of radionuclide scintigraphy, 20 cases of ultrasonography and 29 cases of CT have been taken in 22 cases of parathyroid adenoma, 3 cases of parathyroid hyperplasia and a case of parathyroid cancer. 1) The sensitivities of parathyroid scintigraphy, sonography and CT in detecting parathyroid tumors were 86%, 60% and 74%, while the specificities of respective diagnostic modality were 92%, 92% and 98%. 2) Preoperative localization of parathyroid tumors appeared related not only to the volume of the tumor, but also to the position of the tumor. Ultrasonography and CT were not as sensitive as parathyroid scintigraphy in detecting the tumor located in the left lower lobe of parathyroid gland. 3) Common errors in localizing the tumors were easily made in cases with the volume of tumor less than 1 ㎤, with the tumor surrounded by the normal architecture or the false tumor mimicking parathyroid gland, and with the abnormal thyroid gland nearby. Neck CT was a specific method for the preperative localization especially in case of the tumors involving more than 2 parathyroid gland. 99mTc·201Tl parathyroid scintigraphy was useful for the localization of parathyroid adenomas and hyperplastic glands and the sensitivity of it exceeded that of either ultrasonography or CT. It will be necessary to evaluate the applicability of the preoperative localization modalities extensively in case of, at least, hyperparathyroidism of the primary or persistent types. (J Kor Soc Endocrino 17:52~60, 1992)
갑상선세침흡인검사에 의한 갑상선 조직 및 말초혈액의 시토킨 발현과 말초혈액 단핵구의 인터페론 감마 생성에 관한 연구
권기영,송홍석,한승범,이인규,조성래,박근용,전영준,김윤년,이규보,이재태,김보완 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.1
Cytokine production was studied in thyroid fine needle aspirates and peripheral blood and the production of interferon-gamma by peripheral blood mononuclear cell(PBMC) culture in response to interleukin-2(IL-2) stimulation was also studied from patients with hyperthyroidism, non toxic goiter, thyroid nodule. The expression of glycer aldehyde 3-phosphate dehydrogenase(GAPDH), interleukin-1beta(IL-1beta), IL-2, interleukin-8(IL-8), platelet- derived growth factor-A(PDGF-A) and interferon-gamma(IFN-gamma) chain was assessed by RT-PCR(reverse transcriptase polymerase chain reaction) in fine needle aspirates of thyroid and peripheral blood mononuclear cell : the samples were obtained from 7 patients with hyperthyroidism, 6 patients with non toxic goiter, 7 patients with thyroid nodule. A dose of IL-2(25 U/ml) was utilized to induce IFN-gamma production by PBMC from all patients. The results were as follows: 1) In case of cytokine expression of fine-needle aspirates, GAPDH and IL-1beta, IL-8 were expressed highly but IFN-gamma, IL-2 were not expressed in hyperthyroidism and non-toxic goiter, thyroid nodule. PDGF-A was expressed in hyperthyroidism and thyroid nodule but not in non toxic goiter. 2) In case of cytokine expression of PBMC, GAPDH, IL-1beta were expressed in hyperthyroidism and non toxic goiter, thyroid nodule and highly expressed after IL-2 stimulation than before. But PDGF-A was more expressed in non toxic goiter and thyroid nodule than hyperthyroidism. Also, IFN-gamma was less expressed in thyroid nodule than hyperthyroidism and non toxic goiter. 3) The incremental increase in IFN-gamma value in supernatants of PBMC culture was significantly higher in patients with non toxic goiter than that in PBMC from hyperthyroidism and thyroid nodule(p$lt;0.05). Therefore it seems that the cytokine production was found in hyperthyroidism and non toxic goiter and thyroid nodule. There were variability in their distribution each other, in general, higher expressed in hyperthyroidism than non toxic goiter. And RT-PCR Method that employed should be sufficiently sensitive to permit the analysis of cytokine gene expression in fine needle aspiration biopsies from patients with thyroid disease(J Kor Soc Endocrinol 10: 13-25, 1995)