간질중첩증으로 발현한 시트룰린혈증 1례

장주영(Joo Young Jang),유수정(Su Jeong You),유한욱(Han-Wook Yoo),고태성(Tae-Sung Ko) 대한소아신경학회 2005 대한소아신경학회지 Vol.13 No.2

저자들은 14세 남아에서 고암모니아혈중과 이로인한 뇌증과 간질중첩증으로 발현한 시트룰린혈증을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Status epilepticus and seizure in childhood have various etiologies. Metabolic disorders may be an important cause of seizure and status epilepticus in childhood. Citrullinemia is a form of urea cycle defects and usually presents as an overwhelming neonatal illness. But in mild forms of citrullinemia, patients shows a gradual onset with frequent vomiting and developmental delay. We experienced a case of a 14-year-old boy presenting status epilepticus and hyperammonemia. The diagnosis of citrullinemia was made based on the elevated serum citrulline(about 20 times of the normal), and blood ammonia(over 500 micromol/L) as well as mutation of argininosuccinate synthetase gene. Although hemodialysis was done to remove elevated ammonia, he was expired due to hyperammonemic encephalopathy and brain death. So we suggest that metabolic disorders should be considered as one of the etiologies of status epilepticus in childhood.

원허 지운의 오색 차명상

장주영(Joo-young Jang) 국제차문화학회 2022 차문화ㆍ산업학 Vol.56 No.-

임펄스 측정잡음에 강인한 저가형 볼앤빔 시스템의 접촉식 볼 추적센서 개발

장주영(Joo Young Jang),이자승(Jaseung Lee),윤한솔(Hansol Yoon),나원상(Won-Sang Ra) 제어로봇시스템학회 2014 제어·로봇·시스템학회 논문지 Vol.20 No.11

This paper proposes a new contact type ball tracking sensor to improve the control performance of a low cost ball-and-beam system. It is well-known that the impulsive measurement noise contained in ball position measurement is one of the factors which severely degrades the ball-and-beam control performance. The impulsive ball position measurement noises often appear under the sporadical ball floating on the beam. This fact motivates us to devise a simple analog preprocessing circuit to determine whether the ball loses the contact or not. Once the abnormal ball position measurement is detected, the design problem of the ball tracking sensor can be cast into the typical state estimation problem with missing data. In order to tackle the real-time implementation issue, a steady-state Kalman filter is applied to the problem. Through the experimental results, the usefulness of the proposed scheme is demonstrated.

금속이온, 킬레이트 화합물과 키토산 혼합물의 항칸디다 상승 효과

김주원 ( Joo Won Kim ),김선휘 ( Sun Whi Kim ),최민 ( Min Choi ),김태희 ( Tae Hui Kim ),이우진 ( Woo Jin Lee ),김정민 ( Jung Min Kim ),이종찬 ( Jong Chan Lee ),장주영 ( Joo Young Jang ),박제권 ( Jae Kweon Park ) 한국키틴키토산학회 2017 한국키틴키토산학회지 Vol.22 No.2

The potential of using chitosan as a biological agent for the control of Candida albicans was investigated. A chitosan designated as an active molecular chitosan (AMC) with average molecular weight of 8.5-kDa exhibited an effective and potential anticandidal effect at 100 mg/mL. Although metal ion Zn²⁺ and EDTA had shown the significant growth inhibitory activity, but both had also shown the static effect on reversible growth inhibition, respectively, whereas AMC showed irreversible growth inhibition. In addition, anticandidal activity of those metal ions, chelating agent and a classic drug using as anticandidal agent Amphotericin B was greatly increased in the presence of AMC mg/mL. These results suggest that AMC-Zn²⁺-EDTA exerted their activities through dysregulation of the homeostasis or signaling of different cations in anticandidal effect. Thus, the combination of Zn²⁺, chelating agent EDTA and AMC may be an effective disease management strategy to prevent or delay the development of bactericidal-resistant strains.

소아 만성 B형 간염 환아에서 라미부딘의 치료 효과

이은혜,장주영,김경모,Lee, Eun-Hye,Jang, Joo-Young,Kim, Kyung-Mo 대한소아소화기영양학회 2008 Pediatric gastroenterology, hepatology & nutrition Vol.11 No.2

