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전승원 서울대학교 기술과법센터 2015 Law & technology Vol.11 No.1
동등생물의약품이란 백신, 항체, 호르몬, 효소 와 같이 생물체에서 유래된 것을 원료로 하는 의 약품인 생물의약품의 복제약을 의미한다. 생물의 약품의 임상에서의 사용이 많아지면서 의약품 시 장에서의 비중이 커지고 있고 그에 따라 동등생물 의약품에게도 관심이 커지고 있다. 이런 시점에서 미국에서는 2010년 생물의약품 가격경쟁 및 혁 신법(BPCIA)을 통해 동등생물의약품에 대한 규 제를 확립하였고 한국에서도 2009년 동등생물의 약품 평가 가이드라인이 배포되었다. 한국에서는 평가 규정을 제외한 규정은 소분자 합성의약품과 구별 없이 약사법에 의해 규제를 받 고 있고 미국의 제도와 비교하였을 때 대체가능 동등생물의약품이 정의되지 않은 점, 대조약의 판 매독점권 기간이 짧은 점 등이 동등생물의약품의 특성을 고려하지 못하였다고 생각된다. 허가-특허 연계제도에서는 한국에서는 대조약이 처음 허가 받을 때 관련 특허를 등재하는 특 허목록이 존재하고 이 목록에 등재된 특허를 대상 으로 특허 소송이 이루어지는데 반해 미국에서는 사전에 대조약 제공인이 등재하는 특허목록이 존 재하지 않고 동등생물의약품 신청인과 대조약 제 공인 사이의 관련 특허 목록 교환을 통해 합의하 게 된다. 양국의 허가-특허 연계제도는 이밖에도 동등생물의약품 허가 신청 통지 대상, 소송 대상 이 되는 특허, 대조약 제공인이 신청 가능한 판매 제한 조치의 유무 같은 부분에서 차이를 보이지만 대조약 제공인과 동등생물의약품 신청인 사이의 균형을 유지하려는 목적은 동일하다고 생각된다. 생물의약품은 소분자 합성의약품과 비교하였 을 때 특성이 더 복잡하여 동일한 특성의 복제약 의 제조가 더 어렵다. 이런 점을 고려하여 국민의 건강과 국내 제약산업의 성장에 도움이 되도록 동 등생물의약품에 대한 한국의 제도를 개선해야 한 다고 생각된다. Biosimilar means the copy drug of the biological product which made of materials from organisms like a vaccine, antibody, hormone or enzyme. As clinical use and market share of biological product increase, interest on biosimilars also increase. At this point, in 2010 the United States established regulations for biosimilar through Biologics Price Competition and Innovation Act (BPCIA) and also in 2009 Guidelines on the Evaluation of Biosimilar Products is distributed in South Korea. As compared to the BPCIA of the US, Korea’s regulations about biosimilar lincensure, except evaluation regulation, are written in the Pharmaceutical Affairs Law which regulates the biological products and the small molecule drug without distinction. Because Interchangeable biosimilar is not defined and exclusivity for reference product is short in Korea’s regulations, I think the character of biosimilar was not considered. There are several difference between the Patent Linkage System in Korea and the US. First, there is patent list system in Korea and only patents in the list can be handled in a suit. On the other hand, there is no such system in the US. So the biosimilar applicant and the reference product sponsor exchange the patent list and make agreement about patents which can be handled in a suit. Also there are difference in notification target, number of patents in a suit, and market restriction of biosimilar. But the purpose of the system to maintain a balance between the reference product sponsor and the biosimilar applicant is same in the both nations When compared to small molecule drug, Biological products have complicated characters and it is more difficult to make the copy drug of biological products. In this regard, the Korea’s regulations on Biosimilar should improve for the health of the people and domestic pharmaceutical industry.
전승원,Suhee Jo,정해상,Si Ra Bae 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.12
Poly(sulfosalicylic acid) nanorods (PSSA-NRs) was prepared by electrochemical deposition in PBS solutions, and the PSSA-NRs/GCE modified electrode was investigated by voltammetric methods in buffer solution. The PSSA-NRs/GCE modified electrode demonstrated a substantially enhanced electrochemical sensitivity and selectivity towards xanthine (XA) in the presence of L-ascorbic acid (AA) and uric acid (UA). The PSSA-NRs promoted the electron transfer reaction of XA, while the PSSA-NRs restrained the electrochemical response of the negatively charged AA due to the electrostatic repulsion. The anodic peak potentials of XA, UA and AA were separated by electrochemical techniques, and the interferences from AA and UA were effectively eliminated in the XA determination. The peak currents exhibited two-step linearity according to the XA concentration over the range from 0.1-10 μM with a break point of about 1 μM. The detection limit of the XA oxidation current was 0.02 μM at a signal-to-noise ratio of 3. The results indicated that the modified electrode can be used to determine XA, without interference from UA and AA, with high sensitivity, selectivity and reproducibility.
