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RISS 인기검색어
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- 저자 : 장한원 ( Han Won Jang ) (검색결과 2 건)
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췌장에서 발생한 파골세포양 거대세포를 가지는 미분화 암종
장한원 ( Han Won Jang ),박원규 ( Won Kyu Park ),장재천 ( Jay Chun Chang ),김재운 ( Jae Woon Kim ),배영경 ( Young Kyung Bae ),최준혁 ( Jun Hyuk Choi ),윤성수 ( Sung Su Yun ),이동식 ( Dong Shik Lee ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.5
Undifferentiated carcinoma with osteoclast-like giant cells is a rare neoplasm of exocrine pancreas. Till recently, some cases have been reported, however histogenesis of the tumors are controversial and their characteristic findings have not been described yet. Thirty five-year-old men and 75-year-old men were presented with upper abdominal pain and a palpable mass. On computed tomography, one case showed a well enhancing solid tumor with low density and the other was showed a mainly cystic tumor with peripheral enhancement in the body and tail of the pancreas. One case accompanied multiple metastatic liver masses with subhepatic lymph node enlargement. Tumor staining was seen on angiography. Biopsy and pancreatectomy were performed. Pathological findings revealed tumors composed of neoplastic spindle shaped or pleomorphic large cells with scattered non-neoplastic osteoclast-like giant cells. In one case, there were small foci of adenocarcinoma components in the periphery of the tumor. On immunohistochemical stain, neoplastic cells showed focal positivity for epithelial membrane antigen and vimentin. Tumors were diagnosed as undifferented carcinoma with osteoclast-like giant cells. We report these rare cases with a review of literature. (Korean J Gastroenterol 2006;48:355-359)
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장한원,변우목,조길호,황미수 영남대학교의과대학 1998 Yeungnam University Journal of Medicine Vol.15 No.2
1994년 1월에서 1998년 8월까지의 영남대학교 의과대학 부속병원에서 신경베체트병으로 진단받은 9명의 환자를 대상으로 전신적인 임상증상과 자기공명영상소견을 분석한 결과 주된 전신적인 증상은 구강궤양, 안질환, 음부궤양이었으며, 자기공명영상소견에서 병소부위는 중뇌, 내포, 뇌교, 시상, 대뇌기저핵, 중소뇌각, 연수, 그리고 피지하단백질 순으로 호발되었다. 이들 병소는 T2강조영상에서 불균질의 고신호강도, T1강조영상에서 저신호 강도로 보였으며, 국소적인 조영증강이 비교적 흔하게 관찰되었다. 추적영상에서 병변의 호전 및 재발이 관찰되었으나 1년이상 추적검사에서 병변이 있던 부위에 뇌조직의 위축이 관찰되었다. 결론적으로 신경베체트병의 전신적인 임상증상과 특징적인 자기공명영상소견을 앎으로서 신경베체트병의 진단에 도움이 되리라 생각한다. MR findings in nine patients(three female, six male) with neuro-Behcet's disease were retrospectively analyzed. NeuroBehcet's disease was diagnosed on the basis of typical clinical symptoms. Involved site, pattern, signal intensity, and contrast enhancement pattern on MRI were evaluated. In addition, follow up MR imaging was performed in four patients. The midbrain(7/9), internal capsule(7/9), pons(6/9), thalamus(6/9), basal ganglia(5/9), middle cerebella peduncle(4/9), medulla oblongata(2/9) and subcortical white matter(2/9) are involved on MRI. The size of lesions was 1cm to 3cm and their margin was ill-defined and patchy. Inhomogeneous high signal intensity on the T2-weighted images and low signal intensity on T1-weighted images was seen respectvley. In four of nine cases, there was focal enhancement. On follow up MR imaging, improvement or recurrance of the lesions was found. Also in two cases of follow up cases, there was artophy in brainstem and(or) middle cerebellar peduncles. In conclusion, MR imaging with systemic clinical symptoms is useful for diagnosing neuro-Behcet's disease.
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