Purpose: Lamivudine is known to be effective for the treatment of chronic hepatitis B in adults. However, data on lamivudine therapy in pediatrics is limited. The aim of this study was to evaluate the efficacy and durability of lamivudine therapy for chronic hepatitis B in Korean children. Methods: A total of 44 children (27 males and 17 females, ages 6 months to 14.8 years, mean age 6.7 years) with chronic hepatitis B who received lamivudine (3 mg/kg/day, max 100 mg) for at least 12 months were enrolled. We evaluated the serum AST, ALT and serological HBV markers (HBsAg and anti-HBs, HBeAg and anti HBe, and HBV DNA) periodically. Predictive three year cumulative seroconversion rates were obtained using the Kaplan-Meier method. Results: Twenty one (48%) of 44 children achieved seroconversion of HBeAg by three years, while 23 (42%) children did not. HBV DNA was cleared in 34 (77%) children and the serum ALT levels were normalized in 41 children (93%). The three year cumulative seroconversion rates were 60% for HBeAg, and the clearance rates were 76% for HBV DNA. Eighteen children who discontinued lamivudine after HBeAg seroconversion maintained the therapeutic response for three years (treatment duration 13~58 months mean 24 months). Viral breakthrough developed in 12 children (27%) during the therapy and the YMDD mutation was documented in 11 children (25%). The mean duration for the development of a mutation was 22.7 months. Loss of HBsAg occurred in 6 children (14%). The pretreatment ALT levels were higher in responders; however, the differences were not statistically significant (p>0.05). Conclusion: The results of this study showed that lamivudine treatment had a favorable effect and durable therapeutic response in children with chronic hepatitis B. Long term follow-up and alternative therapy are warranted for those patients who do not respond to this treatment.

HBsAb와 HBcAb가 양성인 장기 공여자의 간조직에서 Hepatitis B Virus DNA의 발현

정창우,장주영,김경모,이승규,Jung, Chang-Woo,Jang, Joo-Young,Kim, Kyung-Mo,Lee, Sung-Gyu 대한소아소화기영양학회 2007 Pediatric gastroenterology, hepatology & nutrition Vol.10 No.2

Purpose: It has recently been reported that de novo HBV infection following liver transplantation is caused by grafts from HBcAb positive donors, and this phenomenon has been observed in one third of the liver transplant patients in our center. Therefore, we investigated the presence of HBV virus DNA in liver tissues obtained from HBcAb positive donors to determine the mechanism by which de novo HBV infection occurs. Methods: This study was conducted on 6 patients that were HBsAg negative, HBsAb positive, and HBcAb positive who were donors for liver transplantation between November 1997 and November 1998 at Asan Medical Center. We isolated DNA from a portion of liver biopsy tissues that were obtained during the operation, and then identified the surface and core region of HBV DNA using nested PCR. In addition, four children who received liver grafts from these donors were monitored to determine if they became afflicted with non-HBV related diseases while receiving prophylaxis consisting of short-term HBIG treatment and long-term treatment with an antiviral agent. Results: The surface antigen region was identified in all 6 donors and the core antigen region was observed in 4 of the 6 donors. However, no episodes of de novo HBV infection with prophylaxis were observed. Conclusion: The results of this study support the results of previous studies, which indicated that HBV infection may be the main cause of de novo HBV infection in patients that receive HBsAb positive and HBcAb positive donor grafts.

소아 크론병에서 영양 치료의 효과

서현아,김성은,장주영,김봉진,김준성,이선연,장수희,김경모,Suh, Hyun Ah,Kim, Sung Eun,Jang, Joo Young,Kim, Bong Jin,Kim, Joon Sung,Lee, Sun Youn,Chang, Soo Hee,Kim, Kyung Mo 대한소아소화기영양학회 2006 Pediatric gastroenterology, hepatology & nutrition Vol.9 No.2

Purpose: Crohn disease (CD) in children is frequently complicated by malnutrition and growth retardation. Conventional treatment with corticosteroid may also affect the growth of children, which may be alleviated by nutritional therapy. Therefore, we performed this study to evaluate the role of nutritional therapy in the treatment of CD in children. Methods: The study cohort consisted of thirty children under the age of 17 years, admitted to the Asan Medical Center from 2001 to 2005. While 11 children received nutritional therapy (NT) with an elemental diet, 19 received conventional corticosteroid therapy (ST). Comparative analysis was performed for the rate of the induction of remission, recurrence, disease activity index of pre and post-treatment, and changes of the growth using mean standard deviation score for weight (zW) and height (zH). Results: Ten of 11 children with NT and 18 of 19 children with ST completed the therapy. Two of them were lost to follow-up during the treatment. All 10 children with NT and 15 of 18 children with ST achieved remission. While there was no recurrence in children with NT, 7 with ST showed recurrence within 1 year. Pre- and post treatment Pediatric Crohn disease Activity Index (PCDAI) did not show a difference between the two groups. There were no differences in zW and zH between the two groups after 1 year of follow-up. Conclusion: This study showed that nutritional therapy could be considered instead of steroid therapy for treatment of children with CD. However, a long-term study will be needed to determine the long-term efficacy.