Evidence for the Significance of Vocabulary in L2 Writing
전승원 한국영어어문교육학회 2014 영어어문교육 Vol.20 No.2
This paper examines empirical and theoretical evidence for the significant role of vocabulary in developing L2 writing skills, arguing for the integration of vocabulary learning into writing instruction. Empirical studies on vocabulary and writing show not only that writing can enhance vocabulary learning, but also that an instructional focus on drawing learner’s attention to the lexico-grammatical aspects of language can be beneficial for the learners at all stages of writing. Nonetheless, these studies do not clearly define the theoretical basis for why such a focus on vocabulary in writing instruction is necessary. Therefore, the paper continues to examine Jiang’s (2000) lexical development and Levelt’s (1989, 1993) language production models and the manners in which cohesion and coherence in a text are established through the use of vocabulary. The two theoretical models and the concepts of cohesion and coherence provide support for the centrality of vocabulary in producing sentences, in connecting sentences, and in creating meaningful texts, respectively. Both empirical and theoretical evidence suggest that vocabulary may be more intrinsically related to writing than has been assumed and that it may provide the key to developing learners’ writing skills.
전승원,Dae-Cheol Jeong,Hyo Kyoung Lee,Taejun Jeong 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.8
We prepared lead ion-selective PVC membranes that were based on N,N'-bis-thiophene-2-ylmethylene-ethane-1,2-diamine as a membrane carrier. The membrane electrode has a linear dynamic range between 1.0 × 105 and 1.0 × 101 M with a Nernstian slope of 29.79 mV per decade, and its detection limit was 2.04 × 106 M at room temperature. The potentiometric response is independent of the pH of the solution in the pH range of 5-7. The proposed electrode revealed good selectivity and response for Pb2+ over a wide variety of other metal ions in pH 5.0 buffer solutions, and there was good reproducibility of the base line on the subsequent measurements. The membrane electrode has a relatively fast response time, satisfactory reproducibility and a relatively long life time.
관여도를 통제한 상태에서 국가이미지가 기업이미지에 미치는 영향: 애플의 한국소비자를 중심으로
전승원,홍성준 국제인문사회연구학회 2024 Studies on Humanities and Social Sciences (SHSC) Vol.6 No.5
Effect of Country Image on Product Image with Engagement Controlled: Focused on Apple’s Korean Consumers* Seungwon Jeon** & Sungjun Hong*** Abstract: This study analyzed the impact of the national image on the corporate image while controlling involvement and suggested that it is necessary to manage the national image in order for Korean companies to operate more actively on the overseas stage. The survey was conducted through both online and offline channels. In the case of offline, the survey was conducted centering on university students, and online was not limited to the target. As a result, 438 surveys were collected and empirical analysis was conducted. First, in the case of the involvement variable, the possibility as a control variable was confirmed by having a statistically significant positive (+) effect on the corporate image. Second, among the sub-variables of the national image, the economic image and the social and political image were found to have a statistically significant positive (+) effect on the corporate image. Through the empirical analysis results of this study, the role of the national image to enhance the corporate image was revealed. In addition, it contributed to the increase in the efficiency of policy fund input by discovering the factors to be managed first among the sub-variables of the national image. Key Words: National Image, Economic Image, Social and Political Image, Cultural Image, Involvement □ 접수일: 2024년 9월 20일, 수정일: 2024년 10월 12일, 게재확정일: 2024년 10월 20일* 본 연구는 순천향대학교 학술연구비 지원으로 수행하였음. ** 주저자, 조선대학교 경영학과 박사수료(First Author, Completion of Doctoral Course, Chosun Univ., Email: swjeon@hotmail.com) *** 교신저자, 순천향대학교 경영학과 교수(Corresponding Author, Professor, Soonchunhyang Univ., Email: hongbob@gmail.com)
제2언어 쓰기능력 향상을 위한 동시 컴퓨터 매개 의사소통 활용
전승원 ( Seung Won Jun ) 공군사관학교 2012 공사논문집 Vol.63 No.2
This study examined how synchronous computer-mediated communication (SCMC) can affectthe development of second language (L2) writing skills. The participant in this study was given6 writing prompts chosen from the Test of Written English (TWE), and was asked to writeshort essays. He wrote an initial draft and a final essay for each topic, and there was aone-on-one online conference after each draft. The essays were compared to the chat logsfor any changes the participant made. Four native speakers of English ranked the essays andtwo of them made detailed comments on them. The participant was interviewed three timesduring the observation period of three months. The findings of this study show that SCMC hadpositive effects on the development of writing skills with respect to short- and possiblylong-term revision. In addition, the participant felt more and more comfortable with writingand the conferences as the study progressed and showed a positive attitude toward usingSCMC as a tool for developing writing skills. Finally, the findings suggest that SCMC has bothadvantages and disadvantages in its application to writing conferences.