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Pattern of Stress-Induced Hyperglycemia according to Type of Diabetes: A Predator Stress Model
장진선,유영혜,박신영,김지운,김헌성,윤건호,조재형 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.6
Background: We aimed to quantify stress-induced hyperglycemia and differentiate the glucose response between normal animals and those with diabetes. We also examined the pattern in glucose fluctuation induced by stress according to type of diabetes. Methods: To load psychological stress on animal models, we used a predator stress model by exposing rats to a cat for 60 minutes and measured glucose level from the beginning to the end of the test to monitor glucose fluctuation. We induced type 1 diabetes model (T1D) for ten Sprague-Dawley rats using streptozotocin and used five Otsuka Long-Evans Tokushima Fatty rats as obese type 2 diabetes model (OT2D) and 10 Goto-Kakizaki rats as nonobese type 2 diabetes model (NOT2D). We performed the stress loading test in both the normal and diabetic states and compared patterns of glucose fluctuation among the three models. We classified the pattern of glucose fluctuation into A, B, and C types according to speed of change in glucose level. Results: Increase in glucose, total amount of hyperglycemic exposure, time of stress-induced hyperglycemia, and speed of glucose increase were significantly increased in all models compared to the normal state. While the early increase in glucose after exposure to stress was higher in T1D and NOT2D, it was slower in OT2D. The rate of speed of the decrease in glucose level was highest in NOT2D and lowest in OT2D. Conclusion: The diabetic state was more vulnerable to stress compared to the normal state in all models, and the pattern of glucose fluctuation differed among the three types of diabetes. The study provides basic evidence for stress-induced hyperglycemia patterns and characteristics used for the management of diabetes patients.
SSR 분자마커를 이용한 튀김옥수수 자식계통 집단의 구조 및 association 분석
장진선,장은하,사규진,김병완,김종화,이주경 한국육종학회 2013 한국육종학회지 Vol.45 No.4
본 연구는 강원도 농업기술원 옥수수연구소에서 튀김옥 수수 품종개발을 위하여 육성한 79개의 자식계통들에 대하 여 대표적인 분자마커인 SSR마커를 이용하여 집단구조 및 association mapping 분석을 실시하였다. 집단구조에 대한 분 석 결과에서 79개의 튀김옥수수 자식계통들은 groups I, II, III, IV, admixed group으로 구분되었다. 4개의 옥수수 자식 계통은 group I에 포함되었고, Group II는 총 17개의 자식계 통들이 포함되었다. 그리고 6개의 자식계통들은 Group III에 포함되었으며, 22개의 자식계통들은 Group IV에 포함되었 다. 그리고 admixed group에는 30개 옥수수 자식계통들이 포함되었다. 튀김옥수수 자식계통들에 대하여 50개 SSR 마 커와 10개의 양적 형질 사이에서 association mapping 분석 을 하였다. Q GLM 분석에서는 0.01의 유의수준에서 92개의 marker-trait association을 확인하였으며, 반면에 Q+K MLM 분석에서는 0.01의 유의수준에서 6개의 marker-trait association 을 확인되었다. 본 연구에서 79개의 튀김옥수수 자식계통들 에 대한 집단구조 및 association mapping 분석의 결과는 앞 으로 강원도농업기술원 옥수수연구소에서 튀김옥수수 품종개 발을 위한 계통 육성 및 교배조합 구성 등에 유용한 정보를 제공할 것으로 기대한다. In this study, genetic diversity and population structure among 79 popcorn inbred lines were investigated using 10 morphological traits and 50 simple sequence repeat (SSR) markers. From population structure analysis, the 79 maize inbred lines were divided into five groups: I, II, III, IV, and admixed. Among them, 4 inbred lines were assigned to group I, 17 inbred lines were assigned to group II, and 6 and 22 inbred lines were respectively assigned to groups III and IV. The rest 30 inbred lines were contained in the admixed group. Association mapping analysis for popcorn inbred lines was performed to assess the marker-trait associations between the 50 SSR markers and the 10 morphological traits. At a significance level of 0.01, we found 92 marker-trait associations using the Q GLM model. While, using the Q+K MLM model, we found 6 marker-trait associations at a significance level of 0.01. Finally, this study's assessment of population structure and association mapping of 79 popcorn inbred lines will be helpful useful for popcorn breeding programs such activities as planning crosses for hybrid and line development at Maize Experiment Station, Gangwon Agricultural Research and Extension Services.