위식도 역류가 의심되는 소아에서 Multichannel Intraluminal Impedance-pH Metry의 유용성

이신혜 ( Shin Hye Lee ),장주영 ( Joo Young Jang ),윤인자 ( In Ja Yoon ),김경모 ( Kyung Mo Kim ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.1

Background/Aims: pH monitoring of the esophagus has been considered as the gold standard for the measurement of acid reflux. However, it has several limitations related to its inability to detect nonacid reflux. We conducted this study to characterize the proportion of acid and non-acid reflux events in children using pH-multichannel intraluminal impedance (MII) monitoring and to determine the correlation of the symptom index with non-acid and acid reflux events. Methods: Seventy-five children, aged from 9 days to 12 years, underwent 24 hour pH-MII monitoring at Asan Medical Center from March 2006 to June 2007. We investigated the underlying disease and main problems related to gastroesophageal reflux (GER) of the patients, the number of acid and nonacid reflux, symptom index, symptom sensitivity index in pH monitoring only and pH-MII monitoring. Results: While 2,247 reflux events were detected by MII, and only 967 reflux events were detected by pH probe alone. The percentage of acid reflux was 43% (967) and that of non-acid was 57% (1,280). The non-acid reflux increased at postprandial time (p<0.001). The symptom index increased when measured by pH-MII (31.1%) compared with those by pH probe alone (8.2%) (p=0.003). Conclusions: This study suggests that significant number of GER include non-acid reflux which cannot be detected by pH probe alone, therefore combining pH with MII monitoring is a valuable diagnostic tool for diagnosing GER in children. (Korean J Gastroenterol 2008;52:9-15)

심지재배를 이용한 절화장미 ‘Vital’의 생육에 미치는 영향

허무룡(Moo Ryong Huh),장주영(Ju Young Jang),박인주(In Joo Park),이정화(Jung Hwa Lee),박천호(Chun Ho Park),박중춘(Joong Choon Park) 한국원예학회 2003 한국원예학회 학술발표요지 Vol.2003 No.10

텍스트 기반 온라인 사회 상호작용(TOSI)의 습관적 이용에 대한 연구

김양하(Yang-Ha Kim),장주영(Joo-Young Jang),김민규(Min-Gyu Kim),김주환(Joo-Han Kim) 한국언론정보학회 2007 한국언론정보학보 Vol.38 No.2

다양한 디지털 매체의 발전에 띠라 멀티미디어 환경이 충분히 조성되었음에도 불구하고, 온라인상의 다양한 관계들은 여전히 텍스트 기반의 커뮤니케이션을 통해 형성되고 유지된다. 본 연구에서는 채팅으로 대표되는 이러한 텍스트 기반의 온라인 사회 상호작용(TOSI: Text-based Online Social Interaction)에 어떠한 요소들이 영향을 미치는가에 초점을 맞추었다. TOSI의 습관적 사용을 유발하는 동기로서 ‘친밀감’을 설정하였고, TOSI가 인터넷이라는 매체를 통해 이루어진다는 점에 착안하여 친밀감에 영향을 미치는 독립변인으로 인터넷 자기효능감과 매체의 시회적 실재감을 실정하였다. 구조방정식 모형을 통해 이러한 모형의 적합도를 살펴보았으며, 아물러 친밀감이라는 매개 요인 없이 인터넷 자기효능감과 사회적 실재감이 TOSI의 습관적 이용에 직접 영향을 미치는지에 대해서도 알아보았다. 연구 결과는 친밀감을 매개로 한 간접 효과가 상당히 의미 있는 것으로 나타났다. 즉, 상대방에게 강한 친밀감을 느낄수록 TOSI를 이용하려는 성향이 높았으며, 인터넷 자기효능감의 경우, 그 수치가 높다 하더라도 친밀감이 형성되지 않으면 TOSI 사용 성향에 별다른 영향을 미치지 않는 것으로 드러났다. The purpose of this paper is to explore the factors causing adolescents' habitual use of text-based online social interaction (TOSI). The authors of the present study assumed that adolescents' perceived intimacy would affect the use of TOSI. Using structural equation modeling, the influences of perceived social presence and Internet self-efficacy on habitual use of TOSI were examined indirectly as well as directly, with and without intimacy as a mediate factor, The results show that the indirect effects were proven to be stronger compared with the direct effects. Perceived intimacy appeared to encourage more frequent uses of TOSI. The effects of intimacy were even more stronger especially with those who had higher levels of Internet self-efficacy.