장진선,권용수,서형원,고보건,신홍준,김유일,임성철,박철규,임정환,오인재,김영철,박하영,김태옥 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.0
Background: Percutaneous dilatational tracheostomy (PDT) is an easy and safe procedure performed in intensive care units. The aim of this study was to compare the efficacy and safety of PDT with bronchoscopic guidance with those of PDT without bronchoscopic guidance. Methods: We reviewed retrospectively the clinical data of 121 patients who underwent PDT at Chonnam National University Hospital between March 2013 and November 2016. Results: The median age of the patients was 72.0 years (interquartile range, 61.5-78.0), and 80 (66.1%) were men. Of all the patients, 44 (36.4%) underwent PDT with bronchoscopic guidance, which was unsuccessful in one patient, thereby the overall success rate of PDT being 99.2% (120/121). The number of complications was higher in patients who underwent PDT without bronchoscopic guidance than in those who underwent bronchoscopy-guided PDT, but the difference was not statistically significant (12 vs 3, p=0.251). All the complications were bleeding during or after the procedure and were easily controlled, except for a major bleeding in one patient who underwent PDT without bronchoscopic guidance and required cardiopulmonary resuscitation because of airway obstruction. Conclusions: PDT has a high success rate and a low complication rate when performed with or without bronchoscopic guidance.
장진선,신주영,김헌성,김경희,신정아,윤건호,차봉연,손호영,조재형 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.1
Background: The aims of this study are to investigate the glycemic efficacy and predictive parameters of vildagliptin therapy in Korean subjects with type 2 diabetes. Methods: In this retrospective study, we retrieved data for subjects who were on twice-daily 50 mg vildagliptin for at least 6 months,and classified the subjects into five treatment groups. In three of the groups, we added vildagliptin to their existing medication regimen;in the other two groups, we replaced one of their existing medications with vildagliptin. We then analyzed the changes in glucose parameters and clinical characteristics. Results: Ultimately, 327 subjects were analyzed in this study. Vildagliptin significantly improved hemoglobin A1c (HbA1c) levels over 6 months. The changes in HbA1c levels (ΔHbA1c) at month 6 were -2.24% (P=0.000), -0.77% (P=0.000), -0.80% (P=0.001),-0.61% (P=0.000), and -0.34% (P=0.025) for groups 1, 2, 3, 4, and 5, respectively, with significance. We also found significant decrements in fasting plasma glucose levels in groups 1, 2, 3, and 4 (P<0.05). Of the variables, initial HbA1c levels (P=0.032) and history of sulfonylurea use (P=0.026) were independently associated with responsiveness to vildagliptin treatment. Conclusion: Vildagliptin was effective when it was used in subjects with poor glycemic control. It controlled fasting plasma glucose levels as well as sulfonylurea treatment in Korean type 2 diabetic subjects.
스테로이드 치료에 반복된 호전으로 진단이 어려웠던 뇌하수체 농양
장진선,윤재승,신정아,김민희,임동준,조재형,윤건호,강무일,차봉연,손호영,홍용길 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.1
Pituitary abscess is a rare pathology, but it is a potentially life-threatening condition. Therefore, timely intervention, including antibiotics and an operation, can prevent the morbidity and mortality in such cases. A 31-year-old woman, who was 16 months after her second delivery, presented with intermittent headache for 3 months. Amenorrhea, polyuria and polydipsia were noticed and the endocrinological hormone studies were compatible with panhypopituitarism and diabetes insipidus. Pituitary MRI demonstrated a 2.3 cm sized cystic mass with an upper small nodular lesion. Her symptoms such as headache and fever were repeatedly improved whenever corticosteroid was administered, which led us to suspect the diagnosis of an inflammatory condition like lymphocytic hypophysitis. During the hormone replacement therapy, her cystic pituitary mass had grown and her symptoms progressively worsened for another two months. The patient underwent trans-sphenoidal exploration and she turned out to have a pituitary abscess. At the 3-month follow-up, amenorrhea was noticed and her residual function of the pituitary was tested by a combined pituitary stimulation test. The results were compatible with panhypopituitarism. She received levothyroxine 100 μg, prednisolone 5 mg and desmopressin spray and she is being observed at the out-patient clinic. The authors experienced a patient with primary pituitary abscess that was confirmed pathologically and we report on its clinical course with a literature review.